CN106729669A - A kind of medicinal external emulsifiable paste for treating nettle rash - Google Patents
A kind of medicinal external emulsifiable paste for treating nettle rash Download PDFInfo
- Publication number
- CN106729669A CN106729669A CN201611262088.XA CN201611262088A CN106729669A CN 106729669 A CN106729669 A CN 106729669A CN 201611262088 A CN201611262088 A CN 201611262088A CN 106729669 A CN106729669 A CN 106729669A
- Authority
- CN
- China
- Prior art keywords
- parts
- emulsifiable paste
- nettle rash
- extract
- soft tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Abstract
The present invention relates to a kind of emulsifiable paste for treating nettle rash, including mussel soft tissue extract, trypsase, licorice, Herba Oxalidis Corniculatae extract and vaseline etc., the beneficial effect of the invention is the emulsifiable paste：The emulsifiable paste has anti-inflammatory, antiallergic, reparation, promoting muscle growth functions, by adjusting skin immune function controlling and promoting skin cell metabolism, there is good effect for treatment nettle rash, glucocorticoids material and antibiotic are not contained in formula of the invention, long-term use does not have dependence, have no toxic side effect, Clinical practice is safe and cure rate ratio is big.
Description
Technical field
The present invention relates to biomedicine technical field, more particularly, to a kind of medicinal external emulsifiable paste for treating nettle rash.
Background technology
Nettle rash is commonly called as wheal, rubella group, wind pimple, wheal, is a kind of common skin disease.This sick fash performance
Skin lesion caused by contacting plant nettle to people is similar, therefore is called nettle rash.Often first there is pruitus, occur immediately
Wheal, in cerise or pale asphyxia, skin-color, small number of patients has edematous erythema.The size and form of wheal differ, during breaking-out
Between it is indefinite.Wheal gradually spreads, and fusion is in blocks, due to papilla oedema, it is seen that epidermis follicular orifice is to lower recess.Wheal continues
To a few hours, minority disappears several minutes after can extending to a couple of days, leaves no trace.Fash occurs in batch repeatedly, with dusk hair author
It is common.The normal general hair of wheal, can also limit to.Sometimes angioedema is merged, wheal surface forms bleb once in a while.Some patientss can companion
There are Nausea and vomiting, headache, alliteration, stomachache, diarrhoea, severe patient can also have uncomfortable in chest, uncomfortable, pale complexion, heart rate to accelerate, arteries and veins
Fight the constitutional symptom such as thin and delicate, drop in blood pressure, short of breath.Disease cured person, referred to as acute urticaria in a short time.If sending out repeatedly
Make up to simultaneously continuous more than 6 weeks persons are referred to as chronic urticaria at least twice weekly.
Mussel (Mytilusedulis Linnaeus) is a kind of sea mollusk, belongs to bivalve shellfish, is commonly called as " making a gift of
Shellfish " and " mussel ", each coastwise contries of throughout world.Mussel species are various, and only coastal area of china just has kind more than 30, and economic worth is higher
Have kind more than 10, wherein Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel is main breed variety.Enriched Mussel containing protein, fat,
The nutrients such as carbohydrate, calcium, phosphorus, iron, riboflavin, niacin, and with medical value very high.
Trypsase (Trypsin, Parenzyme), EC 3.4.21.4 are the one kind extracted from the pancreas of ox, sheep, pig
Serine protein hydrolase.After the precursor trypsinogen of pancreas manufacture is secreted into small intestine, erepsin activates it, as pancreas egg
White enzyme.Trypsase is endopeptidase, the carboxyl that it can optionally in the lysine and arginine residues of hydrolyzed peptide chain.
Trypsase not only plays digestive ferment, and can also limit decomposition chymotrypsinogen, procarboxypeptidase, phosphatide proenzyme etc. other
The precursor of enzyme, plays activation.
Radix Glycyrrhizae (GlycyrrhizauralensisFisch), alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet root.Beans
Section, Glycyrrhiza perennial herb, root are sturdy with root-like stock, are a kind of help Chinese herbal medicines.Medicinal part is root and rhizome, medicinal material
Shape root is long 25~100 centimetres in cylinder, 0.6~3.5 centimetre of diameter.Crust is elastic to differ, surface rufous or taupe brown.
