CN106924471A - A kind of Chinese medicine preparation for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis for treating - Google Patents
A kind of Chinese medicine preparation for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis for treating Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the field of Chinese medicines, more particularly to a kind of Chinese medicine preparation for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis for treating.Its raw material medicaments in part by weight array is into as follows：The 40g of the Radix Astragali 30, the 40g of Radix Codonopsis 30, the 40g of Snakegourd Fruit 30, the 30g of the tuber of pinellia 10, the 40g of the bighead atractylodes rhizome 30, the 40g of Poria cocos 30, the 40g of the red sage root 30, the 15g of honey-fried licorice root 5.The Chinese Herbs are notable, actual with strong points；Be mainly used in heart pain uncomfortable in chest, abundant expectoration shortness of breath, the tired weight of limbs that treatment is caused by chronic stable angina, and with abdomen is big, lassitude, indigestion and loss of appetite loose stool, cough saliva of spitting etc..
Description
Technical field
The turbid coronary disease of insufficiency of the spleen phlegm is caused by atherosclerosis for treating the invention belongs to the field of Chinese medicines, more particularly to one kind
The Chinese medicine preparation of disease.
Background technology
Modern standard of living is improved, operating pressure increase, and motion is lacked while intemperance of taking food, causes insufficiency of the spleen mistake fortune,
The turbid interior life of phlegm, in aggregation, triggers the diseases such as obesity, hyperlipidemia, coronary heart disease；Coronary heart disease is insufficiency of the spleen, and the turbid card common sympton of phlegm is main
There are feeling of oppression and pain in the chest, palpitation, abundant expectoration loose stool etc.；Coronary heart disease patient groups gradually tend to rejuvenation, coronary heart disease the is insufficiency of the spleen turbid card of phlegm
Attention extensively should be caused.
At present, doctor trained in Western medicine is control blood pressure, heart rate, coronary dilatation and reduction blood viscosity to the principle of reatment of coronary heart disease, using nitre
Esters of gallic acid medicine carries out coronary dilatation, and dyslipidemia is improved using fat-reducing medicament.But to serious patients with dyslipidemia, a kind of alone drop
Fat medicine is difficult to reach lipid-lowering effect, must be considered as drug combination.Western medicine palpus long-term prescription, there is certain side effect, palpus
Other drugs are used in combination with caution, improve symptom specific aim not strong.The traditional Chinese medical science improves the medicine of the symptoms such as coronary heart disease is uncomfortable in chest to invigorate blood circulation
Dissolving stasis, clearing and activating the channels and collaterals in the majority, the decoction that invigorating the spleen is used with the mostly diagnosis and treatment based on an overall analysis of the illness and the patient's condition of the pure and impure Chinese medicine of the fat that disappears, with not Portable belt, difficulty
The shortcomings of to mass produce.
Sijunzi Tang first recorded in《The formulary of peaceful benevolent dispensary》, it is made up of ginseng, the bighead atractylodes rhizome, Poria cocos, honey-fried licorice root；It is with ginseng
It is monarch, sweet temperature QI invigorating, strengthening the spleen and stomach；The bighead atractylodes rhizome is minister, the gas that ginseng of both having help others strengthens the spleen and stomach, more with the property of its bitter temperature, invigorating the spleen to dry,
Help spleen transporting；Assistant is with Poria cocos, and benefit profit is simultaneous excellent, and both with the strong fortune temper of the bighead atractylodes rhizome, and sweet inducing diuresis with bland drug is turbid, and makes ginseng, art benefit without stagnant；
5 use honey-fried licorice root, and sweet temperature QI invigorating helps ginseng, the power of art tonifying middle-Jiao and Qi, more simultaneous coordinating the drug actions of a prescription, and takes charge of assistant and be allowed to duty.Snakegourd Fruit Longstamen Onion Bulb half
Summer Tangyuan County side first recorded in《Synopsis Golden Chamber》, medicine group turns into：Snakegourd Fruit, Longstamen Onion Bulb, the tuber of pinellia, white wine, to treat the host of the obstruction of qi in the chest；Fang Zhong
With Snakegourd Fruit as monarch drug in a prescription, specially wash the greasy heresy of dirt, most open-minded phlegm in the heart, wide lower gas with sharp diaphragm chest wide, to control the key medicine of the obstruction of qi in the chest；The tuber of pinellia
It is minister, auxiliary Snakegourd Fruit drop inverseization drink；Assistant dissolves turbid yin with the logical chest sun of Longstamen Onion Bulb a surname.Modern pharmacological research shows that Radix Codonopsis has drop blood
Various effects such as pressure, anti anoxia, endurance, enhancing immunity of organisms, anti-aging, the contraction of regulation stomach and antiulcer；Poria cocos is more
Sugar has the effects such as anti-inflammatory, reducing blood lipid, the immune, hypnosis of enhancing, and the bighead atractylodes rhizome has the function of Gastrointestinal motility adjustment, immune system is played
Anti-inflammatory, antioxidation；The honey-fried licorice root effect such as have analgesia, antitussive and antiasthmatic, anti-arrhythmia, anti-inflammatory, regulation immune；Snakegourd Fruit can increase
Plus coronary flow, antithrombus formation, moreover it is possible to reduction blood fat, kobadrin etc..Tuber of pinellia anti-arrhythmia, suppresses blood coagulation and antithrombotic
Formed, can also eliminating the phlegm；The Radix Astragali can protect blood vessel endothelium, antithrombus formation, reduction blood fat；The red sage root has coronary dilatation arteries and veins, prevents cardiac muscle
The effect such as ischemic and heart infarction, improvement microcirculation, reduce myocardial oxygen consumption.
