CN106728563B - Traditional Chinese medicine for treating Alzheimer's disease and preparation method thereof - Google Patents
Traditional Chinese medicine for treating Alzheimer's disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating Alzheimer's disease, in particular to a traditional Chinese medicine for treating Alzheimer's disease and a preparation method thereof. The traditional Chinese medicine is characterized by being prepared from the following raw materials in parts by weight: 1-6 parts of radix bupleuri, 1-6 parts of astragalus membranaceus, 1-4 parts of rhizoma acori graminei, 1-3 parts of angelica sinensis and 1-3 parts of liquorice. The traditional Chinese medicine preparation disclosed by the invention is suitable in compatibility of selected medicinal materials, accords with the theories of traditional Chinese pharmacology and modern medicine, has the effects of detoxifying, inducing resuscitation, tonifying qi, nourishing blood, strengthening brain and improving intelligence, has obvious effects on improving and treating symptoms such as hypomnesis, lassitude, hypodynamia, dizziness, palpitation, deficiency of qi and blood, dementia and the like caused by the Alzheimer's disease, is safe, has no toxic or side effect, and can be widely applied to clinical treatment of the Alzheimer's disease.
Description
Technical Field
The invention relates to a traditional Chinese medicine for treating Alzheimer's disease, in particular to a traditional Chinese medicine for treating Alzheimer's disease and a preparation method thereof.
Background
Alzheimer's Disease (AD) is a progressive degenerative disease of the nervous system with occult onset. Clinically, it is characterized by generalized dementia such as dysmnesia, aphasia, disuse, agnosia, impairment of visual spatial skills, dysfunction in execution, and personality and behavioral changes. Patients who are older than 65 years are called presenile dementia; the patient after 65 years old is called senile dementia.
The disease is slow in onset or hidden, and when the disease is discovered, symptoms such as decline of cognitive function, mental symptoms, behavior disorder and decline of daily life capacity appear, serious patients completely depend on nursing persons, memory is lost, daily life cannot be self-managed, incontinence of urine and feces appears as mutism, limb stiffness, coma is finally caused, and the disease generally dies from complications such as infection.
From the current research, the possible factors and hypothesis of the disease are as many as 30, such as family history, female, head trauma, low education level, thyroid disease, maternal age, viral infection, neurotransmitter disturbance, gene mutation, free radical damage, neuronal apoptosis, deposition of amyloid β protein and abnormal phosphorylation of tau protein.
Alzheimer's Disease (AD) is clinically manifested by age-related decline in memory and cognitive function, pathologically characterized by intracellular neurofibrillary tangles (NET), formation of extracellular amyloid (a β) plaques and loss of cholinergic nerves, etc.
In recent years, researches on the traditional Chinese medicine preparation and the traditional Chinese medicine extract on prevention and treatment of the Alzheimer's disease are increasingly paid attention to, and the traditional Chinese medicine preparation and the traditional Chinese medicine extract have great progress, and have important significance on prevention and treatment of the Alzheimer's disease.
Disclosure of Invention
One of the purposes of the invention is to provide a traditional Chinese medicine for treating Alzheimer's disease, which has remarkable effects on improving and treating symptoms such as hypomnesis, lassitude and hypodynamia, dizziness and palpitation, deficiency of qi and blood, dementia and the like caused by Alzheimer's disease;
the invention also aims to provide a preparation method of the traditional Chinese medicine.
The traditional Chinese medicine for treating the Alzheimer disease is characterized by being prepared from the following raw material medicines in parts by weight: 1-6 parts of radix bupleuri, 1-6 parts of astragalus membranaceus, 1-4 parts of rhizoma acori graminei, 1-3 parts of angelica sinensis and 1-3 parts of liquorice.
A preparation method of a traditional Chinese medicine for treating Alzheimer's disease is characterized by comprising the following process steps:
(1) mixing bupleuri radix 1-6 parts, radix astragali 1-6 parts, rhizoma Acori Graminei 1-4 parts, radix Angelicae sinensis 1-3 parts, and Glycyrrhrizae radix 1-3 parts to obtain Chinese medicinal materials;
(2) decocting the Chinese herbal materials with 4-12 times of water for 1-5 times (1-5 hr each time), filtering, and mixing filtrates;
or adding 4-12 times of 10% -95% ethanol water solution by weight, heating, refluxing and extracting for 1-5 times (each for 1-5 hr), filtering, and mixing filtrates;
(3) concentrating the combined filtrate to obtain an extract;
(4) adding medicinal adjuvants into the obtained extract, and making into preparation.
The Chinese medicinal auxiliary material in the step (4) is starch.
