CN2699279Y - Carrier for securing biological samples - Google Patents
Carrier for securing biological samples Download PDFInfo
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- CN2699279Y CN2699279Y CN 200420017778 CN200420017778U CN2699279Y CN 2699279 Y CN2699279 Y CN 2699279Y CN 200420017778 CN200420017778 CN 200420017778 CN 200420017778 U CN200420017778 U CN 200420017778U CN 2699279 Y CN2699279 Y CN 2699279Y
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- carrier
- hole
- glass
- sintered body
- tio
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Abstract
The utility model relates to a carrier for securing biological samples, which is characterized in that cavity holes(2)are ranged on the nucleated glass substrate (1) in close-packed lattice. The nanometer pore medium sintered body (3) is filled in the cavity holes (2). The utility model can fix or isolate lots of biologic and chemical samples and stand the synthesis cycle and the erosion of some reagent in the detecting experiment. In this way, the sample can not shed.
Description
Technical field
The utility model relates to a kind of carrier that can be used for the fixed biologically sample.
Background technology
21 century is the century of life science, and the biotechnology application aspect medical diagnosis is tending towards ripe gradually.Meanwhile, relevant biological and chemical device technique has also obtained development fast, as biology sensor, biology information technology, chemical sensor etc.Just become the common problem of whole world life science worker yet how to go to study the function that numerous gene like this and protein born in life process, biochip arises at the historic moment under such background just.From the beginning of the nineties, since beginning to carry out the development of various biochips based on some countries of the U.S., less than the time in 10 years, biochip technology was able to swift and violent development, and external how tame major company and government organs all drop into great amount of manpower and material resources and carry out research and development.
Chip can be divided into glass-chip, silicon, ceramic chip and plastic chip etc. by carrier material, because property and advantage that the glass-chip carrier material is had, people mainly concentrate strength on carrying out the research of this aspect at present.Research about the glass-chip carrier, it mainly is substrate with the ultra-thin glass, has the film that dot matrix is arranged in its surface preparation, reach the purpose of storing the biological or chemical sample, oneself makes protein-chip to utilize glass carrier as Russian expert, when the thin layer on the rayed glass plate of different wave length, just the albuminous cell in the film presents different forms, the transparency of film is changed accordingly, utilize this discovery to make the optical information carrier of precision optical instrument.China mainly concentrates on the preparation of biochip, the analysis of sample and the preparation of device to the development of biochip, and relatively weak to the development of biochip carrier material.
With the ultra-thin glass is substrate, and at its surface preparation carrier thin film, because intensity is low, dimensional controllability is poor, and the preparation of biochip and the analysis of sample are exerted a certain influence.
And the glass carrier biggest advantage is on a large scale, parallelization, little manufacturing, on the unit area of chip, can arrange a large amount of bioprobes to high-density, can once detect multiple disease simultaneously or analyze multiple biological specimen, the glass-chip carrier can satisfy above-mentioned requirement to carrier material simultaneously, and advantages such as its fluorescence background is low, low cost of manufacture, application convenience are widely accepted in the world, biochip is carrier with glass, open up new application approach again for glass material, the progress of glass the reach of science and industry is had great importance.
Summary of the invention
The purpose of this utility model provides a kind of carrier that can be used for the fixed biologically sample, a large amount of biological and chemical samples can be fixed or isolates, and the erosion of some reagent in synthetic circulation of tolerance and the test experience, sample can not come off.
The purpose of this utility model implementation: a kind of carrier that can be used for the fixed biologically sample, it is characterized in that close-packed lattice is arranged with hole, hole 2 on the glass-ceramic substrate 1, nanometer micropore glass medium sintered body 3 is filled in the hole, hole 2.
2 one-tenth 32 in hole, described hole, 64,236 (8 * 32) or 1024 (16 * 64) dot matrix are arranged.
The thickness of described glass-ceramic substrate 1 is 0.5-1.0mm, is of a size of 10 * 10 or 10 * 25 or 25 * 50mm, consists of Li
2O-SiO
2-Al
2O
3-TiO
2-AgO-CeO
2-AuCl-TiO
2
Described nanometer micropore glass medium sintered body 3 apertures are the 1-100 nanometer, consist of Na
2O-Li
2O-B
2O
3-SiO
2-TiO
2-ZrO
2
Close-packed lattice is arranged with hole, hole 2 on the utility model employing glass-ceramic substrate 1, nanometer micropore glass medium sintered body 3 is filled in the hole, hole 2, nanometer micropore glass medium sintered body 3 apertures are the 1-100 nanometer, a large amount of biological and chemical samples can be fixed or isolates, the erosion of some reagent in synthetic circulation of tolerance and the test experience, sample can not come off.
The utility model proposes with the devitrified glass is substrate, provide the aperture controllable biochip carrier material, its intensity height, dot matrix are intensive, and the glass carrier biggest advantage is on a large scale, parallelization, little manufacturing, on the unit area of chip, can arrange a large amount of bioprobes to high-density, can once detect multiple disease simultaneously or analyze multiple biological specimen, the glass-chip carrier can satisfy above-mentioned requirement to carrier material simultaneously, and advantages such as its fluorescence background is low, low cost of manufacture, application convenience.This practicality selects production technology to meet domestic and international production custom, is easy to control and grasp the performance and the preparation of material.