Normal the carrying out sanction on above-mentioned two ancient prescription basis in modern clinic, for treating coronary disease and angina pectoris, heart work(
The disease of cardiovascular systems such as energy exhaustion, myocarditis, myocardial ischemia, arrhythmia cordis.For example：The Snakegourd Fruits such as Shi Hong, Zheng Zhi Longstamen Onion Bulb half
Summer soup closes Sijunzi Tang to Quality of Life [J] Fujian traditional Chinese medicine after 62 turbid impatency type patients with coronary heart disease interventional procedures of phlegm,
2016,04:22-23, Sijunzi Tang is closed to the turbid impatency type patients with coronary heart disease percutaneous coronary chamber of phlegm with Gualou Xiebai Banxia Tang
Transluminal Angioplasty (PCI), patient's quality of life is improved after treatment, and angina pectoris attacks number of times is reduced.Piao Zhi favour strengthening the spleen and reducing phlegm is ruled by law
Clinical research [D] the Shandong Traditional Chinese Medicine University for the treatment of coronary heart disease premature beat, 2004, it uses strengthening the spleen and reducing phlegm method, with modified six nobles decoction
The side treatment coronary heart disease premature beat card insufficiency of the spleen turbid person of phlegm of category, symptom improves obvious after treatment, and blood fat is significantly reduced.The gorgeous melons of Yang Xiao wither Chinese onion
Clinical research [D] the Hubei College Of Traditional Chinese Medicine of the Bai Banxia Tongas taste treatment turbid numbness type Treating Stable Angina Pectoris of Coronary Artery Disease of phlegm, 2007,
With Gualou Xiebai Banxia Tang plus taste side's treatment turbid impatency type stable angina cordis of phlegm, it is possible to decrease Treating Patients of Angina Pectoris quick C high
Reactive protein, Carotid Intimal-medial Thickness, improve blood lipid level, and reduction of patient coronary disease and angina pectoris symptom curative effect is true
Cut, the symptom improvement result to pectoralgia, uncomfortable in chest, shortness of breath, abundant expectoration is especially pronounced.
