CN106728563A - It is a kind of to treat Chinese medicine of Alzheimer's disease and preparation method thereof - Google Patents
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Chinese medicine the present invention relates to treat Alzheimer's disease, it is especially a kind of to treat Chinese medicine of Alzheimer's disease and preparation method thereof.It is characterized in, is formulated by the bulk drug of following weight portion：13 parts of 16 parts of radix bupleuri, 16 parts of the Radix Astragali, 14 parts of grass-leaved sweetflag, 13 parts of Radix Angelicae Sinensis and Radix Glycyrrhizae.Medicinal material compatibility is suitable selected by Chinese medicine preparation of the present invention, meet Chinese pharmacology and modern medical theory, have one's ideas straightened out with removing toxic substances, benefiting qi and nourishing blood, brain tonic and intelligence development the effect of, the improvement and treatment of the symptoms such as the failure of memory, lassitude hypodynamia, dizzy palpitaition, deficiency of qi and blood and the dementia that cause for Alzheimer's disease have remarkable result, and safe without toxic side effect, can be widely applied to the clinical treatment of Alzheimer's disease.
Description
Technical field
Chinese medicine the present invention relates to treat Alzheimer's disease, especially a kind of Chinese medicine for treating Alzheimer's disease and its
Preparation method.
Background technology
Alzheimer's disease (AD) is a kind of nervous system degenerative disease for carrying out sexual development of onset concealment.Clinically
Show as memory disorders, aphasia, appraxia, agnosia, the infringement of visual space technical ability, perform function obstacle and personality and behavior change etc.
Generalized dementia feature.Patient was sent out within 65 years old in the past, claimed alzheimer's disease；Claim senile dementia with sequela person within 65 years old.
Because the illness onset is slow or concealment, there is decrease of cognitive function, mental symptom and row until finding
It is the symptom such as obstacle and activity of daily living decline, severe patient has been completely dependent on caregiver, memory loss, daily life
Work can not be taken care of oneself, gatism, and presentation is kept silent, rigid limbs, ultimately results in stupor, typically dies from the complication such as infection.
With the aging of world population, the incidence of disease of Alzheimer's disease constantly rises, and seriously threatens human health
And social development.Still unclear on its pathogenesis, the disease is probably one group of different substantiality disease, in many factors (including life
Thing and socio-psychological factor) in the presence of fall ill.From the point of view of research at present, the sick possible factor and hypothesis up to more than 30 are planted,
Such as family history, women, head injury, low level of education, thyropathy, too high or too low female reproduction age, viral infection, neurotransmitter
Disorder, gene mutation, radical damage, nerve cell apoptosis, beta-amyloid protein and Protein tau Abnormal Phosphorylation etc. because
Element.
Alzheimer's disease (AD) clinical manifestation is the memory of age correlation and the decline of cognitive function, and pathological characters are thin
Intracellular neurofibrillary tangles (NET), the formation of extracellular amyloid albumen (A β) patch and the missing of cholinergic nerve etc..
In recent years the research for preventing and treating Alzheimer's disease is increasingly subject to pay attention to about Chinese medicine preparation and Chinese medical extract, and is taken
Greater advance was obtained, the prevention and treatment for Alzheimer's disease are significant.
The content of the invention
An object of the present invention is to provide a kind of Chinese medicine for treating Alzheimer's disease, causes for Alzheimer's disease
The symptom such as failure of memory, lassitude hypodynamia, dizzy palpitaition, deficiency of qi and blood and dementia improvement and treatment there is significantly effect
Really；
The second object of the present invention is to provide a kind of preparation method of above-mentioned Chinese medicine.
A kind of Chinese medicine for treating Alzheimer's disease, it is particular in that, by the bulk drug preparation of following weight portion
Into：Radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts and Radix Glycyrrhizae 1-3 parts.
