CN106901362A - A kind of electuary for alleviating abstinence reaction - Google Patents
A kind of electuary for alleviating abstinence reaction Download PDFInfo
- Publication number
- CN106901362A CN106901362A CN201710116102.3A CN201710116102A CN106901362A CN 106901362 A CN106901362 A CN 106901362A CN 201710116102 A CN201710116102 A CN 201710116102A CN 106901362 A CN106901362 A CN 106901362A
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- maltose
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Abstract
The invention discloses a kind of electuary for alleviating abstinence reaction, raw material is that Aglaia odorata, beggar-ticks, wintergreen, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium, hyperici,herba, Semen Lablab Album, Chinese yam rhizome, Semen Nelumbinis, burnt rice sprout, melanoidin malt, maltose are prepared from.Compared with the prior art, smoking cessation food of the invention helps to mitigate abstinence reaction, and relapse rate is low and safe.
Description
Technical field
It is application for a patent for invention the present invention relates to field of food《A kind of smoking cessation food that can mitigate abstinence reaction》（Shen
Please number：2015100274491）Divisional application, and in particular to it is a kind of can be eaten for a long time contribute to smoking cessation food.
Background technology
Smoker force smoking cessation after it is possible that abstinence reaction, such as lather, insomnia, blood pressure rising and
Cardiac arrhythmia etc., can produce great pain.The intensity of abstinence reaction often have impact on the success rate of smoking cessation.
Being at present that the dependence for making body by way of providing substituting nicotine obtains one current smoking abstention method more
Fixed satisfaction, can mitigate withrawal symptom, alleviate the serious hope to tobacco, but fact proved that this mode easily causes to relapse,
It is difficult to give up again.Described substituting nicotine is sometimes tea for smokers to quit smoking, Chinese medicine cigarette, and substitute stimulates instead of cigarette
Tongue taste bud mitigates symptom during smoking cessation, this mode can only part of respite when giving up smoking it is uncomfortable, still can have one
The strong stimulations such as the discomfort at lungs and other positions, or even bitter leaves a bit produce irreversible damage using meeting to oral mucosa for a long time
Wound.And it is generally acknowledged at present can reduce abstinence reaction, the mode for alleviating withrawal symptom is drug withdrawal, Western medicine such as varenicline,
Though withdrawal good, side effect is larger, has 28.6% user that nausea occurs, and the ratio of interruption treatment is caused by nausea
2.7%, headache, insomnia and dreamland are also its common adverse events extremely in addition.
Therefore, still lack it is a kind of can mitigate withrawal symptom give up intervention food.
The content of the invention
Technical assignment of the invention is directed to above the deficiencies in the prior art, there is provided a kind of for alleviating rushing for abstinence reaction
Agent, reduces withrawal symptom.
The present invention solve its technical problem technical scheme be：A kind of electuary for alleviating abstinence reaction, its feature exists
In, including weight is than following raw material：Aglaia odorata 20kg, beggar-ticks 20kg, wintergreen 15kg, Blumea balsamifera 15kg, cinnamomum camphora 15kg,
Stem of noble dendrobium 30kg, hyperici,herba 7kg, Semen Lablab Album 50kg, Chinese yam rhizome 50kg, Semen Nelumbinis 30kg, burnt rice sprout 50kg, melanoidin malt 50kg, maltosemalt sugar
Sugared 15kg.
Preparation method is：
（1）After Aglaia odorata, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium are cleaned and crush, extraction by steam distillation volatile oil is standby, and the dregs of a decoction are standby
With；
（2）By beggar-ticks, Semen Lablab Album, Chinese yam rhizome, Semen Nelumbinis, burnt rice sprout, hyperici,herba, melanoidin malt, wintergreen and step 1 gained
The dregs of a decoction mix, plus 3 times of decoctings boil secondary, and decocting time is 2 hours every time, and collecting decoction, filtration, filtrate is concentrated into relatively respectively
Density is 1.30（60℃）Thick paste；
（3）Take maltose and be ground into fine powder, it is standby；
（4）Step 1 gained volatile oil and step 3 gained maltose are added in step 2 gained thick paste, drying under reduced pressure after mixing
（60 DEG C, 0.09MPa）, dry extract is ground into, dispense.