In above-mentioned Clinic Case, it is higher than WENXIN KELI group that modified six nobles decoction group improves total effective rate for tcm symptom,
Especially shortness of breath and fatigue, uncomfortable in chest, limbs are heavy, dizzy, the indigestion and loss of appetite aspect of deficiency of food；The tcm syndrome index for observing the obstruction of qi in the chest is mainly chosen
Pectoralgia, shortness of breath, tired, powerless, palpitaition etc. five, and for other the insufficiency of the spleen turbid symptom of phlegm such as gastral cavilty feeling of fullness, syndrome characterized by dyspnea, cough saliva phlegm
Turbid, insomnia and dreamful sleep or somnolence, dimly red tongue, greasy tongue, veins is sliding or string are slided and do not make specific observation and record, and observation result has been owed
Whole, the curative effect of its main and disease is simultaneously imprecise.And Chinese medicine preparation flavour of a drug are more, clinical test lacks improves journey for tcm symptom
The description of degree, improves without the stronger specific aim of embodiment for specific symptom.For medicine preparation, experiment medication is decocting
Agent, may lose some fragrant ingredients and liposoluble constituent in decoction of medicinal ingredients decoction process.In addition, no matter in hospital pharmacy
Boil medicine or patient is in and voluntarily boil medicine, the duration and degree of heating and time need to be paid close attention to during decoction, medicinal material is stirred at any time and avoids being burned, decoction process
Waste time and energy；And medicine dose is big, takes up too much space, not Portable belt；Even if decocting well-done decoction bagging and packaging, there is also and guarantee the quality
Phase is limited, the shortcomings of be difficult storage, and take temperature and be difficult to control to.Have research is carried out to part Traditional Chinese medicine granule and decoction
Compare, no matter on chemical composition, pharmacological action or clinical therapeutic efficacy, Compatible Granule can be equal to decoction for as a result display
It is beautiful.Chinese medicine preparation is made pill or granule, while decoction drug effect is ensured, more can be mass-produced, be convenient for carrying,
Be easy to storage, the advantages of dose is small.Chinese medicine preparation composition is clear and definite, can carry out purification using modern technologies in pharmaceutical factory and add
Work, is produced in batches, meets the market demand and patient demand.The Chinese medicine preparation of pill or granule is made, can be dispensed and be taken
Band, takes up space small, instant-drink or with water delivery service, carries, takes simple and convenient.
In sum, research and develop with strong points, drug effect and significantly alleviate Chinese medicine preparation uncomfortable in chest, it appears be particularly important.
The content of the invention
Regarding to the issue above, the present invention is provided and a kind of causes the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis for treating
Chinese medicine preparation.The Chinese Herbs are notable, actual with strong points；It is mainly used in the heart that treatment is caused by chronic stable angina
The tired weight of pain uncomfortable in chest, abundant expectoration shortness of breath, limbs, and with abdomen is big, lassitude, indigestion and loss of appetite loose stool, cough saliva of spitting etc..
To achieve these goals, the Chinese medicine preparation that the present invention is provided, its bulk drug constitutes as follows by weight：Radix Astragali 30-
40g, Radix Codonopsis 30-40g, Snakegourd Fruit 30-40g, tuber of pinellia 10-30g, bighead atractylodes rhizome 30-40g, Poria cocos 30-40g, red sage root 30-40g, honey-fried licorice root
5-15g。
To achieve these goals, the present invention weighs each raw material by required weight, and steam distillation extracts volatile oil；Distillation
The aqueous solution afterwards is collected with the another device of volatile oil；The dregs of a decoction add water decoction 2-3 times, collecting decoction and distillation rear solution, filter,
Under the conditions of 50 DEG C, filtrate is concentrated into the thick paste that relative density is 1.20-1.22；Thick paste is mixed in proportion with proper auxiliary materials
Afterwards, add volatile oil to be made preparation, be distributed into bag.
Described preparation is granule, pill, powder, oral liquid, disintegrating tablet or Disket.Described auxiliary material is sugarcane
Sugar, dextrin, honey or starch etc..
The property of medicine analysis of each raw material in above-mentioned prescription.
The Radix Astragali：Slightly warm in nature, it is sweet.Returns spleen, lung channel.Tonifying Qi and lifting yang, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, row is stagnant to promote blood circulation；Treatment spleen
Stomach Qi deficiency, insufficiency of the spleen with overabundance of dampness etc. are demonstrate,proved, alone to treat cardiac insufficiency symptoms include spiritlessness and weakness, palpitation etc., are closed with the medicine such as Radix Codonopsis
With coronary heart disease symptoms include palpitation, pained, lassitude hypodynamia uncomfortable in chest etc. can be controlled；Modern pharmacological research proves, the Radix Astragali have step-down,
Improve myocardial contraction diastolic function, protection cardiac muscle, increase coronary flow, the effect of protection heart function.
Radix Codonopsis：It is mild-natured, it is sweet.Returns spleen, lung channel.Reinforce the spleen to benefit the lung, nourishes blood and promotes the production of body fluid.It is physically weak tired caused by deficiency-weakness of spleen-QI with controlling
Idle, anorexia and loose stool etc. is demonstrate,proved.The medicines such as Compatibility with Radix Astragali are shared can control coronary heart disease symptoms include palpitation, pained, lassitude hypodynamia uncomfortable in chest etc..It is existing
Proved for pharmacological research, Radix Codonopsis has bidirectional modulation blood pressure, suppresses the effect such as platelet aggregation, and coronary heart disease and myocardial ischemia is drawn
That rises uncomfortable in chest pained has improvement result.