A kind of preparation method of the Chinese medicine for treating Alzheimer's disease, it is particular in that, comprises the following steps that：
(1) radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts, Radix Glycyrrhizae 1-3 parts is taken to mix as medium-height grass
Medicine raw material；
(2) decocting of taken herbal raw material plus 4-12 times of weight is boiled 1-5 times, each 1-5 hours, filtering merges filter
Liquid；
Or by taken herbal raw material plus 4-12 times of volume fraction of weight for the ethanol water of 10%-95% is heated
Refluxing extraction 1-5 times, each 1-5 hours, filtering, merging filtrate；
(3) filtrate after merging is concentrated into medicinal extract shape；
(4) it is made preparation to addition pharmaceutic adjuvant in the medicinal extract for obtaining.
Pharmaceutic adjuvant refers to starch in step (4).
Preparation is tablet, capsule, granule, powder, pill, soft extract, syrup or oral liquid in step (4).
The present invention compared with prior art, has the advantages that：
Medicinal material compatibility is suitable selected by Chinese medicine preparation of the present invention, meets Chinese pharmacology and modern medical theory, is opened with removing toxic substances
The effect of key, benefiting qi and nourishing blood, brain tonic and intelligence development, the failure of memory caused for Alzheimer's disease, lassitude hypodynamia, the dizzy heart
Throb with fear, the improvement of the symptom such as deficiency of qi and blood and dementia and treatment have remarkable result, and safe without toxic side effect, can extensive use
In the clinical treatment of Alzheimer's disease.
Brief description of the drawings
Fig. 1 is that Chinese medicine preparation of the present invention is induced LPS is investigated in embodiment 4NOR experiments provided in an embodiment of the present invention
Practise the statistical results chart of the influence of the new object resolving ability of memory impairment mouse；
Fig. 2 is that embodiment 5Morris water maze laboratories provided in an embodiment of the present invention investigate Chinese medicine preparation of the present invention to LPS
The statistical results chart of the influence of the learning memory injury mouse escape latency of induction.
Specific embodiment
Technical scheme is implemented as follows：
A kind of Chinese medicine preparation for treating Alzheimer's disease, is made the raw material composition and parts by weight of the Chinese medicine preparation
For：Radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts, Radix Glycyrrhizae 1-3 parts.
Composition described above is, by weight as proportioning, can to increase or reduce according to corresponding proportion in production, such as big
Large-scale production can by kilogram in units of, or in units of ton, small-scale production can also in grams, and weight can increase
Or reduce, but the respectively constant rate of the raw material weight proportioning of soup processed between composition.
Chinese medicine preparation of the invention can be any pharmaceutically useful formulation, and these formulations include：Pill, capsule, particle
Agent, powder, tablet, soft extract, syrup or oral liquid.
Chinese medicine preparation of the invention, the preparation that it is administered orally can contain conventional excipient, such as adhesive, filling
Agent, diluent, tablet agent, lubricant, disintegrant, colouring agent, flavor enhancement and wetting agent, can be coated to tablet if necessary.
The form of oral liquid for example can be aqueous or oily suspensions, solution, emulsion or syrup, Huo Zheke
Being a kind of to use the preceding dry products compounded with water or other suitable carriers.This liquid preparation can contain conventional
Additive, such as suspending agent, such as gelatin, sorbierite, methylcellulose, hydroxyethyl cellulose or carboxymethylcellulose calcium；Emulsification
Agent, such as lecithin, anhydro sorbitol-oleate or Arabic gum；Non-aqueous carrier (they can include edible oil), example
Such as apricot kernel oil, fractionated coconut oil, the oily ester of glycerine, propane diols or ethanol；Preservative, such as methyl p-hydroxybenzoate or right
Nipasol or sorbic acid, and if desired, conventional flavouring agent or colouring agent can be contained.
