CN105999390A - Low-cost antimicrobial and hemostasis ointment and preparation method thereof - Google Patents
Low-cost antimicrobial and hemostasis ointment and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a low-cost antimicrobial and hemostasis ointment and a preparation method thereof. The hemostasis ointment is prepared from, by weight 40-60 parts of cafboxymethyl chitosan, 11-18 parts of corn starch, 7-15 parts of aminated dextran, 4-10 parts of potassium alginate, 4-12 parts of earthworm dry powder, 4-9 parts of molecular sieves, 8-16 parts of water-soluble polysaccharide, 14-30 parts of tricalcium phosphate, 8-15 parts of vitamin E acetate, 7-12 parts of lanthanum phosphate, 12-27 parts of glycerinum and 62-90 parts of double distilled water. The hemostasis ointment is short in hemostasis time and small in bleeding amount, the antimicrobial rate is larger than 98.7%, the good hemostasis effect and the good antimicrobial performance in the preliminary stage of a wound are shown, the biological compatibility is good, and the hemostasis ointment is convenient to carry and has the good application prospect.
Description
Technical field
The invention belongs to technical field of biological material, be specifically related to a kind of low cost antibacterial anti hemorrhagic cream and preparation method thereof.
Background technology
In daily life, the emergency treatment of the most various sudden accidents, or the wound hemostasis in repair process, the quick-acting haemostatic powder topically effective to patient is extremely important；In malpractice, the mortality rate causing more than or massive hemorrhage the reason of hemostasis to cause due to hemostasis not in time remains high.Therefore, develop a kind of effective rapid hemostatic material, accelerate coagulant blood speed, be extremely important to reducing the mortality rate caused because of severe loss of blood.
The most conventional hemostatic material has: gelfoam and Gelatin fleece, alginate, collagen protein, Chitosan-phospholipid complex, cellulose and oxidized regenerated cellulose, starch and zeolite etc..But the aspects such as the environmental suitability of these hemostatic materials, shelf-life, use cost, anthemorrhagic speed, haemostatic effect, caking property and mechanical property Shortcomings more or less and defect, it is thus desirable to provide, a kind of haemostatic effect is good, the hemostatic material of low cost, good combination property, meets and is widely applied demand.
Summary of the invention
The technical problem to be solved is existing hemostatic material in problems such as haemostatic effect, use cost and mechanical property are the best, it is provided that a kind of low cost antibacterial anti hemorrhagic cream and preparation method thereof.
In order to solve above-mentioned technical problem, the present invention is achieved by the following technical solutions:
The invention discloses a kind of low cost antibacterial anti hemorrhagic cream, this hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 40-60 part, corn starch 11-18 part, glycosaminoglycan 7-15 part, potassium alginate 4-10 part, earthworm dry powder 4-12 part, molecular sieve 4-9 part, water soluble polysaccharide 8-16 part, tricalcium phosphate 14-30 part, Vitamin E acetate 8-15 part, lanthanum orthophosphate 7-12 part, glycerol 12-27 part, distilled water 62-90 part；
Described water soluble polysaccharide is at least one in hydroxymethyl cellulose, alginate jelly, guar gum.
Preferably, described water soluble polysaccharide includes hydroxymethyl cellulose, alginate jelly and guar gum, and the mass ratio of three is 3:4:1.
Described molecular sieve is ETS-10 molecular sieve or ZSM-5 molecular sieve.
Described hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 48 parts, corn starch 15 parts, glycosaminoglycan 9 parts, potassium alginate 7 parts, earthworm dry powder 8 parts, 6 parts of molecular sieve, water soluble polysaccharide 13 parts, tricalcium phosphate 18 parts, Vitamin E acetate 11 parts, lanthanum orthophosphate 9 parts, glycerol 19 parts, distilled water 70 parts.
