CN106811342A - A kind of Efficient antibacterial Antibacterial soaps composition - Google Patents
A kind of Efficient antibacterial Antibacterial soaps composition Download PDFInfo
- Publication number
- CN106811342A CN106811342A CN201510863007.0A CN201510863007A CN106811342A CN 106811342 A CN106811342 A CN 106811342A CN 201510863007 A CN201510863007 A CN 201510863007A CN 106811342 A CN106811342 A CN 106811342A
- Authority
- CN
- China
- Prior art keywords
- antibacterial
- composition
- efficient
- weight portion
- soaps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention belongs to daily personal care articles for use field, and in particular to a kind of Efficient antibacterial Antibacterial soaps composition.The perfumed soap composition contains：The weight portion of natural plants soap base 81.0~98.0；The weight portion of emollient 1.0~15.0；The weight portion of chelating agent 0.01~1.0；The weight portion of essence 0.01~2.0；The weight portion of NTA antiseptics 0.03~4.0.Described bacteriostasis antibiosis perfumed soap composition can be played efficiently suppress and resist the bacterium on skin, clothing, vessel, and bacteriostasis antibiosis effect substantially, meets modern life theory, with great market prospects and economic worth.
Description
Technical field
The invention belongs to daily personal care articles for use field, and in particular to a kind of Efficient antibacterial Antibacterial soaps combination
Thing.
Background technology
Attention with people to health, daily life health seems increasingly important.Perfumed soap belongs to daily and washes
Articles for use category is washed, is had for health and health and very actively, is effectively acted on.Nowadays except going
Outside dirty function, bacteriostasis antibiosis function is more exposed to public concern.The big more options of people have restraining and sterilizing bacteria work(
The perfumed soap of effect carry out it is daily wash shield, but producer is when perfumed soap is produced, mostly addition chemical bactericide and anti-corrosion
Agent etc., long-term use is not conducive to healthy.How the bacteriostasis antibiosis work(of daily life articles for washing is improved
To the living standard of raising people, can ensure that the health and health tool of people are of great significance.Mesh
The species of preceding in the market perfumed soap is various, though there is various types of perfumed soaps, most effect is substantial
Without big difference.Although also there is Antibacterial soaps, existing perfumed soap generally existing antibacterial effect is not good, right
Skin is irritant, and the larger shortcoming of peculiar smell.
On the other hand global seasonal influenza often breaks out, and bacterium infection happens occasionally, and skin, clothing,
Tableware is the parasitic position of common pathogen.Feed, water drinking utensil contact stain：" illness finds its way in by the mouth ", meal
The bacterium that may adhere on the daily living articles such as tool, tea set, exists potentially hazardous to health of people；
By bus, the contact stain in the working environment such as communication；Inevitable bacterium contact in surrounding air；Day
Apply some make up the pollution of middle microorganism：It is nutritious in daily cosmetics, easily polluted by microorganism,
Cause pathogenic microbes and its metabolite to grow, and then cause health to be compromised；On clothing
The germ contamination of attachment：Underwear is the place for being easiest to breed bacteria, if clean, residual can not be cleaned
Bacterial spore can cause superinfection, easily trigger various inflammation, influence the health of people.And men and women exists
Difference physiologically, also determines that underwear for men and women cleaning will be treated respectively.Compare male, women underwear
On be easier to grow all kinds of bacteriums, especially before and after menstrual period, most of women have the puzzlement that foreign matter increases,
Many inconvenience are caused to life.Clothing, bady's diaper of sweat etc. are speckled with after motion in addition also easily to grow
Endophytic bacteria.The use of the perfumed soap for having bacteriostasis antibiosis effect is one of good measure that prevention infection occurs.
