CN106795110A - 治疗ot‑r活性相关的病症的方法中可用的晶体(3z，5s)‑5‑(羟甲基)‑1‑[(2’‑甲基‑1，1’‑联苯‑4‑基)羰基]吡咯烷‑3‑酮o‑甲基肟 - Google Patents

治疗ot‑r活性相关的病症的方法中可用的晶体(3z，5s)‑5‑(羟甲基)‑1‑[(2’‑甲基‑1，1’‑联苯‑4‑基)羰基]吡咯烷‑3‑酮o‑甲基肟 Download PDF

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Publication number
CN106795110A
CN106795110A CN201580047177.XA CN201580047177A CN106795110A CN 106795110 A CN106795110 A CN 106795110A CN 201580047177 A CN201580047177 A CN 201580047177A CN 106795110 A CN106795110 A CN 106795110A
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China
Prior art keywords
biphenyl
carbonyl
methyl
hydroxymethyl
crystalline compounds
Prior art date
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Pending
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CN201580047177.XA
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English (en)
Chinese (zh)
Inventor
A·乔列特
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Obseva SA
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Obseva SA
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Filing date
Publication date
Application filed by Obseva SA filed Critical Obseva SA
Priority to CN202111229040.XA priority Critical patent/CN114105851A/zh
Priority to CN202111228955.9A priority patent/CN114105850A/zh
Publication of CN106795110A publication Critical patent/CN106795110A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN201580047177.XA 2014-07-02 2015-06-10 治疗ot‑r活性相关的病症的方法中可用的晶体(3z，5s)‑5‑(羟甲基)‑1‑[(2’‑甲基‑1，1’‑联苯‑4‑基)羰基]吡咯烷‑3‑酮o‑甲基肟 Pending CN106795110A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202111229040.XA CN114105851A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体
CN202111228955.9A CN114105850A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462020076P 2014-07-02 2014-07-02
US62/020,076 2014-07-02
PCT/EP2015/062881 WO2016000920A1 (en) 2014-07-02 2015-06-10 Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202111229040.XA Division CN114105851A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体
CN202111228955.9A Division CN114105850A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体

Publications (1)

Publication Number Publication Date
CN106795110A true CN106795110A (zh) 2017-05-31

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201580047177.XA Pending CN106795110A (zh) 2014-07-02 2015-06-10 治疗ot‑r活性相关的病症的方法中可用的晶体(3z，5s)‑5‑(羟甲基)‑1‑[(2’‑甲基‑1，1’‑联苯‑4‑基)羰基]吡咯烷‑3‑酮o‑甲基肟
CN202111228955.9A Pending CN114105850A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体
CN202111229040.XA Pending CN114105851A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体

Family Applications After (2)

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CN202111228955.9A Pending CN114105850A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体
CN202111229040.XA Pending CN114105851A (zh) 2014-07-02 2015-06-10 治疗ot-r活性相关的病症的方法中可用的晶体

Country Status (13)

Country Link
US (2) US9718772B2 (enExample)
EP (2) EP3753921A1 (enExample)
JP (4) JP2017519015A (enExample)
KR (1) KR102470283B1 (enExample)
CN (3) CN106795110A (enExample)
AU (1) AU2015283133B2 (enExample)
CA (1) CA2953722C (enExample)
EA (2) EA031353B1 (enExample)
ES (1) ES2774789T3 (enExample)
IL (1) IL249652B (enExample)
MX (1) MX371068B (enExample)
UA (1) UA122210C2 (enExample)
WO (1) WO2016000920A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109689048A (zh) * 2016-07-21 2019-04-26 奥布赛瓦股份公司 促进胚胎植入和预防流产的催产素拮抗剂给药方案

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EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
UA122210C2 (uk) 2014-07-02 2020-10-12 Обсева С.А. Кристалічний о-метилоксим (3z,5s)-5-(гідроксиметил)-1-[(2'-метил-1,1'-біфеніл-4-іл)карбоніл]піролідин-3-oну, корисний у способах лікування станів, пов'язаних з активністю ot-r
AU2017205254B2 (en) 2016-01-04 2021-05-20 Xoma (Us) Lcc Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
CN114667141A (zh) * 2019-09-03 2022-06-24 奥布赛瓦股份公司 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案
JP7083793B2 (ja) * 2019-09-10 2022-06-13 Ｊｆｅケミカル株式会社 パラターフェニルテトラカルボン酸およびパラターフェニルテトラカルボン酸二無水物の製造方法
WO2021160597A1 (en) 2020-02-10 2021-08-19 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
EP4313061A4 (en) * 2021-03-31 2025-03-05 The Board of Trustees of the Leland Stanford Junior University FORMULATIONS FOR PROLONGATION OF GESTATION AND FOR COMPLICATIONS OF MENSTRUATION OR GESTATION

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109689048A (zh) * 2016-07-21 2019-04-26 奥布赛瓦股份公司 促进胚胎植入和预防流产的催产素拮抗剂给药方案

Also Published As

Publication number Publication date
AU2015283133B2 (en) 2019-05-16
KR102470283B1 (ko) 2022-11-23
EA201891873A1 (ru) 2019-04-30
EP3164384B1 (en) 2019-12-04
ES2774789T3 (es) 2020-07-22
US9718772B2 (en) 2017-08-01
US10752583B2 (en) 2020-08-25
EP3753921A1 (en) 2020-12-23
WO2016000920A1 (en) 2016-01-07
CA2953722C (en) 2022-09-13
US20170320822A1 (en) 2017-11-09
EA201790080A1 (ru) 2017-06-30
JP2017519015A (ja) 2017-07-13
IL249652B (en) 2021-09-30
CN114105850A (zh) 2022-03-01
MX2016016751A (es) 2017-08-08
US20160002160A1 (en) 2016-01-07
AU2015283133A1 (en) 2017-02-16
MX371068B (es) 2020-01-15
IL249652A0 (en) 2017-02-28
EP3164384A1 (en) 2017-05-10
UA122210C2 (uk) 2020-10-12
EA031353B1 (ru) 2018-12-28
CA2953722A1 (en) 2016-01-07
JP2023018037A (ja) 2023-02-07
CN114105851A (zh) 2022-03-01
KR20170023961A (ko) 2017-03-06
JP2025013885A (ja) 2025-01-28
JP2021038236A (ja) 2021-03-11

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Application publication date: 20170531