CN106923346B - Selected composite vitamin health product and application thereof - Google Patents

Selected composite vitamin health product and application thereof Download PDF

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Publication number
CN106923346B
CN106923346B CN201710143132.3A CN201710143132A CN106923346B CN 106923346 B CN106923346 B CN 106923346B CN 201710143132 A CN201710143132 A CN 201710143132A CN 106923346 B CN106923346 B CN 106923346B
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vitamin
powder
health food
fruit powder
essence
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CN106923346A (en
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张磊
张朝当
陈平
王滨燕
徐希平
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AUSA PHARMED Ltd.
SHENZHEN FULAITE NUTRITION & HEALTH Co.,Ltd.
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Shenzhen Fulaite Nutrition & Health Co ltd
AUSA PHARMED Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a health food which has the effect of assisting in preventing cardiovascular diseases or has a health-care function. The health food of the invention is prepared from vitamin A, vitamin D and vitamin B12And proper auxiliary materials, wherein the content of vitamin A is 160-800 mug, the content of vitamin D is 2-15 mug, and vitamin B12The content is 0.5 to 10 μ g. The invention has the advantages that: the functional relevant vitamins are selected, the formula is scientific and reasonable, the components have efficacy synergistic effect, and the health-care food is used for assisting in preventing cardiovascular diseases and embodies the advantage of accurate nutrition.

Description

Selected composite vitamin health product and application thereof
Technical Field
The invention relates to a health food, in particular to a health food which can assist in preventing cardiovascular diseases.
Background
According to the data of 'report 2015 for cardiovascular diseases in China', the death cause of cardiovascular diseases accounts for more than 42% in 2014, and is influenced by factors such as aging, so that the trend is still aggravated at present, and the cardiovascular diseases become the biggest health threat and public health problems in China. With the development of society, the diet of residents is greatly changed, and the compliance of residents on diet guidelines is inversely related to the risks of cardiovascular diseases and the like. Data from reports on nutrition and chronic disease states of Chinese residents (2015) indicate that partial nutrition deficiency of residents such as vitamin A, D is still serious, and investigation shows that the normal blood vitamin D level is only 0.67% in people aged more than 20 years in large Chinese cities, and the serious deficiency reaches 21%.
Vitamin A is commonly used for preventing nyctalopia and xerophthalmia, while vitamin D is mostly used for regulating calcium and phosphorus metabolism, promoting calcium absorption and bone growth, and preventing and treating rickets in children and osteoporosis in the elderly, and the two are not yet applied to the prevention of cardiovascular and cerebrovascular diseases. Vitamin A has effects in inactivating oxygen free radicals, preventing lipid peroxidation, and resisting oxidationThe research shows that the intake of sufficient vitamin A is beneficial to reducing the risk of cardiovascular diseases; vitamin D can inhibit activity of renin-angiotensin-aldosterone system, and has cardiovascular protection effects of preventing atherosclerosis, myocardial hypertrophy and myocardial fibrosis, while deficiency of vitamin D causes atherosclerosis, vascular calcification and inflammatory reaction. In addition, elevated plasma homocysteine (Hcy) is also associated with atherogenesis, the risk of cardiovascular events, and vitamin B12Cardiovascular protection is achieved by lowering the Hcy concentration.
At present, multiple vitamin complex products in the market are pure nutritional supplements and can be taken by various people, but the actual health care effect is unpredictable because of multiple components, low content of each vitamin and lack of pertinence. Therefore, the invention aims to develop a nutritional health-care product for assisting in preventing cardiovascular diseases, which is a significant improvement on the existing vitamin products and conforms to the current trend of accurate nutrition.
Disclosure of Invention
The invention aims to provide a health food with the function of assisting in preventing cardiovascular diseases.
In order to achieve the purpose, the invention adopts the following technical scheme:
a health food for adjuvant prevention of cardiovascular diseases comprises the following components:
(1) vitamin A
(2) Vitamin D
(3) Vitamin B12
(4) And (5) auxiliary materials.
In the health food, the content of vitamin A is 160-800 mug, the content of vitamin D is 2-15 mug, and vitamin B12The content is 0.5 to 10 μ g.
Preferably, the health food has the vitamin A content of 400-800 mu g, the vitamin D content of 5-15 mu g and the vitamin B12The content is 5-10 mug.
In the present invention, the vitamin D includes vitamin D1、D2、D3One or a plurality of combinations thereof。
The health food can be prepared into oral preparations such as common tablets, chewable tablets, soft capsules, hard capsules, powder, granules and the like.
