CN106728236A - It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch - Google Patents
It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch Download PDFInfo
- Publication number
- CN106728236A CN106728236A CN201611247178.1A CN201611247178A CN106728236A CN 106728236 A CN106728236 A CN 106728236A CN 201611247178 A CN201611247178 A CN 201611247178A CN 106728236 A CN106728236 A CN 106728236A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicinal preparation
- chinese medicinal
- borneol
- compound chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 33
- 150000001875 compounds Chemical class 0.000 title claims abstract description 20
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 18
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 17
- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 13
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 32
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229940116229 borneol Drugs 0.000 claims abstract description 32
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 32
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 29
- 230000000694 effects Effects 0.000 claims abstract description 21
- 239000002245 particle Substances 0.000 claims abstract description 18
- 241000218691 Cupressaceae Species 0.000 claims abstract description 15
- 239000006210 lotion Substances 0.000 claims abstract description 14
- 235000008291 Poterium sanguisorba Nutrition 0.000 claims abstract description 13
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims abstract description 13
- 239000002674 ointment Substances 0.000 claims abstract description 13
- 240000004064 Poterium sanguisorba Species 0.000 claims abstract description 12
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 12
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000000443 aerosol Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000007796 conventional method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000003883 ointment base Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 2
- NMKVYLJBDOVKTM-UHFFFAOYSA-N 3-(2-hydroxyethyl)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-ol Chemical compound C1CC2(C)C(O)(CCO)CC1C2(C)C NMKVYLJBDOVKTM-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 210000003491 skin Anatomy 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000012467 final product Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 206010068172 Anal pruritus Diseases 0.000 description 5
- 208000009544 Pruritus Ani Diseases 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 208000016583 Anus disease Diseases 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- -1 polyoxyethylene Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- WITLAWYGGVAFLU-UHFFFAOYSA-N 3-(6-methoxy-1,3-benzodioxol-5-yl)-8,8-dimethylpyrano[2,3-f]chromen-4-one Chemical compound C1=CC(C)(C)OC2=CC=C(C(C(C3=CC=4OCOC=4C=C3OC)=CO3)=O)C3=C21 WITLAWYGGVAFLU-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 208000004680 Rectal Fistula Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 206010002156 anal fistula Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 235000020985 whole grains Nutrition 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 206010002153 Anal fissure Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000009531 Fissure in Ano Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 108010025252 Kassinin Proteins 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 244000173853 Sanguisorba officinalis Species 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003509 anti-fertility effect Effects 0.000 description 1
- 230000001572 anti-trichomonad Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 231100000749 chronicity Toxicity 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 108091008708 free nerve endings Proteins 0.000 description 1
- 230000001456 gonadotroph Effects 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000009251 neurologic dysfunction Effects 0.000 description 1
- 208000015015 neurological dysfunction Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical group [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to the field of Chinese medicines, and in particular to a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch, the compound Chinese medicinal preparation to be made up of the raw material of following weight portion：20 100 parts of kuh-seng, 10 65 parts of golden cypress, 10 65 parts of frutus cnidii, 10 65 parts of Chinese gall, 15 65 parts of garden burnet, 0.5 10 parts of borneol, it is raw material that the present invention uses pure plant, with reference to extraction process, active component in Chinese medicine is extracted, Modern preparations technology is recycled to be made particle lotion, ointment and aerosol, the itch that this pharmaceutical composition causes beneficial to treatment hemorrhoid and perianal eczema is unbearably, it is without any side effects without recurring, treatment no pain, medical expense is low, and does not influence outgoing work in therapeutic process.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of to treat hemorrhoid and perianal eczema causes the Chinese medicine compound prescription system of itch
Agent.
Background technology
Pruritus ani is a kind of neurological dysfunction dermatoses.Lesion is essentially confined to crissum, can occasionally spread to meeting
Cloudy anterior, crowd's incidence of disease is 5%, is more common in person between twenty and fifty, and the incidence of disease is also higher in the elderly crowd, typically without primary skin
Skin is damaged, and Secondary cases itch is easier to treatment, and primary itch is then more to be difficult to cure because reason is not clear, clinical easily recurrence.
The pathogenesis of current pruritus ani is not fully apparent from yet, and its pathogenic factors is main by the common of various stimulus
Caused by effect, especially excrement by the influence with diet, be also not excluded for certainly and local skin of anus
Disease, disease of anus, parasite and some systemic diseases are relevant.The symptom of this sick itch is mainly due to in epidermis and corium is shallow
The free nerve ending of layer is the gargalesthesia receiver for constituting, and local histamine, kassinin kinin and egg are caused after being stimulated by factors such as physics, chemistry
The release of the chemical mediators such as white catabolic enzyme, and act on nerve endings and cause.
