CN106754767A - A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof - Google Patents

A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof Download PDF

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Publication number
CN106754767A
CN106754767A CN201610810687.4A CN201610810687A CN106754767A CN 106754767 A CN106754767 A CN 106754767A CN 201610810687 A CN201610810687 A CN 201610810687A CN 106754767 A CN106754767 A CN 106754767A
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CN
China
Prior art keywords
product
sod
life
vivo
easy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201610810687.4A
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Chinese (zh)
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不公告发明人
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Gao Tianci
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Gao Tianci
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Priority to CN201610810687.4A priority Critical patent/CN106754767A/en
Publication of CN106754767A publication Critical patent/CN106754767A/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SOD claims superoxidase, is the negative oxygen free radical scavenger of human body, is the most popular research topic of modern medicine and pharmacology.SOD is extremely unstable biology enzyme, shorter in people's Half-life in vivo, is easily inactivated.The technology of the present invention uses low temperature, the technical measures such as starvation addition and protective agent.And modified with small molecule fat value body in SOD molecular modifications.Half-life in vivo is set to be no more than eight hours.Product major advantage of the present invention is as follows：It is easy to be absorbed by the body through cell membrane, is not easily blocked capilary.Product of the present invention has fat-soluble, it is easy to through the blood barrier of organ, improves the stability value preserving phase of heat and soda acid up to more than 3 years, and half-life period can extend 10 times after penetrating skin in this product addition cosmetics.This product is completely eliminated immunogenicity, nontoxic, evil of going out, without allergic reaction, and safely.

Description

A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof
SOD production technologies are as follows：
This product is aided in fresh pig blood and corn as primary raw material with the Rosa roxburghii containing SOD, aloe and bean etc. Raw material, operation is protected by anti-freezing, and by centrifugation, washing is broken and the measure such as dissolving antioxygen, then except foreigh protein removing after, then Carry out warm concentration, solvent deposition, etc. operation, ultrafiltration, nanofiltration, after the technological process such as concentration, through chromatographic isolation, freeze-drying, point The programs such as son modification, dispensing goes out finished product after packaging.
Separately pass through fat value body in molecular modification and the addition of fat value body halide carries out molecular modification program again.
Brief description of the drawings：
Accompanying drawing 1 is SOD production technological process.

Claims (1)

1. also known as hepatocuprein (SOD), it is main original based on fresh pig blood and corn to be to this product, by this patent skill Art carries out large-scale production.
SOD bears the scavenger of oxygen radical as human body, is the popular research topic of modern medicine and pharmacology, and SOD is a kind of extremely unstable Fixed biology enzyme, (enzymatic activity only keeps a few minutes) half-life period is shorter in vivo, easily inactivates.The art of this patent using low temperature and Starvation and protective agent etc..
And in SOD molecular modifications, it is small more than 8 to carrying out can reach Half-life in vivo after molecular modification with small molecule fat value body When, this patent product has the advantage that：
1st, by small numerator modified, and it is easy to be absorbed by the body through cell membrane, and is not easily blocked capilary.
2nd, enzyme activity is improved, eight hours can be surpassed in body people Increased Plasma Half-life.
3rd, this product has fat-soluble, it is easy to through the blood barrier of organ, and the stability to heat and soda acid is improved, and the value preserving phase can Up to more than 3 years.
4th, after this product is as added cosmetics, penetrating the half-life period after skin can extend 10 times.
5th, this product is completely eliminated immunogenicity, nontoxic to human body, harmless, without allergic reaction, and safety.Patent requirements：This is specially Sharp effective age is 10 years.
CN201610810687.4A 2016-09-08 2016-09-08 A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof Pending CN106754767A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610810687.4A CN106754767A (en) 2016-09-08 2016-09-08 A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610810687.4A CN106754767A (en) 2016-09-08 2016-09-08 A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof

Publications (1)

Publication Number Publication Date
CN106754767A true CN106754767A (en) 2017-05-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610810687.4A Pending CN106754767A (en) 2016-09-08 2016-09-08 A kind of superoxide dismutase aliphatic acid inclusion compound and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106754767A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112168955A (en) * 2020-08-26 2021-01-05 上海润日生物科技发展有限公司 SOD health-care composition with effects of resisting three highs and losing weight and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1570093A (en) * 2003-07-23 2005-01-26 韩伯钧 Extraction method for SOD complex enzyme fine powder from corn
WO2008087803A1 (en) * 2007-01-16 2008-07-24 Hokkaido University Liposome preparation for iontophoresis having antioxidant component encapsulated therein
CN102181411A (en) * 2011-04-01 2011-09-14 黑龙江宝迪肉类食品有限公司 Method for extracting superoxide dismutase (SOD) from porcine blood red cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1570093A (en) * 2003-07-23 2005-01-26 韩伯钧 Extraction method for SOD complex enzyme fine powder from corn
WO2008087803A1 (en) * 2007-01-16 2008-07-24 Hokkaido University Liposome preparation for iontophoresis having antioxidant component encapsulated therein
CN102181411A (en) * 2011-04-01 2011-09-14 黑龙江宝迪肉类食品有限公司 Method for extracting superoxide dismutase (SOD) from porcine blood red cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张建等: "超氧化物歧化酶脂质体的制备及其药物动力学", 《中国医药工业杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112168955A (en) * 2020-08-26 2021-01-05 上海润日生物科技发展有限公司 SOD health-care composition with effects of resisting three highs and losing weight and preparation method and application thereof

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Application publication date: 20170531