In cylinder, there is bud scar on surface to rhizome, and there is marrow at section middle part.Gas is micro-, and taste is sweet and special.Indication is clearing heat and detoxicating, eliminating the phlegm stops
Cough, gastral cavity abdomen etc..Happiness is dark moist, and the low dry climate of sunshine temperature long is grown in arid, semiarid desert steppe, sand more
Unconcerned edge and loess hill area.Radix Glycyrrhizae contains various chemical compositions, and main component has glycyrrhizic acid, liquiritin etc..The change of Radix Glycyrrhizae
Learn composition extremely complex, the compound isolated from Radix Glycyrrhizae so far has glycyrrhizin, enoxolone, liquiritin, different sweet
Careless glucoside, neoliquriitin, neoisoliquiritin, glycyrrhizin, isoliquiritigenin and licoricidin, glycyrol, isoglycyrol, 7- methyl are fragrant
The tens of kinds of compounds such as beans essence, umbelliferone.Substantial amounts of research shows, glycyrrhizin and Flavonoid substances are most heavy in Radix Glycyrrhizae
The physiological activator wanted, is primarily present in the part within Radix Glycyrrhizae epiblem.Glycyrrhizin can promote BILE PIGMENTS to be metabolized, and reduce
Transaminase, while having the effects such as anti-inflammatory, antiallergy and protection membrane structure；Recognized in Flavonoid substances reaction in vivo
It is nutritious function：Such as it is anti-oxidant grade or reacts effect with some anti-inflammatories, has been recognized as resisting or subtracting
Effect of the formation of slow tumour.
Creeping oxalis (Oxalis corniculata L.), herbaceos perennial, entirety has a thin pubescence, and stem is crawled or tiltedly
Rise, multi-branched.Leaf alternate, palmately compound leaf has 3 leaflets, reversed cardioid, leaflet stockless.Flower yellow, happiness faces south, warm, moistening ring
Border, summer, hot area preferably hid half shade, and drought-resistant ability is stronger, can not resist cold, and general garden mould can grow, but enriched with humus
Sand loam growth is vigorous, and there is short-term dormancy summer.All herbal medicine, there is clearing heat and detoxicating, the effectiveness of Sweeling-eliminating medicine powder disease.Research display
Creeping oxalis is rich in flavone compound, with stronger bactericidal, anti-inflammatory antioxidation.
Treatment to nettle rash at present is mainly using Loratadine, suppresses mast cell degranulation, reduces
The medicine of histamine release such as tranilast, glucocorticoid or immunodepressant etc..Long-time or heavy dose of external application use cortex
Hormone medicine, meeting habituation causes drug dependence, and most commonly sb.'s illness took a favorable turn after medication, after being discontinued, agents area
Primary affection is aggravated.After hormone is used again, above-mentioned sb.'s illness took a favorable turn or disappears；It is rebound to send out again as being discontinued again, and than former
It is more serious.In order to avoid the pain after drug withdrawal, place one's entire reliance upon patient hormone.Meeting skin is substantially thinning, and telangiectasis has
When there is purpura etc., particularly may occur in which deeper persistent erythema in face.With the hormone time it is more long, produce rebound allergy
Also it is heavier.Thinning of skin, fragility, atrophy, telangiectasis, purpura, fungal infection, acne sample dermatitis etc. can be made.Become
Subject to damage；It may also occur that slight crinosity, hidrosis, subcutaneous hemorrhage and wound healing difficulty etc..Especially some skin diseases are less
Steroids preparation is suitably used, is made troubles to patient work, life.
The content of the invention
For solve the treatment existing for existing nettle rash treatment product not thoroughly, easily repeatedly, side effect is strong, easily form anti-medicine
Property or the defect such as DeGrain, the present invention proposes a kind of emulsifiable paste for treating nettle rash, including：Mussel soft tissue extract,
Trypsase, licorice, Herba Oxalidis Corniculatae extract and vaseline etc..