Raw material described in formula is specific as follows：
Aglaia odorata, is the branches and leaves of Meliaceae plant Aglaia odorata Aglaia odorata Lour.；Nature and flavor are pungent；Tepor；Return lung；Stomach；Liver
Through；Work(can wind-damp dispelling；The stasis of blood is dissipated to swell；
Beggar-ticks, is the draft of composite family beggar-ticks Bidens bipinnata L；Nature and flavor bitter；Cold nature；Work(can it is clearing heat and detoxicating,
Blood-stasis-dissipating blood-circulation-promoting；
Wintergreen, is Pyrolaceae plant wintergreen Pyrola calliantha H. Andres or ovum leaf wintergreen Pyrola
Decorata H. Andres' dries herb；Nature and flavor are sweet, hardship, temperature；Return liver and kidney channel；Work(can qi-restoratives, kidney-nourishing, dispelling wind and eliminating dampness, work
Blood menstruation regulating；
Blumea balsamifera, is the leaf and spray of feverfew Blumea balsamifera Blumea balsamifera；Nature and flavor are pungent, hardship, temperature；Work(can middle benefit gas
Promoting blood circulation, dispelling wind and eliminating dampness, desinsection；
Cinnamomum camphora, is the aiphyllium of canella camphor tree, uses its branches and leaves；Nature and flavor micro-pungent, temperature；Work(can warm in pain, ward off it is dirty and in, dispel
Wind dehumidifies；
The stem of noble dendrobium, is orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., stem of Eyeshaped Dendrobium Dendrobium
Fimbriatum Hook. var. oculatum Hook, HERBA DENDROBII Dendrobium chrysanthum Wall.,
Dendrobium candidum Dendrobium candidum Wall. ex Lindl. or HERBA DENDROBII Dendrobium nobile
Lindl. fresh dries stem；Nature and flavor are sweet, are slightly cold；Return stomach, kidney channel；Work(can reinforcing stomach reg fluid, nourishing Yin and clearing heat；
Hyperici,herba, is the herb of Hypericaceae hypericum hyperici,herba Hypericum ascyron L.；It is bitter in taste；It is cold；
Return liver warp；Work(can cooling blood and hemostasis；Promoting blood circulation for regulating menstruation；It is clearing heat and detoxicating；
Semen Lablab Album, is the dry mature seed of pulse family French beans platymiscium French beans Dolichos lablab L.；Nature and flavor are sweet, tepor；
Returns spleen, stomach；Work(can invigorating the spleen for eliminating dampness, and in relieve summer heat；
Chinese yam rhizome, is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb.；Nature and flavor are sweet, put down；Return
Spleen, lung, kidney channel；Work(can tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying；
Semen Nelumbinis, are that the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn. removes lotus nut；Nature and flavor
It is sweet, puckery, put down；Returns spleen, kidney, the heart channel of Hang-Shaoyin；Work(can tonifying spleen and stopping diarrhea, puckery essence, mental-tranquilization；
Burnt rice sprout, is grass grain Setaria italica（L.）Beauv. ripening fruits is shone through drying of germinateing
The method of frying is fried to burnt brown；Nature and flavor are sweet, temperature；Returns spleen, stomach；Work(can help digestion with, spleen benefiting and stimulating the appetite；
Melanoidin malt, be grass barley Hordeum vulgare L. ripening fruits through germinate drying, according to fry method fry
To burnt brown, cool, weed out grey bits；Nature and flavor are sweet, put down；Returns spleen, stomach；Work(can promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling；
Maltose, is the fermented carbohydrate food being made that is saccharified of the grains such as rice, barley, wheat, grain or maize；Nature and flavor are sweet；Temperature；Return
Spleen, stomach, lung channel；During work(can delay, qi-restoratives, promote the production of body fluid, moisturize；
Honey, is apidae insect apis cerana Apis cerana Fabricius or apis mellifera Linnaeus APis mellifera
The honey that Linnaeus is made；Nature and flavor are sweet, put down；Return lung, spleen, large intestine channel；Work(can bowl spares, moisturize, relieve pain, removing toxic substances；
Tortoise-shell glue, be Testudinidae animal tortoise crust infusion into solid blob of viscose；Property it is partially gentle, it is sweet and salty, work(can enriching yin, mend
Blood, hemostasis；
Yellow rice wine, is that, with rice, milled glutinous broomcorn millet as raw material, alcohol content is 14% ~ 20% low brewed wine.