Described hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 53 parts, corn starch 16 parts, glycosaminoglycan 12 parts, potassium alginate 6 parts, earthworm dry powder 7 parts, 5 parts of molecular sieve, water soluble polysaccharide 14 parts, tricalcium phosphate 16 parts, Vitamin E acetate 12 parts, lanthanum orthophosphate 10 parts, glycerol 22 parts, distilled water 78 parts.
The present invention also provides for the preparation method of a kind of low cost antibacterial anti hemorrhagic cream, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 33-38 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 50-65 DEG C, add corn starch, stir 2-10 hour with 20-100rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 110-160 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Preferably, described step is warming up to 57 DEG C in (2), stirs 6 hours with 50rpm speed.
In described step (4), rotating evaporation temperature is 126 DEG C.
Owing to have employed above technical scheme, the present invention compared with prior art has the advantages that
The hemostatic plaster bleeding stopping period of the present invention is short, amount of bleeding is few, and bacteriostasis rate is more than 98.7%, shows good haemostatic effect and at wound initial stage preferably biocidal property, good biocompatibility, is convenient for carrying, has a good application prospect.Being tested by comparative example, glycosaminoglycan, lanthanum orthophosphate, corn starch and earthworm dry powder have certain impact to the anthemorrhagic performance of hemostatic plaster, and the biocidal property of hemostatic plaster is affected bigger by glycosaminoglycan and lanthanum orthophosphate simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Hemostatic plaster described in the present embodiment is made up of the component of following weight portion: carboxymethyl chitosan 40 parts, corn starch 11 parts, glycosaminoglycan 7 parts, potassium alginate 4 parts, earthworm dry powder 4 parts, 4 parts of molecular sieve, water soluble polysaccharide 8 parts, tricalcium phosphate 14 parts, Vitamin E acetate 8 parts, lanthanum orthophosphate 7 parts, glycerol 12 parts, distilled water 62 parts；
Described water soluble polysaccharide is hydroxymethyl cellulose.
Described molecular sieve is ETS-10 molecular sieve.
The preparation method of low cost antibacterial anti hemorrhagic cream described in the present embodiment, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 33 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 50 DEG C, add corn starch, stir 2 hours with 20rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 110 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Embodiment 2
Hemostatic plaster described in the present embodiment is made up of the component of following weight portion: carboxymethyl chitosan 60 parts, corn starch 18 parts, glycosaminoglycan 15 parts, potassium alginate 10 parts, earthworm dry powder 12 parts, 9 parts of molecular sieve, water soluble polysaccharide 16 parts, tricalcium phosphate 30 parts, Vitamin E acetate 15 parts, lanthanum orthophosphate 12 parts, glycerol 27 parts, distilled water 90 parts；
Described water soluble polysaccharide is alginate jelly.
Described molecular sieve is ZSM-5 molecular sieve.
The preparation method of low cost antibacterial anti hemorrhagic cream described in the present embodiment, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 38 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 65 DEG C, add corn starch, stir 10 hours with 100rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 160 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Embodiment 3
Hemostatic plaster described in the present embodiment is formed carboxymethyl chitosan 50 parts, corn starch 15 parts, glycosaminoglycan 11 parts, potassium alginate 7 parts, earthworm dry powder 8 parts, 6 parts of molecular sieve, water soluble polysaccharide 12 parts, tricalcium phosphate 22 parts, Vitamin E acetate 12 parts, lanthanum orthophosphate 10 parts, glycerol 20 parts, distilled water 76 parts by the component of following weight portion；
Described water soluble polysaccharide is hydroxymethyl cellulose and guar gum, and two kinds of mass ratioes are 1:3.
Described molecular sieve is ETS-10 molecular sieve.
