CN106889368A - A kind of chicken feed addictive of safe noresidue and its preparation method and application - Google Patents
A kind of chicken feed addictive of safe noresidue and its preparation method and application Download PDFInfo
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- CN106889368A CN106889368A CN201710108776.9A CN201710108776A CN106889368A CN 106889368 A CN106889368 A CN 106889368A CN 201710108776 A CN201710108776 A CN 201710108776A CN 106889368 A CN106889368 A CN 106889368A
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- parts
- feed addictive
- reseda
- felwort
- leaf
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
Abstract
The invention discloses a kind of chicken feed addictive of safe noresidue and its preparation method and application, the feed addictive is made up of the following raw material according to weight portion：Husky fluffy 28 36 parts, 15 25 parts of reseda, 15 parts of rutin sophorin, 31 39 parts of felwort, 7 15 parts of leaf of Moringa.Rutin sophorin, leaf of Moringa are crushed, mixes to obtain mixed powder A；Added water to cook twice after husky fluffy, reseda, felwort are mixed, filtering merges, and stands, and takes supernatant, is concentrated under reduced pressure into medicinal extract, is then mixed with mixed powder A, mixture vacuum freeze drying, crushing are obtained final product.Obtained feed addictive of the invention is high to preventing and treating checken pest curative effect highly significant, instant effect, cure rate, and with strong points, addition is few, does not have toxic and side effect, environmental protection, noresidue to animal.Additionally, feed addictive of the present invention can also improve production performance, laying hen egg yield is improved, and extends ovipository cycle, and broiler growth is delivered for sale in advance, and improving the aspects such as livestock products quality has obvious effect.
Description
Technical field
The present invention relates to field of feed additive technology for animals, the chicken feed addictive of specifically a kind of safe noresidue and
Its preparation method and application.
Background technology
Feed addictive refers to a small amount of or micro substance added during Feed Manufacturing processing, use, in feed
Consumption is seldom but effect is notable.Feed addictive is the raw material that modern feed industry is necessarily used, to reinforcing basal feed nutrition
Value, improves breeding performonce fo animals, it is ensured that animal health, saves feed cost, and improving the aspects such as livestock products quality has significantly
Effect.
Current poultry is susceptible to suffer from bird flu, particularly chicken, this disease an infected chicken, all ages and classes, sex, product under field conditions (factors)
The chicken and pheasant planted are all susceptible, can occur throughout the year.Diseased chicken is major source of infection, diseased chicken excreta and secretion, is died of illness
Chicken and internal organs and corpse, anxious blood, meat, internal organ, waste water, the feed of waste entrainment for killing diseased chicken, drinking-water can all disseminate virus, checken pest
Propagation mainly by contact, through infection of digestive canal.Existing therapeutic scheme due to without general vaccines, abuse of antibiotics, effect is not
Substantially, the death rate may be up to more than 50%, and pollute, and harmful components residual is exceeded.Chicken is carried out by feed addictive
Prevention and treatment bird flu is a kind of extremely convenient method.But lack the feed addictive with above-mentioned effect at present.
The content of the invention
It is an object of the invention to provide a kind of chicken feed addictive of safe noresidue and its preparation method and application, with
Solve the problems, such as to be proposed in above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of chicken feed addictive of safe noresidue, is made up of the following raw material according to weight portion：It is husky it is fluffy 28-36 parts,
Reseda 15-25 parts, rutin sophorin 1-5 parts, felwort 31-39 parts, leaf of Moringa 7-15 parts.
As further scheme of the invention：The chicken feed addictive of the safe noresidue, by following according to weight portion
Raw material composition：It is husky it is fluffy 30-34 parts, reseda 18-22 parts, rutin sophorin 2-4 parts, felwort 33-37 parts, leaf of Moringa 9-13 parts.
As further scheme of the invention：The chicken feed addictive of the safe noresidue, by following according to weight portion
Raw material composition：Husky fluffy 32 parts, 20 parts of reseda, 3 parts of rutin sophorin, 35 parts of felwort, 11 parts of leaf of Moringa.
Another object of the present invention is to provide a kind of preparation method of the chicken feed addictive of safe noresidue, by following steps
Composition：
1) Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, peppery
Wooden leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A；
2) the husky fluffy, reseda that will weigh, felwort add water to cook twice after mixing, and each 2.5h, filtering merges filter
Liquid, stands 24 hours, take supernatant, medicinal extract is concentrated under reduced pressure into, then with step 1) the mixed powder A that obtains mixes, by mixture
Vacuum freeze drying, and the powder of 80 mesh is ground into, obtain final product feed addictive.
