CN106729956A - A kind of medical aquogel foam dressing and preparation method thereof - Google Patents
A kind of medical aquogel foam dressing and preparation method thereof Download PDFInfo
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- CN106729956A CN106729956A CN201611120063.6A CN201611120063A CN106729956A CN 106729956 A CN106729956 A CN 106729956A CN 201611120063 A CN201611120063 A CN 201611120063A CN 106729956 A CN106729956 A CN 106729956A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/0085—Porous materials, e.g. foams or sponges
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a kind of medical aquogel foam dressing, including following component, polyurethane foam, pulullan, gelatin, konjac glucomannan, keratin fiber, bata-carotene, D Sodium Glucuronates, magnesium chloride, earthworm dry powder, GINKGO BILOBA EXTRACT, cervus and cucumis polypeptide, notoginseng triol-saponin, starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, glycerine, distilled water.The invention also discloses the preparation method of the medical aquogel foam dressing.Wound healing rate is more than 65% behind 3 days of hydrogel foam casting product prepared by various embodiments of the present invention, wound healing time is short, and wound healing effect is good, produced without scar after healing, and nothing is adhered between wound and dressing, caused secondary insult, wide market when avoiding change of dressing.
Description
Technical field
The invention belongs to medical material tech field, and in particular to a kind of medical aquogel foam dressing and its preparation side
Method.
Background technology
Traditional dryness healing theory thinks, the healing of wound needs dry environment, it is necessary to the effect of oxygen, but is doing
In dry environment, not only easily make wound dehydrates, incrustation, be unfavorable for that epithelial cell is creeped, and easily make biological active matter
Matter is lost, and causes speed of wound healing slow, it is therefore desirable to the environment of moistening is provided for wound, can just promote wound quickly to heal
Close.
Medical hydrogel dressings are gel state due to it, can provide moisture to wound, it is to avoid wound is dried, with good
Moistening effect, can not only be effectively promoted wound healing, may also function as it is anti-be adhered and avoid secondary insult etc. from acting on, but
Aerogel dressing cannot be applied to the more wound of diffusate, and its application is limited to a certain extent.Polyurethane foam dressing is non-
Often it is applied to moderate to moderate diffusate wound, the above-mentioned deficiency of aerogel dressing can be made up；In addition the bullet of polyurethane foam dressing
Property it is good and compression strong, the position that covering is difficult in some human bodies can be applied.In consideration of it, the present invention provides one kind has water-setting concurrently
The composite water gel of both glue dressing and foam dressing performance, plays respective advantage, wound healing effect is improved, while entering
One step widens its clinical application range.
The content of the invention
Therefore, the present invention provides a kind of medical aquogel foam dressing and preparation method thereof, in solution prior art problem
At least one.
Therefore, the present invention provides a kind of medical aquogel foam dressing, including following component, it is calculated by weight as：It is poly-
30-46 parts of urethane foam, pulullan 10-16 parts, gelatin 5-12 parts, konjac glucomannan 7-11 parts, keratin fiber 3-10 parts, β-Hu
2-6 parts of radish element, 4-7 parts of D-Glucose aldehydic acid sodium, magnesium chloride 1-3 parts, earthworm dry powder 0.5-2 parts, GINKGO BILOBA EXTRACT 1.4-3 parts, deer
2.2-4 parts of melon polypeptide, notoginseng triol-saponin 2.1-4.3 parts, 6-14 parts of starch acrylic acid graft copolymer, trimethylolpropane contracting
4-11 parts, glycerine 15-24 parts, distilled water 20-35 parts of water glycerin ether.
An implementation method of the invention, wherein, the keratin fiber is by human hair, ox hair, wool, pig hair and rabbit
Any hair raw material of hair is prepared from, and specific preparation process is：It is 5 that hair raw material is placed in containing mass ratio:11:2 mercapto
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution of guanidine-acetic acid, thiocarbamide and lauryl sodium sulfate, separated through diafiltration
And be obtained, wherein the mass concentration of TGA is 2%-5%.