Description of drawings
Fig. 1 is the utility model structural representation
Fig. 2 is a close-packed lattice glass-ceramic substrate synoptic diagram
Fig. 3 is a nanoporous dot matrix synoptic diagram
Fig. 4 is the utility model sectional structure synoptic diagram
Among the figure: 1-glass-ceramic substrate, hole, 2-hole, 3-nanometer micropore glass medium sintered body.
Embodiment
As Fig. 1, Fig. 2, Fig. 3, shown in Figure 4, a kind of carrier that can be used for the fixed biologically sample, close-packed lattice is arranged with hole, hole 2 on the glass-ceramic substrate 1, and nanometer micropore glass medium sintered body 3 is filled in the hole, hole 2.
2 one-tenth 32 in hole, described hole, 64,236 (8 * 32) or 1024 (16 * 64) dot matrix are arranged.
The thickness of described glass-ceramic substrate 1 is 0.5-1.0mm, is of a size of 10 * 10 or 10 * 25 or 25 * 50mm, consists of Li
2O-SiO
2-Al
2O
3-TiO
2-AgO-CeO
2-AuCl-TiO
2
Described nanometer micropore glass medium sintered body 3 apertures are the 1-100 nanometer, consist of Na
2O-Li
2O-B
2O
3-SiO
2-TiO
2-ZrO
2
The nanometer micropore glass medium mixes with gel solution to grind at a high speed to be made paste mixture (gel solution is made up of acrylamide and methylene diacrylamine, and its content concn is respectively 4.0 and 1.6%.), the nanometer micropore glass medium accounts for 30～40% (V/V) of sol solutions and nanometer micropore glass medium cumulative volume, inject the hole, hole 2 of close-packed lattice glass-ceramic substrate 1 by extruding, by drying, thermal treatment can form the 2000-10000 low-density and arrange, density is arranged among the 10000-20000, the substrate material that the 20000-500000 high density is arranged, satisfy and utilize the diagnosis of screen lithographic printing to the DNA chip, biology sensor, the preparation of special gas detecting sensor, adopt UV-photosensitive glass-ceramics graphic model to the sign of DNA chip and UV-phase detachment technique needs to DNA analysis research and others.
Claims (4)
1. a carrier that can be used for the fixed biologically sample is characterized in that the last close-packed lattice of glass-ceramic substrate (1) is arranged with hole, hole (2), and nanometer micropore glass medium sintered body (3) is filled in the hole, hole (2).
2. a kind of carrier that can be used for the fixed biologically sample according to claim 1 is characterized in that: hole, described hole (2) becomes 32,64,8 * 32 or 16 * 64 dot matrix to arrange.
3. a kind of carrier that can be used for the fixed biologically sample according to claim 1 is characterized in that: the thickness of described glass-ceramic substrate (1) is 0.5-1.0mm, is of a size of 10 * 10 or 10 * 25 or 25 * 50mm, consists of Li
2O-SiO
2-Al
2O
3-TiO
2-AgO-CeO
2-AuCl-TiO
2
4. a kind of carrier that can be used for the fixed biologically sample according to claim 1 is characterized in that: the aperture of described nanometer micropore glass medium sintered body (3) is the 1-100 nanometer, consists of Na
2O-Li
2O-B
2O
3-SiO
2-TiO
2-ZrO
2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420017778 CN2699279Y (en) | 2004-04-16 | 2004-04-16 | Carrier for securing biological samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420017778 CN2699279Y (en) | 2004-04-16 | 2004-04-16 | Carrier for securing biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2699279Y true CN2699279Y (en) | 2005-05-11 |
Family
ID=34769202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200420017778 Expired - Fee Related CN2699279Y (en) | 2004-04-16 | 2004-04-16 | Carrier for securing biological samples |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2699279Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418928C (en) * | 2006-04-04 | 2008-09-17 | 武汉理工大学 | Method for preparing composite carrier material contg, nanometer porous glass and aluminium oxide ceramic substrate |
| WO2014180172A1 (en) * | 2013-05-09 | 2014-11-13 | 上海派莱星生物技术有限公司 | Biochip and application thereof |
| CN107557269A (en) * | 2013-02-26 | 2018-01-09 | 伊鲁米那股份有限公司 | The surface of gel medelling |
-
2004
- 2004-04-16 CN CN 200420017778 patent/CN2699279Y/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418928C (en) * | 2006-04-04 | 2008-09-17 | 武汉理工大学 | Method for preparing composite carrier material contg, nanometer porous glass and aluminium oxide ceramic substrate |
| CN107557269A (en) * | 2013-02-26 | 2018-01-09 | 伊鲁米那股份有限公司 | The surface of gel medelling |
| US11173466B2 (en) | 2013-02-26 | 2021-11-16 | Illumina, Inc. | Gel patterned surfaces |
| WO2014180172A1 (en) * | 2013-05-09 | 2014-11-13 | 上海派莱星生物技术有限公司 | Biochip and application thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050511 Termination date: 20100416 |