Another object of the present invention is to provide application of the feed addictive in chicken feed.
Another object of the present invention is to provide application of the described feed addictive in treatment checken pest feed is prepared.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention under the synergy of each raw material, to preventing and treating checken pest curative effect highly significant be shown in by obtained feed addictive
Effect is fast, and cure rate is high, with strong points, and addition is few, does not have toxic and side effect, environmental protection, noresidue to animal；Body is effectively improved to exempt from
Epidemic disease power prevent so as to reach various broiler chicken laying hens bacterium and virus disease (such as ewcastle disease, Marek's disease, bursa fabricic is yellow
Dysentery characterized by white mucous stool etc.).Additionally, feed addictive of the present invention can also improve production performance, laying hen egg yield is improved, and extends ovipository cycle, meat
Chicken increases weight, and delivers for sale in advance, and improving the aspects such as livestock products quality has obvious effect.Pure Chinese medicine composition of the present invention, without any Western medicine
Addition, green safety environmental protection.Raw material of the present invention and preparation process are simple, low production cost, are suitable to large-scale promotion with production.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of chicken feed addictive of safe noresidue, by the following raw material group according to weight portion
Into：Husky fluffy 28 parts, 15 parts of reseda, 1 part of rutin sophorin, 31 parts of felwort, 7 parts of leaf of Moringa.
Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, Moringa
Leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A.The husky fluffy, reseda that to weigh, felwort add water pan-fried after mixing
Boil twice, each 2.5h, filter, merging filtrate, stand 24 hours, take supernatant, be concentrated under reduced pressure into medicinal extract, then with acquisition
Mixed powder A is mixed, and by mixture vacuum freeze drying, and is ground into the powder of 80 mesh, obtains final product feed addictive.
Embodiment 2
In the embodiment of the present invention, a kind of chicken feed addictive of safe noresidue, by the following raw material group according to weight portion
Into：Husky fluffy 36 parts, 25 parts of reseda, 5 parts of rutin sophorin, 39 parts of felwort, 15 parts of leaf of Moringa.
Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, Moringa
Leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A.The husky fluffy, reseda that to weigh, felwort add water pan-fried after mixing
Boil twice, each 2.5h, filter, merging filtrate, stand 24 hours, take supernatant, be concentrated under reduced pressure into medicinal extract, then with acquisition
Mixed powder A is mixed, and by mixture vacuum freeze drying, and is ground into the powder of 80 mesh, obtains final product feed addictive.
Embodiment 3
In the embodiment of the present invention, a kind of chicken feed addictive of safe noresidue, by the following raw material group according to weight portion
Into：Husky fluffy 30 parts, 18 parts of reseda, 2 parts of rutin sophorin, 33 parts of felwort, 9 parts of leaf of Moringa.
Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, Moringa
Leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A.The husky fluffy, reseda that to weigh, felwort add water pan-fried after mixing
Boil twice, each 2.5h, filter, merging filtrate, stand 24 hours, take supernatant, be concentrated under reduced pressure into medicinal extract, then with acquisition
Mixed powder A is mixed, and by mixture vacuum freeze drying, and is ground into the powder of 80 mesh, obtains final product feed addictive.
Embodiment 4
In the embodiment of the present invention, a kind of chicken feed addictive of safe noresidue, by the following raw material group according to weight portion
Into：Husky fluffy 34 parts, 22 parts of reseda, 4 parts of rutin sophorin, 37 parts of felwort, 13 parts of leaf of Moringa.
Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, Moringa
Leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A.The husky fluffy, reseda that to weigh, felwort add water pan-fried after mixing
Boil twice, each 2.5h, filter, merging filtrate, stand 24 hours, take supernatant, be concentrated under reduced pressure into medicinal extract, then with acquisition
Mixed powder A is mixed, and by mixture vacuum freeze drying, and is ground into the powder of 80 mesh, obtains final product feed addictive.
Embodiment 5
In the embodiment of the present invention, a kind of chicken feed addictive of safe noresidue, by the following raw material group according to weight portion
Into：Husky fluffy 32 parts, 20 parts of reseda, 3 parts of rutin sophorin, 35 parts of felwort, 11 parts of leaf of Moringa.
Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, Moringa
Leaf is respectively crushed into the powder of 100 mesh, mixes to obtain mixed powder A.The husky fluffy, reseda that to weigh, felwort add water pan-fried after mixing
Boil twice, each 2.5h, filter, merging filtrate, stand 24 hours, take supernatant, be concentrated under reduced pressure into medicinal extract, then with acquisition
Mixed powder A is mixed, and by mixture vacuum freeze drying, and is ground into the powder of 80 mesh, obtains final product feed addictive.