The preparation method of low cost antibacterial anti hemorrhagic cream described in the present embodiment, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 35 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 57 DEG C, add corn starch, stir 6 hours with 60rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 135 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Embodiment 4
Hemostatic plaster described in the present embodiment is made up of the component of following weight portion: carboxymethyl chitosan 48 parts, corn starch 15 parts, glycosaminoglycan 9 parts, potassium alginate 7 parts, earthworm dry powder 8 parts, 6 parts of molecular sieve, water soluble polysaccharide 13 parts, tricalcium phosphate 18 parts, Vitamin E acetate 11 parts, lanthanum orthophosphate 9 parts, glycerol 19 parts, distilled water 70 parts；
Described water soluble polysaccharide includes hydroxymethyl cellulose, alginate jelly and guar gum, and the mass ratio of three is 3:4:1.
Described molecular sieve is ETS-10 molecular sieve.
The preparation method of low cost antibacterial anti hemorrhagic cream described in the present embodiment, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 35 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 57 DEG C, add corn starch, stir 6 hours with 50rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 126 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Embodiment 5
Hemostatic plaster described in the present embodiment is made up of the component of following weight portion: carboxymethyl chitosan 53 parts, corn starch 16 parts, glycosaminoglycan 12 parts, potassium alginate 6 parts, earthworm dry powder 7 parts, 5 parts of molecular sieve, water soluble polysaccharide 14 parts, tricalcium phosphate 16 parts, Vitamin E acetate 12 parts, lanthanum orthophosphate 10 parts, glycerol 22 parts, distilled water 78 parts；
Described water soluble polysaccharide includes hydroxymethyl cellulose, alginate jelly and guar gum, and the mass ratio of three is 3:4:1.
Described molecular sieve is ZSM-5 molecular sieve.
The preparation method of low cost antibacterial anti hemorrhagic cream described in the present embodiment, including following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 36 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 57 DEG C, add corn starch, stir 6 hours with 50rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 126 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
Comparative example 1
This comparative example is in place of the difference of embodiment 1: do not comprise glycosaminoglycan and lanthanum orthophosphate.
Comparative example 2
This comparative example is in place of the difference of embodiment 1: do not comprise corn starch and earthworm dry powder.
Performance test
The performance of the antibacterial anti hemorrhagic cream prepared by above-described embodiment 1 to 5 and comparative example 1,2 is tested, using TWO as test object, TWO anesthesia is fixed onboard, first labelling on rabbit leg, then prune the rabbit hair, cut the wound of 1cm length after disinfecting, smear rapidly the hemostatic plaster of preparation in petechia, and with etc. weight dry gauze absorb flow out blood, Weighing amount of bleeding.For the ease of comparing, process as blank example using gauze parcel pressing.Test result is as shown in the table:
| Bleeding stopping period/second | Amount of bleeding/gram | Bacteriostasis rate/% | |
| Embodiment 1 | 64 | 0.15 | 98.7 |
| Embodiment 2 | 60 | 0.12 | 99.1 |
| Embodiment 3 | 57 | 0.10 | 98.9 |
| Embodiment 4 | 50 | 0.07 | 99.4 |
| Embodiment 5 | 51 | 0.09 | 99.2 |
| Comparative example 1 | 76 | 0.26 | 90.5 |
| Comparative example 2 | 81 | 0.29 | 97.2 |
| Blank example | 224 | 1.26 | 83% |
As seen from the above table, the hemostatic plaster bleeding stopping period of the present invention is short, amount of bleeding is few, and bacteriostasis rate is more than 98.7%, shows good haemostatic effect and at wound initial stage preferably biocidal property, good biocompatibility, is convenient for carrying, has a good application prospect.
Compare and embodiment 1, comparative example 1 and 2 bleeding stopping period extend, amount of bleeding increases, illustrate that glycosaminoglycan, lanthanum orthophosphate, corn starch and earthworm dry powder have certain impact to the anthemorrhagic performance of hemostatic plaster, what the bacteriostasis rate of comparative example 1 declined simultaneously is obvious, illustrates that glycosaminoglycan and lanthanum orthophosphate are bigger on biocidal property impact.