In the invention, the auxiliary materials are selected from one or a combination of more of a filling agent (dispersing agent), a solubilizer, a bonding agent, a disintegrating agent, a lubricant, a suspending agent, a flavoring agent, a stabilizing agent, an edible pigment, an embedding material and a coating premix.
The filler (dispersing agent) comprises one or more of starch, soluble starch, dextrin, maltodextrin, potato starch, corn starch, wheat starch, D-mannitol, calcium hydrophosphate, anhydrous calcium hydrophosphate, maltose, xylitol, sorbitol, microcrystalline cellulose, isomaltulose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, lactose, pregelatinized starch, edible vegetable oil, polyethylene glycol and the like.
The suspending agent comprises one or more of beeswax, insect wax, lecithin, glyceryl monostearate, ethyl cellulose and the like, the wetting agent comprises purified water and ethanol, and the adhesive comprises one or more of hydroxypropyl methyl cellulose, povidone, hydroxypropyl cellulose, sodium carboxymethyl cellulose, starch, methyl cellulose, ethyl cellulose, gelatin, polyethylene glycol, pregelatinized starch, sucrose, glucose and the like.
The disintegrating agent comprises one or more of starch, carboxymethyl starch sodium, crospovidone, croscarmellose sodium, low-substituted hydroxypropyl cellulose, sodium bicarbonate, citric acid and the like.
The lubricant comprises one or more of magnesium stearate, stearic acid, talcum powder, silicon dioxide, hydrogenated vegetable oil, polyethylene glycol, sodium dodecyl sulfate, glyceryl behenate, sodium stearyl fumarate and the like.
The flavoring agent comprises one or more of fruit powder, edible essence, high-intensity sweetener, sour agent and the like, wherein the fruit powder comprises one or more of orange powder, lemon powder, cherry powder, apple powder, strawberry powder, kiwi fruit powder, orange powder, seabuckthorn fruit powder, green plum fruit powder, mango fruit powder, mulberry fruit powder, hawthorn fruit powder, watermelon fruit powder, pineapple fruit powder, blueberry fruit powder, honey peach fruit powder, hami melon fruit powder, grape fruit powder, vanilla fruit powder, pomegranate fruit powder, rose fruit powder and the like.
The edible essence comprises one or more of vanilla essence, sweet orange essence, milk essence, apple essence, grape essence, strawberry essence, pineapple essence, honey peach essence, hami melon essence, lemon essence, cherry essence, sweet corn essence, banana essence, grape essence, rose essence, blackcurrant essence, green apple essence, mango essence, green mango essence, orange essence, fragrant orange essence, snow pear essence, strawberry essence, green plum essence, blueberry essence, waxberry essence, grapefruit essence, pineapple essence, guava essence, passion fruit essence, kiwi fruit essence, cherry essence, kiwi fruit essence, watermelon essence, papaya essence, hami melon essence, durian essence, lychee essence, hawthorn essence, olive essence, mulberry essence and the like.
The sweetening agent comprises sucralose, aspartame, mogroside, neotame and stevioside, the acidulant comprises citric acid, malic acid, lactic acid, tartaric acid and fumaric acid, the edible pigment comprises caramel color, gardenia yellow, curcumin, chlorophyll, capsicum orange, capsanthin, grape skin red, carmine and aluminum lake thereof, sunset yellow and aluminum lake thereof, brilliant blue and aluminum lake thereof, indigo blue and aluminum lake thereof, beet red, natural amaranth, gardenia blue, vegetable carbon black, iron oxide red, black bean red, quinoline yellow, lycopene, monascus red, yellow iron oxide, cocoa shell color, safflower yellow, monascus yellow and the like.
The stabilizer provided by the invention comprises one or more of vitamin E, dibutyl hydroxy toluene (BHT), Butyl Hydroxy Anisol (BHA), vitamin C, L-ascorbic acid, tricalcium phosphate, magnesium phosphate, calcium carbonate and the like.
The embedding substance comprises one or more of beta-cyclodextrin, alpha-cyclodextrin, gamma-cyclodextrin, dextrin, starch, edible modified starch, sucrose, maltodextrin, gum arabic and the like.
The vitamins with synergistic health-care food screening function are scientifically formulated, so that the use and efficacy of the product are ensured, and the optimal dosage of vitamin A, vitamin D and vitamin B is supplemented12It has effects of reducing homocysteine and oxidized low density lipoprotein, and preventing lipid peroxidation, atherosclerosis, vascular calcification and thrombosis, so as to achieve the purpose of adjuvant prevention of cardiovascular diseases.