The preparation in the step (4) is tablets, capsules, granules, powder, pills, soft extract, syrup or oral liquid.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine preparation disclosed by the invention is suitable in compatibility of selected medicinal materials, accords with the theories of traditional Chinese pharmacology and modern medicine, has the effects of detoxifying, inducing resuscitation, tonifying qi, nourishing blood, strengthening brain and improving intelligence, has obvious effects on improving and treating symptoms such as hypomnesis, lassitude, hypodynamia, dizziness, palpitation, deficiency of qi and blood, dementia and the like caused by the Alzheimer's disease, is safe, has no toxic or side effect, and can be widely applied to clinical treatment of the Alzheimer's disease.
Drawings
FIG. 1 is a graph of the statistical results of the NOR experiment of example 4 provided in the present invention to examine the effect of the present invention on the discrimination ability of LPS-induced learning memory impairment mouse neoplasms;
FIG. 2 is a graph of the results of Morris water maze experiment in example 5, which is provided by the present invention, examining the effect of the present invention on the escape latency of mice with learning and memory impairment induced by LPS.
Detailed Description
The technical scheme of the invention is implemented as follows:
a traditional Chinese medicine preparation for treating Alzheimer's disease comprises the following raw materials in parts by weight: 1-6 parts of radix bupleuri, 1-6 parts of astragalus membranaceus, 1-4 parts of rhizoma acori graminei, 1-3 parts of angelica sinensis and 1-3 parts of liquorice.
The components are proportioned according to the parts by weight, and can be increased or reduced according to the corresponding proportion during production, for example, the weight can be increased or reduced in a large-scale production by taking kilogram as a unit or ton as a unit, and the weight can be increased or reduced in a small-scale production by taking gram as a unit, but the proportion of the weight proportion of the raw materials among the components is unchanged.
The Chinese medicinal preparation can be any medicinal preparation, and the preparation comprises the following components in parts by weight: pill, capsule, granule, powder, tablet, soft extract, syrup or oral liquid.
The Chinese medicinal preparation of the present invention for oral administration may contain conventional excipients such as binders, fillers, diluents, tabletting agents, lubricants, disintegrants, coloring agents, flavoring agents and wetting agents, and the tablet may be coated if necessary.
Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions or syrups, or may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example, gelatin, sorbitol, methyl cellulose, hydroxyethyl cellulose or carboxymethyl cellulose; emulsifying agents, for example lecithin, sorbitan-oleate or acacia; non-aqueous carriers (which may include edible oils), such as almond oil, fractionated coconut oil, oily esters of glycerin, propylene glycol or ethyl alcohol; preservatives, for example methyl or propyl p-hydroxybenzoate or sorbic acid, and, if desired, conventional flavouring or colouring agents.
A preparation method of a traditional Chinese medicine preparation for treating Alzheimer's disease comprises the following process steps:
a is prepared from bupleuri radix 1-6 parts, radix astragali 1-6 parts, rhizoma Acori Graminei 1-4 parts, radix Angelicae sinensis 1-3 parts, and Glycyrrhrizae radix 1-3 parts;
b, adding 4-12 times of water into the Chinese herbal medicines taken in the step A, decocting for 1-5 times, each time for 1-5 hours, filtering, and combining the filtrates.
And C, concentrating the filtrate obtained in the step B to be paste.
And D, adding pharmaceutically acceptable auxiliary materials (such as starch and the like) into the extract obtained in the step C to prepare a preparation.
Another preparation method of the traditional Chinese medicine preparation for treating the Alzheimer disease comprises the following process steps:
a is prepared from bupleuri radix 1-6 parts, radix astragali 1-6 parts, rhizoma Acori Graminei 1-4 parts, radix Angelicae sinensis 1-3 parts, and Glycyrrhrizae radix 1-3 parts;
b, adding 4-12 times of ethanol water (the ethanol concentration is 10% -95%) into the Chinese herbal medicines taken in the step A, heating, refluxing and extracting for 1-5 times, wherein the ethanol concentration is 1-5 hours each time, filtering, and combining the filtrates.
And C, concentrating the filtrate obtained in the step B to be paste-like.
And D, adding pharmaceutically acceptable auxiliary materials (such as starch and the like) into the extract obtained in the step C to prepare a preparation.
The traditional Chinese medicine used by the invention has the following medicinal properties:
bupleurum root: bitter and slightly cold in taste; it enters liver and gallbladder meridians. Has the effects of clearing away heat and toxic materials, harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, and menoxenia.
Astragalus root: being sweet in nature and warm in nature, it enters lung meridian and has the functions of tonifying qi, invigorating yang, benefiting wei and consolidating superficial resistance. Radix astragali has effects in enhancing immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and resisting bacteria.
Grassleaf sweelflag rhizome: pungent and warm in property, entering heart and stomach meridians. Has effects of eliminating phlegm, inducing resuscitation, eliminating dampness, stimulating appetite, tranquilizing mind, and improving intelligence. Is mainly used for treating coma, palpitation, insomnia, dementia, amnesia, chest and abdomen distending pain and anemofrigid-damp arthralgia.