A kind of preparation method of the Chinese medicine preparation for treating Alzheimer's disease, comprises the following steps that：
A takes radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts, Radix Glycyrrhizae 1-3 parts；
B will take the decocting that Chinese herbal medicine plus 4-12 times measure and boil 1-5 times in step A, each 1-5 hours, filtering, merge filter
Liquid.
Step B gained filtrates are concentrated into medicinal extract shape by C.
D to step C gained medicinal extract in add pharmaceutically acceptable auxiliary material (such as starch) to be made preparation.
A kind of another preparation method for the Chinese medicine preparation for treating Alzheimer's disease, comprises the following steps that：
A takes radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts, Radix Glycyrrhizae 1-3 parts；
B will take the ethanol water (concentration of alcohol 10%-95%) that Chinese herbal medicine plus 4-12 times measure and be heated to reflux in step A
Extract 1-5 times, each 1-5 hours, filtering, merging filtrate.
Gained filtrate in step B is concentrated into medicinal extract shape by C.
D to step C gained medicinal extract in add pharmaceutically acceptable auxiliary material (such as starch) to be made preparation.
The property of medicine of Chinese medicine used of the invention is as follows：
Radix bupleuri：Bitter, is slightly cold；Return liver, gallbladder channel.Have clearing heat and detoxicating, and in inducing diaphoresis, the effect of soothing the liver rising Yang.For catching a cold
Heating, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation.
The Radix Astragali：Property sweet temperature, return lung warp, there is tonifying Qi and lifting yang, benefit to defend the function of solid table.The Radix Astragali have enhancing body's immunity,
Liver protection, diuresis, anti-aging, resisting stress, step-down and wide antibacterial action.
Grass-leaved sweetflag：Property pungent, temperature, the thoughts of returning home, stomach.There is eliminating the phlegm to have one's ideas straightened out, dampness elimination appetizing, the effect for intelligence development of allaying excitement.It is mainly used in
Lose consciousness, palpitate with fear, insomnia is dull-witted, forgetful, chest and abdomen swelling and pain, wind-cold-dampness arthralgia.
Radix Angelicae Sinensis：Sweet, pungent, slight bitter, it is warm in nature；Return liver, the heart, the spleen channel；Fragrant strongly fragrant row dissipates, and can rise to drop, and with enriching blood, invigorates blood circulation,
The effect of menstruction regulating and pain relieving；Cure mainly all diseases of the deficiency of blood, blood stasis, dizziness and headache, palpitaition limb fiber crops, irregular menstruation, Amenorrhea, dysmenorrhoea, cold of insufficiency type abdomen
Bitterly.
Radix Glycyrrhizae：Property is sweet, flat, enters spleen, stomach, lung channel.With middle emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription.Use is processed, taste is controlled empty
It is weak, deficiency of food, loose stool of suffering from abdominal pain, overstrain heating, consumptive lung disease cough, palpitaition, frightened epilepsy；It is raw to use, control abscess of throat, peptic ulcer, ulcer
Sore, antidote poison and food poisoning.
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Application principle of the invention is further described with reference to specific embodiment.
Embodiment 1：
Use the Chinese medicine material of following weight portion：
6 parts of radix bupleuri, 6 parts of the Radix Astragali, 4 parts of grass-leaved sweetflag, 3 parts of Radix Angelicae Sinensis, 3 parts of Radix Glycyrrhizae.
Proportionally mix after Chinese herbal medicine is crushed, take mixed Chinese herbal medicine 1kg, plus the decocting of 8 times of weight is boiled 3 times,
2 hours every time, the dregs of a decoction are filtered to remove, merge the filtrate after 3 decoctions.Gained filter vacuum is concentrated under reduced pressure into relative density
More than 1.20, vacuum drying obtains 0.22kg medicinal extract in 12 hours, obtains final product Chinese herbal medicine extract.
Embodiment 2：
5 parts of radix bupleuri, 5 parts of the Radix Astragali, 3 parts of grass-leaved sweetflag, 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Glycyrrhizae.