Antibacterial toilet soap on the market is the material that will have fungistatic effect and is added directly into ordinary hot system at present
In method perfumed soap, wherein antibacterial substance be divided into chemical substance it is antibacterial (triclocarban, parachlorometaxylenol,
DMDMH etc.) and Chinese herbal medicine antibacterial substance.Antibacterial its security of chemical substance needs to probe into,
And long-term use certain chemosterilant is easily caused microorganism and produces drug resistance.Chinese herbal medicine antibacterial substance
Specific antipathogenic composition, antifungal mechanism and antimicrobial stability need to be furtherd investigate.
In addition, continuing to develop with modern civilization construction, the continuous improvement of people's daily life level,
Increasing people begin to focus on green health, environmentally friendly natural plants daily chemical product.But perfumed soap
Belong to daily life and wash protector for collar domain, because of its relatively low commercial profit, green grass or young crops that is current and being not affected by more businessmans
Look at and capital input.Therefore it is this neck to develop a kind of friendly Efficient antibacterial Antibacterial soaps composition of safety
The vital work in domain, daily perfumed soap field is urgently to be resolved hurrily to ask to overcome the deficiencies in the prior art to turn into
Topic.
The content of the invention
Therefore, the technical problems to be solved by the invention are to overcome perfumed soap bacteriostasis antibiosis in the prior art to imitate
Technical bottleneck really poor, big to skin irritation, meets demand of the people to natural plant kind daily chemical products
Propose it is a kind of it is soft do not stimulate, natural plant raw material, bacteriostasis antibiosis effect be good and height of bacteriostasis property stabilization
Effect bacteriostasis antibiosis perfumed soap composition.
To solve the above problems, the invention discloses a kind of Efficient antibacterial Antibacterial soaps composition, described group
Compound includes following component：
Preferably, described Efficient antibacterial Antibacterial soaps composition, wherein, the composition includes as follows
Component：
Preferably, described Efficient antibacterial Antibacterial soaps composition, wherein, the NTA antiseptics into
Part is glyceryl laurate ester and the complex composition of ZPT.
It is more highly preferred to, described Efficient antibacterial Antibacterial soaps composition, wherein, described laurate is sweet
Grease is 0.02~2.0 weight portion, and the ZPT is 0.01~2.0 weight portion.
Further, described Efficient antibacterial Antibacterial soaps composition, wherein, the natural plants soap base
Active ingredient be vegetable fatty acid sodium, account for the natural plants soap base mass percent be 60~80%.
Further, described Efficient antibacterial Antibacterial soaps composition, wherein, the emollient be glycerine,
At least one in cocoyl glutamic acid or lauroyl glutamate.
More further, described Efficient antibacterial Antibacterial soaps composition, wherein, the chelating agent is
The sodium of EDTA tetra-.
Above-mentioned technical proposal of the invention has advantages below compared to existing technology：It is fragrant with common bacteriostasis antibiosis
Soap is compared, from terms of fungistatic effect, bacteriostasis antibiosis perfumed soap composition of the invention can play efficiently suppress and
Bacterium on resistance skin, clothing, vessel, fungistatic effect is obvious；From safety considerations, the present invention
Bacteriostasis antibiosis perfumed soap composition use natural plant raw material, NTA antiseptics are by authoritative inspection center
Skin mutation testing, skin irritation test detection, meet modern life theory.
Specific embodiment
Efficient antibacterial Antibacterial soaps composition of the invention can by it is any oneself know or other are effective suitable
Prepared by the technology for providing perfumed soap composition, prepare Efficient antibacterial Antibacterial soaps composition of the invention
Method includes conventional preparation and hybrid technology.
Here is the non-limiting example of Efficient antibacterial Antibacterial soaps composition of the invention.These embodiments
Be only given for illustrative purposes, limitation of the invention can not be interpreted as, because not taking off
On the basis of the spirit and scope of the present invention, many changes can be carried out to the present invention.