Chinese angelica: sweet, pungent, slightly bitter and warm in nature; it enters liver, heart and spleen meridians; the medicine has the effects of tonifying blood, promoting blood circulation, regulating menstruation and relieving pain; it can be used for treating blood deficiency and blood stasis, vertigo, headache, palpitation, numbness of limbs, menoxenia, amenorrhea, dysmenorrhea, and abdominal pain due to deficiency cold.
Licorice root: sweet in nature and neutral in nature, enter spleen, stomach and lung meridians. Harmonize the middle energizer and relieve urgency, moisten lung, remove toxicity, and harmonize the recipe. It is stir-baked to treat weakness of spleen and stomach, poor appetite, abdominal pain, loose stool, fatigue, fever, consumptive lung disease, cough, palpitation, fright epilepsy; unprocessed, indicated for swollen and sore throat, peptic ulcer, abscess, deep-rooted carbuncle, sores and ulcers, relieving toxicity of herbs and food poisoning.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The application of the principles of the present invention will now be described in further detail with reference to specific embodiments.
Example 1:
the following traditional Chinese medicine raw materials in parts by weight are used:
6 parts of radix bupleuri, 6 parts of astragalus membranaceus, 4 parts of rhizoma acori graminei, 3 parts of angelica sinensis and 3 parts of liquorice.
Pulverizing the Chinese herbal medicines, mixing at a certain proportion, taking 1kg of the mixed Chinese herbal medicines, adding 8 times of water, decocting for 3 times, each time for 2 hours, filtering to remove residues, and mixing the filtrates after 3 times of decoction. Vacuum concentrating the filtrate under reduced pressure to relative density of above 1.20, and vacuum drying for 12 hr to obtain 0.22kg extract.
Example 2:
5 parts of radix bupleuri, 5 parts of astragalus membranaceus, 3 parts of rhizoma acori graminei, 2 parts of angelica sinensis and 2 parts of liquorice.
Pulverizing the Chinese herbal medicines, mixing at a certain proportion, taking 1kg of the mixed Chinese herbal medicines, adding 10 times of water, decocting for 5 times, each time for 4 hours, filtering to remove residues, and mixing the filtrates after 5 times of decoction. Vacuum concentrating the filtrate to relative density of above 1.20, vacuum drying for 12 hr to obtain 0.25kg extract, mixing the obtained extract with lactose 30%, pregelatinized starch 15% and sodium carboxymethyl starch 3%, sieving, mixing, making soft mass with 5% polyvidone ethanol solution as binder, sieving, granulating, drying at 60 deg.C, grading, adding 1% silica gel micropowder, mixing, and tabletting to obtain Chinese medicinal extract tablet.
Example 3:
3 parts of radix bupleuri, 3 parts of astragalus membranaceus, 2 parts of rhizoma acori graminei, 2 parts of angelica sinensis and 2 parts of liquorice.
Pulverizing the Chinese herbal medicines, mixing at a certain proportion, taking 1kg of the mixed Chinese herbal medicines, adding 6 times of ethanol water solution (ethanol content 70%) by weight, decocting for 4 times, 3 hours each time, filtering to remove residue, and mixing the filtrates after 4 times of decoction. Vacuum concentrating the filtrate to relative density of above 1.20, vacuum drying for 12 hr to obtain 0.21kg extract, mixing the extract with microcrystalline cellulose 25 wt%, starch 15 wt% and crospovidone 2 wt%, making soft mass with povidone ethanol solution 3 wt% as binder, granulating, drying at 60 deg.C, grading, and encapsulating to obtain Chinese medicinal extract capsule.
Example 4:
new Object discrimination (NOR) experiment examines the influence of Chinese herbal medicine extract on the discrimination ability of new objects in mice with learning and memory impairment induced by LPS.
Materials animals: ICR male mouse, 18-22 g;
medicine preparation: lipopolysaccharide (LPS); chinese herbal medicine extract; donepezil hydrochloride;
the method comprises the following steps: herbal extracts were prepared as described in example 1. ICR mice were taken and randomly divided into 6 groups of 12 mice each: a blank control group, a model control (LPS) group, a Chinese herbal medicine extract group and a positive control group (donepezil hydrochloride). Animals in each group were lightly anesthetized with chloral hydrate and then fixed in their heads for lateral ventriculo-ventricular injection. Model group, Chinese herbal medicine extract low, medium and high dose group (100,200,400mg/kg) and positive control group (donepezil 5mg/kg) were injected with LPS solution (5mg/ml, 3. mu.l/mouse), and blank control group mice were injected with an equal volume of physiological saline. From the next day after LPS injection, the mice of each Chinese herbal medicine extract administration group are intragastrically administered with the solution prepared by the Chinese herbal medicine extract every day according to the weight of the mice, the mice of the positive control group are intragastrically administered with the donepezil hydrochloride solution every day, and the mice of the blank group and the model group are intragastrically administered with the physiological saline with the same volume every day. A novelty discrimination experiment was started on day 8 and the preference index for each mouse was determined. The calculation formula is as follows:
as a result: in the NOR experiment, the preference index of mice for new things was significantly reduced by injecting LPS into the lateral ventricle. After the Chinese herbal medicine extract and the positive drug donepezil hydrochloride of 5mg/kg are treated, the preference of mice for new things can be obviously increased. Experimental results show that the Chinese herbal medicine extract can obviously improve the discrimination capability of a new object of a mouse with learning and memory impairment induced by LPS.