One or more implementation methods of the invention, the emulsifiable paste can be by weight：Mussel soft tissue is extracted
Thing 0.2-20 parts, trypsase 0.2-10 parts, licorice 1-10 parts, Herba Oxalidis Corniculatae extract 5-10 parts and appropriate all scholars
Woods.One or more implementation methods of the invention, based on the weight of emulsifiable paste, mussel soft tissue extract can be for example
0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75
Part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5
Part, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5
Part, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19
Part, 19.5 parts, 20 parts etc., trypsase can be such as 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5
Part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts,
2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts,
10 parts etc., licorice can be such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts,
6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts etc., Herba Oxalidis Corniculatae extract can be such as 5 parts, 5.5
Part, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, any specific weight portion in 10 parts etc..
Further, the emulsifiable paste also includes by weight：Vitamin C：10~40 parts, vitamin B2：1~10 part, dimension
Raw element P：10~20 parts, honey：5~20 parts.
One or more implementation methods of the invention, in the emulsifiable paste：Mussel soft tissue extract, trypsase,
Licorice and Herba Oxalidis Corniculatae extract can be individually insulated presence or can be mixed.Here, " isolation is present " refers to four
Composition is planted to exist with the non-interfering independent packaging for keeping respective property." being mixed " refer to four kinds of compositions be mixed in
In one packaging, then or, the combination of two component/tri- components is present, and separates with other components and exist.
One or more implementation methods of the invention, in the emulsifiable paste：Mussel soft tissue extract and trypsase,
Licorice and Herba Oxalidis Corniculatae extract can be dry powder.
One or more implementation methods of the invention, in the emulsifiable paste：Mussel soft tissue extract and trypsase,
Licorice and Herba Oxalidis Corniculatae extract can be liquid.
One or more implementation methods of the invention, the final ph after the emulsifiable paste is prepared is 2.5-9.0, example
Such as, preferable ph is 4.5-8.0, or, such as preferable ph is 5.5-7.0.
One or more implementation methods of the invention, the mussel soft tissue extract refer to mussel except shell with
Outer component namely mussel soft tissue are raw material, the wherein supernatant for being extracted by acidic aqueous solution and being obtained, protein content
It is 0.2-15mg/ml, pH value 1.0-6.0.Especially, can be with byssus as raw material.
One or more aspects of the invention, the mussel includes in Mytilus galloprovincialis, Perna viridis, Trachyostracous mussel
Kind, two or three.
One or more implementation methods of the invention, the acidic aqueous solution can include：Acetic acid-acetate buffer
Liquid, acetic acid, citric acid, perchloric acid etc., but not limited to this.
One or more implementation methods of the invention, the protein content of the mussel soft tissue extract can be
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml etc., but not limited to this.
One or more implementation methods of the invention, the trypsase can be conventional purchase from the market.
Alternatively, the trypsase can be by saltouing, it is prepared by the method such as column chromatography.
One or more implementation methods of the invention, the licorice can be conventional purchase from the market
's.
One or more implementation methods of the invention, the Herba Oxalidis Corniculatae extract can be conventional purchase from the market
's.
A further object of the present invention is related to a kind of for treating the method for nettle rash, including gives emulsifiable paste of the invention,
To treat the symptoms such as rash block, itch that nettle rash causes.
One or more implementation methods of the invention, emulsifiable paste of the invention is given to subject in need,
The emulsifiable paste is including mussel soft tissue extract, trypsase, licorice and Herba Oxalidis Corniculatae extract etc..
One or more implementation methods of the invention, the mussel soft tissue extract, trypsase, Radix Glycyrrhizae are extracted
Thing and Herba Oxalidis Corniculatae extract can be mixed in emulsifiable paste.