Compared with prior art, invention has beneficial effect following prominent：
1st, with Aglaia odorata, beggar-ticks as core, the triterpenes components and its isomers contained in described Aglaia odorata have this formula
There is slight central nervous excitation to act on and antifatigue effect, occur during smoking cessation tired, drowsiness, tired etc. can be resisted and guarded against
Disconnected symptom, zoopery confirms the nicotine dependence rat model caused for oral pipe tobacco filtrate, gavages Aglaia odorata decompression low
Temperature decocts filtrate（Crude drug amount 2g/kgd）, can be effectively reduced withrawal symptom, and low dose group（Crude drug amount 1g/kgd）
Then effect and model group no difference of science of statistics.Can produce the chemical composition of local excitation in Aglaia odorata in order to resist, therefore addition
Beggar-ticks turns into medicine pair.Zoopery confirmation, gavages nicotine dependence rat model 28 days, viscous according to Guth criterion evaluations stomach
Membrane damage and accumulative score：Compound group（Equivalent Aglaia odorata, beggar-ticks decompression low temperature decoct filtrate, total crude drug amount 4g/kgd）For
5.31 ± 1.71, single group（Aglaia odorata decompression low temperature decocts filtrate, crude drug amount 2g/kgd）It is 13.63 ± 3.75, with bright
Significant difference is different（P<0.05）.
2nd, in prescription wintergreen water and the leachate of alcohol plays the role of expansion bronchus, it is possible to reduce during smoking cessation
Respiratory tract spasm triggers the probability of syndrome characterized by dyspnea, and wintergreen water extract can suppress the skin-sensitizing antibodies and house mouse spleen in mice serum
The generation of hemolytic cell, alleviates the overall stimulation for oral mucosa of formula.
3rd, contain special spice substance in Blumea balsamifera, cinnamomum camphora, taste bud can be stimulated, but without additive.
4th, smoking smoker lasting often the dryness of the lung is serious, and can also induce lung-fire, internal heat, unfounded fire during giving up smoking,
This formula takes low dose of hyperici,herba fall fire, and heavy dose of stem of noble dendrobium, Semen Nelumbinis antagonism give up the fire of deficiency type of generation, flaring up of heart fire.
5th, collocation Semen Lablab Album, Chinese yam rhizome, burnt rice sprout, melanoidin malt coordinate stem of noble dendrobium reinforcing stomach reg fluid, spleen benefiting and stimulating the appetite, prevent from giving up
The anorexia produced in journey.
6th, each herbal medicine is safe and reliable, with long-term taking, can improve the security of smoking cessation.
Specific embodiment
Below in conjunction with actual conditions, specific embodiment of the invention is elaborated.
Embodiment 1 is oral herbal paste.
Bulk drug weight proportion：12 parts of Aglaia odorata, 12 parts of beggar-ticks, 10 parts of wintergreen, 10 parts of Blumea balsamifera, 10 parts of cinnamomum camphora,
15 parts of the stem of noble dendrobium, 5 parts of hyperici,herba, 20 parts of Semen Lablab Album, 20 parts of Chinese yam rhizome, 15 parts of Semen Nelumbinis, burnt 20 parts of rice sprout, 20 parts of melanoidin malt, maltosemalt sugar
10 parts of sugar, 10 parts of honey, 30 parts of tortoise-shell glue, 30 parts of yellow rice wine.
