CN106890269A - A kind of external medicine composition for treating induced by chemotherapeutic agents peripheral neuropathy and application thereof - Google Patents
A kind of external medicine composition for treating induced by chemotherapeutic agents peripheral neuropathy and application thereof Download PDFInfo
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Abstract
The present invention relates to tcm field, specifically a kind of external medicine composition for treating induced by chemotherapeutic agents peripheral neuropathy, by Rhizoma Arisaematis (processed), the tuber of pinellia processed, scorpio, edible tulip, the root of Chinese clematis, cassia twig, safflower, eight kinds of honey-fried licorice root there is the traditional Chinese medicine that the stagnation resolvation of dissolving phlegm dredging collateral and promoting blood circulation is acted on to constitute, there is promoting blood circulation and removing obstruction in channels, analgesic eliminating impediment, the purposes such as the extremity numbness, the pain that can be used for caused by induced by chemotherapeutic agents peripheral neuropathy, its determined curative effect, have no toxic side effect, it is with low cost, there is the advantage for being easy to application.
Description
Technical field
It is a kind of to treat induced by chemotherapeutic agents peripheral neuropathy specifically the present invention relates to tcm field
External medicine composition is formulated and its multiple use.
Background technology
Induced by chemotherapeutic agents peripheral neuropathy (chemotherapy-induced peripheral
Neuropathy, CIPN) refer to by neurotoxicity lesion caused by chemotherapeutics coup injury peripheral nervous system, it is chemotherapeutics
One of most common adverse reaction, governs the application of chemotherapeutics.Its clinical manifestation be limb end numbness, swelling, pain,
Feel to go down and the sensory nerve obstacle such as abnormal, and limb spasm, powerless, myalgia, atrophy, limitation of activity such as are even paralysed at the fortune
Dynamic neurological disorder.
The generation of CIPN is through platinum class, Japanese yew class, vinca, Thalidomide and albumen alcohol inhibitor canopy Bortezomib etc.
The use overall process of many Common Chemotherapy medicines.As may occur in which the disease after oxaliplatin administration a few hours, incidence reaches 85%-
95%；The CIPN of taxol and vincristine is dose-limiting, and the former is in dosage more than 200mg/m2When, the incidence of disease is
59%-78%, the incidence of disease of the latter is then about 40%, and the toxic degree of the two is relevant with drug accumulation dosage, causes chemotherapy
The dose intensity and intergal dose of medicine are restricted, and chemotherapy effectiveness cannot obtain maximum performance, and severe patient is even forced temporarily
Or permanent drug withdrawal, influence being smoothed out for chemotherapy.Sensation that moreover, CIPN is caused (and/or) kinesitherapy nerve disfunction
Shape sustainable long-term existence after drug withdrawal, middle position recovery time is more long and not fully reversible, once form permanent dysfunction
Tumor patient physiology, psychology and many HDs economically can be aggravated, life quality is influenceed, shortens life span, while burying
The hidden danger of medical tangle.
With Cancer Mortality rise year by year and chemotherapeutics extensive use, research to CIPN mechanism and explain
State and be increasingly becoming focus.Because CIPN generation mechanisms are complicated, phase interaction of the Western medicine derived from different mechanisms with antineoplastic in itself
It is limited with not clear, unified treatment standard is there is no at present.
Traditional Chinese medicine as preventing and treating tumor complication important householder method, because its " treating different diseases with same method " dialectical characteristic and
The administration thought of " inner disease outer treat " shows certain advantage and prospect, especially starts with from " etiology and pathogenesis " anti-to explore traditional Chinese medicine
Controlling CIPN has important practical significance.
The symptom such as numb in every limb caused by CIPN, pain and moving obstacle, it is seen that in the category such as the traditional Chinese medical science " meciless ", " bi Zheng ",
Ancient Chinese medicine doctor is discussed very in detail to it, understands rich, inquires into " phlegm " long-standing with the relation of above-mentioned disease.As " phlegm is thing, stream
The whole body is inside and outside all to be arrived, and the vital organs of the human body all have for dynamic accident, therefore it is caused harm ... ", " phlegm is made a return journey without calmly, and Meeting and departing are irregular, and the vital organs of the human body are not
It is not trouble ", illustrate that " phlegm " can flee whole body, stop gathering between train of thought.Conclude " phlegm " pathogenic characteristic rather similar to this disease.It is swollen
Knurl patient healthy tendency is consumed, and chemotherapeutics is the product of the big poison of cold sensation of the genitalia in addition, kills the impairment of the spleen, and spleen weakness is stomach Qi rising, then aqueous are stopped
Stagnant, stagnation of turbid phlegm in middle-JIAO, phlegm-blood stasis knot, numbness resistance channels and collaterals make qi-blood-body fluid sensible, and tendon and vessel muscle loses foster in moistening, and causes not general rule
Bitterly, it is apathetic, joint stuffiness etc..Its disease and evil is " phlegm wet ", and sick position is in close relations with taste in " train of thought ".