One or more implementation methods of the invention, the mussel soft tissue extract, trypsase, Radix Glycyrrhizae are extracted
Thing and Herba Oxalidis Corniculatae extract can be individually insulated to be present in emulsifiable paste.Here, when by mussel soft tissue extract, tryptose
When enzyme, licorice and Herba Oxalidis Corniculatae extract combination medicine-feeding, administration can be order of administration or be administered simultaneously, preferably can be with
It is order of administration.For order of administration, mussel soft tissue extract, trypsase, licorice and jealous woman can be starched
Careless extract is administered in any order.For example, can first give mussel soft tissue extract give again trypsase give again it is sweet
Careless extract and Herba Oxalidis Corniculatae extract, continue whole treatment, or can first give trypsase again with the administration of this sequence alternate
Give mussel soft tissue extract and give licorice and Herba Oxalidis Corniculatae extract again, continue entirely to control with the administration of this sequence alternate
Treat, or can be administered with different order in every day for the treatment of.
The beneficial effect of the invention is：The emulsifiable paste has anti-inflammatory, antiallergic, reparation, promoting muscle growth functions, is exempted from by adjusting skin
Epidemic disease function and promotion skin cell metabolism, have good effect, for treatment nettle rash in formula of the invention not
Containing glucocorticoids material and antibiotic, long-term use does not have dependence, has no toxic side effect, and Clinical practice is safe simultaneously
And cure rate ratio is big.
Specific embodiment
Embodiment 1：The preparation method of mussel soft tissue extract.
Take mussel to shell, collect soft tissue 300g, be divided into three parts, in every part of table 1 below of addition 100ml contents 0.3%
Acid solution, centrifugation obtains supernatant as mussel soft tissue extract after homogenate 10min.
Protein content and pH value in supernatant are determined, protein content is determined using Coomassie Brilliant Blue.
Table 1
| Example | Acid solution | Protein content | PH value |
| 1 | Citric acid | 2.6mg/ml | 4.5 |
| 2 | Acetic acid | 3.5mg/ml | 3.2 |
| 3 | Perchloric acid | 3.0mg/ml | 1.0 |
Embodiment 2：A kind of emulsifiable paste of mussel soft tissue extract, trypsase, licorice and Herba Oxalidis Corniculatae extract.
From Shaanxi, trypsase is bought by Yuan Tai biotechnologies company, and from Zhengzhou, dimension is bought by Fu Run moral bioengineering Co., Ltd
Raw element C, vitamin B2, citrin, honey is bought from Jingdone district store, and from Suzhou, vaseline is bought by Kang Shuo Chemical Co., Ltd.s.This
The emulsifiable paste of the treatment nettle rash in embodiment, is combined by following weight：Mussel soft tissue extract 100mg, tryptose
Enzyme 100mg, licorice 15mg and Herba Oxalidis Corniculatae extract 15mg, citrin：5mg, vitamin B2：3mg, vitamin C：
16mg, adds vaseline to 100g, fully to melt and form ointment after mixing.
Collect 11 chronic urticaria volunteers and participate in test, using emulsifiable paste manufactured in the present embodiment, be applied twice a day, 14
Be discontinued record curative effect after it, and recurrence is paid a return visit and recorded after 3 months.
Curative effect determinate standard：
1. fully recover：Rash block disappears, and itch disappears, without repeatedly after half a year.
2. effective：Rash block disappears, and itch disappears substantially.Attack times are reduced, and time interval extension, itch substantially mitigates,
Still there is petit mal after half a year.
3. effective：Rash block is reduced, and attack times slightly have reduction, and interval time is slightly longer, and scabies ancient term for country school mitigates.
4. invalid：Endanthem block on the 3rd is with itch without improvement.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 2.
Table 2:Experiment curative effect
Embodiment 3：A kind of emulsifiable paste of mussel soft tissue extract, trypsase, licorice and Herba Oxalidis Corniculatae extract.
From Shaanxi, trypsase is bought by Yuan Tai biotechnologies company, and from Zhengzhou, dimension is bought by Fu Run moral bioengineering Co., Ltd
Raw element C, vitamin B2, citrin, honey is bought from Jingdone district store, and from Suzhou, vaseline is bought by Kang Shuo Chemical Co., Ltd.s.This
The emulsifiable paste of the treatment nettle rash in embodiment, is combined by following weight：Mussel soft tissue extract 200mg, tryptose
Enzyme 200mg, licorice 20mg and Herba Oxalidis Corniculatae extract 25mg, citrin：10mg, vitamin B2：8mg, vitamin C：
25mg, adds vaseline to 100g, fully to melt and form ointment after mixing.
