CN106795219B - 抗il-17抗体及其生产和使用的方法 - Google Patents

抗il-17抗体及其生产和使用的方法 Download PDF

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CN106795219B
CN106795219B CN201480027341.6A CN201480027341A CN106795219B CN 106795219 B CN106795219 B CN 106795219B CN 201480027341 A CN201480027341 A CN 201480027341A CN 106795219 B CN106795219 B CN 106795219B
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disease
antibody
transplant rejection
amino acid
cancer
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CN106795219A (zh
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安德烈·鲍里索维奇·乌里京
斯坦尼斯拉夫·鲁道夫维奇·叶夫多基莫夫
瓦列里·弗拉基米洛维奇·索洛维耶夫
尤利娅·谢尔盖耶夫娜·切尔尼
奥尔加·弗拉基米洛夫那·宫察洛娃
德米特里·瓦列里耶维奇·喀尔扎维
塔季杨娜·维尼亚米诺夫娜·切尔诺夫斯卡雅
罗曼·阿列克谢耶维奇·伊万诺夫
德米特里·瓦林基诺维奇·莫罗佐夫
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2979219A1 (en) * 2015-03-10 2016-09-15 Sorrento Therapeutics, Inc. Antibody therapeutics that bind psma
CN107488227A (zh) * 2016-06-12 2017-12-19 三生国健药业（上海）股份有限公司 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
EA201990673A1 (ru) * 2016-09-14 2019-08-30 Бэйцзин Ханми Фарм. Ко., Лтд. Антитела, специфически связывающиеся с il-17a, и их функциональные фрагменты
CN108359011B (zh) 2017-07-21 2019-06-25 华博生物医药技术（上海）有限公司 靶向于白介素17a的抗体、其制备方法和应用
CN107522783B (zh) * 2017-09-30 2020-07-07 华博生物医药技术（上海）有限公司 一种抗白介素17a的抗体、其制备方法和应用
JP7445977B2 (ja) 2018-01-29 2024-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｔｌｒ２媒介性疾患及び障害の治療法
CN108333373B (zh) * 2018-03-28 2021-04-27 徐昉 血清炎症因子的应用
CN110551215A (zh) * 2018-05-30 2019-12-10 中山康方生物医药有限公司 抗白细胞介素-17a抗体、其药物组合物及其用途
WO2020024931A1 (en) * 2018-07-31 2020-02-06 Shen Weiqun Anti-il-17a antibodies and use thereof
CN111303283A (zh) * 2018-12-12 2020-06-19 上海君实生物医药科技股份有限公司 抗il-17a抗体及其应用
CN120025437A (zh) 2019-01-31 2025-05-23 努玛治疗有限公司 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法
EP3689907A1 (en) 2019-01-31 2020-08-05 Numab Therapeutics AG Antibodies targeting il-17a and methods of use thereof
RU2754760C2 (ru) * 2019-04-02 2021-09-07 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция анти-il17a антитела и ее применение
CN112915201B (zh) * 2019-12-06 2023-06-27 珠海市丽珠单抗生物技术有限公司 包含抗il-17抗体的液体制剂
CN116063493B (zh) * 2022-07-22 2023-09-01 贵州省赛尔生物科技有限公司 包含抗体和间充质干细胞外泌体的药物组合物及其制备方法
AU2024240129A1 (en) 2023-03-17 2025-10-09 Oxitope Pharma B.V. Anti-phosphocholine antibodies and methods of use thereof
CN120399065B (zh) * 2023-12-21 2025-10-14 北京贝来药业有限公司 抗il-17a纳米抗体、药物组合物、方法及用途
CN117820475B (zh) * 2023-12-21 2024-10-29 北京贝来生物科技有限公司 针对il-17a的新型纳米抗体、药物、制备、方法及应用
CN117843777B (zh) * 2023-12-21 2024-08-27 北京贝来药业有限公司 用于炎性疾病治疗的新型纳米抗体及其产品和方法
CN117820479B (zh) * 2023-12-29 2025-03-07 北京贝来药业有限公司 抗il-17a的新型纳米抗体
CN117843802B (zh) * 2023-12-29 2024-09-06 北京贝来药业有限公司 串联抗体及其下游产品和应用
CN118005785B (zh) * 2023-12-29 2024-10-22 北京贝来药业有限公司 用于疾病治疗的串联纳米抗体
CN117903304B (zh) * 2023-12-29 2025-03-11 北京贝来药业有限公司 抗体的序列结构及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1963368T6 (da) * 2005-12-13 2020-06-29 Lilly Co Eli Anti-il-17-antistoffer
EP2377887A1 (en) * 2006-03-10 2011-10-19 Zymogenetics Inc Antibodies that bind both IL-17A and IL-17F and methods of using the same
WO2007147019A2 (en) * 2006-06-13 2007-12-21 Zymogenetics, Inc. Il-17 and il-23 antagonists and methods of using the same
TW200815469A (en) * 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) * 2006-06-29 2006-08-09 Ucb Sa Biological products
US7846443B2 (en) * 2006-08-11 2010-12-07 Schering Corporation Antibodies to IL-17A
TWI667346B (zh) * 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
NZ607615A (en) * 2010-08-05 2015-03-27 Anaptysbio Inc Antibodies directed against il-17
EP2625199B1 (en) * 2010-10-08 2017-11-22 Novartis AG Methods of treating psoriasis using il-17 antagonists

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