There are traditional western medical treatment, traditional Chinese medical science interior oral administration, traditional Chinese medical science internal-external therapy, traditional Chinese and western medicine knot on pruritus ani treatment method
Conjunction and other treatment method etc., but the either inside and outside treatment of the traditional Chinese medical science or therapy of combing traditional Chinese and Western medicine at this stage, for clinically being permitted
More obstinate primary pruritus ani does not have preferable therapeutic effect yet.
Eczema is caused by various internal and external factors, in acute phase based on papulo-vesicle, in chronic phase with epidermis fertilizer
Pruritus dermatopathy based on thick and lichenification.Modern medicine thinks allergic constitution, external physics, chemical irritation and essence
Refreshing factor may be relevant with the generation of this disease.The traditional Chinese medical science thinks its etiology and pathogenesis always by insufficiency of natural endowment, and wind, wet, thermal resistance are in skin
It is caused.This disease has the incidence of disease high, big to patient effect, clinically there is polymorphy skin damaged, symmetrical, it is easy to ooze out, from
Feel that acute pruritus, recurrent exerbation and chronicity are characterized.
Chinese medicine external is the well-established law for treating eczema, i.e., the selection such as property, site of pathological change and season according to skin damaged is appropriate
Formulation and medicine, medication or soak or cleaning are embrocated or smoked and wash or soak or various method integrated uses, are promoted with dispeling disease and evil
Enter skin damaged recovery from illness.
Controlled outside eczema, there is Traditional Chinese Medicine formulation to enrich, and use the advantage such as flexible, safe and reliable, but each doctor
There is oneself treatment method, initiative prescription and method are numerous, and the report of clinical practice external therapy of Chinese herb eczema is a lot of, but how to select
Medicine, the transdermal study of drug dose, drug concentration, formulation and medicine also needs further effort.
The content of the invention
For problems of the prior art, present invention combination theory of traditional Chinese medical science, with reference on tradition and modernity preparation technique,
Hemorrhoid are treated there is provided a kind of and perianal eczema causes the compound Chinese medicinal preparation of itch.
To realize object above, the present invention is achieved by the following technical programs：
It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch, it is made up of the raw material of following weight portion：
Kuh-seng 20-100 parts, golden cypress 10-65 parts, frutus cnidii 10-65 parts, Chinese gall 10-65 parts, garden burnet 15-65 parts, borneol 0.5-10
Part.
Preferably, the compound Chinese medicinal preparation is made up of the raw material of following weight portion：Kuh-seng 20-60 parts, golden cypress 10-45
Part, frutus cnidii 10-45 parts, Chinese gall 10-45 parts, garden burnet 15-50 parts, borneol 0.5-10 parts.
Preferably, the raw material by following weight portion is made：27 parts of kuh-seng, 13.5 parts of golden cypress, 13.5 parts of frutus cnidii, five
13.5 parts of gall nut, 22.5 parts of garden burnet, 0.5 part of borneol.
Compound Chinese medicinal preparation of the invention is prepared as follows activity extract：By the raw medicinal material in addition to borneol by matching somebody with somebody
In side's mixing input extractor, add water or water and ethanol mixture as solvent, decoct 1 hour, collect filtrate, so repeatedly
3 times, merging filtrate, filtering obtains extract solution, and extract solution is thick for 1.15-1.30 in relative density is condensed at 70-80 DEG C
Cream, obtains activity extract.
Compound Chinese medicinal preparation of the present invention, activity extract can be with any one or more pharmaceutically acceptable load
The external preparation that body is mixed, including but not limited to particle lotion, ointment, aerosol.External preparation of the invention is preferred
Particle lotion.
The preparation method of particle lotion：Foregoing active extract is made particle according to conventional method, borneol is configured to ice
Piece ethanol solution, is sprayed onto in above-mentioned particle, and mixing is made granule.
The preparation method of aerosol：Foregoing active extract is spray-dried, then by the treatment of its nanosizing, is added
Borneol, supensoid agent and propellant, are fitted into spray bottle, obtain final product aerosol.
The preparation method of ointment：Foregoing active extract is added into ointment bases, borneol, mixing is made ointment.
Other raw medicinal materials are ground to form into impalpable powder by conventional method in addition to borneol, ointment bases, borneol is added, mixed
Ointment can also be made.
