CN106728848A - 一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法 - Google Patents

一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法 Download PDF

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CN106728848A
CN106728848A CN201710087831.0A CN201710087831A CN106728848A CN 106728848 A CN106728848 A CN 106728848A CN 201710087831 A CN201710087831 A CN 201710087831A CN 106728848 A CN106728848 A CN 106728848A
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罗兴兰
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Abstract

本发明属于中药制剂领域,目的是根据中医治疗血虚风燥型皮肤瘙痒症的认识机理而提供的一种治疗血虚风燥型皮肤瘙痒症的内服药物,所述药物的各个组分及其质量份比如下:当归80~200g、麦冬100~250g、川芎50~120g、地骨皮150~360g、生地黄90~180g、白芍100~250g、白鲜皮50~100g、丹参50~180g、苦参30~120g、五味子30~100g、地肤子60~180g、乌梢蛇90~160g、防风50~120g;本发明提供的药物是一个很好的中药组方。

Description

一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法
技术领域
本发明属于中药制剂领域,具体涉及一种治疗血虚风燥型皮肤瘙痒症的内服药物,特别是供血虚风燥型皮肤瘙痒症患者使用的内服药物及其制备方法的领域。
背景技术
据有关资料显示:血虚风燥,其实是中医学中血虚和风燥两个辩证术语。血虚指营血不足出现虚弱的病理。由于失血过多或慢性出血、脏腑虚损、化生精血机能减退或障碍等原因,均可造成血虚,出现贫血症状。临床上一般分为心血虚、肝血虚、心脾两虚等症型。风燥指风与燥两种邪气的相合,多感于秋燥时令。临床表现为头痛、发热、恶寒无汗、鼻塞、唇燥、咽干、干咳、胸滞、肋痛、皮肤干燥、舌苔白薄而干、脉浮涩。如血虚风燥一起理解即指血虚生风和和液燥生风,总称虚风内动。
瘙痒是一种仅有皮肤瘙痒而无原发性皮肤损害的皮肤病症状。根据皮肤瘙痒的范围及部位,一般分为全身性和局限性两大类。
临床表现:
A.全身性瘙痒症
多见于成人,瘙痒常从一处开始,逐渐扩展到全身。常为阵发性,尤以夜间为重,严重者呈持续性瘙痒伴阵发性加剧,饮酒、咖啡、茶、情绪变化、辛辣饮食刺激、机械性搔抓、温暖被褥、甚至某种暗示都能促使瘙痒的发作和加重。常继发抓痕、血痂、色素沉着,甚至出现湿疹样变、苔藓样变、脓皮病以及淋巴管炎和淋巴结炎。
(a)老年性瘙痒症 多发于老年人,常以躯干最痒,多因皮脂腺功能减退、皮肤干燥等因素所致,女性患者可能是绝经后综合征的一种表现。
(b)冬季瘙痒症: 多见于成年人,儿童也可发病。多发生于秋末和冬季气温急剧变化时,病人常在进入温暖的室内或睡前脱衣时,便开始瘙痒。
(c)夏季瘙痒症: 常以湿热为诱因而引起瘙痒,夏日汗液增多可使瘙痒加重。
B.局限性瘙痒症
(a)肛门瘙痒症: 多见于中年男性,患蛲虫病的儿童也可患病。瘙痒一般局限于肛门及其周围皮肤,有时可蔓延至会阴、女阴和阴囊。因经常搔抓只是肛门皮肤肥厚,亦可呈苔藓样变或湿疹样变等继发性损害。
(b)阴囊瘙痒症: 瘙痒主要局限于阴囊,有时也可累及阴茎、会阴和肛门。由于不断搔抓,引起苔藓样变、湿疹样变及继发感染等。
(c)女阴瘙痒症: 瘙痒常发生于大、小阴唇。因不断搔抓,阴唇部常有皮肤肥厚及浸渍,阴蒂及阴道黏膜可有红肿及糜烂。
那么,就如何找到一种可有效治疗血虚风燥型皮肤瘙痒症的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗血虚风燥型皮肤瘙痒症上,人们逐渐意识到了中医治疗血虚风燥型皮肤瘙痒症的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗血虚风燥型皮肤瘙痒症的现状,本发明的目的是在于提供一种治疗血虚风燥型皮肤瘙痒症的内服药物,以解决血虚风燥型皮肤瘙痒症患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述血虚风燥型皮肤瘙痒症。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归80~200g、麦冬100~250g、川芎50~120g、地骨皮150~360g、生地黄90~180g、白芍100~250g、白鲜皮50~100g、丹参50~180g、苦参30~120g、五味子30~100g、地肤子60~180g、乌梢蛇90~160g、防风50~120g。
一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归90~170g、麦冬115~220g、川芎60~105g、地骨皮180~310g、生地黄100~160g、白芍115~220g、白鲜皮58~90g、丹参58~160g、苦参38~105g、五味子38~90g、地肤子70~160g、乌梢蛇100~140g、防风58~105g。
一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
当归150g、麦冬200g、川芎95g、地骨皮280g、生地黄140g、白芍200g、白鲜皮80g、丹参140g、苦参95g、五味子80g、地肤子140g、乌梢蛇120g、防风95g。
一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质、粉尘及干燥后,按照质量份比共研为极细末待用;
