CN106860827A - It is a kind of to treat Chinese medicine composition of cervical carcinoma and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of cervical carcinoma and preparation method thereof Download PDFInfo
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Abstract
Chinese medicine composition of cervical carcinoma and preparation method thereof is treated the invention discloses a kind of, by curcuma zedoary, it is windproof, Ligusticum wallichii, Dongfeng-u Atalantia Buxifolia, asarum, Cassia occidentalis, rejuvenate careless, fructus viticis, polygala, Veronicastrum Herb, cynomorium songaricum, butterflybush flower, the seed of feather cockscomb, safflower, mountain kalimeris, Mazus japonicus, acalyphae,herba and radix polygonati officinalis are prepared from, above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, grinding and sieving mixes, extracted using supercritical carbon dioxide extraction method, filtered fluid carries out temperature extraction with ethanol and takes, extract solution adds water refluxing extraction, filtering, obtain target Chinese medicine composition.The present invention is by after above drug regimen, drug effect has synergy, with tonifying middle-Jiao and Qi, strengthening the spleen and stomach, tonify the liver and kidney, nourishing yin and nourishing blood, promoting blood circulationization, it is antiviral the effect of, the Recurrence of tumour is can remove, the chance of transfer is reduced, progressively strengthen immunity, cervical carcinoma can effectively be treated, the life quality of cervical cancer patient is improved, extends the life of patient, reduce the death rate.
Description
Technical field
It is specifically a kind of to treat Chinese medicine composition of cervical carcinoma and preparation method thereof the present invention relates to technical field of traditional Chinese medicines.
Background technology
Cervical carcinoma refers to the malignant tumour of the columnar epithelial cell intersection that squamous cell and neck tube inner membrance in ectocervical or transitional zone occur, cervical carcinoma is most commonly seen uterine cervix malignant tumour in feminine proses, main clinical manifestation is menstruation or leukorrhea, Irregular vagina bleeding, waist and belly pain, anaemia, the cachexia symptom such as become thin.In recent years, the incidence of disease of cervical carcinoma persistently rises, and morbidity crowd is also gradually developed to rejuvenation.Long-term clinical point thinks that the susceptibility of Chemotherapy of Cervical Cancer is poor, effective percentage below 15%, the chemotherapeutics of current cervical carcinoma can enter row vein or local injection using 5- fluorine urine crash steep, adriamycin etc., but toxicity of adriamycin reaction is heavier, and carcinogenesis is found in zoopery, potential carcinogenic, mutagenesis is there is also in human body, has significant impact to reproductive function.And current operation plan excision cancerous issue and chemicotherapy, not only cure rate is low, and excessive to the actual bodily harm of women.Treatment by Chinese herbs has Small side effects, and the good advantage of anti-recurrence rate effect can stablize the state of an illness, and indiffusion, part Chinese medicine preparation Clinical Practice, therapeutic effect is less desirable, therefore is badly in need of seeking the cervical carcinoma treatment by Chinese herbs medicine of a kind of low toxicity, effect is significant.
The content of the invention
Chinese medicine composition of cervical carcinoma and preparation method thereof is treated it is an object of the invention to provide a kind of, to solve the problems, such as to be proposed in above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese medicine composition for treating cervical carcinoma, is prepared from by the raw material of following weight portion：12~14 parts of curcuma zedoary, windproof 16~18 parts, 13~17 parts of Ligusticum wallichii, 19~21 parts of Dongfeng-u Atalantia Buxifolia, 11~13 parts of asarum, 16~18 parts of Cassia occidentalis, rejuvenate careless 14~18 parts, 12~16 parts of fructus viticis, 8~12 parts of polygala, 6~8 parts of Veronicastrum Herb, 11~15 parts of cynomorium songaricum, 9~13 parts of butterflybush flower, 7~9 parts of the seed of feather cockscomb, 5~9 parts of safflower, 5~7 parts of mountain kalimeris, 4~8 parts of Mazus japonicus, 9~11 parts of acalyphae,herba, 10~16 parts of radix polygonati officinalis.
As further scheme of the invention：Specifically it is prepared from by the raw material of following weight portion：13 parts of curcuma zedoary, windproof 17 parts, 15 parts of Ligusticum wallichii, 20 parts of Dongfeng-u Atalantia Buxifolia, 12 parts of asarum, 17 parts of Cassia occidentalis, rejuvenate careless 16 parts, 14 parts of fructus viticis, 10 parts of polygala, 7 parts of Veronicastrum Herb, 13 parts of cynomorium songaricum, 11 parts of butterflybush flower, 89 parts of the seed of feather cockscomb, 7 parts of safflower, 6 parts of mountain kalimeris, 6 parts of Mazus japonicus, 10 parts of acalyphae,herba, 13 parts of radix polygonati officinalis.