An implementation method of the invention, wherein, including following component, it is calculated by weight as：Polyurethane foam
33-42 parts, pulullan 11-15 parts, gelatin 6.4-10 parts, konjac glucomannan 7.5-10 parts, keratin fiber 3.2-8.7 parts, β-Hu
2.3-5.4 parts of radish element, 4.5-6.8 parts of D-Glucose aldehydic acid sodium, magnesium chloride 1.4-2.6 parts, earthworm dry powder 0.8-1.6 parts, ginkgo
Flavones 1.7-2.6 parts, cervus and cucumis polypeptide 2.4-3.5 parts, notoginseng triol-saponin 2.7-4 parts, starch acrylic acid graft copolymer 7.2-
12 parts, 4.5-9.8 parts, glycerine 17-22 parts, distilled water 24-32 parts of trimethylolpropane glycidol ether.
An implementation method of the invention, wherein, including following component, it is calculated by weight as：Polyurethane foam
28 parts, 12.6 parts of pulullan, 7.4 parts of gelatin, 8.7 parts of konjac glucomannan, 5.2 parts of keratin fiber, 3.8 parts of beta carotene, D- Portugals
5.5 parts of grape uronic acid sodium, 2.3 parts of magnesium chloride, 1.2 parts of earthworm dry powder, 2.1 parts of GINKGO BILOBA EXTRACT, 2.7 parts of cervus and cucumis polypeptide, pseudo-ginseng three
3 parts of alcohol saponin(e, 1 part of starch acrylic acid graft copolymer 1,6.9 parts of trimethylolpropane glycidol ether, 21 parts of glycerine, steaming
28 parts of distilled water.
Therefore, the present invention provides the preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 7-12, heat up
To 60-85 DEG C of stirring 10-40min, room temperature is then down to, adds starch acrylic acid graft copolymer, trimethylolpropane to shrink
Glycerin ether, is uniformly mixed, and obtains solution A, standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 50-80 DEG C 5-24 hours, is taken out
Polyurethane foam, dries, and obtains final product medical aquogel foam dressing.
An implementation method of the invention, wherein, in step 4, regulation system pH value is 8-11, is warming up to 70 DEG C
Stirring 18min.
An implementation method of the invention, wherein, in steps of 5, it is stirred continuously at 65 DEG C 12 hours.
Beneficial effects of the present invention are：
Wound healing rate is more than 65%, wound healing behind 3 days of hydrogel foam casting product prepared by various embodiments of the present invention
Within time foreshortens to 7 days, and wound healing effect is good, is produced without scar after healing, and nothing is adhered between wound and dressing,
Caused secondary insult when avoiding change of dressing.Hydrogel foam dressing prepared by the present invention combines aerogel dressing and bubble
The respective advantage of foam dressing, it is ensured that wound is in good moisturizing environment, while wound healing can be effectively promoted, and is also suitable
In wound fluid compared with wound and privileged sites wound, widened the clinical application range of dressing, wide market.
Specific embodiment
With reference to embodiment, the present invention is described in further detail.Following examples are not used to illustrate the present invention, but not
For limiting the scope of the present invention.
Embodiment 1
A kind of medical aquogel foam dressing, including following component, are calculated by weight as：30 parts of polyurethane foam, Propiram
10 parts of sugar, 5 parts of gelatin, 7 parts of konjac glucomannan, 3 parts of keratin fiber, 2 parts of beta carotene, 4 parts of D-Glucose aldehydic acid sodium, magnesium chloride 1
Part, 0.5 part of earthworm dry powder, 1.4 parts of GINKGO BILOBA EXTRACT, 2.2 parts of cervus and cucumis polypeptide, 2.1 parts of notoginseng triol-saponin, starch acrylic acid graft
6 parts of copolymer, 4 parts of trimethylolpropane glycidol ether, 15 parts of glycerine, 20 parts of distilled water.
The keratin fiber is prepared from by human hair, ox hair, wool, pig hair and rabbit hair any one hair raw material, is had
Preparation step is：It is 5 that hair raw material is placed in containing mass ratio:11:2 TGA, thiocarbamide and lauryl sodium sulfate
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution, separated through diafiltration and be obtained, wherein the mass concentration of TGA
It is 2%.
The preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 7, be warming up to 60
DEG C stirring 10min, is then down to room temperature, adds starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, stirring
It is well mixed, solution A is obtained, it is standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 50 DEG C 5 hours, takes out polyurethane
Foam, dries, and obtains final product medical aquogel foam dressing.