Comparative example 1
In addition to rutin sophorin is not contained, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Only contain rutin sophorin, its preparation process is consistent with embodiment 5.
The toxicity test of embodiment 6
1 material and method
1.1 materials
1.1.1 experimental animal Kunming hybridizes healthy mice, and 18~24g of body weight is purchased from Hunan Medical University's zoopery
Portion.
1.1.2 feed addictive obtained in the embodiment of the present invention 5.
1.2 methods
1.2.1 acute toxicity test
60 small white mouses are taken using administration by gavage, six groups are randomly divided into, every group 10, male and female half and half, every small white mouse presses body
It is administered again and is：First group of given low is 10g/kg, and second group of given low is 20g/kg, and the 3rd group is 50g/kg, the 4th group
It is 100g/kg, the 5th group is 150g/kg.Control group gavage distilled water 150g/kg.
1.2.2 chronic toxicity test
50 small white mouses are randomly divided into five groups, every group 10, male and female half and half (are separately fed), each group small white mouse gavages
Dosage is calculated by body weight per 20g, and first group is 0.3g, and second group is 0.4g, and the 3rd group is 0.6g, and the 4th group is 0.8g.Daily
Gavage once in the morning, and control group gavages 1.00g/ distilled water daily, daily observation small white mouse spirit, appetite, activity, fecaluria and
Death condition.When beginning is tested, each group is weighed once, is then weighed once within every 15 days, and Germicidal efficacy is whole at the end of 45 days
Cut open inspection is slaughtered, 0.8g group control group small white mouses liver, the heart, stomach, kidney is taken and is done pathological examination.
2 result of the tests
2.1 the acute toxicity tests
Test result indicate that, do not cause mice dying yet when feed addictive gavage of the present invention is by 150g/kg dosage.Respectively
The no abnormality seen compared with control group small white mouse such as experimental group small white mouse spirit, appetite, activity.The internal organ of each group small white mouse after cut open inspection
Organ no abnormality seen phenomenon compared with control group, histopathologic examination's also no abnormality seen lesion, it was demonstrated that small white mouse is to the present invention
More than the maximal tolerance dose stomach 150g/kg of feed addictive, can be considered nontoxic level.
2.2 chronic toxicity test results
2.2.1 clinical observation gavage each test group small white mouse spirit of feed addictive of the present invention, appetite, activity, hair color,
Fecaluria was observed through 45 days, was showed no obvious abnormal response, but the weightening of small white mouse is obvious, the significant difference compared with control group
(0.05 ＞ P ＞ 0.01).
2.2.2 cut open after viewing test observes 45 days, by whole small white mouse cut open inspections, as a result each group small white mouse internal organs are not sent out
Existing pathological change.
2.2.3 pathologic examination does disease to the liver of 0.8g dosage groups and control group small white mouse, kidney, stomach, the heart, spleen tissue
Reason histological observation, does not as a result find pathological change.
3 brief summaries
Experiment proves that the maximal tolerance dose of feed addictive gavage small white mouse of the present invention, in more than 150g/kg, can be considered nothing
Malicious level.0.2~0.8g/20g dosage each groups are gavaged daily, was observed through 45 days, all health, find no poisoning or the phenomena of mortality
And weightening is obvious, cut open inspection and histological observation do not show any abnormalities change.So as to confirm that it is substantially nontoxic that the present invention is gavaged, safely may be used
Lean on.
Embodiment 7
Experiment of preventive effects：Using 7 Japanese instar chickling 900, wherein 100 are only used as control group isolation and support, using common
Feed；100 are only used as blank group, using normal diet；Another 700 experiment isolated rearings, are randomly divided into 7 groups, every group 100
Only, the feed addictive+normal diet for being prepared using embodiment 1-5 and comparative example 1-2, the addition of feed addictive is common
The 1% of feed.Feeding manner is free choice feeding, and free water after 24h, takes the chick intramuscular injection inoculation in test group and control group
Influenza A virus liquid after dilution, records 120h death conditions, and result of the test refers to table 1 below.
Therapeutic effect is tested：Using 7 Japanese instar chickling 800, the influenza A virus liquid after 800 eye droppings inoculation dilutions,
Feeding manner is free choice feeding and free water, after infection 12h, wherein 100 are only used as control group, uses normal diet；Another 700
Only it is test group, is randomly divided into 7 groups, every group 100, the feed addictive prepared using embodiment 1~5 and comparative example 1~2+
Normal diet, the addition of feed addictive is the 2% of normal diet, the death condition of continuous record 120h each groups, experiment knot
Fruit refers to table 1 below.