Snakegourd Fruit：It is cold in nature, sweet and slightly bitter taste, return lung, stomach, large intestine channel；Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens；The turbid numbness resistance for the treatment of phlegm, chest sun
Obstruction of qi in the chest pectoralgia caused by obstructed, to activate yang and remove abstruction, resolving sputum open chest；Also control accumulation of pathogens in chest caused by combination of phlegm and heat, symptoms include chest diaphragm feeling of fullness, by it then
Bitterly；Modern pharmacological research shows Snakegourd Fruit energy coronary artery dilator, increases coronary flow, and heart can be suppressed during larger dose, reduces
Myocardial contractive power, reducing heart rate.
The tuber of pinellia：It is warm in nature, taste is pungent, returns spleen, stomach, lung channel.It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；The turbid retardance for the treatment of phlegm,
Chest is opened in hypofunction of YANG QI in chest, the obstruction of qi in the chest chested pain radiating to the back, resolving sputum；Control the accumulation of pathogens in chest of combination of phlegm and heat, clearing heat and eliminating phlegm, dissolving lump and resolving mass；Control damp and hot resistance
Stagnant, weakness of the spleen and the stomach epigastric fullness expires, and dispersing the stagnated pathogen with pungent drugs and lowering the adverse QI with bitter drugs opens ruffian dissipating bind.
The bighead atractylodes rhizome：It is warm in nature, it is bitter, sweet.Returns spleen, stomach.Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect；Weakness of the spleen and the stomach all cards are treated, with the red sage root
The disease category syndrome of deficiency of both heart and spleen such as treatment palpitaition, shortness of breath and fatigue, insomnia and dreamful sleep is shared Deng medicine.
Poria cocos：It is mild-natured, it is sweet, light；Returns spleen, kidney, the heart channel of Hang-Shaoyin.Clearing damp and promoting diuresis, invigorating the spleen, antitoxic heart-soothing and sedative；Treatment the insufficiency of heart and spleen it
Palpitaition is uncomfortable in chest, phlegm and retained fluid, diarrhea etc..
The red sage root：Cold nature, bitter.The thoughts of returning home, Liver Channel；Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire；The treatment coronary heart disease heart is twisted
Bitterly, symptoms include uncomfortable in chest, pareordia shouting pain etc..
Honey-fried licorice root：It is mild-natured, sweet, the thoughts of returning home, lung, spleen, stomach；Invigorate the spleen and benefit qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；
Treatment syndrome of deficiency of spleen qi, severe palpilation, intermittent pulse caused by the heart qi deficiency etc..
With the Radix Astragali, Radix Codonopsis as monarch in the present invention, Radix Astragali tonifying Qi and lifting yang, blood-nourishing of promoting the production of body fluid, Radix Codonopsis nourishing generate fluid, function of spleen and stomach regulating,
Two medicines are shared, and are replenished qi to invigorate the spleen as a means of source of generating QI and blood；Snakegourd Fruit, the tuber of pinellia are minister, and Snakegourd Fruit is sweet to tremble with fear into stomach, kind to wash phlegm dissipating bind, qi-regulating
Chest wide；Tuber of pinellia pungent-warm resolving sputum, dissolving lump and resolving mass, both cold property sweet with Snakegourd Fruit, increased Snakegourd Fruit resolving sputum, opened the work(of chest again；The bighead atractylodes rhizome, Poria cocos,
The red sage root is assistant, and it is all excellent that Poria cocos mends profit, and with the strong fortune temper of the bighead atractylodes rhizome, it is turbid to ooze dampness removing again, ginseng, art is mended without stagnant；Red sage root work(is kind to live
Blood and dissolving stasis, help Snakegourd Fruit, tuber of pinellia blood-activating and qi-promoting to relieve pain；The sweet temperature QI invigorating of honey-fried licorice root, helps the power for replenishing gas, again can resolving sputum, and emergency stops
Bitterly, more simultaneous coordinating the drug actions of a prescription, to make medicine.
Beneficial effects of the present invention.
The treatment chronic stable angina pectoris that are made up of pure Chinese medicine of the present invention and the heart pain uncomfortable in chest, abundant expectoration shortness of breath, the limb that cause
The tired weight of body, and with lassitude, indigestion and loss of appetite loose stool, the active drug for coughing the illnesss such as saliva of spitting, from traditional tcm prescription " four gentleman
Soup " and " Gualou Xiebai Banxia Tang " share exploitation.Gualou Xiebai Banxia Tang, Sijunzi Tang compatibility relationship are clear and definite, curative effect is true
Cut significantly, but two ancient prescriptions mixture be market blank, but original side combine contained by flavour of a drug quantity it is more, it is imprecise to the ill,
The aspects such as active principle extraction, quality control, cost control many unfavorable factors for large-scale industrial production brings.