And optimal screening of the present invention goes out one group of Chinese medicine composition with treatment induced by chemotherapeutic agents peripheral neuropathy,
May be used to make various formulations such as ointment, gel, lotion, spray, it is higher with relative purity, can be done directly on lesion
Position, dispersion of medicine, infiltration rate is fast, and availability is high, and the features such as property of medicine stabilization, application prospect is extensive.Meanwhile, we's composition
Medicine with dissolving phlegm dredging collateral, it is promoting blood circulation and removing blood stasis based on, external application can also improve the symptoms such as numb limb pain.
The content of the invention
It is an object of the invention to provide a kind of Chinese traditional medicine composition with treatment induced by chemotherapeutic agents peripheral neuropathy
Composition formula, formulation process method and application thereof.By the strict compatibility and the unique technology of preparing of application of each Chinese medicine, medicine is made
Various formulations such as cream, gel, spray, directly act on diseased region, play promoting blood circulation and removing obstruction in channels, analgesic eliminating impediment the effects such as.
The raw material selection of Chinese medicine composition of the present invention and proportioning are that inventor combines Chinese medical discrimination prescription, through Long-term clinical reality
Trample and grope to draw.Southern Star, the tuber of pinellia are altogether the monarch drug in a prescription for controlling phlegm in side, and both are made with the work(for both helping resolving sputum, and pungent dry power is subtracted again.Mountain is kind
Mushroom it is sweet it is cool enter spleen, drop lets out wet fire, dissolving phlegm heresy stasis blocking because；Scorpio searches phlegm and picks network, and extending from the interior to the exterior, anti-phlegm heresy flees channels and collaterals；Wheeling
Celestial being dispels wind and dampness and relieve pain, and pass through the twelve regular channels, phlegm is had outlet, and upper three taste strengthens the power of monarch drug in a prescription dissolving phlegm, is altogether ministerial drug.Cassia twig,
Safflower is pungent to dissipate warm, clearing and activating the channels and collaterals, altogether for adjutant in order to avoid phlegm-coagulation and blood-stagnation.Radix Glycyrrhizae is used to make, and middle soil system of mending is wet, phlegm raw absolutely it
Source.The work(of dissolving phlegm dredging collateral is played altogether by full side, and " with this dredging the channel, then stasis phlegm resistance is stood and slitted invariably.”
A kind of the first aspect of the present invention, there is provided external application Chinese medicine combination for treating induced by chemotherapeutic agents peripheral neuropathy
Thing, described Chinese medicine composition is made up of the bulk drug of following weight portion：1~45 part of Rhizoma Arisaematis (processed), 1~45 part of the tuber of pinellia processed, mountain are kind
1~30 part of mushroom, 1~15 part of scorpio, 1~30 part of the root of Chinese clematis, 1~45 part of cassia twig, 1~30 part of safflower, 1~30 part of honey-fried licorice root.This
Invention Chinese medicine composition extraction process determines that the consumption of each component extracts tool with described ratio after being tested through multiple strict orthogonal
There is good therapeutic effect.
Preferably, described Chinese medicine composition is made up of the bulk drug of following weight portion：1~30 part of Rhizoma Arisaematis (processed), the tuber of pinellia processed 1
~30 parts, 1~20 part of edible tulip, 1~10 part of scorpio, 1~20 part of the root of Chinese clematis, 1~30 part of cassia twig, 1~20 part of safflower, honey-fried licorice root
1~20 part.
It is furthermore preferred that described Chinese medicine composition is made up of the bulk drug of following weight portion：1~15 part of Rhizoma Arisaematis (processed), system half
1~15 part of summer, 1~10 part of edible tulip, 1~5 part of scorpio, 1~10 part of the root of Chinese clematis, 1~15 part of cassia twig, 1~10 part of safflower, process it is sweet
1~10 part of grass.
Most preferably, described Chinese medicine composition is made up of the bulk drug of following weight portion：15 parts of Rhizoma Arisaematis (processed), the tuber of pinellia processed 15
Part, 10 parts of edible tulip, 5 parts of scorpio, 10 parts of the root of Chinese clematis, 15 parts of cassia twig, 10 parts of safflower, 10 parts of honey-fried licorice root.