, present embodiment discloses a kind of Efficient antibacterial Antibacterial soaps composition, concrete component is such as embodiment 1
Under：
The composition of the NTA antiseptics is the complex composition of glyceryl laurate ester and ZPT.It is described
Glyceryl laurate ester is 0.02~2.0 weight portion, and the ZPT is 0.01~2.0 weight portion.
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the natural plants soap base
Mass percent is 60~80%.
, present embodiment discloses a kind of Efficient antibacterial Antibacterial soaps composition, concrete component is such as embodiment 2
Under：
The composition of the NTA antiseptics is the complex composition of glyceryl laurate ester and ZPT.It is described
Glyceryl laurate ester is 1.2 weight portions, and the ZPT is 1.2 weight portions.
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the natural plants soap base
Mass percent is 70%.
, present embodiment discloses a kind of Efficient antibacterial Antibacterial soaps composition, concrete component is such as embodiment 3
Under：
The composition of the NTA antiseptics is the complex composition of glyceryl laurate ester and ZPT.It is described
Glyceryl laurate ester is 1.2 weight portions, and the ZPT is 1.2 weight portions.
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the natural plants soap base
Mass percent is 60%.
, present embodiment discloses a kind of Efficient antibacterial Antibacterial soaps composition, concrete component is such as embodiment 4
Under：
The composition of the NTA antiseptics is the complex composition of glyceryl laurate ester and ZPT.It is described
Glyceryl laurate ester is 0.02 weight portion, and the ZPT is 0.01 weight portion.
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the natural plants soap base
Mass percent is 80%.
, present embodiment discloses a kind of Efficient antibacterial Antibacterial soaps composition, concrete component is such as embodiment 5
Under：
The composition of the NTA antiseptics is the complex composition of glyceryl laurate ester and ZPT.It is described
Glyceryl laurate ester is 2.0 weight portions, and the ZPT is 2.0 weight portions.
The main active ingredient of the natural plants soap base is vegetable fatty acid sodium.
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the natural plants soap base
Mass percent is 75%
In composition described in embodiment 1-5：
The anti-microbial property of NTA antiseptics is protruded, and is carried weight the bacteriostasis antibiosis that inspection center makes using safety
Effect experiment, skin mutation testing, skin irritation test detection data.
ZPT (abbreviation ZPT) is a kind of effectively anti-mildew and antibacterial compound, extensively
It is applied to the broad-spectrum sterilization bacteriostatic agent of commodity such as lubricant, cosmetics and toiletry.Its advantage is：
Sterilizing and itch-relieving effect is significant, heat endurance is good, and compatibility is good, product be it is light, tasteless, will not
Influence is produced on finished product.Have the disadvantage：It is dissolved in organic solvent and water because its is extremely difficult, therefore breast can only be made
Shape product, are not easy to commonly used.
Glyceryl laurate ester (GML) is a kind of safe and efficient broad spectrum antimicrobicide, and its antibacterial effect
Stabilization, is not influenceed by pH.Ministry of Health of China approval GML adds according to actual needs as food additives
Plus, there is no consumption to limit.GML is again simultaneously a kind of good emulsifying agent, can be with ZPT compounding uses
While Efficient antibacterial antibacterial is played, can be very good to disperse ZPT suspension again, in this way, compounding
NTA antiseptics are evenly scattered in perfumed soap and liquid, so as to more comprehensively effectively play bacteriostasis antibiosis effect
Really.
Experimental example
The fungistatic effect of experimental example 1 is detected
Test group：Bacteriostasis antibiosis perfumed soap composition described in embodiment 3
Control group：Conventional toilet soaps
Detection project：Bacteriostatic test
Detection method：GB 19877.3-2005
Analysis testing result is specifically shown in Table 1：
The fungistatic effect testing result of table 1
Result judges：Show according to table 1, the bacteriostasis antibiosis perfumed soap composition described in embodiment 2 it is antibacterial
Effect is better than conventional toilet soaps, and Escherichia coli, staphylococcus aureus and white read ball under 0.1% concentration
The equal asepsis growth of bacterium.