Coronary heart disease belongs to the traditional Chinese medical science " obstruction of qi in the chest " category, has eating and drinking without temperance, such as overfeeding delicious food savoury Modern human populations more, so that taste are damaged
Wound, transporting loses strong, accumulatively wet raise phlegm, the peaceful and spacious area in upper criminal ambition, checks heart-yang, chest sun mistake exhibition, functional activity of QI being not smooth, heart vessel blockage stasis, and
Into the obstruction of qi in the chest.Therefore focused in treatment replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity.With the Radix Astragali, Radix Codonopsis as monarch in prescription, the sweet temperature of the Radix Astragali, returns spleen,
Lung channel, tonifying Qi and lifting yang, blood-nourishing of promoting the production of body fluid；Radix Codonopsis is sweet flat, and returns spleen, lung channel, nourishing generate fluid, function of spleen and stomach regulating, two medicines are shared, and are replenished qi to invigorate the spleen
As a means of source of generating QI and blood, chest sun is rouse oneself with a surname's numbness of activating yang.Snakegourd Fruit, the tuber of pinellia are minister, and Snakegourd Fruit is sweet to tremble with fear into stomach, kind to wash phlegm dissipating bind, are managed
Gas chest wide；Tuber of pinellia pungent-warm resolving sputum, dissolving lump and resolving mass, both cold property sweet with Snakegourd Fruit, increased Snakegourd Fruit resolving sputum, opened the work(of chest again.The bighead atractylodes rhizome, Fu
Siberian cocklebur, the red sage root are assistant, and the bighead atractylodes rhizome is warm in nature, strengthening the spleen and replenishing qi, help stilbene, ginseng to rise and lift yang-energy；Poria cocos is sweet light flat, and returns spleen, kidney, the heart channel of Hang-Shaoyin mend profit all
Excellent, both with the strong fortune temper of the bighead atractylodes rhizome, it is turbid to ooze dampness removing again, ginseng, art is mended without stagnant；Red sage root hardship is slightly cold, the thoughts of returning home, Liver Channel, and work(is kind to live
Blood and dissolving stasis, help Snakegourd Fruit, tuber of pinellia blood-activating and qi-promoting to relieve pain.To make, sweet temperature QI invigorating helps the power for replenishing gas to honey-fried licorice root, again can resolving sputum, it is and slow
Anxious analgesic, more simultaneous coordinating the drug actions of a prescription.
Proved by clinical test, this prescription can significantly improve chest impediment and cardialgia, expelling phlegm and resolving turbidity；With composition it is simple, match somebody with somebody
5 is proper, consumption is smaller, determined curative effect the advantages of；Full side's prescription safety, Small side effects；Granular preparation is adapted to large-scale production,
Have the advantages that easy to carry, evident in efficacy.
Specific embodiment
With reference to specific embodiment, the present invention will be described in detail.
Embodiment 1.
A kind of granule for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis, its raw material is as follows by weight ratio：It is yellow
Stilbene 30g, Radix Codonopsis 30g, Snakegourd Fruit 30g, tuber of pinellia 20g, bighead atractylodes rhizome 30g, Poria cocos 30g, red sage root 30g, honey-fried licorice root 10g.
The preparation method of above-mentioned Chinese herbal granules is as follows：10 times of amount water are added with above-mentioned 8 taste medicinal material, steam distillation is extracted
Volatile oil 4 hours, the aqueous solution after distillation is collected with the another device of volatile oil；The decoctings that the dregs of a decoction add 8 times of amounts are boiled twice, and every time 2
Hour, collecting decoction is concentrated into the thick paste that relative density is 1.20-1.22 with rear solution, filtration is distilled（50℃）；Thick paste with
Dextrin, sucrose press 1:3:1 ratio mixing, adds ethanol in proper amount to be made particle, and volatile oil is sprayed into after drying, and dispenses.
Embodiment 2.
A kind of granule for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis, its raw material is as follows by weight ratio：It is yellow
Stilbene 35g, Radix Codonopsis 35g, Snakegourd Fruit 32g, tuber of pinellia 15g, bighead atractylodes rhizome 30g, Poria cocos 35g, red sage root 30g, honey-fried licorice root 6g.
