CN106769174B - Plant tissue slice receptor blank wax stone boring instrument - Google Patents
Plant tissue slice receptor blank wax stone boring instrument Download PDFInfo
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- CN106769174B CN106769174B CN201611045049.4A CN201611045049A CN106769174B CN 106769174 B CN106769174 B CN 106769174B CN 201611045049 A CN201611045049 A CN 201611045049A CN 106769174 B CN106769174 B CN 106769174B
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- folding rod
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Earth Drilling (AREA)
Abstract
Plant tissue slice receptor blank wax stone boring instrument of the present invention includes pedestal (100), is fixed with rack；Pillar (210), bottom are fixed with the pedestal (100)；First connecting rod (221) is fixed with the top of the pillar (210)；First telescopic mast (231), fixing end are connect with the top hinge of the first connecting rod (221), and telescopic end is connect with the top hinge of second connecting rod (222)；Second telescopic mast (232), fixing end are connect with the bottom hinge of the first connecting rod (221), and telescopic end is connect with the bottom hinge of second connecting rod (222)；Drill body (300), fixed with the second connecting rod (222), the bottom of the drill body (300) is equipped with multiple drill bits (400) being arranged side by side；Wherein, the first connecting rod (221) is fixed with first motor, and the output shaft of the first motor and the fixing end of first telescopic mast (231) are fixed.
Description
Technical field
The present invention relates to a kind of biochemical fields, more particularly to a kind of brill of plant tissue chip receptor blank wax stone
Kong Yi.
Background technology
Organization chip (tissue chip) is also known as micro-array tissue (tissuem icroarray, TMA), be by it is tens of extremely
Thousands of a cells are fitly arranged on a glass slide and manufactured histotomy, it is after genetic chip, protein core
Another the important biochip occurred after piece, is mainly used for studying same gene or protein molecule in different cells
Or the case where being expressed in tissue.
Organization chip and genetic chip, protein-chip, cell chip together form biochip series, make the mankind the
Hundreds and thousands of parts of tissue specimens can be once efficiently used, are ground in three genome, transcript profile and protein group levels
Study carefully, is known as the revolution of medicine, field of biology.Tissue array technology can be with other many routine techniques such as immune groups
The connected applications such as weave chemistry (IHC), nucleic acid hybridization in situ (ISH), fluorescence in situ hybridization (FISH), In situPCR, its application neck
Domain is constantly expanded.The biological study technology emerging as one, just shows oneself with its absolute superiority
Potentiality.Organization chip is mainly improved to manufacturing technology and sample medical history information improves two directions and develops, frozen tissue chip,
Ultra high density organization chip is all the breakthrough for having in terms of original organization chip bigger.
As soon as the substance chip of plant needs in the elongated grid mounted in wax stone, this wax stone as organization chip by
Body.The production method of traditional wax stone is：The wax liquor of fusing is injected in mold, then demoulds and organization chip receptor blank wax is made
Block.However, if requiring the surface of wax stone more fine, it is necessary to which price is more expensive, weight is compared with the mold attached most importance to.Common
In laboratory, it can not select that relatively advanced, price is more expensive, weight is compared with the mold attached most importance to, but the wax stone that common die makes
It is unable to reach the requirement of the surface roughness of requirement of experiment again.
Therefore, there is an urgent need for a kind of devices that can reasonably prepare organization chip receptor blank wax stone in the lab at present.