In the preparation process of ointment, it is also possible to add some additives such as anti-corrosion in the ointment bases for being added
Agent, penetrating agent, surfactant, the preferred DMSO of penetrating agent, azone, propane diols, glycerine, polyethylene glycol, surfactant are preferred
Nonionic surfactant such as fatty acid sorbitan, polysorbate, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether are prevented
Rotten agent such as ethyl-para-hydroxybenzoate.
Effect of each taste Chinese medicine selected by the present invention is as follows：
Kuh-seng：Bitter, cold in nature, liver；Kidney；Large intestine；Small intestinl channel；Bladder, the heart channel of Hang-Shaoyin；Bladder warp.Primary efficacy：Heat-clearing and damp-drying drug；
Wind dispelling insecticide.Main damp-heat dysentery；Hematochezia；Jaundice；Difficult urination；Oedema；Under band；Pruritus vulvae；Mange；Leprosy；Pruitus；
Wet poison sore.
Golden cypress：Golden cypress is conventional Chinese medicine, its cold in nature, bitter, the effects such as having heat-clearing and damp-drying drug, rush down scorching removing toxic substances, is usually used in damp and hot
The disease such as rush down dysentery, jaundice, leukorrhea and hot numbness, heat gonorrhea.Modern study shows that golden cypress has containing main components such as jamaicin, obakunones
Antibacterial, convergence, the effect of anti-inflammatory, to symptoms such as various skin wet poisons, sores, effect is good.
Frutus cnidii：Arduous, temperature, bitter is put down, and Xin Gan is nontoxic, slightly poisonous, and mildly bitter flavor gas is pungent, warm in nature.Indication：Warm kidney
It is supporing yang, wind-dispelling, eliminating dampness, desinsection.The pharmacological action related to attending effectiveness：Anti-trichomonal, gonadotropic Effect, relieving asthma, anti-inflammatory, resist
Arrhythmia cordis, suppresses cardiac enlargement blood vessel, and antibacterial is antipruritic, anti-mutagenesis, anticancer, and disease-resistant former emblem is biological.
Chinese gall：It is sour, cold in nature, arrest sweating, hemostasis, relieving diarrhea with astringents.In want composition containing a large amount of tannic acids, and resin, fat,
Starch.Pharmacological action：Astriction, antibacterial.
Garden burnet：Picric acid, trembles with fear, return through：Enter liver, large intestine channel.Function is cured mainly：Blood in cool blood is clearing heat and detoxicating.Control haematemesis, bleeding from five sense organs or subcutaneous tissue,
Bloody flux, uterine bleeding, intestines wind, anal fistula, carbuncle swells, eczema, metal-inflicted wound, burn.
Borneol：Effect of borneol：For closing card coma, for red eye, swell pain, larynx numbness aphtha.For sore swell and ache curative, after bursting
Do not hold back.Main Function：The effect of Central nervous system, antiinflammatory action, antibacterial action, antifertility action, with other drugs
Interact, other effects.
The beneficial effects of the invention are as follows：
It is raw material that the present invention uses pure plant, with reference to extraction process, the active component in Chinese medicine is extracted, then
Using Modern preparations technology, and particle lotion, ointment and the aerosol being made, this pharmaceutical composition beneficial to treatment hemorrhoid and
Eczema and the itch that causes are unbearably, without any side effects without recurring, and treat no pain, and medical expense is low, and in therapeutic process not
The outgoing work of influence.
Specific embodiment
Technical solution of the invention is further illustrated with reference to specific embodiment, embodiment is not to be construed as right
The limitation of technical solution.
Embodiment 1：Particle lotion
Chinese medicine preparation：27 parts of kuh-seng, 13.5 parts of golden cypress, 13.5 parts of frutus cnidii, 13.5 parts of Chinese gall, 22.5 parts of garden burnet, ice
0.5 part of piece.
Preparation method：In addition to borneol, by the medicinal material input extractor of above-mentioned formula ratio, add water to cook 1 hour, collect filter
Liquid, 3 times repeatedly, adds water 10 times and measures every time, merging filtrate, filtering, discards residue, extract solution is obtained, by extract solution in dense at 70 DEG C
The thick paste that relative density is 1.20 is reduced to, appropriate starch is added, is well mixed, wet granular is prepared with 20 mesh sieves, 50-70 DEG C is done
It is dry, moisture control to 1.0-2.5%, whole grain, then the borneol of recipe quantity is dissolved in absolute ethyl alcohol, concentrated solution is configured to, spray
To in the particle of above-mentioned preparation, particle lotion is obtained final product.