Embodiment 3.
A kind of granule for causing the turbid coronary heart disease of insufficiency of the spleen phlegm by atherosclerosis, its raw material is as follows by weight ratio：It is yellow
Stilbene 40g, Radix Codonopsis 40g, Snakegourd Fruit 40g, tuber of pinellia 18g, bighead atractylodes rhizome 38g, Poria cocos 40g, red sage root 40g, honey-fried licorice root 5g.
First, clinical test.
Using random, control, double blinding, multicenter optimal efficiency clinical trial design, with control group（Routine medication）Suffer from
Person 80 compares, the turbid numbness resistance card patient 80 of preparation Coronary Intervention stable angina cordis phlegm prepared with embodiment 1
(i.e. test group), intervenes 12 weeks, follow-up 2 weeks, clinical efficacy of the observation embodiment 1 for Treating Patients of Angina Pectoris.Two groups of trouble
The improvement situation of person, is shown in Table 1；Test group patient's Syndrome in TCM marquis's individual event symptom disappearance rate analyzes situation, is shown in Table 2；Test group patient
Blood fat and improving situation, is shown in Table 3.
The test group of table 1. and the improvement situation of control group patient.
Note：Compare with control group: ** P<0.05；It can be seen that comparing with control group, test group can significantly reduce patient's heart strand
Pain attack times (P<0.05), illustrate that the prescription can more excellently improve angina pectoris situation.
The test group patient's Syndrome in TCM marquis's individual event symptom disappearance rate of table 2. analyzes situation (FAS).
Note：Compare with control group: ** P<0.05；It can be seen that comparing with control group, administration group can significantly improve limbs of patient
The tcm syndrome such as heavy, sallow complexion, burnout, weak, (P<0.05), illustrate that the prescription can more excellently improve patient's heart strand
Pain situation.
The test group patients with lipid of table 3. improves situation (FAS).
Note：Compare with control group: ** P<0.05；It can be seen that comparing with control group, administration group can significantly reduce the total courage of patient
Sterol, low-density lipoprotein, ox-LDL, HMG-COA reductase (P<0.05), illustrate that the prescription can more excellently improve patient
Blood lipid level.
Test group patient antiinflammatory action (FAS) of table 4..
Note：Compare with control group: ** P<0.05.
It can be seen that compare with control group, fat eliminating Anxin Granules can significantly reduce high-sensitive C-reactive protein, homocysteine,
Chemotactic factor (CF) MCP-1, illustrates that the prescription has more excellent antiinflammatory action.
Case 1：First visit：Zhang, man, 70 years old, the first visit of March 15 in 2015, " pain uncomfortable in chest is made 2 years repeatedly, aggravates 3 for main suit
My god "；Before patient 2 years, after heavy drinking and overfeeding delicious food savoury, there is pain uncomfortable in chest, with abundant expectoration shortness of breath, lassitude.Rest about 5
Minute, above-mentioned symptom spontaneous remission；Patient goes up symptom recurrent exerbation over 2 years, once go to a doctor in Shenyang * * hospitals, is diagnosed as " coronary disease
Sick stable angina cordis ", specific therapeutic scheme is unknown；Before 3 days, patient sends out again without obvious inducement, above-mentioned symptom, after normal
Rule doctor trained in Western medicine Primary Care, effect on driving birds is not good.To ask further therapy of combing traditional Chinese and Western medicine, go to a doctor in the attached doctor of Liaoning University of TCM
Institute；Look into electrocardio diagram：Sinus rhythm, 78 beats/min, accidental room morning, pink tongue, tongue is greasy in vain, wiry and rolling pulse；Color Sonography shows：2nd, three
Reflux that cusp is slight, aortosclerosis changes；EF:62%；Biochemical analysis：T-CHOL 5.30mmo/L, triglycerides 3.25
Mmo/L, low-density lipoprotein 4.70mmo/L.The dialectical turbid card of insufficiency of the spleen phlegm；Therapy：Replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity；Square medicine：According to reality
14 pairs of 1 medication of example is applied, 100ml twice-dailies warmly take；Two examine：After two weeks, patient examines again, and pain symptom uncomfortable in chest has been delayed earlier above
Solution, lassitude hypodynamia symptom mitigation；Disposal：Patient is advised to take a good rest；Continue oral 7 pairs of we, with continual cure pain uncomfortable in chest, burnout
It is weak to wait malaise symptoms；Three examine：Patient examines again after one week, and private prosecution pain symptom uncomfortable in chest has disappeared, and lassitude hypodynamia symptom is obvious
Alleviate, tongue is weak, tongue is thin white, deep-slow pulse.