The second aspect of the present invention, there is provided the external application Chinese medicine group of above-mentioned treatment induced by chemotherapeutic agents peripheral neuropathy
Compound as active ingredient pharmaceutical preparation, described pharmaceutical preparation is to be prepared into pharmacy using this area customary preparation methods
On common formulations.
Described pharmaceutical preparation is ointment, gel, lotion, aerosol etc..
Pharmaceutical preparation of the invention may be used to lower section method and prepare：
(A) each medicinal material component is weighed, is mixed, obtain mixture；
(B) pharmaceutically acceptable carrier is added in the mixture, is obtained using this area customary preparation methods.
The third aspect of the present invention, there is provided the external application Chinese medicine group of above-mentioned treatment induced by chemotherapeutic agents peripheral neuropathy
The application of compound and pharmaceutical preparation in the medicine or health food for preparing treatment induced by chemotherapeutic agents peripheral neuropathy.
Chinese medicine composition raw material system conventional Chinese medicine of the present invention, it is inexpensive with raw material, simplicity is prepared, easy to use is excellent
Gesture, has significant curative effect to peripheral neuropathy after Prophylactic chemotherapy, can also be promoting blood circulation and removing obstruction in channels, four limbs end after analgesic eliminating impediment and improvement chemotherapy
The tip is numb, the symptom such as pain, and compound Chinese medicinal preparation of the present invention have it is nontoxic, can long-term use the characteristics of, therefore, with wide
Market prospects.
Specific embodiment
The specific embodiment that the present invention is provided is elaborated with reference to embodiment.
The experimental technique of unreceipted actual conditions in the following example, generally according to normal condition, or according to manufacturer
Proposed condition.Medicinal material used by the embodiment of the present invention can be obtained except as otherwise indicating from Chinese medicine sales company.Obtained
Medicinal material except as otherwise indicate, be tcm and herbal slice.Medicine materical crude slice both can from sales company obtain, or obtain after through processing
Form.
Embodiment 1:It is prepared by ointment of the invention
Weigh Rhizoma Arisaematis (processed) 15g, tuber of pinellia 15g processed, edible tulip 10g, scorpio 5g, root of Chinese clematis 10g, cassia twig 15g, safflower 10g, process
Radix Glycyrrhizae 10g, meal is broken into by above-mentioned 8 taste Chinese medicine, and after the dipping 24h that adds water, 8 times of amount water water extraction 2 times, each 2h separates the dregs of a decoction, decocts
Boil liquid crosses 100 eye mesh screens, is concentrated into (60 DEG C) Zuo You of relative density about 1.20, plus 2 times of amount ethanol, stirs evenly, and stands 48 hours, takes
Supernatant liquid filtering, reclaims ethanol to without alcohol taste.Albolene, glycerol monostearate vinegar, stearic acid and atoleine is taken to be heated to
70 DEG C, it is oil phase to melt；It is another that glycerine, distilled water and medicinal extract are heated to 90 DEG C, and add triethanolamine and potassium sorbate to dissolve
It is water phase, is then mutually added slowly in oil phase water, forward stirred when adding, is removed from water-bath after a few minutes, plus
Enter transdermal agent borneol and azone, and continue to whisk in yellow semisolid at room temperature, ointment is both obtained after cooling.
Embodiment 2：It is prepared by gel of the invention
Weigh Rhizoma Arisaematis (processed) 15g, tuber of pinellia 15g processed, edible tulip 10g, scorpio 5g, root of Chinese clematis 10g, cassia twig 15g, safflower 10g, process
Radix Glycyrrhizae 10g, meal is broken into by above-mentioned 8 taste Chinese medicine, and after the dipping 24h that adds water, 8 times of amount water water extraction 2 times, each 2h separates the dregs of a decoction, decocts
Boil liquid crosses 100 eye mesh screens, is concentrated into (60 DEG C) Zuo You of relative density about 1.20, plus 2 times of amount ethanol, stirs evenly, and stands 48 hours, takes
Supernatant liquid filtering, reclaims ethanol to without alcohol taste.With Carbomer as matrix, with glycerine as lubricant, azone is transdermal agent, with medicine
1000g is mixed and made into, gel is obtained final product.