Each treatment group of table 1 prevents and treats the result of checken pest
Conclusion：As shown in Table 1, the feed addictive that prepared by embodiment 1-5 has good prophylactic-therapeutic effect to checken pest, protects
Rate and survival rate more than 95%, and comparative example 1-2 prepare feed addictive protective rate and survival rate below 50%,
Effect compared with embodiment is poor.Can be seen that the present invention with the comparing of embodiment 5 from comparative example 1-2 is to cooperate with work in each raw material
Flu-A can be effectively prevented and treated under.Meanwhile, A type stream is also carried out to poultry such as duck, geese using embodiment of the present invention medicine
The preventing and treating experiment of Influenza Virus, as a result finds, feed addictive prepared by embodiment 1-5 has preferably anti-to the Flu-A of duck
Effect is controlled, more than 90%, the Flu-A prophylactic-therapeutic effect to goose is general, and protective rate and survival rate are equal for protective rate and survival rate
More than 82%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (6)
1. a kind of chicken feed addictive of safe noresidue, it is characterised in that be made up of the following raw material according to weight portion：Sha Peng
28-36 parts, reseda 15-25 parts, rutin sophorin 1-5 parts, felwort 31-39 parts, leaf of Moringa 7-15 parts.
2. the chicken feed addictive of safe noresidue according to claim 1, it is characterised in that by following according to weight portion
Raw material composition：It is husky it is fluffy 30-34 parts, reseda 18-22 parts, rutin sophorin 2-4 parts, felwort 33-37 parts, leaf of Moringa 9-13 parts.
3. the chicken feed addictive of safe noresidue according to claim 1, it is characterised in that by following according to weight portion
Raw material composition：Husky fluffy 32 parts, 20 parts of reseda, 3 parts of rutin sophorin, 35 parts of felwort, 11 parts of leaf of Moringa.
4. a kind of preparation method of the chicken feed addictive of safe noresidue as described in claim 1-3 is any, its feature exists
In comprising the steps of：
1) Sha Peng, reseda, rutin sophorin, felwort, leaf of Moringa are weighed by the weight portion of each raw material, and by rutin sophorin, leaf of Moringa
The powder of 100 mesh is respectively crushed into, mixes to obtain mixed powder A；
2) the husky fluffy, reseda that will weigh, felwort add water to cook twice after mixing, and each 2.5h, filtering, merging filtrate is quiet
Put 24 hours, take supernatant, medicinal extract is concentrated under reduced pressure into, then with step 1) obtain mixed powder A mix, mixture vacuum is cold
It is lyophilized dry, and the powder of 80 mesh is ground into, obtain final product feed addictive.
5. application of the feed addictive as described in claim 1-3 is any in chicken feed.
6. application of the feed addictive as described in claim 1-3 is any in treatment checken pest feed is prepared.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710108776.9A CN106889368A (en) | 2017-02-27 | 2017-02-27 | A kind of chicken feed addictive of safe noresidue and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710108776.9A CN106889368A (en) | 2017-02-27 | 2017-02-27 | A kind of chicken feed addictive of safe noresidue and its preparation method and application |
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| Publication Number | Publication Date |
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| CN106889368A true CN106889368A (en) | 2017-06-27 |
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| CN201710108776.9A Pending CN106889368A (en) | 2017-02-27 | 2017-02-27 | A kind of chicken feed addictive of safe noresidue and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108029855A (en) * | 2017-11-13 | 2018-05-15 | 佛山科学技术学院 | A kind of chicken feed addictive for preventing bursa fabricic |
-
2017
- 2017-02-27 CN CN201710108776.9A patent/CN106889368A/en active Pending
Non-Patent Citations (6)
| Title |
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| 何阳: "鸡瘟防治验方", 《四川农业科技》 * |
| 桂镜生: "《中药商品学》", 31 August 2015 * |
| 盛军: "《现代辣木生物学》", 31 January 2015 * |
| 福建省农业科学实验站: "《赤脚兽医手册》", 28 February 1971 * |
| 贾昆峰: "《乌拉特后旗植物图鉴》", 31 January 2016 * |
| 郭建生、潘清平: "《实用临床中药手册》", 31 August 2016 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108029855A (en) * | 2017-11-13 | 2018-05-15 | 佛山科学技术学院 | A kind of chicken feed addictive for preventing bursa fabricic |
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