B、按照传统的常规工艺及辅料制备中药胶囊剂的方法,将研磨好的极细末药物过筛后,和辅料一并放入药器中混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),继而消毒、分装,密封即可。
一种治疗血虚风燥型皮肤瘙痒症的内服药物及其制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2.5g(5粒)/次,温开水送服。15天为一个疗程。服药1~3个疗程,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
当归,性味:味甘、辛、微苦、性温,具有补血和血、调经止痛、润燥滑肠之功效,用于治疗月经不调、经闭腹痛、癥瘕结聚、崩漏、血虚头痛、眩晕、痿痹,肠燥便难、赤痢后重,痈疽疮窃、跌扑损伤等症;
麦冬,性味:甘、微苦、微寒,具有养阴生津、润肺清心之功效,用于治疗肺燥干咳、虚痨咳嗽、津伤口渴、心烦失眠、内热消渴、肠燥便秘、咽白喉等症;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛;
地骨皮,性味:甘、寒,具有清热、凉血之功效,用于治疗虚劳潮热盗汗、肺热咳喘、吐血、衄血、血淋、消渴、高血压、痈肿、恶疮等症;
生地黄,性味:甘、寒,具有清热凉血、养阴、生津之功效,用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹等症;
白芍,性味:苦、酸、微寒,养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症;
白鲜皮,性味:苦、寒,具有清热燥湿、祛风解毒之功效,用于治疗湿热疮毒、黄水淋漓、湿疹、风疹、疥癣疮癞、风湿热痹、黄疸尿赤;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
苦参,性味:味苦、性寒,具有清热燥湿、祛风杀虫之功效,用于治疗湿热泻痢、肠风便血、黄疸、小便不利、水肿、带下、阴痒、疥癣、麻风、皮肤瘙痒、湿毒疮疡;
五味子,性味:酸、甘、温,具有收敛固涩、益气生津、补肾宁心之功效,用于治疗久泻不止、久咳虚喘、心悸、失眠、多梦、自汗、盗汗、津伤口渴、消渴、遗精、滑精等症;
地肤子,性味:苦、性寒,具有清热利湿、法风止痒之功效,用于治疗小便不利、淋浊、带下、血痢、风疹、湿疹、疥癣、皮肤瘙痒、疮毒等症;
乌梢蛇,性味:甘、平,具有祛风、通络、止痉之功效,用于治疗风湿顽痹、麻木拘挛、中风口眼歪斜、半身不遂、抽搐痉挛、破伤风、麻风疥癣、瘰疬恶疮;
防风,性味:辛、甘、温,具有解表祛风、胜湿、止痉之功效,用于治疗感冒头痛、风湿痹痛、风疹瘙痒、破伤风。
本发明药物是基于中医治疗血虚风燥型皮肤瘙痒症的原则,从依据血虚风燥型皮肤瘙痒症的病理机制及药理作用认为:就血虚风燥型皮肤瘙痒症,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述血虚风燥型皮肤瘙痒症的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归150g、麦冬200g、川芎95g、地骨皮280g、生地黄140g、白芍200g、白鲜皮80g、丹参140g、苦参95g、五味子80g、地肤子140g、乌梢蛇120g、防风95g。
实施例2:
一种治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归170g、麦冬220g、川芎105g、地骨皮310g、生地黄160g、白芍220g、白鲜皮90g、丹参160g、苦参105g、五味子90g、地肤子160g、乌梢蛇140g、防风105g。
实施例3:
一种治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归200g、麦冬250g、川芎120g、地骨皮360g、生地黄180g、白芍250g、白鲜皮100g、丹参180g、苦参120g、五味子100g、地肤子180g、乌梢蛇160g、防风120g。
典型病例
经临床诊断治疗血虚风燥型皮肤瘙痒症患者共900例,年龄为56岁以上的499例,只有401例为56岁以下。900例患者中痊愈的770例,有效的112例,无效18例。总有效率达98%。

Claims (3)

1.一种治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归80~200g、麦冬100~250g、川芎50~120g、地骨皮150~360g、生地黄90~180g、白芍100~250g、白鲜皮50~100g、丹参50~180g、苦参30~120g、五味子30~100g、地肤子60~180g、乌梢蛇90~160g、防风50~120g。
2.根据权利要求1所述的治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归90~170g、麦冬115~220g、川芎60~105g、地骨皮180~310g、生地黄100~160g、白芍115~220g、白鲜皮58~90g、丹参58~160g、苦参38~105g、五味子38~90g、地肤子70~160g、乌梢蛇100~140g、防风58~105g。
3.根据权利要求1至2所述的治疗血虚风燥型皮肤瘙痒症的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
当归150g、麦冬200g、川芎95g、地骨皮280g、生地黄140g、白芍200g、白鲜皮80g、丹参140g、苦参95g、五味子80g、地肤子140g、乌梢蛇120g、防风95g。
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CN106177163A (zh) * 2016-09-22 2016-12-07 四川兴聚焦医药科技有限责任公司 一种用于治疗瘙痒症的汤剂药物及其制备方法
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