Invention content
The technical problem to be solved in the present invention is to provide a kind of plant tissues simple in structure, at low cost, easy to operate to cut
Piece receptor blank wax stone boring instrument.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, including
Pedestal is fixed with rack；
Pillar, bottom are fixed with the pedestal；
First connecting rod is fixed with the top of the pillar；
First telescopic mast, fixing end are connect with the top hinge of the first connecting rod, telescopic end and second connecting rod
Top hinge connects；
Second telescopic mast, fixing end are connect with the bottom hinge of the first connecting rod, telescopic end and second connecting rod
Bottom hinge connects；
Drill body is fixed with the second connecting rod, and the bottom of the drill body is equipped with multiple drill bits being arranged side by side；
Wherein, the first connecting rod is fixed with first motor, the output shaft of the first motor and first telescopic mast
Fixing end fix.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, wherein first telescopic mast is beam hanger, described the
The piston cylinder of one telescopic mast is connect with the top hinge of the first connecting rod, the piston rod of first telescopic mast and described second
The top hinge of connecting rod connects.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, wherein second telescopic mast is beam hanger, described the
The piston cylinder of two telescopic masts is connect with the bottom hinge of the first connecting rod, the piston rod of second telescopic mast and described second
The bottom hinge of connecting rod connects.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, wherein the drill body includes the first folding rod, second
Folding rod, third folding rod, the 4th folding rod, third telescopic mast, the first arc rubber rods, the second arc rubber rods, the first shield
Plate, the second backplate, third backplate, the 4th backplate, the first interior bar, the second interior bar, third interior bar, the 4th interior bar；
The top of first folding rod is connect with the top hinge of the second folding rod, the bottom of second folding rod with
The top hinge of third folding rod connects, and the bottom of the third folding rod is connect with the bottom hinge of the 4th folding rod,
The top of 4th folding rod is connect with the bottom hinge of first folding rod, between the first folding rod, the second folding rod
The hinge of connection is fixed on the output shaft of the second motor, and second motor is fixed with the second connecting rod, third folding rod,
The hinge connected between 4th folding rod is fixed on the middle part of the first arc rubber rods；
The hinge connected between first folding rod and the 4th folding rod is fixed on the telescopic end of the third telescopic mast
On, specified hinge is connected between second folding rod and third folding rod to be fixed in the fixing end of the third telescopic mast；
The middle part of the first arc rubber rods and the middle part of the second arc rubber rods are fixed, the first arc rubber rods,
The opening direction of two arc rubber rods is towards underface；The both ends of the first arc rubber rods respectively with the second backplate, the 4th
Backplate is fixed, and the both ends of the second arc rubber rods are fixed with the first backplate, third backplate respectively, first backplate,
Two backplates, third backplate, the 4th backplate are for protecting drill bit, one end hinge connection of first backplate and the first interior bar, institute
State the other end of the first interior bar and the drill bit hinge connection, one end hinge connection of second backplate and the second interior bar, institute
State the other end of the second interior bar and the drill bit hinge connection, one end hinge connection of the third backplate and third interior bar, institute
The other end of third interior bar and the drill bit hinge connection are stated, the 4th backplate and one end hinge of the 4th interior bar connect
It connects, the other end and the drill bit hinge connection of the 4th interior bar；
Spring is equipped between the middle part and the top of the drill bit of the second arc rubber rods.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, wherein the third telescopic mast is beam hanger, and third is stretched
The hinge connected between the piston cylinder of contracting column and second folding rod, third folding rod is fixed, the piston rod of third telescopic mast
The hinge connected between first folding rod, the 4th folding rod is fixed.
Plant tissue slice receptor blank wax stone boring instrument of the present invention, wherein the first motor, the second motor, first
Telescopic mast, the second telescopic mast, third telescopic mast are connect with server, and the server is according to original plant of plant tissue chip
Height A, weight B, age C, the moisture content D of object export drilling depth E, and control drill bit and drill out depth to wax stone as follows
Spend the hole of E；
Wherein, the unit of the height A of original plant is decimetre, and the unit of weight B is 50 grams, and the unit of age C is the moon,
The unit of depth E is millimeter.
Plant tissue slice receptor blank wax stone boring instrument difference from prior art of the present invention is plant of the present invention
Histotomy receptor blank wax stone boring instrument constitutes one by first connecting rod, second connecting rod, the first telescopic mast, the second telescopic mast
Four-bar linkage structure can make drill body keep same direction when four-bar linkage structure rotates, also, pass through by this four-bar linkage structure
First telescopic mast, the second telescopic mast telescopic action and make drill body in same lateral position, keep drill bit vertically flexible up and down.
The plant tissue slice receptor blank wax stone boring instrument of the present invention is described further below in conjunction with the accompanying drawings.
Description of the drawings
Fig. 1 is the front view of the first motion state of plant tissue slice receptor blank wax stone boring instrument；
Fig. 2 is the front view of the second motion state of plant tissue slice receptor blank wax stone boring instrument；
Fig. 3 is the structural schematic diagram of the drill body of plant tissue slice receptor blank wax stone boring instrument.
Specific implementation mode
As shown in Figure 1, 2, plant tissue slice receptor blank wax stone boring instrument of the present invention includes
Pedestal 100, is fixed with rack；
Pillar 210, bottom are fixed with the pedestal 100；
First connecting rod 221 is fixed with the top of the pillar 210；
First telescopic mast 231, fixing end are connect with the top hinge of the first connecting rod 221, telescopic end and second
The top hinge of connecting rod 222 connects；
Second telescopic mast 232, fixing end are connect with the bottom hinge of the first connecting rod 221, telescopic end and second
The bottom hinge of connecting rod 222 connects；
Drill body 300 is fixed with the second connecting rod 222, and the bottom of the drill body 300 is equipped with multiple brills being arranged side by side
First 400, drill bit 400 is arranged right below wax stone 200, and the wax stone 200 is arranged on the pedestal 100；
Wherein, the first connecting rod 221 is fixed with first motor, and the output shaft of the first motor is flexible with described first
The fixing end of column 231 is fixed.