Embodiment 3：It is prepared by lotion of the invention
Weigh Rhizoma Arisaematis (processed) 15g, tuber of pinellia 15g processed, edible tulip 10g, scorpio 5g, root of Chinese clematis 10g, cassia twig 15g, safflower 10g, process
Radix Glycyrrhizae 10g, meal is broken into by above-mentioned 8 taste Chinese medicine, and after the dipping 24h that adds water, 8 times of amount water water extraction 2 times, each 2h separates the dregs of a decoction, decocts
Boil liquid crosses 100 eye mesh screens, is concentrated into (60 DEG C) Zuo You of relative density about 1.20, plus 2 times of amount ethanol, stirs evenly, and stands 48 hours, takes
Supernatant liquid filtering, reclaims ethanol to without alcohol taste.Plus hydroxypropyl methyl cellulose and sodium dodecyl sulfate solution, stirring addition Buddhist nun
The golden ethyl ester alcoholic solution of pool, adds water to 1000ml, stirs evenly, and obtains final product lotion.
Embodiment 4：It is prepared by spray of the invention
Weigh Rhizoma Arisaematis (processed) 15g, tuber of pinellia 15g processed, edible tulip 10g, scorpio 5g, root of Chinese clematis 10g, cassia twig 15g, safflower 10g, process
Radix Glycyrrhizae 10g, meal is broken into by above-mentioned 8 taste Chinese medicine, and after the dipping 24h that adds water, 8 times of amount water water extraction 2 times, each 2h separates the dregs of a decoction, decocts
Boil liquid crosses 100 eye mesh screens, is concentrated into (60 DEG C) Zuo You of relative density about 1.20, plus 2 times of amount ethanol, stirs evenly, and stands 48 hours, takes
Supernatant liquid filtering, reclaims ethanol to without alcohol taste.It is another to take borneol, menthol, the dissolving of anesin appropriate amount of ethanol, add filtrate
In, glycerine, polyvinylpyrrolidone are added, stir evenly, 1000ml is added water to, obtain final product spray.
Embodiment 5：The experimental study of peripheral neuropathy after Chinese medicine composition Prophylactic chemotherapy
Healthy SPF grades of female Wistar rats 40,180 ± 20g of body weight is randomly divided into 4 groups, every group 10：1. model
Group：With reference to the 4th group of modeling method modeling in G.Cavalettia methods, the next day 1 intraperitoneal injection oxaliplatin 3mg/kg,
8 times altogether；2. Chinese medicine group, (2g/kg represents per kilogram of body weight 2g Chinese medicines to external washout with traditional Chinese herbs while intraperitoneal injection oxaliplatin
Composition crude drug amount, equivalent to clinical dosage)；3. Mecobalamin group：Intraperitoneal injection first cobalt while intraperitoneal injection oxaliplatin
Amine 104 μ g/kg, 2 times/week；4. Normal group：Isometric 5% glucose of intraperitoneal injection.From the modeling same day, with reference to clinical
Administering mode, Chinese herbs group soaks four limbs and rat-tail with 30 DEG C of Chinese medicine externals of respective concentration, and one time a day, each 60min；Mould
Type group and Normal group are compareed with 30 DEG C of distilled water immersion four limbs and rat-tail, until modeling terminates.Final injection is surveyed after finishing
Sciatic Nerve Conduction Velocity (separates sciatic nerve, that life signal acquisition system is placed on free sciatic nerve irritates electricity
Pole and recording electrode；The difference i.e. difference in incubation period of the time that 2 recording electrodes recorded, MNCV=2 record electricity
The difference in the distance between pole/incubation period)；After Sciatic Nerve Conduction Velocity has been surveyed, abdominal vein takes blood and surveys nerve growth rat
The factor (NGF) content.
(1) influence of the Experimental agents to each group rat sciatic nerve conduction of velocity
The each group rat sciatic nerve conduction of velocity of table 2
Note：Compare with Normal group, * * P<0.01；Compare with model group,#P<0.01
(2) influence of the Experimental agents to each group rat plasma NGF
The each group rat plasma NGF contents of table 3
Note：Compare with Normal group, * * P<0.01；Compare with model group,#P<0.01。
Conclusion：
External washout with traditional Chinese herbs is used while rats by intraperitoneal injection oxaliplatin, rat sciatic nerve conduction can be significantly improved
Speed and blood plasma NGF contents, compare tool and are statistically significant (P with model group and intraperitoneal injection Mecobalamin group<0.01), treat
Effect is definite.