Preparation method：
（1）The preparation of clear cream：By Aglaia odorata, beggar-ticks, wintergreen, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium, hyperici,herba, Semen Lablab Album, Chinese yam
Medicine, Semen Nelumbinis, burnt rice sprout, melanoidin malt are soaked 4 hours, then add water to cook 2~3 times, and 2~3h, collecting decoction, stand clear every time
Clear 35h, filtering, 90 DEG C of heating concentrations, and be kept stirring for, the clear cream that relative density is 1.35 must be concentrated into；
（2）The refining of carbohydrate：Maltose mixing and water adding is taken, 120 DEG C of heating are stirred continuously to liquid glucose and start aobvious golden yellow, are soaked bright
Light and it is micro- have a blue or green cigarette, stop heating, obtain sugar refinery standby；
（3）The refining of honey：Take honey, 120 DEG C of heating, occur it is light yellow it is glossiness seethe even and fine bubble when stop plus
Heat, obtains refined honey standby；
（4）The preparation of molten glue：Take tortoise-shell glue and be ground into and break into fine powder, to add and soak molten after 2h in yellow rice wine, obtain molten glue standby
With；
（5）The molten glue of gained in the sugar refinery of gained, refined honey, the step 4 of step 3 gained in step 2 is poured into step 1 gained
In clear cream, cream is received in stirring, 90 DEG C of heating, is concentrated into when relative density is 1.20 and is stopped heating, is dispensed after cooling.
Wherein, step（1）In decoction, the low temperature that preferably depressurizes decocts, and Extracting temperature is not more than 100 DEG C.
Instructions of taking：According to giving up situation several oral.Dosage is each taken equivalent to crude drug amount 62g.The initial stage of giving up can
Think that 4 times a day, divide 4 times and take, give up the maintenance phase and can divide 2 times and take for 2 times a day, can be that one time a day after giving up,
Pause clothes.
Embodiment 2 reconstitutes formulation for instant.
Bulk drug weight proportion：Aglaia odorata 20kg, beggar-ticks 20kg, wintergreen 15kg, Blumea balsamifera 15kg, cinnamomum camphora 15kg,
Stem of noble dendrobium 30kg, hyperici,herba 7kg, Semen Lablab Album 50kg, Chinese yam rhizome 50kg, Semen Nelumbinis 30kg, burnt rice sprout 50kg, melanoidin malt 50kg, maltosemalt sugar
Sugared 15kg.
Preparation method：
（1）After Aglaia odorata, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium are cleaned and crush, extraction by steam distillation volatile oil is standby, and the dregs of a decoction are standby
With；
（2）By beggar-ticks, Semen Lablab Album, Chinese yam rhizome, Semen Nelumbinis, burnt rice sprout, hyperici,herba, melanoidin malt, wintergreen and step 1 gained
Dregs of a decoction mixing, plus 3 times of decoctings boil secondary, and decocting time is 2 hours every time, and collecting decoction, filtration, filtrate is concentrated into phase respectively
It is 1.30 to density（60℃）Thick paste；
（3）Take maltose and be ground into fine powder, it is standby；
（4）Step 1 gained volatile oil and step 3 gained maltose are added in step 2 gained thick paste, drying under reduced pressure after mixing
（60 DEG C, 0.09MPa）, dry extract is ground into, it is divided into 2000 independent packagings.
Instructions of taking：A bag, oral according to situation is given up every time.Give up the initial stage to be taken for 4 times a day, giving up the maintenance phase can
Think that 2 times a day to take, can be the clothes that once a day, pause after giving up.
Embodiment 3 is to mix with formulation.
Bulk drug weight proportion：16 parts of Aglaia odorata, 16 parts of beggar-ticks, 12 parts of wintergreen, 12 parts of Blumea balsamifera, 12 parts of cinnamomum camphora,
22 parts of the stem of noble dendrobium, 6 parts of hyperici,herba, 35 parts of Semen Lablab Album, 35 parts of Chinese yam rhizome, 22 parts of Semen Nelumbinis, burnt 35 parts of rice sprout, 35 parts of melanoidin malt, maltosemalt sugar
12 parts of sugar.