Since the entire wax stone body of organization chip receptor blank wax stone 200 is relatively easy to produce, using it is relatively advanced,
Price is more expensive, weight carries out batch production to wax stone compared with the mold attached most importance to and is relatively easy to.In the lab, according to demand, make
The hole of different size of wax stone is drilled out to load organization chip with different drill bits.The cost of drill bit relative to mold cost more
Low, the surface roughness in the hole processed is more preferable.Specifically, the present invention passes through first connecting rod 221, second connecting rod 222, first
Telescopic mast 231, the second telescopic mast 232 constitute a four-bar linkage structure, drill body 300 can be made to connect four by this four-bar linkage structure
Rod structure keeps same direction when rotating, also, by the first telescopic mast 231, the second telescopic mast 232 telescopic action by make brill
Body 300 keeps drill bit vertically flexible up and down in same lateral position.
Preferably, first telescopic mast 231 is beam hanger, and the piston cylinder of first telescopic mast 231 connects with described first
The top hinge of bar 221 connects, and the piston rod of first telescopic mast 231 is connect with the top hinge of the second connecting rod 222.
Preferably, second telescopic mast 232 is beam hanger, and the piston cylinder of second telescopic mast 232 connects with described first
The bottom hinge of bar 221 connects, and the piston rod of second telescopic mast 232 is connect with the bottom hinge of the second connecting rod 222.
The present invention by way of the holding position at any time of beam hanger can after above-mentioned drill bit enters wax stone, by beam hanger shutdown be
The position that can keep drill bit, more saves the energy.
Preferably, referring to Fig. 3, the drill body 300 includes the first folding rod 301, the second folding rod 302, third folding rod
303, the 4th folding rod 304, third telescopic mast 305, the first arc rubber rods 311, the second arc rubber rods 312, the first backplate
321, the second backplate 322, third backplate 323, the 4th backplate 324, the first interior bar 331, the second interior bar 332, third interior bar 333,
4th interior bar 334；
The top of first folding rod 301 is connect with the top hinge of the second folding rod 302, second folding rod
302 bottom is connect with the top hinge of third folding rod 303, and the bottom of the third folding rod 303 is folded with the described 4th
The bottom hinge of bar 304 connects, and the top of the 4th folding rod 304 is connect with the bottom hinge of first folding rod 301,
The hinge connected between first folding rod 301, the second folding rod 302 is fixed on the output shaft of the second motor, second electricity
Machine and the second connecting rod 222 are fixed, and the hinge connected between third folding rod 303, the 4th folding rod 304 is fixed on described the
The middle part of one arc rubber rods 311；
The hinge connected between first folding rod, 301 and the 4th folding rod 304 is fixed on the third telescopic mast 305
Telescopic end on, specified hinge is connected between second folding rod 302 and third folding rod 303, and to be fixed on the third flexible
In the fixing end of column 305；
The middle part and the middle part of the second arc rubber rods 312 of the first arc rubber rods 311 are fixed, the first arc rubber
Bar 311, the second arc rubber rods 312 opening direction towards underface；The both ends of the first arc rubber rods 311 respectively with
Second backplate 322, the 4th backplate 324 are fixed, the both ends of the second arc rubber rods 312 respectively with the first backplate 321, third
Backplate 323 is fixed, and first backplate 321, the second backplate 322, third backplate 323, the 4th backplate 324 are for protecting drill bit
400, one end hinge connection of first backplate, 321 and first interior bar 331, the other end of first interior bar 331 with it is described
400 hinge connection of drill bit, one end hinge connection of second backplate, 322 and second interior bar 332, second interior bar 332
The other end and 400 hinge connection of the drill bit, one end hinge connection of the third backplate 323 and third interior bar 333, described the
The other end of three interior bars 333 and 400 hinge connection of the drill bit, one end of the 4th backplate 324 and the 4th interior bar 334
Hinge connection, the other end and 400 hinge connection of the drill bit of the 4th interior bar 334；
Spring is equipped between the middle part and the top of the drill bit 400 of the second arc rubber rods 312.