Embodiment 2
A kind of medical aquogel foam dressing, including following component, are calculated by weight as：46 parts of polyurethane foam, Propiram
16 parts of sugar, 12 parts of gelatin, 11 parts of konjac glucomannan, 10 parts of keratin fiber, 6 parts of beta carotene, 7 parts of D-Glucose aldehydic acid sodium, chlorination
3 parts of magnesium, 2 parts of earthworm dry powder, 3 parts of GINKGO BILOBA EXTRACT, 4 parts of cervus and cucumis polypeptide, 4.3 parts of notoginseng triol-saponin, starch acrylic acid graft are common
14 parts of polymers, 11 parts of trimethylolpropane glycidol ether, 24 parts of glycerine, 35 parts of distilled water.
The keratin fiber is prepared from by human hair, ox hair, wool, pig hair and rabbit hair any one hair raw material, is had
Preparation step is：It is 5 that hair raw material is placed in containing mass ratio:11:2 TGA, thiocarbamide and lauryl sodium sulfate
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution, separated through diafiltration and be obtained, wherein the mass concentration of TGA
It is 5%.
The preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 12, be warming up to
85 DEG C of stirring 40min, are then down to room temperature, add starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, stir
Mix well mixed, obtain solution A, it is standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 80 DEG C 24 hours, takes out poly- ammonia
Ester foam, dries, and obtains final product medical aquogel foam dressing.
Embodiment 3
A kind of medical aquogel foam dressing, including following component, are calculated by weight as：33 parts of polyurethane foam, Propiram
11 parts of sugar, 6.4 parts of gelatin, 7.5 parts of konjac glucomannan, 3.2 parts of keratin fiber, 2.3 parts of beta carotene, D-Glucose aldehydic acid sodium 4.5
Part, 1.4 parts of magnesium chloride, 0.8 part of earthworm dry powder, 1.7 parts of GINKGO BILOBA EXTRACT, 2.4 parts of cervus and cucumis polypeptide, 2.7 parts of notoginseng triol-saponin, shallow lake
7.2 parts of powder acrylic acid graft copolymer, 4.5 parts of trimethylolpropane glycidol ether, 17 parts of glycerine, 24 parts of distilled water.
The keratin fiber is prepared from by human hair, ox hair, wool, pig hair and rabbit hair any one hair raw material, is had
Preparation step is：It is 5 that hair raw material is placed in containing mass ratio:11:2 TGA, thiocarbamide and lauryl sodium sulfate
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution, separated through diafiltration and be obtained, wherein the mass concentration of TGA
It is 3.5%.
The preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 9, be warming up to 7
DEG C stirring 20min, is then down to room temperature, adds starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, stirring
It is well mixed, solution A is obtained, it is standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 65 DEG C 18 hours, takes out poly- ammonia
Ester foam, dries, and obtains final product medical aquogel foam dressing.
Embodiment 4
A kind of medical aquogel foam dressing, including following component, are calculated by weight as：42 parts of polyurethane foam, Propiram
15 parts of sugar, 10 parts of gelatin, 10 parts of konjac glucomannan, 8.7 parts of keratin fiber, 5.4 parts of beta carotene, D-Glucose aldehydic acid sodium 6.8
Part, 2.6 parts of magnesium chloride, 1.6 parts of earthworm dry powder, 2.6 parts of GINKGO BILOBA EXTRACT, 3.5 parts of cervus and cucumis polypeptide, 4 parts of notoginseng triol-saponin, starch
12 parts of acrylic acid graft copolymer, 9.8 parts of trimethylolpropane glycidol ether, 22 parts of glycerine, 32 parts of distilled water.
The keratin fiber is prepared from by human hair, ox hair, wool, pig hair and rabbit hair any one hair raw material, is had
Preparation step is：It is 5 that hair raw material is placed in containing mass ratio:11:2 TGA, thiocarbamide and lauryl sodium sulfate
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution, separated through diafiltration and be obtained, wherein the mass concentration of TGA
It is 3.5%.
The preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 10, be warming up to
80 DEG C of stirring 35min, are then down to room temperature, add starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, stir
Mix well mixed, obtain solution A, it is standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 65 DEG C 12 hours, takes out poly- ammonia
Ester foam, dries, and obtains final product medical aquogel foam dressing.