Preparation method：By Aglaia odorata, beggar-ticks, wintergreen, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium, hyperici,herba, Semen Lablab Album, Chinese yam
After medicine, Semen Nelumbinis, burnt rice sprout, melanoidin malt cleaning are air-dried, crush, cross 100 mesh sieves, add the maltose after crushing, flour, pure
Water is stirred, and into dough, cake is made according to a conventional method, will keep low temperature in vacuum tank（100~120 DEG C）Dried
It is roasting, subpackage is taken out after the completion of baking and is contained, edible by several times, daily amount is not more than bulk drug crude drug amount 270g/d.
Embodiment 4 is biscuit.
Raw material weight proportioning of soup processed：16 parts of Aglaia odorata, 16 parts of beggar-ticks, 12 parts of wintergreen, 12 parts of Blumea balsamifera, 12 parts of cinnamomum camphora, stone
22 parts of dry measure used in former times, 6 parts of hyperici,herba, 35 parts of Semen Lablab Album, 35 parts of Chinese yam rhizome, 22 parts of Semen Nelumbinis, burnt 35 parts of rice sprout, 35 parts of melanoidin malt, maltose
12 parts.
Preparation method：
（1）After Aglaia odorata, Blumea balsamifera, cinnamomum camphora, the stem of noble dendrobium are cleaned and crush, extraction by steam distillation volatile oil is standby, and the dregs of a decoction are standby
With；
（2）In the maltose syrup that the volatile oil of step 1 gained is added to after molten, mixing molasses are obtained standby；
（3）Semen Lablab Album, Chinese yam rhizome, Semen Nelumbinis are cleaned and dried after crushing, cross 100 mesh sieves standby；
（4）The dregs of a decoction of beggar-ticks, burnt rice sprout, hyperici,herba, melanoidin malt, wintergreen and step 1 gained are mixed, plus 3 times of decoctings are boiled
Secondary, decocting time is 2 hours every time, collecting decoction, filtration, and it is 1.30 that filtrate is concentrated into relative density respectively（60℃）'s
Thick paste；
（5）Step 3 gained fine powder is added in step 4 gained thick paste, appropriate pure water is added and is stirred, and into
Dough, is made biscuit baking, after the completion of baking when temperature drops to 60 DEG C, the mixing molasses of surface brush step 2 gained, cooling point
Bag is contained.
Edible by several times, daily amount is not more than raw material crude drug amount 270g/d.
Above-mentioned each composition efficient combination, coordinates mutually, effectively reaches the purpose of thorough smoking cessation, and has no toxic side effect.It is above-mentioned
Result fully proves that relevant information is as follows for clinical data.
1 object and method.
1.1 objects：Receive smoking cessation investigation in selection in January, 2011~2014 year January, the length of smoking was more than 1 year, age
In the range of 18-60 Sui, without serious hepatic and renal function exception, and non-allergic constitution smoker 120.It is randomly divided into six groups, it is right
According to group 20, varenicline group 20, thick paste group 20, electuary group 20, cake group 20, biscuit group 20, six groups of smokings
Person compares in sex, age, length of smoking, health, no significant difference（P>0.05）, with comparativity.
1.2 methods.
1.2.1 interference method：The intervention course for the treatment of of each intervention group is 4w.
1. control group：The autonomous smoking cessation of any intervention is not carried out；
2. varenicline group：Varenicline piece is taken, the 1-3 days are once a day, each 0.5mg, the 4-7 days daily 2 times, every time
0.5mg, terminates daily 2 times, each 1mg in the 8th day to intervention；
3. thick paste group：Using the thick paste of gained in embodiment 1, dosage is each taken equivalent to crude drug amount 62g.The initial stage of giving up can
Think that 4 times a day, divide 4 times and take, give up the maintenance phase and can divide 2 times and take for 2 times a day, can be that one time a day after giving up,
Pause clothes；
4. electuary group：Formulation is reconstituted using the instant of gained in embodiment 2, a bag, oral according to situation is given up every time.Give up
Initial stage is taken for 4 times a day, is given up the maintenance phase and can be taken for 2 times a day, can be for once a day after giving up, a clothes；
5. cake group：Using the cake of gained in embodiment 3, when there is the impulsion of smoking, you can edible, daily measure not
More than bulk drug crude drug amount 270g；
6. biscuit group：Using the biscuit of gained in embodiment 4, when there is the impulsion of smoking, edible biscuits replace smoking, daily
Oral cumulant is no more than crude drug amount 270g.
