CN1682759A - Health article useful for preventing and treating cardiovascular diseases - Google Patents
Health article useful for preventing and treating cardiovascular diseases Download PDFInfo
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- CN1682759A CN1682759A CNA2004100231159A CN200410023115A CN1682759A CN 1682759 A CN1682759 A CN 1682759A CN A2004100231159 A CNA2004100231159 A CN A2004100231159A CN 200410023115 A CN200410023115 A CN 200410023115A CN 1682759 A CN1682759 A CN 1682759A
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- calcium
- health product
- prescription
- homocysteine
- milligram
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The present invention belongs to the field of health article and medical, dental and cosmetic preparation, and a kind of health article for preventing and treating cardiac vascular diseases. The health article contains calcium, folic acid, vitamin B12 and other components in certain proportion; can inhibit the damage of homocysteine and other similar matter on vascular endothelial cell and relevant diseases; and is favorable to preventing and treating atherosclerosis and hypertension.
Description
(1) technical field
The present invention is the healthcare field patent of invention, and Chinese patent Main classification A61K belongs to " preparation that medical, dental or dressing are used " field.
(2) background technology
Homocysteine is atherosclerotic important related, has had much to research and propose to adopt medicine to treat, and reduces the homocysteine concentration in the blood.But the therapy effect that reduces homocysteine concentration merely is limited, does not also have suitable health product available.The inventor studies show that for the homocysteine mechanism of causing a disease, homocysteine can cause atherosclerosis and hypertension by blood vessel endothelium being caused damage, and other material with this characteristic of homocysteine also might bring same pathological changes, and the therefore simple concentration that reduces homocysteine is not enough.In addition, human body always has a certain amount of homocysteine under normal condition, can also should not eliminate fully.The present invention addresses this problem by another approach.Calcium is an important substance keeping the integrity of blood vessel endothelium; homocysteine can form the damage to blood vessel endothelium by the effect to calcium; conversely, the calcium that replenishes just has antagonism for homocysteine, thereby provides protection to blood vessel endothelium.
(3) summary of the invention
The invention provides a kind of health product of the confession taking; rather than medicine; can take for a long time; this health product are when helping to reduce homocysteine concentration; blood vessel endothelium is protected; even under the prerequisite that homocysteine exists; and under the prerequisite that other material with this characteristic of homocysteine exists; blood vessel endothelium is protected; and to taking the blood vessel endothelium that has damaged before these health product because of this class factor; has repair; thereby help to prevent and treat the disease, particularly atherosclerosis that the material that similar characteristics arranged because of homocysteine and other causes or increases the weight of the damage of blood vessel endothelium; hypertension.
1. to Vascular Endothelial
Obtain solution A, B and C are the Hanks buffer of no calcium magnesium, and contain 30 μ M (micromole) homocysteines.Solution B and C also contain 15nM (nanomole) folic acid, 0.1 μ M vitamin B6,0.2nM vitamin B12.Solution C also contains 1mM (mM) calcium, forms to add the calcium solution mother solution to solution B.The calcium solution mother solution is prepared with calcium carbonate, is that 2 hydrochloric acid solution makes dissolution of calcium carbonate (simulation gastric environment) with pH value.
Cultivate at the external human vascular endothelial of doing, be divided into 4 groups, behind the formation monolayer, wherein wash cell monolayer 3 times with solution A, B or C immediately for 3 groups, add solution A or B to cell monolayer again, 37 ℃ of vibrations 10 minutes.The 4th group is the blank group, vibrates in cell culture fluid.Then in test under microscope cell detachment situation.The results are shown in table 1, the cell detachment data account for the percentage ratio of total mirror downward view area in the table for the area (blank area) that comes off.
Table 1. pair Vascular Endothelial
| The solution A group | The solution B group | The solution C group | The blank group | |
| Cell detachment | ????14％ | ????11％ | ????3％ | ????2％ |
The result shows that health product provided by the present invention have good protective action to vascular endothelial cell.
2. to the repair of injury of vascular endothelial cells
Obtain solution D, E and F are the no calcium magnesium Hanks buffer that contains 0.2% calf serum, and contain 30 μ M homocysteines.Solution E and F also contain 15nM folic acid, 0.1 μ M vitamin B6,0.2nM vitamin B12.Solution F also contains 1mM calcium, forms to add the calcium solution mother solution to solution E.The calcium solution mother solution is prepared with calcium carbonate, is that 2 hydrochloric acid solution makes dissolution of calcium carbonate (simulation gastric environment) with pH value.