Below the preferred embodiment to the invention is illustrated, but the invention be not limited to it is described
Embodiment, those of ordinary skill in the art can also make a variety of equivalent on the premise of without prejudice to the invention spirit
Modification or replacement, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (8)
1. a kind of external medicine composition for treating induced by chemotherapeutic agents peripheral neuropathy, it is characterised in that in described
Drug composition is made up of the bulk drug of following weight portion：It is 1~45 part of Rhizoma Arisaematis (processed), 1~45 part of the tuber of pinellia processed, 1~30 part of edible tulip, complete
1~15 part of scorpion, 1~30 part of the root of Chinese clematis, 1~45 part of cassia twig, 1~30 part of safflower, 1~30 part of honey-fried licorice root.
2. the external medicine composition for the treatment of induced by chemotherapeutic agents peripheral neuropathy according to claim 1, it is special
Levy and be, described Chinese medicine composition is made up of the bulk drug of following weight portion：1~30 part of Rhizoma Arisaematis (processed), 1~30 part of the tuber of pinellia processed,
1~20 part of edible tulip, 1~10 part of scorpio, 1~20 part of the root of Chinese clematis, 1~30 part of cassia twig, 1~20 part of safflower, honey-fried licorice root 1~20
Part.
3. the external medicine composition for the treatment of induced by chemotherapeutic agents peripheral neuropathy according to claim 1, it is special
Levy and be, described Chinese medicine composition is made up of the bulk drug of following weight portion：1~15 part of Rhizoma Arisaematis (processed), 1~15 part of the tuber of pinellia processed,
1~10 part of edible tulip, 1~5 part of scorpio, 1~10 part of the root of Chinese clematis, 1~15 part of cassia twig, 1~10 part of safflower, 1~10 part of honey-fried licorice root.
4. the external medicine composition for the treatment of induced by chemotherapeutic agents peripheral neuropathy according to claim 1, it is special
Levy and be, described Chinese medicine composition is made up of the bulk drug of following weight portion：15 parts of Rhizoma Arisaematis (processed), 15 parts of the tuber of pinellia processed, edible tulip
10 parts, 5 parts of scorpio, 10 parts of the root of Chinese clematis, 15 parts of cassia twig, 10 parts of safflower, 10 parts of honey-fried licorice root.
5. the external application Chinese medicine combination of a kind for the treatment of induced by chemotherapeutic agents peripheral neuropathy as described in claim 1-4 is any
Thing as active ingredient pharmaceutical preparation, it is characterised in that described pharmaceutical preparation is using this area customary preparation methods system
It is standby into the common formulations in pharmacy.
6. the external medicine composition for the treatment of induced by chemotherapeutic agents peripheral neuropathy according to claim 5 is used as work
The pharmaceutical preparation of sexual element, it is characterised in that described pharmaceutical preparation is ointment, gel, lotion, aerosol.
7. the external application Chinese medicine combination of a kind for the treatment of induced by chemotherapeutic agents peripheral neuropathy as described in claim 1-4 is any
Application of the thing in the medicine or health food for preparing treatment induced by chemotherapeutic agents peripheral neuropathy.
8. the external medicine composition of a kind for the treatment of induced by chemotherapeutic agents peripheral neuropathy as described in claim 5 or 6
As the pharmaceutical preparation of active ingredient in the medicine or health food for preparing treatment induced by chemotherapeutic agents peripheral neuropathy
Application.
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| CN108704067A (en) * | 2018-08-20 | 2018-10-26 | 杨明兰 | It is a kind of to treat gout, periostitis, cervical spondylosis pharmaceutical composition and its therapy |
| CN112386557A (en) * | 2020-11-27 | 2021-02-23 | 王玥 | Preparation method of traditional Chinese medicine skin cream based on external washing and aiming at chemotherapy-related peripheral neuropathy |
| CN116832086A (en) * | 2023-08-11 | 2023-10-03 | 中国人民解放军海军第九〇五医院 | External traditional Chinese medicine composition for treating chapped skin and application thereof |
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| CN108704067A (en) * | 2018-08-20 | 2018-10-26 | 杨明兰 | It is a kind of to treat gout, periostitis, cervical spondylosis pharmaceutical composition and its therapy |
| CN112386557A (en) * | 2020-11-27 | 2021-02-23 | 王玥 | Preparation method of traditional Chinese medicine skin cream based on external washing and aiming at chemotherapy-related peripheral neuropathy |
| CN116832086A (en) * | 2023-08-11 | 2023-10-03 | 中国人民解放军海军第九〇五医院 | External traditional Chinese medicine composition for treating chapped skin and application thereof |
| CN116832086B (en) * | 2023-08-11 | 2024-05-14 | 中国人民解放军海军第九〇五医院 | External traditional Chinese medicine composition for treating chapped skin and application thereof |
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