1.2.2 observation item：
1. intervene and start rear 4w, calculate every group of withdrawal rate；
2. relapse rate is calculated in 12w after intervention starts；
3. carry out giving up impression scoring in 4w after intervention starts：Subjective sensation mode is taken in scoring, with the process of giving up smoking without any
Sense of discomfort is 0 point, slight, heavier, strong according to sense of discomfort but do not influence life for 1,2,3 points, is produced by force with during smoking cessation
Strong sense of discomfort simultaneously influences life for 4 points.Described sense of discomfort include dysphoria, depressive emotion, insomnia, irritability, sense of frustration,
Indignation, anxiety, notice cannot be concentrated, be on tenterhooks, blood pressure is raised, heart rate declines.
1.2.4 statistical analysis：SPSS 16.0 carries out statistical analysis, and measurement data is checked with t, enumeration data χ2
Inspection.
2 results.
Withdrawal rate compares during 2.1 6 groups of 4w：Intervention starts rear 4w withdrawal rates respectively control group 15%, varenicline group
90%, thick paste group 85%, electuary group 75%, cake group 90%, biscuit group 90%.As can be seen that varenicline group, thick paste group, electuary
The withdrawal rate of group, cake group and biscuit group is apparently higher than control group（p<0.01）, varenicline group and thick paste group, electuary group, cake
Select group and biscuit group withdrawal rate difference is not statistically significant（p>0.05）.
Given up during 2.2 6 groups of 4w and experience scoring and be respectively:Control group 3.41 ± 0.51, varenicline group 0.98 ± 0.23,
Thick paste group 1.29 ± 0.17, electuary group 1.52 ± 0.31, cake group 1.38 ± 0.42, biscuit group 1.36 ± 0.25.Result shows
Control group gives up impression scoring highest, and it is bright that varenicline group, thick paste group, electuary group, cake group and biscuit group give up impression scoring
It is aobvious to be less than control group（p<0.01）, and the no significant difference between five intervention groups（p>0.05）.
2.3 6 groups of 12w relapse rates compare：Give up relapse rate of the successful sample in 12w respectively control group 33.3%
（1/3）, varenicline group 16.67%（3/18）, thick paste group 11.76%（2/17), electuary group 20%（3/15), cake group 11.11%
（2/18）, biscuit group 11.11%（2/18）.Relapse rate compares, and six groups of differences are not obvious（p>0.05）.
2.4 5 intervention group adverse reaction rates compare：In addition to the sense of discomfort that nicotine withdrawal brings, varenicline
Group also has 55.0%（11/20）Smoker there is nausea, headache, drowsiness, apocleisis, vomiting, constipation, suffer from diarrhoea, have a stomach upset etc. no
Good reaction；And the adverse reaction rate of thick paste group, electuary group, cake group and biscuit group is respectively 15%（3/20）、20%（4/
20）、15%（3/20）、10%（2/20）, constipation, diarrhoea are embodied in, compared with varenicline group, with statistical significance（p
<0.01, p<0.05）.It can be confirmed that prescription adverse reaction rate of the present invention is significantly lower than varenicline group.Five intervention groups are done
Before and after pre- there is no significant change in hepatic and renal function, blood picture.
3 conclusions.
This result of study is shown, is contributed to increase using the thick paste group of inventive formulation, electuary group, cake group and biscuit group
Impression is given up in nicotine withdrawal rate, improvement, and relapse rate is low, and adverse reaction relatively light, security is higher.Its nicotine withdrawal is intervened
Effect is similar with varenicline, effect affirmative, and the related adverse reaction of medicine is significantly lower than varenicline.
It should be noted that the particular of invention has been described in detail to invention, for this area
For technical staff, the various obvious change that it is carried out all is existed in the case of without departing substantially from the spirit and scope of invention
Within the protection domain of invention.