Embodiment 2：Ointment
Chinese medicine preparation：100 parts of kuh-seng, 10 parts of golden cypress, 65 parts of frutus cnidii, 65 parts of Chinese gall, 15 parts of garden burnet, 10 parts of borneol.
Preparation method：In addition to borneol, by the medicinal material input extractor of above-mentioned formula ratio, add water to cook 1 hour, collect filter
Liquid, 3 times repeatedly, adds water 10 times and measures every time, merging filtrate, filtering, discards residue, extract solution is obtained, by extract solution in dense at 75 DEG C
The thick paste that relative density is 1.15 is reduced to, by spray drying, dry powder is obtained, dry cream is then ground into 150 mesh above fine powders, plus
Enter 1 times of vaseline or lanolin or vaseline and each half of lanolin, and add the borneol of recipe quantity, grind together be mixed it is even,
Obtain final product ointment.
Embodiment 3：Ointment
Chinese medicine preparation：60 parts of kuh-seng, 35 parts of golden cypress, 45 parts of frutus cnidii, 28 parts of Chinese gall, 50 parts of garden burnet, 8 parts of borneol.
Preparation method：In addition to borneol, by the medicinal material input extractor of above-mentioned formula ratio, add water to cook 1 hour, collect filter
Liquid, 3 times repeatedly, adds water 10 times and measures every time, merging filtrate, filtering, discards residue, extract solution is obtained, by extract solution in dense at 80 DEG C
The thick paste that relative density is 1.30 is reduced to, the glycerine of recipe quantity is added, is well mixed, and be incubated standby at 80 DEG C；Separately take tristearin
Acid, hexadecanol, glycerin monostearate, atoleine are heated to 80-85 DEG C, make fusing, and are well mixed, and then delay oil phase
Slowly it is added in water phase, emulsifies 5-6min, take out cooling, and add borneol, stir evenly, obtains final product ointment.
Embodiment 4：Aerosol
Chinese medicine preparation：20 parts of kuh-seng, 65 parts of golden cypress, 10 parts of frutus cnidii, 10 parts of Chinese gall, 65 parts of garden burnet, 0.5 part of borneol.
Preparation method：In addition to borneol, by the medicinal material input extractor of above-mentioned formula ratio, add water to cook 1 hour, collect filter
Liquid, 3 times repeatedly, adds water 10 times and measures every time, merging filtrate, filtering, discards residue, extract solution is obtained, by extract solution in dense at 70 DEG C
The thick paste that relative density is 1.20 is reduced to, is spray-dried, then carry out nanosizing treatment, add borneol, supensoid agent and propellant,
It is fitted into spray bottle, obtains final product aerosol.
Embodiment 5：Particle lotion
Chinese medicine preparation：40 parts of kuh-seng, 45 parts of golden cypress, 25 parts of frutus cnidii, 45 parts of Chinese gall, 32 parts of garden burnet, 5 parts of borneol.
Preparation method：In addition to borneol, by the medicinal material input extractor of above-mentioned formula ratio, add water to cook 1 hour, collect filter
Liquid, 3 times repeatedly, adds water 10 times and measures every time, merging filtrate, filtering, discards residue, extract solution is obtained, by extract solution in dense at 80 DEG C
The thick paste that relative density is 1.30 is reduced to, appropriate starch is added, is well mixed, wet granular is prepared with 20 mesh sieves, 50-70 DEG C is done
It is dry, moisture control to 1.0-2.5%, whole grain, then the borneol of recipe quantity is dissolved in absolute ethyl alcohol, concentrated solution is configured to, spray
To in the particle of above-mentioned preparation, particle lotion is obtained final product.
Clinical data
1st, general data
For the pruritus that compound Chinese medicinal preparation prepared by the checking embodiment of the present invention causes to treatment hemorrhoid and perianal eczema
Therapeutic effect, random selection patient 104 carry out clinical observation.It is wherein male 59, female 45.
2nd, case selection
Test group：52, man 32, female 20；Age 20-28 Sui 10,30-52 Sui 42, the course of disease -3 years 3 months.
Slight itch 22, moderate itch 25；Idiopathic itch 5.
Control group：52, man 27, female 25；Age 19-28 Sui 12,30-50 Sui 40, the course of disease -3 years 3 months,
Slight itch 21, moderate itch 24；Idiopathic itch 7.