A kind of preparation method of the Chinese medicine composition of described treatment cervical carcinoma, specific preparation process is as follows：
（1）Above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, after being crushed with pulverizer respectively, cross 100~120 mesh sieves, be sufficiently mixed uniform；
（2）Supercritical carbon dioxide extraction method, 54~60 DEG C of extraction temperature, 6~8MPa of extracting pressure, 2~3h of extraction time is used to collect extract, filter, Temperature fall the raw material of mixing；
（3）It is solvent by the ethanol of filtered fluid concentration 90~95%, temperature extraction takes at 75~80 DEG C, and extraction time is 2~4 times, each extraction time is 2~3h, each solvent load is 10~12 times of raw material gross weight, and extract solution is collected in filtration, and extract solution reclaims ethanol；
（4）Extract solution is added water refluxing extraction, extraction time is 2~4 times, each extraction time is 2~3h, each water consumption is 7~9 times of raw material gross weight, and filtering obtains target Chinese medicine composition.
Compared with prior art, the beneficial effects of the invention are as follows：By after above drug regimen, drug effect has synergy to the present invention, with tonifying middle-Jiao and Qi, strengthening the spleen and stomach, tonify the liver and kidney, nourishing yin and nourishing blood, promoting blood circulationization, it is antiviral the effect of, can remove the Recurrence of tumour, the chance that reduction is shifted, progressively strengthen immunity.The present invention can effectively treat cervical carcinoma, improve the life quality of cervical cancer patient, extend the life of patient, reduce the death rate.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made belongs to the scope of protection of the invention.
Embodiment 1
The Chinese medicine composition of cervical carcinoma is treated, is prepared from by the raw material of following weight portion：12 parts of curcuma zedoary, windproof 18 parts, 13 parts of Ligusticum wallichii, 21 parts of Dongfeng-u Atalantia Buxifolia, 11 parts of asarum, 18 parts of Cassia occidentalis, rejuvenate careless 14 parts, 16 parts of fructus viticis, 8 parts of polygala, 8 parts of Veronicastrum Herb, 11 parts of cynomorium songaricum, 13 parts of butterflybush flower, 7 parts of the seed of feather cockscomb, 9 parts of safflower, 5 parts of mountain kalimeris, 8 parts of Mazus japonicus, 9 parts of acalyphae,herba, 16 parts of radix polygonati officinalis.
In above-described embodiment, the preparation process for treating the Chinese medicine composition of cervical carcinoma is as follows：
（1）Above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, after being crushed with pulverizer respectively, cross 100 mesh sieves, be sufficiently mixed uniform；
（2）Supercritical carbon dioxide extraction method, 54 DEG C of extraction temperature, extracting pressure 8MPa, extraction time 3h is used to collect extract, filter, Temperature fall the raw material of mixing；
（3）It is solvent by the ethanol of filtered fluid concentration 90%, temperature extraction takes at 80 DEG C, and extraction time is 4 times, each extraction time is 3h, each solvent load is 10 times of raw material gross weight, and extract solution is collected in filtration, and extract solution reclaims ethanol；
（4）Extract solution is added water refluxing extraction, extraction time is 4 times, each extraction time is 3h, each water consumption is 7 times of raw material gross weight, and filtering obtains target Chinese medicine composition.
Embodiment 2
The Chinese medicine composition of cervical carcinoma is treated, is specifically prepared from by the raw material of following weight portion：13 parts of curcuma zedoary, windproof 17 parts, 15 parts of Ligusticum wallichii, 20 parts of Dongfeng-u Atalantia Buxifolia, 12 parts of asarum, 17 parts of Cassia occidentalis, rejuvenate careless 16 parts, 14 parts of fructus viticis, 10 parts of polygala, 7 parts of Veronicastrum Herb, 13 parts of cynomorium songaricum, 11 parts of butterflybush flower, 89 parts of the seed of feather cockscomb, 7 parts of safflower, 6 parts of mountain kalimeris, 6 parts of Mazus japonicus, 10 parts of acalyphae,herba, 13 parts of radix polygonati officinalis.
In above-described embodiment, the preparation process for treating the Chinese medicine composition of cervical carcinoma is as follows：
（1）Above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, after being crushed with pulverizer respectively, cross 110 mesh sieves, be sufficiently mixed uniform；
（2）Supercritical carbon dioxide extraction method, 57 DEG C of extraction temperature, extracting pressure 7MPa, extraction time 2.5h is used to collect extract, filter, Temperature fall the raw material of mixing；
（3）It is solvent by the ethanol of filtered fluid concentration 90~95%, temperature extraction takes at 78 DEG C, and extraction time is 3 times, each extraction time is 2.5h, each solvent load is 11 times of raw material gross weight, and extract solution is collected in filtration, and extract solution reclaims ethanol；
（4）Extract solution is added water refluxing extraction, extraction time is 3 times, each extraction time is 2.5h, each water consumption is 8 times of raw material gross weight, and filtering obtains target Chinese medicine composition.