Experimental example 2 is to new zealand rabbit Skin Irritation Test examining report
Sample：Bacteriostasis antibiosis perfumed soap composition described in embodiment 2
Detection project：Intact skin irritant test.
Detection foundation：Ministry of Health of the People's Republic of China,《Disinfection technology standard》(version in 2002), one
Secondary intact skin irritant test.
Test result：Under this experimental condition, the NTA antiseptics described in embodiment 2 are to new zealand rabbit
It is nonirritant that intact skin stimulates.
Result is observed and evaluated：In each observing time point, by table 2 to the erythema and oedema of animal
Formational situation is scored, and respectively temporally o'clock is added 3 scorings of animal, divided by number of animals,
Obtain different time points skin wound repair integral mean value (SI).Take wherein highest skin irritatin
Index, rank of the tested material to animal skin stimulus intensity is evaluated by table 3.
The skin wound repair standards of grading of table 2
| Skin wound repair | Skin wound repair scores |
| Erythema is formed： | |
| Nothing | 0 |
| It is visible reluctantly | 1 |
| Substantially | 2 |
| Seriously | 3 |
| Aubergine erythema, and have to eschar | 4 |
| Oedema is formed： | |
| Nothing | 0 |
| It is visible reluctantly | 1 |
| Cutaneous protuberance, profile understands | 2 |
| Oedema swells about 1mm | 3 |
| Oedema is swelled more than 1mm | 4 |
The skin irritatin strength grading of table 3
| Skin irritation index | Stimulus intensity rank |
| 0~<0.5 | It is nonirritant |
| 0.5~<2.0 | Subexcite |
| 2.0~<6.0 | Medium excitant |
| 6.0~8.0 | Strong and stimulating |
Experimental result：1h, 24h and the 48h of experiment side and control sides skin after tested material is removed respectively see
Examine in time point it was observed that erythema, oedema or other toxic actions, experiment side each time occurs in skin
Point skin irritatin scoring is 0, and skin wound repair integral mean value (SI) is 0, skin thorn
It is nonirritant to swash intensity.
Experiment conclusion：Under this experimental condition, NTA antiseptics are to new zealand rabbit one described in embodiment 2
It is nonirritant that secondary intact skin stimulates, referring specifically to table 4.
The given the test agent of table 4 is to new zealand rabbit single Skin Irritation Test result (♀)
Experimental example 3 is to guinea pig skin allergy testing inspection
Sample：Bacteriostasis antibiosis perfumed soap composition described in embodiment 2
Detection project：Skin allergy test.
Detection foundation：Ministry of Health of the People's Republic of China《Disinfection technology standard》(version in 2002) skin
Allergy is tested.
Test result：Under this experimental condition, with the suppression described in the embodiment 2 described in embodiment 2
Bacterium Antibacterial soaps composition carries out Skin allergy test, and animal excites position to have no that erythema, oedema are produced
Raw, sensitization rate is 0%, has no skin allergic reaction.
Result is observed：Each group cavy excitation area dermoreaction is observed after 24h and 48h, by table 5 to skin
Skin reaction is scored.
Evaluation of result：According to the standard of table 5, will appear from the number of animals of dermoreaction (scoring >=1) divided by
This group of experimental animal number, tries to achieve sensitization rate (%).Sensitization intensity is evaluated according to table 6.