Cultivate at the external human vascular endothelial of doing, be divided into 3 groups, wash cell monolayer 3 times with the no calcium magnesium Hanks buffer that contains 100 μ M homocysteines immediately after forming monolayer, after the 4th adds this kind solution, vibrating to cell detachment at 37 ℃ reaches 30% (using microscopy), respectively centrifugal collection exfoliative cyte.Add solution D, E or F to culture dish (leave on it 70% cell still keep adherent), and the exfoliative cyte of centrifugal collection respectively put back to former culture dish separately, leave standstill at 37 ℃ and cultivated 5 hours.Then at test under microscope cell attachment and growing state.The results are shown in table 2, the cell blank data are the percentage ratio that blank area (acellular) accounts for total mirror downward view area in the table.
Table 2. pair Vascular Endothelial
| The solution D group | The solution E group | Solution F group | |
| Cell blank | ???24％ | ???21％ | ???11％ |
The result shows that health product provided by the present invention have good facilitation to vascular endothelial cell is adherent with growth, help the reparation of blood vessel endothelium.
Above-mentioned result of study shows; at the homocysteine that exists in the blood or have other material of homocysteine related characteristics; health product provided by the present invention have protective effect to blood vessel endothelium; and can promote the growth and the reparation of damaged blood vessels endotheliocyte; help to prevent and treat disease, particularly atherosclerosis, the hypertension that the material that similar characteristics arranged because of homocysteine and other causes or increases the weight of the damage of blood vessel endothelium.
(4) specific embodiment
1. fill a prescription (dosage every day): 1000 milligrams of calcium carbonate, 5 milligrams of folic acid, 25 milligrams of vitamin Bies, 0.25 milligram of vitamin B12.Make capsule, tablet, oral liquid, powder or granule through conventional method, be used for oral, once or gradation take.Or add in the food through conventional method, edible with food.
2. with embodiment 1, but calcium carbonate is changed to a kind of or several arbitrarily in the identical calcium chloride of calcium content, calcium acetate, calcium citrate, calcium lactate, calcium gluconate, threonic acid calcium, calcium maleate, amino acid calcium or other inorganic calcium or the organic calcium.
Claims (6)
1. the prescription of health product, this prescription is (amount in the prescription is people's a dose on the one): the calcium containing compound of calcic 10-2000 milligram, 0.1-10 milligram folic acid, 1-100 milligram vitamin B6,0.01-10 milligram vitamin B12.
2. the prescription of health product described in the claim 1 and purposes is characterized in that and can help prevention and treat atherosclerosis, hypertensive health product according to formulation described in the claim 1.
3. the purposes of health product described in the claim 1, it is characterized in that taking described health product and can suppress homocysteine (homocysteine) and other material that similar characteristics is arranged injury of vascular endothelial cells, and the disease of damaging initiation or increasing the weight of thus, thereby help prevention and treatment atherosclerosis, hypertension, and can take for a long time.
4. the prescription of health product described in the claim 1 is characterized in that calcium containing compound in the described health product is a kind of or several arbitrarily in calcium carbonate, calcium chloride, calcium acetate, calcium citrate, calcium lactate, calcium gluconate, threonic acid calcium, calcium maleate, amino acid calcium or other inorganic calcium or the organic calcium.
5. the preparation of health product described in the claim 1 is characterized in that, uses suitable adjuvant, and described health product can be prepared into capsule, tablet, oral liquid, powder, granule, are used for oral.
6. the preparation of health product described in the claim 1 is characterized in that described health product can be used as additive and add in the various food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100231159A CN1682759A (en) | 2004-04-16 | 2004-04-16 | Health article useful for preventing and treating cardiovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100231159A CN1682759A (en) | 2004-04-16 | 2004-04-16 | Health article useful for preventing and treating cardiovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1682759A true CN1682759A (en) | 2005-10-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100231159A Pending CN1682759A (en) | 2004-04-16 | 2004-04-16 | Health article useful for preventing and treating cardiovascular diseases |
Country Status (1)
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| CN (1) | CN1682759A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461525B (en) * | 2008-03-31 | 2012-06-13 | 张奎天 | Flour special for preventing cardiovascular disease |
| CN106901379A (en) * | 2017-03-11 | 2017-06-30 | 深圳泰乐德营养与健康有限公司 | A kind of vitamin health food of auxiliary prevention of cardiovascular disease |
| CN106923346A (en) * | 2017-03-10 | 2017-07-07 | 深圳泰乐德营养与健康有限公司 | A kind of selected B B-complex health products and application thereof |
-
2004
- 2004-04-16 CN CNA2004100231159A patent/CN1682759A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461525B (en) * | 2008-03-31 | 2012-06-13 | 张奎天 | Flour special for preventing cardiovascular disease |
| CN106923346A (en) * | 2017-03-10 | 2017-07-07 | 深圳泰乐德营养与健康有限公司 | A kind of selected B B-complex health products and application thereof |
| CN106901379A (en) * | 2017-03-11 | 2017-06-30 | 深圳泰乐德营养与健康有限公司 | A kind of vitamin health food of auxiliary prevention of cardiovascular disease |
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