Embodiment 3
The Chinese medicine composition of cervical carcinoma is treated, is prepared from by the raw material of following weight portion：14 parts of curcuma zedoary, windproof 16 parts, 17 parts of Ligusticum wallichii, 19 parts of Dongfeng-u Atalantia Buxifolia, 13 parts of asarum, 16 parts of Cassia occidentalis, rejuvenate careless 18 parts, 12 parts of fructus viticis, 12 parts of polygala, 6 parts of Veronicastrum Herb, 15 parts of cynomorium songaricum, 9 parts of butterflybush flower, 9 parts of the seed of feather cockscomb, 5 parts of safflower, 7 parts of mountain kalimeris, 4 parts of Mazus japonicus, 11 parts of acalyphae,herba, 10 parts of radix polygonati officinalis.
In above-described embodiment, the preparation process for treating the Chinese medicine composition of cervical carcinoma is as follows：
（1）Above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, after being crushed with pulverizer respectively, cross 120 mesh sieves, be sufficiently mixed uniform；
（2）Supercritical carbon dioxide extraction method, 60 DEG C of extraction temperature, extracting pressure 6MPa, extraction time 2h is used to collect extract, filter, Temperature fall the raw material of mixing；
（3）It is solvent by the ethanol of filtered fluid concentration 95%, temperature extraction takes at 75 DEG C, and extraction time is 4 times, each extraction time is 2h, each solvent load is 12 times of raw material gross weight, and extract solution is collected in filtration, and extract solution reclaims ethanol；
（4）Extract solution is added water refluxing extraction, extraction time is 2 times, each extraction time is 3h, each water consumption is 9 times of raw material gross weight, and filtering obtains target Chinese medicine composition.
Clinical test
Selection crowd：In April, -2015 in March, 2014, according to diagnostic criteria, there are the patient 288 of cervical carcinoma, age 37-62 Sui, 46.8 scholar of average age 3.2 years old, wherein squamous carcinoma 169, gland cancer 64, adenosquamous carcinoma 55 in six hospital's screenings.All patients obey the principle of voluntariness without cardiovascular and cerebrovascular disease, diabetes, high fat of blood, hypertension, serious liver and kidney disease, thyroid disease and other good, malignant tumours etc..
Before experiment, patient is randomly divided into two groups, experimental group 177 and control group 111, two groups the age, the course of disease,
The aspects such as the state of an illness are without significant difference.Control group uses chemotherapy means, and experimental group takes products obtained therefrom of the present invention on the basis of chemotherapy, and twice a day, each 200-300ml, warm is taken, and is within 30 days a course for the treatment of.During medication two groups of patients are carried out with Continuous Observation, symptom and change is recorded.
Curative effect determinate standard：Reference literature criterion of therapeutical effect,（1）Complete incidence graph (CR)：All lesions are wholly absent and continue more than 4 weeks；（2）Alleviate part（PR）：The footpath product of tumor focus maximum perpendicular two reduces >=50%, and maintains more than 4 weeks；（3）Stabilization (SD)：Tumor regression or increase are not less than 50%；（4）Progress (PD)：Tumor focus increase above 50%, or new focus occur.Efficient=（CR+PI）/（CR+PR+SD+PD）×100%.
Clinical effectiveness：After through three medications of the course for the treatment of, two groups for the treatment of results are as follows:
The patient of experimental group complete incidence graph is 117（66.1%) patient that, part is alleviated is 42（23.7%）, the patient of stabilization is 16（9.0%）, effective percentage is 89.8%, and the patient of control group complete incidence graph is 56（50.5%）, the patient that part is alleviated is 29（26.1%）, the patient of stabilization is 14（12.6%）, efficient 76.6%, hence it is evident that less than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, the therapeutic effect to cervical carcinoma is more preferable.
Model case
Model case 1：Leaf, female, 51 years old.After patient was because of menopause 5 years, leucorrhea increasing, color Huang has stink, and many with Irregular vagina bleeding half a year, it is squamous cell carcinoma to go examination in hospital August to break through local hospital Gynecology examination and diagnosis.Clinical diagnosis:The cervical carcinoma second phase.After defecated not well through chemotherapy aggravation twice, underbelly pain, oliguria color is yellow；After taking one course for the treatment of of medicine of the present invention, symptom is clearly better, and yellowish leukorrhea is reduced, pain relief.Continue to take three courses for the treatment of of the medicine, symptom disappears substantially, diet is normal, spirit such as ordinary person.