The dermoreaction standards of grading of table 5
| Dermoreaction | Integration |
| Erythema and eschar are formed： | |
| Without erythema | 0 |
| Slight erythema | 1 |
| Moderate erythema | 2 |
| Severe erythema | 3 |
| Edematous erythema | 4 |
| Oedema is formed： | |
| Without oedema | 0 |
| Slight oedema | 1 |
| Intermediate edema | 2 |
| Severe edema | 3 |
The sensitivity response grade scale of table 6
| Sensitization rate % | Sensitization intensity |
| 0-8 | It is extremely slight |
| 9-28 | Slightly |
| 29-64 | Moderate |
| 65-80 | Intensity |
| 81-100 | Pole strength |
Note：When sensitization rate is 0%, can determine whether to have no skin allergic reaction
Experimental result
Induction period negative control group, the skin of test group animal have no erythema and oedema.After exciting contact
Scored according to table 5, negative control group, test group animal skin are showed no erythema and oedema is produced, sensitization
Rate is 0%；The reaction of positive controls animal skin is main with slightly to obvious erythema and slightly to medium water
Based on swollen, the sensitization rate for exciting contact is 94%.
Result judges
According to the evaluation criterion of table 6, negative controls and test sample sensitization intensity are abnormal anti-to have no skin
Should, positive reference substance sensitization intensity is pole strength sensitization.
Experiment conclusion
Under this experimental condition, skin allergic reaction examination is carried out to the NTA antiseptics described in embodiment 2
Test, animal excites position to have no that erythema, oedema are produced, and sensitization rate is 0%, has no skin allergic reaction.
Obviously, above-described embodiment is only intended to clearly illustrate example, and not to implementation method
Restriction.For those of ordinary skill in the field, can also do on the basis of the above description
Go out the change or variation of other multi-forms.There is no need and unable to give thoroughly all of implementation method
Lift.And the obvious change thus extended out or change protection domain still in the invention
Among.
Claims (7)
1. a kind of Efficient antibacterial Antibacterial soaps composition, it is characterised in that the composition includes as follows
Component：
2. Efficient antibacterial Antibacterial soaps composition as claimed in claim 1, it is characterised in that described
Composition includes following component：
3. Efficient antibacterial Antibacterial soaps composition as claimed in claim 1 or 2, it is characterised in that institute
It is glyceryl laurate ester and the complex composition of ZPT to state the composition of NTA antiseptics.
4. Efficient antibacterial Antibacterial soaps composition as claimed in claim 3, it is characterised in that described
Glyceryl laurate ester is 0.02~2.0 weight portion, and the ZPT is 0.01~2.0 weight portion.
5. Efficient antibacterial Antibacterial soaps composition as claimed in claim 1 or 2, it is characterised in that
The active ingredient of the natural plants soap base is vegetable fatty acid sodium, accounts for the quality of the natural plants soap base
Percentage is 60~80%.
6. Efficient antibacterial Antibacterial soaps composition as claimed in claim 1 or 2, it is characterised in that
The emollient is at least one in glycerine, cocoyl glutamic acid or lauroyl glutamate.
7. Efficient antibacterial Antibacterial soaps composition as claimed in claim 1 or 2, it is characterised in that
The chelating agent is the sodium of EDTA tetra-.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510863007.0A CN106811342A (en) | 2015-12-01 | 2015-12-01 | A kind of Efficient antibacterial Antibacterial soaps composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510863007.0A CN106811342A (en) | 2015-12-01 | 2015-12-01 | A kind of Efficient antibacterial Antibacterial soaps composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106811342A true CN106811342A (en) | 2017-06-09 |
Family