Claims (8)
1. a low cost antibacterial anti hemorrhagic cream, it is characterized in that, this hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 40-60 part, corn starch 11-18 part, glycosaminoglycan 7-15 part, potassium alginate 4-10 part, earthworm dry powder 4-12 part, molecular sieve 4-9 part, water soluble polysaccharide 8-16 part, tricalcium phosphate 14-30 part, Vitamin E acetate 8-15 part, lanthanum orthophosphate 7-12 part, glycerol 12-27 part, distilled water 62-90 part；
Described water soluble polysaccharide is at least one in hydroxymethyl cellulose, alginate jelly, guar gum.
A kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterised in that described water soluble polysaccharide includes hydroxymethyl cellulose, alginate jelly and guar gum, and the mass ratio of three is 3:4:1.
A kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterised in that described molecular sieve is ETS-10 molecular sieve or ZSM-5 molecular sieve.
A kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterized in that, this hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 48 parts, corn starch 15 parts, glycosaminoglycan 9 parts, potassium alginate 7 parts, earthworm dry powder 8 parts, 6 parts of molecular sieve, water soluble polysaccharide 13 parts, tricalcium phosphate 18 parts, Vitamin E acetate 11 parts, lanthanum orthophosphate 9 parts, glycerol 19 parts, distilled water 70 parts.
A kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterized in that, this hemostatic plaster is made up of the component of following weight portion: carboxymethyl chitosan 53 parts, corn starch 16 parts, glycosaminoglycan 12 parts, potassium alginate 6 parts, earthworm dry powder 7 parts, 5 parts of molecular sieve, water soluble polysaccharide 14 parts, tricalcium phosphate 16 parts, Vitamin E acetate 12 parts, lanthanum orthophosphate 10 parts, glycerol 22 parts, distilled water 78 parts.
The preparation method of a kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterised in that include following preparation process:
(1) water soluble polysaccharide, tricalcium phosphate, glycosaminoglycan, potassium alginate, lanthanum orthophosphate, molecular sieve, earthworm dry powder are placed in distilled water, stir and be placed in 33-38 DEG C of constant water bath box, carboxymethyl chitosan is added, stirs 30 minutes；
(2) treat that constant water bath box is warming up to 50-65 DEG C, add corn starch, stir 2-10 hour with 20-100rpm speed, be cooled to room temperature, obtain mixture A standby；
(3) Vitamin E acetate is added in glycerol, after stirring at 60 DEG C, obtain mixture B standby；
(4) by mixture A and mixture B mix homogeneously, at a temperature of 110-160 DEG C, rotary evaporation to thickness mastic, described low cost antibacterial anti hemorrhagic cream is obtained.
The preparation method of a kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterised in that described step is warming up to 57 DEG C in (2), stirs 6 hours with 50rpm speed.
The preparation method of a kind of low cost antibacterial anti hemorrhagic cream the most according to claim 1, it is characterised in that in described step (4), rotating evaporation temperature is 126 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106729956A (en) * | 2016-12-08 | 2017-05-31 | 苏州艾博迈尔新材料有限公司 | A kind of medical aquogel foam dressing and preparation method thereof |
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2016
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|---|---|---|---|---|
| US4822349A (en) * | 1984-04-25 | 1989-04-18 | Hursey Francis X | Method of treating wounds |
| CN101138611A (en) * | 2007-04-13 | 2008-03-12 | 彭嵬骅 | Compound radiating empyrosis aerosol |
| CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
| CN101804218A (en) * | 2010-04-13 | 2010-08-18 | 王艳 | Human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive |
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| CN102755414A (en) * | 2012-07-20 | 2012-10-31 | 河南科技大学 | Traditional Chinese medicine ointment for trauma wound and preparation method thereof |
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| CN106729956A (en) * | 2016-12-08 | 2017-05-31 | 苏州艾博迈尔新材料有限公司 | A kind of medical aquogel foam dressing and preparation method thereof |
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Application publication date: 20161012 |