The present invention is folded by telescopic drive the first folding rod 301, the second folding rod 302, third of third telescopic mast 305
The deformation of four-bar linkage structure between bar 303, the 4th folding rod 304, to be lifted up or extend downwardly drill bit 400, also,
By the rotation of the second motor, the first backplate 321, the second backplate 322, third backplate 323, the 4th backplate 324 generate centrifugation fortune
Dynamic, drill bit 400 can be downward when the first backplate 321, the second backplate 322, third backplate 323, the 4th backplate 324 are displaced outwardly
It stretches out.When second motor does not turn, drill bit can pass through spring reset again.
Preferably, the third telescopic mast 305 is beam hanger, the piston cylinder of third telescopic mast 305 and second folding rod
302, the hinge connected between third folding rod 303 is fixed, the piston rod of third telescopic mast 305 and first folding rod 301,
The hinge connected between 4th folding rod 304 is fixed.
Preferably, the first motor, the second motor, the first telescopic mast 231, the second telescopic mast 232, third telescopic mast
305 connect with server, the server according to the height A of original plant of plant tissue chip, weight B, age C, contain
Water rate D exports drilling depth E, and controls the hole that drill bit 400 drills out depth E to wax stone as follows；
Wherein, the unit of the height A of original plant is decimetre, and the unit of weight B is 50 grams, and the unit of age C is the moon,
The unit of depth E is millimeter.
The present invention by above-mentioned formula can reasonably according to original plant the case where of organization chip by configure drilling depth
E。
Embodiment described above is only that the preferred embodiment of the present invention is described, not to the model of the present invention
It encloses and is defined, under the premise of not departing from design spirit of the present invention, technical side of the those of ordinary skill in the art to the present invention
The various modifications and improvement that case is made should all be fallen into the protection domain of claims of the present invention determination.
Claims (5)
1. a kind of plant tissue slice receptor blank wax stone boring instrument, it is characterised in that：Including
Pedestal (100), is fixed with rack；
Pillar (210), bottom are fixed with the pedestal (100)；
First connecting rod (221) is fixed with the top of the pillar (210)；
First telescopic mast (231), fixing end are connect with the top hinge of the first connecting rod (221), telescopic end and second
The top hinge of connecting rod (222) connects；
Second telescopic mast (232), fixing end are connect with the bottom hinge of the first connecting rod (221), telescopic end and second
The bottom hinge of connecting rod (222) connects；
Drill body (300), fixed with the second connecting rod (222), the bottom of the drill body (300) is equipped with multiple be arranged side by side
Drill bit (400)；
Wherein, the first connecting rod (221) is fixed with first motor, the output shaft of the first motor and first telescopic mast
(231) fixing end is fixed.
2. plant tissue slice receptor blank wax stone boring instrument according to claim 1, it is characterised in that：Described first stretches
Contracting column (231) is beam hanger, and the piston cylinder of first telescopic mast (231) is connect with the top hinge of the first connecting rod (221),
The piston rod of first telescopic mast (231) is connect with the top hinge of the second connecting rod (222).
3. plant tissue slice receptor blank wax stone boring instrument according to claim 1, it is characterised in that：Described second stretches
Contracting column (232) is beam hanger, and the piston cylinder of second telescopic mast (232) is connect with the bottom hinge of the first connecting rod (221),
The piston rod of second telescopic mast (232) is connect with the bottom hinge of the second connecting rod (222).