Proportionally mix after Chinese herbal medicine is crushed, take mixed Chinese herbal medicine 1kg, plus the decocting of 10 times of weight is boiled 5 times,
4 hours every time, the dregs of a decoction are filtered to remove, merge the filtrate after 5 decoctions.Gained filter vacuum is concentrated under reduced pressure into relative density
More than 1.20, vacuum drying obtains 0.25kg medicinal extract in 12 hours, by gained medicinal extract and lactose, the 15% pre- glue of medicinal extract weight 30%
Change starch, the mixing of 3% sodium carboxymethyl starch, sieving is well mixed, and is adhesive softwood with 5% PVP ethanol solution,
Sieving granulation, whole grain after 60 DEG C of dryings adds 1% superfine silica gel powder to be well mixed, compressing tablet, you can Chinese herbal medicine extract piece is obtained
Agent.
Embodiment 3：
3 parts of radix bupleuri, 3 parts of the Radix Astragali, 2 parts of grass-leaved sweetflag, 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Glycyrrhizae.
Proportionally mix after Chinese herbal medicine is crushed, take mixed Chinese herbal medicine 1kg, plus 6 times of ethanol waters of weight
(ethanol content 70%) is decocted 4 times, 3 hours every time, is filtered to remove the dregs of a decoction, merges the filtrate after 4 decoctions.Gained filtrate is true
Sky is concentrated under reduced pressure into relative density more than 1.20, and vacuum drying obtains 0.21kg medicinal extract in 12 hours, by medicinal extract and medicinal extract weight 25%
Microcrystalline cellulose, 15% starch, 2% PVPP be well mixed, it is soft as adhesive system with 3% PVP ethanol
Material, granulation, whole grain after 60 DEG C of dryings, filling capsule obtains final product Chinese herbal medicine extract capsule.
Embodiment 4：
New things distinguish that (Novel Object Recognition, NOR) experiment investigates Chinese herbal medicine extract and LPS is induced
The new object resolving ability of learning memory injury mouse influence.
Material animal：ICR male mices, 18-22g；
Medicine：Lipopolysaccharides (lipopolysaccharide, LPS)；Chinese herbal medicine extract；Doneppezil Hydrochloride；
Method：Chinese herbal medicine extract is prepared by the methods described of embodiment 1.ICR mouse are taken, 6 groups, every group 12 are randomly divided into
Only：Blank control group, model comparison (LPS) group, Chinese herbal medicine extract group and positive controls (Doneppezil Hydrochloride).Each group is moved
Thing fixing head after chloraldurate light anaesthesia, carries out intracerebroventricular injection.The basic, normal, high dosage of model group, Chinese herbal medicine extract
Group (100,200,400mg/kg) and positive controls (donepezil 5mg/kg) injection LPS solution (5mg/ml, 3 μ l/ are only), it is empty
White control group mice injects isometric physiological saline.From next day after lps injection, each Chinese herbal medicine extract administration group mouse root
According to the solution that the daily gavage Chinese herbal medicine extract of the size of its body weight is made into, more than the daily gavage hydrochloric acid of mouse of positive controls how
The neat solution of piperazine, the daily gavage of the mouse of blank group and model group gives isometric physiological saline.Proceed by new things within 8th day
Experiment is distinguished, every preference index of mouse is determined.Computing formula is as follows：
As a result：In NOR experiments, intracerebroventricular injection LPS can make the mouse substantially reduce the preference index of new things.In
Can substantially increase preference of the mouse to new things after herb extracts and positive drug Doneppezil Hydrochloride 5mg/kg treatments.Experiment
Result shows that the Chinese herbal medicine extract can substantially increase the new object resolving ability of learning memory injury mouse of LPS inductions.