Note：It is coronary heart disease that this case patient's doctor trained in Western medicine is clarified a diagnosis（Stable angina cordis）, dyslipidemia.Patient is old age
Male, this aged debility, addiction delicious food savoury and excessive drinking, with the passing of time injure taste in addition, cause temper virtual loss.Li Dong Yuan has
Cloud " disorder of the spleen and stomach caused by internal damage, all kinds of diseases and ailments are by giving birth to ".Insufficiency of the spleen and cause water-damp not being transformed, sthenia symptoms caused by asthenia, generation phlegm is turbid.So as to occur insufficiency of the spleen phlegm it is turbid it
As.For this case, treatment should treat both principal and secondary aspect of disease, and replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity is laid equal stress on.The Radix Astragali, Radix Codonopsis in side, replenish qi to invigorate the spleen as a means of
Source of generating QI and blood.Snakegourd Fruit, the tuber of pinellia, resolving sputum, open chest, dissipating bind；Poria cocos benefit profit is all excellent, and fortune temper can be good for the bighead atractylodes rhizome, can ooze again
Dampness removing is turbid；The red sage root, promoting blood circulation helps Snakegourd Fruit, tuber of pinellia blood-activating and qi-promoting to relieve pain.Honey-fried licorice root, QI invigorating resolving sputum, relieving spasm to stop pain, more simultaneous tune
With all medicines.We treat both principal and secondary aspect of disease, and can replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity.
The first visit of case 2.：Certain is thanked, female, 55 years old, the first visit on the 8th of September in 2015, main suit " uncomfortable in chest, shortness of breath recurrent exerbation 1 year,
Aggravate 3 days "；Before patient 1 year, uncomfortable in chest, shortness of breath after fatigue, with lassitude, the tired weight of limbs receives difference.Can be certainly after rest 3-5 minutes
Row is alleviated.Patient's above-mentioned symptom discontinuity breaking-out over 2 years, can alleviate after rest, once remove * * hospital admissions, but do not advise over one year
Rule medication；Before 3 days, patient is sent out again without obvious inducement, above-mentioned symptom, and compares earlier above, and symptom is substantially aggravated, buccal nitroglycerin
After alleviate, to seek further systematic treating, go to a doctor in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine's outpatient service；Look into electrocardio diagram：Dou Xingxin
Rule, 88 beats/min, substantially normally；Patient's body is partially fat, and there is indentation on tongue is weak side, and tongue is greasy in vain, and deeptensepulse is slided；Color Sonography shows：Sustainer
Hardening changes；EF:65%；Biochemical analysis：T-CHOL 5.20mmo/L, low-density lipoprotein 4.15mmo/L.Dialectical insufficiency of the spleen phlegm is turbid
Card；Therapy：Replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity；Square medicine：According to 14 pairs of 1 medication of embodiment, 100ml twice-dailies warmly take；Two examine：Two weeks
Further consultation afterwards, uncomfortable in chest, shortness of breath symptom is relieved, lassitude, and the tired weight of limbs substantially mitigates earlier above；Disposal：Patient is advised to note stopping
Breath；Continue oral 7 pairs of we, to replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity；Three examine：Further consultation after one week, tongue is weak, tongue is thin white, deep-slow pulse.From
Tell that uncomfortable in chest, shortness of breath symptom disappears substantially, without significant discomfort symptom.