Claims (2)
1. a kind of electuary for alleviating abstinence reaction, it is characterised in that including weight than following raw material：Aglaia odorata 20kg,
Beggar-ticks 20kg, wintergreen 15kg, Blumea balsamifera 15kg, cinnamomum camphora 15kg, stem of noble dendrobium 30kg, hyperici,herba 7kg, Semen Lablab Album 50kg, Chinese yam
Medicine 50kg, Semen Nelumbinis 30kg, burnt rice sprout 50kg, melanoidin malt 50kg, maltose 15kg；Preparation method is：（1）By Aglaia odorata, Ai Na
After perfume, cinnamomum camphora, the stem of noble dendrobium are cleaned and crush, extraction by steam distillation volatile oil is standby, and the dregs of a decoction are standby；（2）By beggar-ticks, white flat
The dregs of a decoction mixing of beans, Chinese yam rhizome, Semen Nelumbinis, burnt rice sprout, hyperici,herba, melanoidin malt, wintergreen and step 1 gained, plus 3 times of decoctings are boiled
Secondary, decocting time is 2 hours every time, collecting decoction, filtration, and it is 1.30 that filtrate is concentrated into relative density respectively（60℃）'s
Thick paste；（3）Take maltose and be ground into fine powder, it is standby；（4）Step 1 gained volatile oil and step 3 gained maltose are added to step 2
In gained thick paste, drying under reduced pressure after mixing is ground into dry extract, packing.
2. a kind of electuary for alleviating abstinence reaction according to claim 1, it is characterized by：Described drying under reduced pressure bar
Part is 60 DEG C, 0.09MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710116102.3A CN106901362B (en) | 2015-01-21 | 2015-01-21 | Electuary for relieving withdrawal reaction |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510027449.1A CN104522678B (en) | 2015-01-21 | 2015-01-21 | Smoking-quitting food capable of alleviating abstinence reaction |
| CN201710116102.3A CN106901362B (en) | 2015-01-21 | 2015-01-21 | Electuary for relieving withdrawal reaction |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510027449.1A Division CN104522678B (en) | 2015-01-21 | 2015-01-21 | Smoking-quitting food capable of alleviating abstinence reaction |
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| Publication Number | Publication Date |
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| CN106901362A true CN106901362A (en) | 2017-06-30 |
| CN106901362B CN106901362B (en) | 2020-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710116101.9A Active CN106620419B (en) | 2015-01-21 | 2015-01-21 | Cake for quitting smoking |
| CN201510027449.1A Expired - Fee Related CN104522678B (en) | 2015-01-21 | 2015-01-21 | Smoking-quitting food capable of alleviating abstinence reaction |
| CN201710116102.3A Active CN106901362B (en) | 2015-01-21 | 2015-01-21 | Electuary for relieving withdrawal reaction |
| CN201710116093.8A Active CN106922791B (en) | 2015-01-21 | 2015-01-21 | Biscuit beneficial to relieving withdrawal reaction |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710116101.9A Active CN106620419B (en) | 2015-01-21 | 2015-01-21 | Cake for quitting smoking |
| CN201510027449.1A Expired - Fee Related CN104522678B (en) | 2015-01-21 | 2015-01-21 | Smoking-quitting food capable of alleviating abstinence reaction |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710116093.8A Active CN106922791B (en) | 2015-01-21 | 2015-01-21 | Biscuit beneficial to relieving withdrawal reaction |
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| Country | Link |
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| CN (4) | CN106620419B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN86108668A (en) * | 1986-12-22 | 1988-07-06 | 李庆东 | A kind of method that beggar-ticks is processed into drink tea |
| CN101874837A (en) * | 2010-02-10 | 2010-11-03 | 宋风鸣 | Product for quitting smoking and preparation method thereof |