Embodiment 5
A kind of medical aquogel foam dressing, including following component, are calculated by weight as：28 parts of polyurethane foam, Propiram
12.6 parts of sugar, 7.4 parts of gelatin, 8.7 parts of konjac glucomannan, 5.2 parts of keratin fiber, 3.8 parts of beta carotene, D-Glucose aldehydic acid sodium
5.5 parts, 2.3 parts of magnesium chloride, 1.2 parts of earthworm dry powder, 2.1 parts of GINKGO BILOBA EXTRACT, 2.7 parts of cervus and cucumis polypeptide, 3 parts of notoginseng triol-saponin,
1 part of starch acrylic acid graft copolymer 1,6.9 parts of trimethylolpropane glycidol ether, 21 parts of glycerine, 28 parts of distilled water.
The keratin fiber is prepared from by human hair, ox hair, wool, pig hair and rabbit hair any one hair raw material, is had
Preparation step is：It is 5 that hair raw material is placed in containing mass ratio:11:2 TGA, thiocarbamide and lauryl sodium sulfate
After being soaked 24h hours at a temperature of 55 DEG C in the aqueous solution, separated through diafiltration and be obtained, wherein the mass concentration of TGA
It is 4%.
The preparation method of medical aquogel foam dressing, including following preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 11, be warming up to
70 DEG C of stirring 18min, are then down to room temperature, add starch acrylic acid graft copolymer, trimethylolpropane glycidol ether, stir
Mix well mixed, obtain solution A, it is standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 65 DEG C 12 hours, takes out poly- ammonia
Ester foam, dries, and obtains final product medical aquogel foam dressing.
Comparative example 1
The hydrogel foam dressing of this comparative example and differing only in for embodiment 1：Include keratin fiber, pulullan and
Earthworm dry powder.
Comparative example 2
The hydrogel foam dressing of this comparative example and differing only in for embodiment 1：Do not include magnesium chloride, starch acrylic acid graft
Copolymer and beta carotene.
Performance test
Embodiment of the present invention 1-5 and comparative example 1, the correlated performance of 2 products obtained therefroms are detected, as a result such as following table：
| Numbering | Wound healing rate/% after 3 days | Wound healing time | Wound healing effect | Whether it is adhered |
| Embodiment 1 | 68.3 | 6-7 days | Well, produced without scar | It is no |
| Embodiment 2 | 71.6 | 6-7 days | Well, produced without scar | It is no |
| Embodiment 3 | 74.2 | 5-6 days | Well, produced without scar | It is no |
| Embodiment 4 | 75.8 | 5-6 days | Well, produced without scar | It is no |
| Embodiment 5 | 77.1 | 4-5 days | Well, produced without scar | It is no |
| Comparative example 1 | 36.8 | 10-12 days | In, slight scar is produced | Slightly |
| Comparative example 2 | 39.4 | 9-11 days | In, slight scar is produced | Slightly |
As seen from the above table, wound healing rate is more than behind 3 days of the hydrogel foam casting product prepared by various embodiments of the present invention
65%, within wound healing time is foreshortened to 7 days, and wound healing effect is good, is produced without scar after healing, and wound with apply
Nothing is adhered between material, it is to avoid caused secondary insult during change of dressing.Hydrogel foam dressing prepared by the present invention is combined
The respective advantage of aerogel dressing and foam dressing, it is ensured that wound is in good moisturizing environment, while wound can be effectively promoted
Mouthful healing, and be also applied for wound fluid compared with wound and privileged sites wound, widened the clinical practice model of dressing
Enclose, wide market.
Claims (7)
1. a kind of medical aquogel foam dressing, it is characterised in that including following component, be calculated by weight as：Polyurethane foam
Foam 30-46 parts, pulullan 10-16 parts, gelatin 5-12 parts, konjac glucomannan 7-11 parts, keratin fiber 3-10 parts, beta carotene
2-6 parts, 4-7 parts of D-Glucose aldehydic acid sodium, magnesium chloride 1-3 parts, earthworm dry powder 0.5-2 parts, GINKGO BILOBA EXTRACT 1.4-3 parts, deer melon it is many
Peptide 2.2-4 parts, notoginseng triol-saponin 2.1-4.3 parts, 6-14 parts of starch acrylic acid graft copolymer, trimethylolpropane shrink it is sweet
Oily ether 4-11 parts, glycerine 15-24 parts, distilled water 20-35 parts.
2. medical aquogel foam dressing according to claim 1, it is characterised in that the keratin fiber by human hair,
Ox hair, wool, pig hair and rabbit hair any one hair raw material are prepared from, and specific preparation process is：Hair raw material is placed in and is contained
Mass ratio is 5:11:Immersion 24h is small at a temperature of 55 DEG C in the aqueous solution of 2 TGA, thiocarbamide and lauryl sodium sulfate
Shi Hou, separates and is obtained through diafiltration, and wherein the mass concentration of TGA is 2%-5%.