Note：It is coronary heart disease that this case patient's doctor trained in Western medicine is clarified a diagnosis（Stable angina cordis）, dyslipidemia.Early in China
Song, first period, the saying for just having " the fat many phlegm of people, many fire of lath ".Patient's body of this case is fat, with reference to patient is uncomfortable in chest, shortness of breath,
With lassitude, the tired weight of limbs receives difference.There is indentation on tongue is weak side, and tongue is greasy in vain, the Clinical symptoms such as deeptensepulse cunning, is not difficult to discern this patient
It is the obstruction of qi in the chest that insufficiency of the spleen phlegm is turbid.For this card, we application first recorded in《The formulary of peaceful benevolent dispensary》Sijunzi Tang close first recorded in
《Synopsis Golden Chamber》Gualou Xiebai Banxia Tangization cut out to replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity.Radix Astragali tonifying Qi and lifting yang in side, blood-nourishing of promoting the production of body fluid,
Radix Codonopsis nourishing generate fluid, function of spleen and stomach regulating, two medicines are shared, and are replenished qi to invigorate the spleen as a means of source of generating QI and blood；Snakegourd Fruit, specially washs the greasy heresy of dirt, most
The phlegm for slitting in the heart, wide lower gas is with sharp diaphragm chest wide；The auxiliary Snakegourd Fruit drop inverseization drink of the tuber of pinellia；Poria cocos benefit profit is all excellent, with the strong fortune temper of the bighead atractylodes rhizome,
Dampness removing can be oozed again turbid, ginseng, art is mended without stagnant；Red sage root work(is apt to promoting blood circulation, helps Snakegourd Fruit, tuber of pinellia blood-activating and qi-promoting to relieve pain.Honey-fried licorice root,
Sweet temperature QI invigorating, resolving sputum, relieving spasm to stop pain, coordinating the drug actions of a prescription.The work(of " replenish qi to invigorate the spleen, expelling phlegm and resolving turbidity " is played altogether.
Claims (7)
1. a kind of Chinese medicine preparation for treating the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm, it is characterised in that it is former
Material medicine is included by number：Radix Astragali 30-40g, Radix Codonopsis 30-40g, Snakegourd Fruit 30-40g, tuber of pinellia 10-30g, bighead atractylodes rhizome 30-40g, Poria cocos 30-
40g, red sage root 30-40g, honey-fried licorice root 5-15g.
2. it is used to treat the Chinese medicine preparation of the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as claimed in claim 1, its
It is characterised by, its raw material medicaments in part by weight array is into as follows：30 parts of the Radix Astragali, 30 parts of Radix Codonopsis, Snakegourd Fruit 30g, tuber of pinellia 20g, the bighead atractylodes rhizome
30g, Poria cocos 30g, red sage root 30g, honey-fried licorice root 10g.
3. it is used to treat the Chinese medicine preparation of the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as claimed in claim 1, its
It is characterised by, its raw material medicaments in part by weight array is into as follows：Radix Astragali 35g, Radix Codonopsis 35g, Snakegourd Fruit 32g, tuber of pinellia 15g, bighead atractylodes rhizome 30g,
Poria cocos 35g, red sage root 30g, honey-fried licorice root 6g.
4. it is used to treat the Chinese medicine preparation of the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as claimed in claim 1, its
It is characterised by, its raw material medicaments in part by weight array is into as follows：Radix Astragali 40g, Radix Codonopsis 40g, Snakegourd Fruit 40g, tuber of pinellia 18g, bighead atractylodes rhizome 38g,
Poria cocos 40g, ginseng 40g, honey-fried licorice root 5g.
5. the Chinese medicine system for treating the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as described in claim 1-4 is any
Agent, it is characterised in that described preparation is granule, pill, powder, oral liquid, disintegrating tablet or Disket etc..
6. the Chinese medicine system for treating the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as described in claim 1-5 is any
Agent, it is characterised in that described auxiliary material is sucrose, dextrin, honey or starch.
7. the Chinese medicine system for treating the coronary heart disease chronic stable angina pectoris turbid card of insufficiency of the spleen phlegm as described in claim 1-6 is any
Agent, it is characterised in that specifically include following steps：Each raw material is weighed by required parts by weight, steam distillation extracts volatile oil；
The aqueous solution after distillation is collected with the another device of volatile oil；The dregs of a decoction add water decoction 2-3 times, collecting decoction and distillation rear solution, filter
Cross, under the conditions of 50 DEG C, filtrate is concentrated into the thick paste that relative density is 1.20-1.22；Thick paste is mixed in proportion with proper auxiliary materials
After uniform, add volatile oil to be made preparation, be distributed into bag.
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| CN113262262A (en) * | 2021-07-07 | 2021-08-17 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating phlegm-heat stasis type stable coronary heart disease and preparation method thereof |
| CN115089676A (en) * | 2022-06-20 | 2022-09-23 | 江苏省中医药研究院 | Application of swertia mileensis-containing traditional Chinese medicine compound composition in preparation of secondary prevention medicine for treating coronary heart disease |
| CN116942771A (en) * | 2023-08-20 | 2023-10-27 | 谷医堂(湖南)健康科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and application thereof |
| CN116942771B (en) * | 2023-08-20 | 2023-12-22 | 谷医堂(湖南)健康科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and application thereof |
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