Vitamin A is known as retinol, and is easily absorbed by oral administration and mainly stored in liver. The vitamin A is used as an antioxidant, and is beneficial to protecting vascular endothelium from being damaged by free radicals, maintaining the elasticity of blood vessels and the like. The vitamin A can inhibit the oxidation of low-density lipoprotein, simultaneously resist the oxidation of the low-density lipoprotein induced by oxygen-nitrogen free radical, prevent atherosclerosis, effectively slow down the progression of the atherosclerosis and promote the regression of plaque, and is helpful for preventing the occurrence of atherosclerotic cardiovascular diseases.
Vitamin D can regulate calcium and phosphorus metabolism, prevent and treat rickets in children and senile osteoporosis, and inhibit nuclear transcription factor-kB (NF-kB) widely existing in human cells, thereby blocking inflammatory cascade reaction and preventing thrombosis; in addition, vitamin D also affects the activity of renin-angiotensin-aldehyde synketone system, and has effects of resisting myocardial hypertrophy and hyperplasia, and resisting myocardial fibrosis.
Vitamin B12Is one of intervention means for reducing the concentration of plasma homocysteine (Hcy), and a large number of researches show that the high Hcy of plasma is closely related to the occurrence of cardiovascular and cerebrovascular diseases, and the Hcy can participate in the occurrence and development of atherosclerosis through oxidative stress, inflammatory reaction and the like. The B vitamins have poor thermal stability, and the habit of cooking food at high temperature easily causes the loss of the B vitamins, so people lack the B vitamins and are relatively common. Vitamin B12The coenzyme exists in a coenzyme form, the utilization rate of folic acid can be enhanced, and the two components are synergistic to be more beneficial to reducing the Hcy level of blood plasma. In addition, vitamin B12In for maintenanceThe function of the central nervous system and the trophic nerves also play important roles.
Animal experiments prove that the health food has the effects of synergistically reducing the contents of oxidized low-density lipoprotein, Hcy and the like and inhibiting the formation of atherosclerosis, so that the health food has auxiliary, promoting or health-care effects on preventing cardiovascular and cerebrovascular diseases, and is a vitamin nutritional supplement with better and more accurate effect compared with the existing product. Embodiments of the present invention are further described below with reference to examples.
Examples of the invention
Example 1: tablet preparation (1000 tablets) of the health food of the invention
The formula is as follows:
Figure BDA0001243416740000041
the preparation method comprises the following steps: mixing vitamin A, D and vitamin B12Mixing with microcrystalline cellulose and sodium dodecylbenzenesulfonate, and sieving; adding lactose, polyvinylpolypyrrolidone and passion fruit essence and mixing; adding magnesium stearate, mixing, and tabletting. And preparing the coating premix into a solution, and coating plain tablets to obtain the tablets of the health food.
The health food prepared in this example was subjected to an animal function test and a safety toxicology evaluation test according to the evaluation method of "health food test and evaluation technical Specification" of Ministry of health.
Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases, so animal experiments prove that the health food inhibits the formation of atherosclerosis, and further proves the efficacy of the health food in preventing cardiovascular and cerebrovascular diseases. Rat animal experiments show that when rats are fed with the health food for 8 weeks, the levels of plasma oxidized low-density lipoprotein and Hcy are obviously reduced, and the health food has antioxidant efficacy (see tables 1 and 2). Lipid Peroxides (LPO) on serum and artery walls are parallel to atherosclerosis, lipid peroxide metabolite is Malondialdehyde (MDA), and the detection of MDA content can reflect the degree of lipid peroxidation of blood vessels, namely the degree of atherosclerosis. Rat experiments show that the health food can obviously reduce blood serum, artery wall LPO and metabolite MDA thereof and inhibit arteriosclerosis.
TABLE 1 test results of the health food on oxidized low density lipoprotein (oxLDL) of rat animals
Figure BDA0001243416740000051
Note: p values were all compared to normal controls
TABLE 2 test results of health foods for homocysteine (Hcy) in rat animals
Figure BDA0001243416740000052
Note: p values were all compared to normal controls
TABLE 3 results of the test of the health food on Malondialdehyde (MDA) of rat animals
Figure BDA0001243416740000053
Figure BDA0001243416740000061
Note: p values were all compared to normal controls
Example 2: preparation of soft capsules (1000 capsules) for health food of the invention
The formula is as follows:
Figure BDA0001243416740000062
the preparation method comprises the following steps: adding Cera flava into soybean oil, heating at 50 deg.C to dissolve Cera flava, standing to room temperature, and collecting vitamin A, vitamin D and vitamin B12And adding the L-ascorbic acid into the soybean oil to prepare a suspension for later use. Taking gelatinPreparing glue solution from purified water, grape skin red and p-hydroxybenzoate, pelleting the prepared suspension by a pelleting machine to prepare soft capsules, and carrying out shaping, washing and drying treatment to obtain the soft capsules of the health food.