Model case 2：It is good certain, female, 41 years old.Patient aches small distention and fullness in the abdomen more than January because of waist, nearly 1 year of leucorrhea increasing, unregular vaginal bleeding and contact bleeding more than the nearly moon, and Via vagina smear, pathological diagnosis is cervix cancer.After taking one course for the treatment of of treatment by Chinese herbs of the present invention, symptom mitigation, colporrhagia is reduced.Continue to take three courses for the treatment of of the medicine, symptom disappears, and diet is normal, spirit such as ordinary person.
Model case 3：Wu, female, 46 years old.Patient hypogastralgia often, Irregular vagina bleeding over the past half year, leukorrhea is more and has peculiar smell.Cervix cancer, aggravation after underwent operative, chemotherapeutic treatment are diagnosed as through the section of certain Hospital Pathological Department.After taking two courses for the treatment of of drug therapy of the present invention, bleeding is substantially eliminated, and hypogastralgia mitigates, and constitution improves, and after continuing to take three courses for the treatment of of medicine of the present invention, complication phenomenon all disappears.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, can in other specific forms realize the present invention.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by appended claims rather than described above, it is intended that all changes fallen in the implication and scope of the equivalency of claim are included in the present invention.
Claims (3)
1. a kind of Chinese medicine composition for treating cervical carcinoma, it is characterised in that be prepared from by the raw material of following weight portion：12~14 parts of curcuma zedoary, windproof 16~18 parts, 13~17 parts of Ligusticum wallichii, 19~21 parts of Dongfeng-u Atalantia Buxifolia, 11~13 parts of asarum, 16~18 parts of Cassia occidentalis, rejuvenate careless 14~18 parts, 12~16 parts of fructus viticis, 8~12 parts of polygala, 6~8 parts of Veronicastrum Herb, 11~15 parts of cynomorium songaricum, 9~13 parts of butterflybush flower, 7~9 parts of the seed of feather cockscomb, 5~9 parts of safflower, 5~7 parts of mountain kalimeris, 4~8 parts of Mazus japonicus, 9~11 parts of acalyphae,herba, 10~16 parts of radix polygonati officinalis.
2. it is according to claim 1 treatment cervical carcinoma Chinese medicine composition, it is characterised in that be specifically prepared from by the raw material of following weight portion：13 parts of curcuma zedoary, windproof 17 parts, 15 parts of Ligusticum wallichii, 20 parts of Dongfeng-u Atalantia Buxifolia, 12 parts of asarum, 17 parts of Cassia occidentalis, rejuvenate careless 16 parts, 14 parts of fructus viticis, 10 parts of polygala, 7 parts of Veronicastrum Herb, 13 parts of cynomorium songaricum, 11 parts of butterflybush flower, 89 parts of the seed of feather cockscomb, 7 parts of safflower, 6 parts of mountain kalimeris, 6 parts of Mazus japonicus, 10 parts of acalyphae,herba, 13 parts of radix polygonati officinalis.
3. a kind of preparation method of the Chinese medicine composition for the treatment of cervical carcinoma as claimed in claim 1 or 2, it is characterised in that specific preparation process is as follows：
（1）Above-mentioned each raw material is respectively washed and is dried, each raw material is weighed by proportioning, after being crushed with pulverizer respectively, cross 100~120 mesh sieves, be sufficiently mixed uniform；
（2）Supercritical carbon dioxide extraction method, 54~60 DEG C of extraction temperature, 6~8MPa of extracting pressure, 2~3h of extraction time is used to collect extract, filter, Temperature fall the raw material of mixing；
（3）It is solvent by the ethanol of filtered fluid concentration 90~95%, temperature extraction takes at 75~80 DEG C, and extraction time is 2~4 times, each extraction time is 2~3h, each solvent load is 10~12 times of raw material gross weight, and extract solution is collected in filtration, and extract solution reclaims ethanol；
（4）Extract solution is added water refluxing extraction, extraction time is 2~4 times, each extraction time is 2~3h, each water consumption is 7~9 times of raw material gross weight, and filtering obtains target Chinese medicine composition.
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| CN112022964A (en) * | 2020-10-09 | 2020-12-04 | 杨大华 | Traditional Chinese medicine composition for preventing and treating cervical cancer and preparation method thereof |
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| CN103611094A (en) * | 2013-12-12 | 2014-03-05 | 王学玲 | Medicament for treating cervical cancer |
| CN104998212A (en) * | 2015-08-13 | 2015-10-28 | 李荣勤 | Medicament for treating cervical cancer and preparation method thereof |
| CN105012888A (en) * | 2015-08-13 | 2015-11-04 | 李荣勤 | Composition for treating carcinoma of uterine cervix and preparing method |
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| CN103611094A (en) * | 2013-12-12 | 2014-03-05 | 王学玲 | Medicament for treating cervical cancer |
| CN104998212A (en) * | 2015-08-13 | 2015-10-28 | 李荣勤 | Medicament for treating cervical cancer and preparation method thereof |
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