4. plant tissue slice receptor blank wax stone boring instrument according to claim 1, it is characterised in that：The drill body
(300) include the first folding rod (301), the second folding rod (302), third folding rod (303), the 4th folding rod (304), third
Telescopic mast (305), the first arc rubber rods (311), the second arc rubber rods (312), the first backplate (321), the second backplate
(322), third backplate (323), the 4th backplate (324), the first interior bar (331), the second interior bar (332), third interior bar (333),
4th interior bar (334)；
The top of first folding rod (301) is connect with the top hinge of the second folding rod (302), second folding rod
(302) bottom is connect with the top hinge of third folding rod (303), the bottom of the third folding rod (303) and described the
The bottom hinge of four folding rods (304) connects, the top of the 4th folding rod (304) and first folding rod (301)
Bottom hinge connects, and the hinge connected between the first folding rod (301), the second folding rod (302) is fixed on the defeated of the second motor
On shaft, second motor and the second connecting rod (222) are fixed, third folding rod (303), the 4th folding rod (304) it
Between the hinge that connects be fixed on the middle parts of the first arc rubber rods (311)；
The hinge connected between first folding rod (301) and the 4th folding rod (304) is fixed on the third telescopic mast
(305) it connects specified hinge on telescopic end, between second folding rod (302) and third folding rod (303) and is fixed on institute
In the fixing end for stating third telescopic mast (305)；
The middle part of the first arc rubber rods (311) and the middle part of the second arc rubber rods (312) are fixed, the first arc rubber
Bar (311), the second arc rubber rods (312) opening direction towards underface；The both ends of the first arc rubber rods (311)
Fixed with the second backplate (322), the 4th backplate (324) respectively, the both ends of the second arc rubber rods (312) are respectively with first
Backplate (321), third backplate (323) are fixed, first backplate (321), the second backplate (322), third backplate (323), the
Four backplates (324) are for protecting drill bit (400), one end hinge connection of first backplate (321) and the first interior bar (331),
The other end of first interior bar (331) and the drill bit (400) hinge connection, second backplate (322) and the second interior bar
(332) one end hinge connection, the other end and the drill bit (400) hinge connection of second interior bar (332), the third
One end hinge connection of backplate (323) and third interior bar (333), the other end and the drill bit of the third interior bar (333)
(400) hinge connection, one end hinge connection of the 4th backplate (324) and the 4th interior bar (334), the 4th interior bar
(334) the other end and the drill bit (400) hinge connection；
Spring is equipped between the middle part and the top of the drill bit (400) of the second arc rubber rods (312).
5. plant tissue slice receptor blank wax stone boring instrument according to claim 4, it is characterised in that：The third is stretched
Contracting column (305) is beam hanger, the piston cylinder of third telescopic mast (305) and second folding rod (302), third folding rod (303)
Between the hinge that connects fix, the piston rod of third telescopic mast (305) and first folding rod (301), the 4th folding rod
(304) hinge connected between is fixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611045049.4A CN106769174B (en) | 2016-11-22 | 2016-11-22 | Plant tissue slice receptor blank wax stone boring instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611045049.4A CN106769174B (en) | 2016-11-22 | 2016-11-22 | Plant tissue slice receptor blank wax stone boring instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106769174A CN106769174A (en) | 2017-05-31 |
| CN106769174B true CN106769174B (en) | 2018-07-13 |
Family
ID=58975222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611045049.4A Active CN106769174B (en) | 2016-11-22 | 2016-11-22 | Plant tissue slice receptor blank wax stone boring instrument |
Country Status (1)
| Country | Link |
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| CN (1) | CN106769174B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110132702A (en) * | 2019-06-11 | 2019-08-16 | 河南科技学院 | A kind of embedding method for particular pathologies tissue |
| CN114018680B (en) * | 2021-10-28 | 2022-10-21 | 上海交通大学医学院附属第九人民医院 | Manufacturing method of choroid melanoma specimen wax block and chip |
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| CN1356553A (en) * | 2001-09-13 | 2002-07-03 | 陕西超英生物医学研究开发有限公司 | Tissue microarray biochip |
| CN1595097A (en) * | 2004-06-22 | 2005-03-16 | 浙江大学 | Process for preparing tissue chips and apparatus thereof |
| CN1635157A (en) * | 2004-11-08 | 2005-07-06 | 西安交通大学 | Biological tissue micro array chip automatic preparation instrument and control method thereof |
| CN104535751A (en) * | 2015-01-23 | 2015-04-22 | 胡苹 | Tissue chip receptor blank wax block preparation device and using method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2611379Y (en) * | 2003-01-29 | 2004-04-14 | 陕西西大北美基因股份有限公司 | Appts. for preparing structural micro-array secondary embedded wax block |
| CN101319971B (en) * | 2008-07-01 | 2010-12-01 | 南通大学 | Preparation method of paraffin organization chip |
| US8846416B1 (en) * | 2013-03-13 | 2014-09-30 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method for forming biochips and biochips with non-organic landings for improved thermal budget |
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2016
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356553A (en) * | 2001-09-13 | 2002-07-03 | 陕西超英生物医学研究开发有限公司 | Tissue microarray biochip |
| CN1595097A (en) * | 2004-06-22 | 2005-03-16 | 浙江大学 | Process for preparing tissue chips and apparatus thereof |
| CN1635157A (en) * | 2004-11-08 | 2005-07-06 | 西安交通大学 | Biological tissue micro array chip automatic preparation instrument and control method thereof |
| CN104535751A (en) * | 2015-01-23 | 2015-04-22 | 胡苹 | Tissue chip receptor blank wax block preparation device and using method thereof |
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| CN106769174A (en) | 2017-05-31 |
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