Example 3: the invention relates to a preparation method of hard capsules (1000 granules) for health care food
The formula is as follows:
Figure BDA0001243416740000063
Figure BDA0001243416740000071
the preparation method comprises the following steps: mixing vitamin A, vitamin D, and vitamin B12Mixing with stearic acid and 50% microcrystalline cellulose, sieving, adding lactose and magnesium stearate, mixing, filling by using a full-automatic capsule filling machine, and polishing to obtain the hard capsule of the health food.
Example 4: preparation of granules of health food (1000 parts)
The formula is as follows:
Figure BDA0001243416740000072
the preparation method comprises the following steps: crushing sucrose and sieving with a 80-mesh sieve for later use; mixing polyvidone K90 with 50% ethanol solution to obtain binder, and mixing with vitamin A, vitamin D, and vitamin B12Adding into adhesive, stirring, and keeping. Adding sugar powder, maltodextrin, carboxymethyl starch sodium, Hami melon fruit powder, and Hami melon essence, mixing, and adding prepared vitamin A, vitamin D, and vitamin B12Preparing a soft material by using an adhesive, granulating by using a 24-mesh sieve, drying for 2 hours at 50 ℃, and finishing granules by using the 24-mesh sieve to obtain the health food granules.
Example 5: preparation of chewable tablets (1000 tablets) of the health food of the invention
The formula is as follows:
Figure BDA0001243416740000081
the preparation method comprises the following steps: preparing hydroxypropyl methylcellulose into adhesive with purified water, adding vitamin A, D into the adhesive, and stirring. Vitamin B is taken in addition12Mixing with microcrystalline cellulose, sieving, adding stevioside, pineapple essence, milk powder and xylitol, mixing, adding a prepared binder containing vitamin A, D to prepare a soft material, granulating by using a 24-mesh sieve, drying for 2 hours at 55 ℃, granulating by using the 24-mesh sieve, adding magnesium stearate, mixing, and tabletting to obtain the chewable tablet of the health food.

Claims (6)

1. A health food for adjuvant prevention of cardiovascular diseases is prepared from vitamin A800 μ g, vitamin D10 μ g, and vitamin B10 μ g12And auxiliary materials acceptable for health-care food.
2. The health food according to claim 1, wherein: said vitamin D comprises vitamin D1、D2、D3One or a combination of several of them.
3. The health food according to claim 1, wherein: the auxiliary materials are selected from one or more of filling agent, solubilizer, adhesive, disintegrating agent, lubricant, suspending agent, flavoring agent, edible pigment, stabilizer, embedding material and coating premixing agent.
4. The health food according to claim 3, wherein: the filler comprises one or more of starch, dextrin, maltodextrin, D-mannitol, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, maltose, xylitol, sorbitol, microcrystalline cellulose, lactose, isomaltulose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, edible vegetable oil and polyethylene glycol; the suspending agent comprises: one or more of beeswax, insect wax, lecithin, glyceryl monostearate and ethyl cellulose; the stabilizer comprises one or more of vitamin E, dibutyl hydroxy toluene, butyl hydroxy anisol and L-ascorbic acid; the flavoring agent comprises one or more of fruit powder, edible essence, high sweetener and sour agent; the fruit powder comprises one or more of orange powder, lemon powder, cherry powder, apple powder, strawberry powder, kiwi fruit powder, orange powder, sea buckthorn fruit powder, green plum fruit powder, mango fruit powder, mulberry fruit powder and hawthorn fruit powder.
5. The health food according to claim 1, wherein: the health food can be made into common tablet, chewable tablet, soft capsule, hard capsule, powder and granule.
6. Use of the health food according to any one of claims 1 to 5 in the preparation of a health food useful for the adjuvant prevention of cardiovascular diseases.
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US20060024384A1 (en) * 2004-07-29 2006-02-02 Giordano John A Compositions and methods for nutrition supplementation
CN102150854B (en) * 2011-02-01 2013-08-28 完美（中国）有限公司 Health food with auxiliary protection function to chemical liver injury
CN102631370B (en) * 2011-02-11 2014-04-09 中国科学院上海生命科学研究院 Composition for preventing or improving hyperlipidemia and supplementing vitamin D
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