ID=59107744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510863007.0A Pending CN106811342A (en) | 2015-12-01 | 2015-12-01 | A kind of Efficient antibacterial Antibacterial soaps composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106811342A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107164118A (en) * | 2017-06-19 | 2017-09-15 | 西双版纳汉纳生物科技发展有限公司 | A kind of antibacterial bacteriostatic health care fancy soap and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427990A (en) * | 2008-12-12 | 2009-05-13 | 上海蔻漫生物科技有限公司 | Skin cleaning article |
| CN102242026A (en) * | 2011-06-30 | 2011-11-16 | 侯耀光 | Skin care fancy soap |
| CN102776087A (en) * | 2012-07-10 | 2012-11-14 | 广东名臣有限公司 | Multifunctional perfumed soap |
| CN103409251A (en) * | 2013-08-29 | 2013-11-27 | 严积芳 | Preparation method of anti-microbial Chinese herbal medicine toilet soap |
| CN103520022A (en) * | 2013-10-21 | 2014-01-22 | 广州立白企业集团有限公司 | Antibacterial hand sanitizer and preparation method thereof |
| CN104312782A (en) * | 2014-10-11 | 2015-01-28 | 青岛叁鼎卫生制品有限公司 | Natural plant antibacterial soap |
-
2015
- 2015-12-01 CN CN201510863007.0A patent/CN106811342A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427990A (en) * | 2008-12-12 | 2009-05-13 | 上海蔻漫生物科技有限公司 | Skin cleaning article |
| CN102242026A (en) * | 2011-06-30 | 2011-11-16 | 侯耀光 | Skin care fancy soap |
| CN102776087A (en) * | 2012-07-10 | 2012-11-14 | 广东名臣有限公司 | Multifunctional perfumed soap |
| CN103409251A (en) * | 2013-08-29 | 2013-11-27 | 严积芳 | Preparation method of anti-microbial Chinese herbal medicine toilet soap |
| CN103520022A (en) * | 2013-10-21 | 2014-01-22 | 广州立白企业集团有限公司 | Antibacterial hand sanitizer and preparation method thereof |
| CN104312782A (en) * | 2014-10-11 | 2015-01-28 | 青岛叁鼎卫生制品有限公司 | Natural plant antibacterial soap |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107164118A (en) * | 2017-06-19 | 2017-09-15 | 西双版纳汉纳生物科技发展有限公司 | A kind of antibacterial bacteriostatic health care fancy soap and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103041376A (en) | Bacteria removing solution and preparation method thereof | |
| CN103013699B (en) | Infant laundry detergent containing marine organism component and preparation method of infant laundry detergent | |
| CN104080341B (en) | Antimicrobial compositions | |
| CN103305352A (en) | Chinese traditional medicine environment-friendly tableware detergent | |
| CN102894001A (en) | Antiseptic and mildew inhibitor composition for wet tissues and production method thereof | |
| CN107753310A (en) | A kind of gentle three-in-one washing lotion of the non-stimulated antibacterial cleaning-nursing of women privates and preparation method thereof of new type of safe | |
| CN104232338A (en) | Green sterilizing detergent | |
| CN110974717B (en) | Moisturizing baby wet tissue capable of removing dirt and preparation method thereof | |
| CN102293199A (en) | Disinfectant and preparation method thereof | |
| CN103215146A (en) | Liquid clothes detergent added with natural citrus extract | |
| CN104666285B (en) | The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy | |
| CN106811342A (en) | A kind of Efficient antibacterial Antibacterial soaps composition | |
| CN104513716A (en) | Botanical environmentally-friendly kitchen cleaner | |
| CN109620743B (en) | Mouthwash containing acidic bactericide and preparation method thereof | |
| CN103688998A (en) | Portable washing-free tableware bactericide | |
| CN110721103A (en) | Chinese herbal medicine essential oil bacteriostatic skin-care washing-free hand sanitizer and preparation method thereof | |
| KR20110054940A (en) | Kitchen detergent composition using herb medicine materials,and preparation thereof | |
| CN105820888A (en) | Decontaminating bactericidal clothing detergent | |
| Sukamdi et al. | Formula Optimization of Antimicrobial Hand Sanitizer With Lemongrass Essential Oil | |
| CN108096183A (en) | A kind of women long acting antibiotic gel and preparation method thereof | |
| CN105255620A (en) | Leather detergent | |
| CN109044872A (en) | Skin cleans concentrate and preparation method thereof | |
| KR101487987B1 (en) | A eco-friendly detergent or cleaner comprising the glasswort | |
| KR100384538B1 (en) | A compound for disinfecting and washing a baby articles such as a nursing bottle | |
| CN109135953A (en) | A kind of dish washing liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170609 |