Collect 26 acute urticaria volunteers and participate in test, be divided into control group and test group, control group is controlled using commercially available
999 PINGYANPING RUANGAOs of nettle rash are treated, the emulsifiable paste that test group is prepared using the present embodiment is applied twice a day, and be discontinued note after 7 days
Record curative effect, pays a return visit and records recurrence after one month.
Curative effect determinate standard：
1. fully recover：Rash block disappears, and itch disappears, and more than 1 week without breaking-out.
2. effective：Rash block disappears, and itch disappears substantially.Still there is within more than 1 week a small amount of rash block, there is slight itch.
3. effective：Rash block is reduced, and scabies ancient term for country school mitigates.
4. invalid：1 week endanthem block is with itch without improvement.
Total effective rate fully recovering+it is effective in terms of.
Curative effect is shown in Table 3.
Table 3:Experiment curative effect
| Recovery from illness | It is effective | Effectively | It is invalid | It is total | Efficient (%) | |
| Control group | 3 | 5 | 3 | 2 | 13 | 61.54 |
| Test group | 8 | 4 | 1 | 0 | 13 | 92.31 |
It can be seen that, after the emulsifiable paste using mussel soft tissue extract, trypsase, licorice and Herba Oxalidis Corniculatae extract,
Nettle rash symptom has clear improvement, it was demonstrated that mussel soft tissue extract, trypsase, licorice and Herba Oxalidis Corniculatae extract system
Into emulsifiable paste have treatment nettle rash function.
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Knowing those skilled in the art can make various corresponding changes and deformation, but these corresponding changes and deformation according to the present invention
The protection domain of the claims in the present invention should all be belonged to.
Claims (10)
1. a kind of emulsifiable paste for treating nettle rash, it is characterised in that extracted including mussel soft tissue extract, trypsase, Radix Glycyrrhizae
Thing, Herba Oxalidis Corniculatae extract and vaseline.
2. it is according to claim 1 treatment nettle rash emulsifiable paste, it is characterised in that the emulsifiable paste includes by weight：Mussel is soft
Tissue extract 0.2-20 parts, trypsase 0.2-10 parts, licorice 1-10 parts and Herba Oxalidis Corniculatae extract 5-10 parts, press
The weight meter of emulsifiable paste, mussel soft tissue extract is, for example, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5
Part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts,
2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts,
10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts,
16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, trypsase is, for example, 0.2 part, 0.25 part,
0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85
Part, 0.9 part, 0.95 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7
Part, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, licorice is, for example, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5
Part, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, creeping oxalis carries
Take thing be, for example, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, it is any specific in 10 parts
Weight portion.
3. the emulsifiable paste of the treatment nettle rash according to claim 1 or 2, it is characterised in that the emulsifiable paste also includes：Vitamin C, dimension
Raw element B2, citrin, honey.
4. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, it is characterised in that mussel soft tissue in the emulsifiable paste
Extract, trypsase, licorice and Herba Oxalidis Corniculatae extract are individually insulated presence or are mixed.
5. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, it is characterised in that in the emulsifiable paste：Mussel soft tissue
Extract, trypsase, licorice and Herba Oxalidis Corniculatae extract are dry powder or liquid.
6. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, wherein the final ph after the emulsifiable paste is prepared is
2.5-9.0, for example, it is preferable to pH value is 4.5-8.0, for example, it is preferable to pH value is 5.5-7.0.
7. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, wherein the mussel soft tissue extract is with mussel
Soft tissue is raw material, and the supernatant for being extracted by acidic aqueous solution and being obtained, wherein protein content are 0.2-15mg/ml, pH
Value 1.0-6.0.
8. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, wherein the mussel include Mytilus galloprovincialis, Perna viridis,
One kind in Trachyostracous mussel, two or three.
9. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, wherein the acidic aqueous solution includes：Acetic acid-acetic acid
Sodium buffer solution, acetic acid, citric acid, perchloric acid, or the protein content of wherein described mussel soft tissue extract is, for example,
0.2mg/ml、0.3mg/ml、0.4mg/ml、0.5mg/ml、0.6mg/ml、0.7mg/ml、0.8mg/ml、0.9mg/ml、
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml.
10. the emulsifiable paste of the treatment nettle rash according to foregoing any claim, wherein the nettle rash include acute urticaria and
Chronic urticaria.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262088.XA CN106729669A (en) | 2016-12-30 | 2016-12-30 | A kind of medicinal external emulsifiable paste for treating nettle rash |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262088.XA CN106729669A (en) | 2016-12-30 | 2016-12-30 | A kind of medicinal external emulsifiable paste for treating nettle rash |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106729669A true CN106729669A (en) | 2017-05-31 |
Family
ID=58953989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611262088.XA Withdrawn CN106729669A (en) | 2016-12-30 | 2016-12-30 | A kind of medicinal external emulsifiable paste for treating nettle rash |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106729669A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
-
2016
- 2016-12-30 CN CN201611262088.XA patent/CN106729669A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106729669A (en) | A kind of medicinal external emulsifiable paste for treating nettle rash | |
| CN105394428A (en) | Traditional Chinese medicine chicken feed capable of improving quality of eggs | |
| CN103463297B (en) | A kind of Chinese medicine composition for the treatment of eczema scrotum and its production and use | |
| CN104208245A (en) | Traditional Chinese medicine medicated bath for tinea of feet and hands and preparation method thereof | |
| CN103877247B (en) | Medicine being used for the treatment of decubital ulcer and preparation method thereof | |
| CN104815192A (en) | Pharmaceutical composition for treating hypertension and application of pharmaceutical composition | |
| KR20140098491A (en) | Mixture extract of yacon(Smallanthus sonchifolius), Torilis japonica and Acorus gramineus, health food composition and cosmetic composition for preventing or improving benign prostatic hyperplasia or alopecia containing the same | |
| CN109549958A (en) | The composition and preparation method thereof for treating steroid dependent dermatitis | |
| CN102100707B (en) | Cordyceps sinensis health-care liquor | |
| CN107998242A (en) | A kind of Chinese medicine composition for treating mastitis for milk cows and preparation method thereof | |
| CN112755143A (en) | Traditional Chinese medicine composition for treating eczema and application thereof | |
| CN110742923A (en) | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating parturient milk contraction and preparation method thereof | |
| CN105250747A (en) | Health maintenance paste | |
| CN101199652A (en) | Medicament for treating acute, subacute eczema and preparing method thereof | |
| CN109663081B (en) | Zhuang medicine composition for treating functional unsmooth urination of bladder and preparation method thereof | |
| CN109248244A (en) | A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation | |
| CN107875284A (en) | A kind of Chinese medicine composition for treating atopic dermatitis and preparation method thereof | |
| CN102000244B (en) | Traditional Chinese medicine preparation for treating diabetes mellitus | |
| CN105748610A (en) | Solid fermentation method for polygonum hydropiper linn preparations by aid of bacillus subtilis, fermentation products of solid fermentation method and application | |
| CN105362993A (en) | Tincture for treating ichthyophthiriasis of parrotfish and preparation method of tincture for treating ichthyophthiriasis of parrotfish | |
| CN105106590A (en) | Medicine for treating allergic rhinitis | |
| CN104257797A (en) | Traditional Chinese medicine oral decoction for treating skin allergy | |
| CN104524270A (en) | Pills for relieving renal dysfunction caused by diabetes mellitus and preparation method thereof | |
| CN115779063A (en) | Traditional Chinese medicine composition for improving immunity | |
| CN112546127A (en) | A medicinal liquid for treating skin injury caused by fungi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170531 |
|
| WW01 | Invention patent application withdrawn after publication |