Example 5:
the Morris water maze experiment inspects the influence of the Chinese herbal medicine extract on the escape latency of the mouse with learning and memory impairment induced by LPS;
materials animals: ICR male mouse, 18-22 g;
medicine preparation: LPS; chinese herbal medicine extract; donepezil hydrochloride;
the method comprises the following steps: ICR mice were taken and randomly divided into 6 groups of 12 mice each: a blank control group, a model control (LPS) group, a Chinese herbal medicine extract group and a positive control group (donepezil hydrochloride). Animals in each group were lightly anesthetized with chloral hydrate and then fixed in their heads for lateral ventriculo-ventricular injection. Model group, Chinese herbal medicine extract low, medium and high dose group (100,200,400mg/kg) and positive control group (donepezil 5mg/kg) were injected with LPS solution (5mg/ml, 3. mu.l/mouse), and blank control group mice were injected with an equal volume of physiological saline. From the next day after LPS injection, the mice of each Chinese herbal medicine extract administration group are intragastrically administered with the solution prepared by the Chinese herbal medicine extract every day according to the weight of the mice, the mice of the positive control group are intragastrically administered with the donepezil hydrochloride solution every day, and the mice of the blank group and the model group are intragastrically administered with the physiological saline with the same volume every day. The Morris water maze experiment was started on day 10 for 5 days. The escape latency of the mice in the experiment of the positioning voyage experiment is determined.
As a result: in the Morris water maze experiment, the escape latency of LPS group mice on the 5 th day of the localized voyage experiment was significantly increased compared to the blank group. The escape latency of the herbal extract group and the positive drug donepezil hydrochloride group was significantly reduced on day 5 compared to the LPS group. There was no significant difference in swimming speed between the groups of animals during the experiment. The experimental result shows that the Chinese herbal medicine extract can obviously improve the space learning and memory ability of mice with learning and memory impairment induced by LPS.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (4)
1. The traditional Chinese medicine for treating the Alzheimer disease is characterized by being prepared from the following raw material medicines in parts by weight: 1-6 parts of radix bupleuri, 1-6 parts of astragalus membranaceus, 1-4 parts of rhizoma acori graminei, 1-3 parts of angelica sinensis and 1-3 parts of liquorice.
2. A preparation method of a traditional Chinese medicine for treating Alzheimer's disease is characterized by comprising the following process steps:
(1) mixing bupleuri radix 1-6 parts, radix astragali 1-6 parts, rhizoma Acori Graminei 1-4 parts, radix Angelicae sinensis 1-3 parts, and Glycyrrhrizae radix 1-3 parts to obtain Chinese medicinal materials;
(2) decocting the Chinese herbal materials with 4-12 times of water for 1-5 times (1-5 hr each time), filtering, and mixing filtrates;
or adding 4-12 times of 10% -95% ethanol water solution by weight, heating, refluxing and extracting for 1-5 times (each for 1-5 hr), filtering, and mixing filtrates;
(3) concentrating the combined filtrate to obtain an extract;
(4) adding medicinal adjuvants into the obtained extract, and making into preparation.
3. The preparation method of the traditional Chinese medicine for treating alzheimer's disease as claimed in claim 2, characterized in that: the Chinese medicinal auxiliary material in the step (4) is starch.
4. The preparation method of the traditional Chinese medicine for treating alzheimer's disease as claimed in claim 2, characterized in that: the preparation in the step (4) is tablets, capsules, granules, powder, pills, soft extract, syrup or oral liquid.
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| CN101269179A (en) * | 2008-04-10 | 2008-09-24 | 贵阳医学院 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
| CN103041137A (en) * | 2011-10-13 | 2013-04-17 | 雷佰理 | Pharmaceutical composition for preventing and treating senile dementia, and preparation method thereof |
| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
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| CN101269179A (en) * | 2008-04-10 | 2008-09-24 | 贵阳医学院 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
| CN103041137A (en) * | 2011-10-13 | 2013-04-17 | 雷佰理 | Pharmaceutical composition for preventing and treating senile dementia, and preparation method thereof |
| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
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