3. medical aquogel foam dressing according to claim 1, it is characterised in that including following component, by weight
Number is calculated as：Polyurethane foam 33-42 parts, pulullan 11-15 parts, gelatin 6.4-10 parts, konjac glucomannan 7.5-10 parts, keratin fibre
3.2-8.7 part of dimension, beta carotene 2.3-5.4 parts, 4.5-6.8 parts of D-Glucose aldehydic acid sodium, magnesium chloride 1.4-2.6 parts, earthworm it is dry
Powder 0.8-1.6 parts, GINKGO BILOBA EXTRACT 1.7-2.6 parts, cervus and cucumis polypeptide 2.4-3.5 parts, notoginseng triol-saponin 2.7-4 parts, starch acrylamide
Sour graft copolymer 7.2-12 parts, 4.5-9.8 parts of trimethylolpropane glycidol ether, glycerine 17-22 parts, distilled water 24-
32 parts.
4. medical aquogel foam dressing according to claim 1, it is characterised in that including following component, by weight
Number is calculated as：28 parts of polyurethane foam, 12.6 parts of pulullan, 7.4 parts of gelatin, 8.7 parts of konjac glucomannan, 5.2 parts of keratin fiber, β-
3.8 parts of carrotene, 5.5 parts of D-Glucose aldehydic acid sodium, 2.3 parts of magnesium chloride, 1.2 parts of earthworm dry powder, 2.1 parts of GINKGO BILOBA EXTRACT, deer melon
2.7 parts of polypeptide, 3 parts of notoginseng triol-saponin, 1 part of starch acrylic acid graft copolymer 1, trimethylolpropane glycidol ether 6.9
Part, 21 parts of glycerine, 28 parts of distilled water.
5. according to the preparation method of any described medical aquogel foam dressings of claim 1-4, it is characterised in that including with
Lower preparation process：
Step 1, pulullan, beta carotene, D-Glucose aldehydic acid sodium, notoginseng triol-saponin add glycerine, stirring is equal
It is even, it is standby；
Step 2, by gelatin, konjac glucomannan, cervus and cucumis polypeptide and GINKGO BILOBA EXTRACT add half distillation in, stir, it is standby；
Step 3, magnesium chloride, earthworm dry powder, keratin fiber add second half distilled water, be uniformly dispersed, it is standby；
Step 4, by step 1, step 2 and step 3 prepare mixed liquor be well mixed, regulation system pH value be 7-12, heat up
To 60-85 DEG C of stirring 10-40min, room temperature is then down to, adds starch acrylic acid graft copolymer, trimethylolpropane to shrink
Glycerin ether, is uniformly mixed, and obtains solution A, standby；
In step 5, the solution A for preparing polyurethane foam immersion step 4, it is stirred continuously at 50-80 DEG C 5-24 hours, is taken out
Polyurethane foam, dries, and obtains final product medical aquogel foam dressing.
6. the preparation method of medical aquogel foam dressing according to claim 5, it is characterised in that in step 4, adjusts
Section system pH is 8-11, is warming up to 70 DEG C of stirring 18min.
7. the preparation method of medical aquogel foam dressing according to claim 5, it is characterised in that in steps of 5,
It is stirred continuously at 65 DEG C 12 hours.
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| CN201611120063.6A CN106729956A (en) | 2016-12-08 | 2016-12-08 | A kind of medical aquogel foam dressing and preparation method thereof |
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| CN201611120063.6A CN106729956A (en) | 2016-12-08 | 2016-12-08 | A kind of medical aquogel foam dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106474533A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of it is applied to combine dressing of the surface of a wound and preparation method thereof |
| CN117004236A (en) * | 2023-07-27 | 2023-11-07 | 广东菲塔赫医药生物科技有限公司 | Hydrogel and preparation method thereof |
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| CN105536038A (en) * | 2015-12-25 | 2016-05-04 | 厦门百美特生物材料科技有限公司 | Foam substrate dressing and preparation method thereof |
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| CN106474533A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of it is applied to combine dressing of the surface of a wound and preparation method thereof |
| CN117004236A (en) * | 2023-07-27 | 2023-11-07 | 广东菲塔赫医药生物科技有限公司 | Hydrogel and preparation method thereof |
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