| CN102327569A (en) * | 2011-10-08 | 2012-01-25 | 李莉 | Preparation method and application method of drug and herbal medicine thereof for curing chronic hepatitis B |
| CN102755479A (en) * | 2011-04-24 | 2012-10-31 | 孙逊 | Smoking-quitting Chinese medicine |
| CN103520269A (en) * | 2013-10-11 | 2014-01-22 | 孙殿良 | Traditional Chinese medicine composition for smoking cessation |
| CN103751504A (en) * | 2013-12-18 | 2014-04-30 | 张振江 | Chinese medicinal composition for smoking cessation |
| CN103948888A (en) * | 2014-04-04 | 2014-07-30 | 谢文茹 | Traditional Chinese medicinal preparation for treating neurasthenia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054060C (en) * | 1995-04-25 | 2000-07-05 | 刘忠川 | Ginseng candy for abstention from smoking |
| CN1158930C (en) * | 2001-06-19 | 2004-07-28 | 李秀华 | Cracker containing Chinese medicine for mourishing spleen and kidney and its preparing process |
| JP2007028997A (en) * | 2005-07-27 | 2007-02-08 | Kanebo Seiyaku Kk | Liquid food mixed with crude drug essence and use of the same |
| CN102406040A (en) * | 2010-09-23 | 2012-04-11 | 魏孟兵 | Antialcoholic chewing gum |
| CN102161948A (en) * | 2011-01-20 | 2011-08-24 | 吴承望 | Anti-fatigue glutinous rice wine |
| CN103070471B (en) * | 2012-10-09 | 2015-08-05 | 方力 | A kind of edible cigarette and preparation method thereof |
| CN104027760A (en) * | 2014-05-21 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicament for treating wind-phlegm in lung type asthma |
| CN104255865A (en) * | 2014-09-03 | 2015-01-07 | 杨翔宇 | Health care biscuit capable of relieving child anorexia and making method thereof |
-
2015
- 2015-01-21 CN CN201710116101.9A patent/CN106620419B/en active Active
- 2015-01-21 CN CN201510027449.1A patent/CN104522678B/en not_active Expired - Fee Related
- 2015-01-21 CN CN201710116102.3A patent/CN106901362B/en active Active
- 2015-01-21 CN CN201710116093.8A patent/CN106922791B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86108668A (en) * | 1986-12-22 | 1988-07-06 | 李庆东 | A kind of method that beggar-ticks is processed into drink tea |
| CN101874837A (en) * | 2010-02-10 | 2010-11-03 | 宋风鸣 | Product for quitting smoking and preparation method thereof |
| CN102755479A (en) * | 2011-04-24 | 2012-10-31 | 孙逊 | Smoking-quitting Chinese medicine |
| CN102327569A (en) * | 2011-10-08 | 2012-01-25 | 李莉 | Preparation method and application method of drug and herbal medicine thereof for curing chronic hepatitis B |
| CN103520269A (en) * | 2013-10-11 | 2014-01-22 | 孙殿良 | Traditional Chinese medicine composition for smoking cessation |
| CN103751504A (en) * | 2013-12-18 | 2014-04-30 | 张振江 | Chinese medicinal composition for smoking cessation |
| CN103948888A (en) * | 2014-04-04 | 2014-07-30 | 谢文茹 | Traditional Chinese medicinal preparation for treating neurasthenia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106922791B (en) | 2020-09-15 |
| CN106620419A (en) | 2017-05-10 |
| CN104522678B (en) | 2017-04-19 |
| CN106620419B (en) | 2020-09-01 |
| CN106922791A (en) | 2017-07-07 |
| CN106901362B (en) | 2020-08-18 |
| CN104522678A (en) | 2015-04-22 |
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Effective date of registration: 20200721 Address after: 276826 Yantai Road, Donggang District, Rizhao City, Shandong Province, No. 169 Applicant after: RIZHAO XUANYI INFORMATION TECHNOLOGY Co.,Ltd. Address before: 101100, Beijing, Tongzhou District Cloud Bridge homes 7-412 Applicant before: Liu Danchi |
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Denomination of invention: A granule for relieving withdrawal reaction Effective date of registration: 20211223 Granted publication date: 20200818 Pledgee: Rizhao Bank Co.,Ltd. Donggang sub branch Pledgor: RIZHAO XUANYI INFORMATION TECHNOLOGY CO.,LTD. Registration number: Y2021980016133 |