Embodiment 5：
Morris water maze laboratories investigate the learning memory injury mouse escape latency that Chinese herbal medicine extract is induced LPS
Influence；
Material animal：ICR male mices, 18-22g；
Medicine：LPS；Chinese herbal medicine extract；Doneppezil Hydrochloride；
Method：ICR mouse are taken, 6 groups, every group 12 are randomly divided into：Blank control group, model comparison (LPS) group, Chinese herbal medicine
Extract group and positive controls (Doneppezil Hydrochloride).Each group animal fixing head after chloraldurate light anaesthesia, is carried out
Intracerebroventricular injection.Model group, Chinese herbal medicine extract basic, normal, high dosage group (100,200,400mg/kg) and positive controls are (more
Donepezil 5mg/kg) injection LPS solution (5mg/ml, 3 μ l/ are only), blank control group mouse injects isometric physiological saline.From
After lps injection from next day, size daily gavage Chinese herbal medicine extract of each Chinese herbal medicine extract administration group mouse according to its body weight
The mouse of the solution being made into, the daily gavage Doneppezil Hydrochloride solution of mouse of positive controls, blank group and model group is daily
Gavage gives isometric physiological saline.Proceed by Morris water maze laboratories within 10th day, continue 5 days.Mouse is determined fixed
Escape latency in position navigation experiments experiment.
As a result：In Morris water maze laboratories, compare with blank group, LPS group mouse orientation navigation experiment the 5th day is escaped
Keeping away incubation period substantially increases.Compare with LPS groups, Chinese herbal medicine extract group and positive drug Doneppezil Hydrochloride group were escaped at the 5th day
Keeping away incubation period substantially reduces.Swimming rate of each group animal during testing is without significant difference.Test result indicate that, Chinese herbal medicine is carried
Taking thing can be obviously improved the Spatial memory ability of learning memory injury mouse of LPS inductions.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in essence of the invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (4)
1. a kind of Chinese medicine for treating Alzheimer's disease, it is characterised in that be formulated by the bulk drug of following weight portion：Radix bupleuri
1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts and Radix Glycyrrhizae 1-3 parts.
2. a kind of preparation method of the Chinese medicine for treating Alzheimer's disease, it is characterised in that comprise the following steps that：
(1) radix bupleuri 1-6 parts, Radix Astragali 1-6 parts, grass-leaved sweetflag 1-4 parts, Radix Angelicae Sinensis 1-3 parts, Radix Glycyrrhizae 1-3 parts is taken to mix as Chinese herbal medicine original
Material；
(2) decocting of taken herbal raw material plus 4-12 times of weight is boiled 1-5 times, each 1-5 hours, filtering, merging filtrate；
Or by taken herbal raw material plus 4-12 times of volume fraction of weight for the ethanol water of 10%-95% is heated to reflux
Extract 1-5 times, each 1-5 hours, filtering, merging filtrate；
(3) filtrate after merging is concentrated into medicinal extract shape；
(4) it is made preparation to addition pharmaceutic adjuvant in the medicinal extract for obtaining.
3. a kind of preparation method of the Chinese medicine for treating Alzheimer's disease as claimed in claim 2, it is characterised in that：Step
(4) pharmaceutic adjuvant refers to starch in.
4. a kind of preparation method of the Chinese medicine for treating Alzheimer's disease as claimed in claim 2, it is characterised in that：Step
(4) preparation is tablet, capsule, granule, powder, pill, soft extract, syrup or oral liquid in.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269179A (en) * | 2008-04-10 | 2008-09-24 | 贵阳医学院 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
| CN103041137A (en) * | 2011-10-13 | 2013-04-17 | 雷佰理 | Pharmaceutical composition for preventing and treating senile dementia, and preparation method thereof |
| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269179A (en) * | 2008-04-10 | 2008-09-24 | 贵阳医学院 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
| CN103041137A (en) * | 2011-10-13 | 2013-04-17 | 雷佰理 | Pharmaceutical composition for preventing and treating senile dementia, and preparation method thereof |
| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 徐三文 等: "《常见脑病中医外治法》", 31 January 2008, 科学技术文献出版社 * |
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