Two groups in terms of sex, age and characteristic of disease, the course of disease through statistical analysis there are no significant difference (P>0.05), have
Comparativity.
3rd, treatment method
Test group：The lotion that patient is prepared with the embodiment of the present invention 1 daily adds alkali hip bath, sooner or later each 1 time.First smoke and wash recoil
Bath about 20min, 7 days is 1 course for the treatment of.
Control group：Using calamine lotion part washout, each 20min is daily sooner or later each 1 time.It is within 7 days 1 course for the treatment of.
Two groups with treat 7 days be a course for the treatment of, statistics after 2 courses for the treatment of.
4th, efficacy assessment standard
Cure：Symptom disappears, and skin recovers normal, and follow-up half a year is without recurrence；
It is effective：Itch substantially mitigates, and skin damaged is clearly better；
Take a turn for the better：Itch mitigates, and can control not scratch, and occasionally still needs to medication antipruritic；
It is invalid：Itch and skin damaged are without recurrence after change, or drug withdrawal.
5th, treatment results
After by clinical observation, 1 is the results are shown in Table.
The clinical treatment outcome of table 1
| Group | Case load | Cure | It is effective | Take a turn for the better | It is invalid | Total effective rate (%) |
| Treatment group | 52 | 30 | 12 | 9 | 1 | 98.1 |
| Control group | 52 | 16 | 18 | 15 | 3 | 94.2 |
6th, discuss
As can be seen from the above table, treatment group's total effectses are higher than control group, illustrate the lotion of present invention preparation to treatment hemorrhoid
Or the pruritus that perianal eczema causes has definite curative effect.
7th, model case
Case 1
Zhang, man, 40 years old.Patient's podex itch recurrent exerbation half a year, nearly 1 week itch is continuous unbearably day and night to have hair,
Night especially, during breaking-out very itches hard to bear.Once the medicine such as used Cremor Mentholi Compositus, carbamide ointment, Chinese medicine was for oral administration applies outward, effect on driving birds is not good.Inspection
Look into：The coarse plumpness of anal skin, dipping is in canescence, and poor flexibility has radial chap line, and skin damaged boundary line is unclear, non-pigment
Calmness, non-wind has the pathological change of anorectal such as hemorrhoid, anal fissure, anal fistula, and it is primary pruritus ani to examine.
Treatment：Alkali is added to be washed from bath is smoked using the particle lotion of the embodiment of the present invention 1.Symptom substantially mitigates after 1 course for the treatment of, 2
Symptom is wholly absent after the course for the treatment of, follow-up half a year, no relapse.
Case 2
Wang, man, 38 years old.5 days causes of patient's readme are drunk, whole body itch and a small amount of measles after a few hours, especially with anus
All itch are for very.Check：Whole body has a small amount of fash, and crissum has scratch and skin damaged, crissum humidity and fash.Chinese medical discrimination：It is damp and hot
Heresy stop up knot skin, strongly fragrant long and infested, worm-eaten causes to itch in crissum.Control with heat-clearing and damp-drying drug, desinsection is antipruritic.
Treatment：Bathe to smoke using the particle lotion of the embodiment of the present invention 1 and wash crissum, each 10-15min, 2 doses/day.Treatment 1
After the course for the treatment of, the recovery from illness of perianal pruritus disease.Symptom is wholly absent after 2 courses for the treatment of, follow-up half a year, no relapse.
Claims (8)
1. it is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch, it is characterised in that by following weight portion
Raw material is made：Kuh-seng 20-100 parts, golden cypress 10-65 parts, frutus cnidii 10-65 parts, Chinese gall 10-65 parts, garden burnet 15-65 parts, ice
Piece 0.5-10 parts.
2. compound Chinese medicinal preparation according to claim 1, it is characterised in that be made up of the raw material of following weight portion：Kuh-seng
20-60 parts, golden cypress 10-45 parts, frutus cnidii 10-45 parts, Chinese gall 10-45 parts, garden burnet 15-50 parts, borneol 0.5-10 parts.
3. compound Chinese medicinal preparation according to claim 2, it is characterised in that be made up of the raw material of following weight portion：Kuh-seng
27 parts, 13.5 parts of golden cypress, 13.5 parts of frutus cnidii, 13.5 parts of Chinese gall, 22.5 parts of garden burnet, 0.5 part of borneol.
4. the compound Chinese medicinal preparation according to claim any one of 1-3, it is characterised in that the compound Chinese medicinal preparation press with
Lower section method prepares activity extract：By the raw medicinal material in addition to borneol by formula mixing input extractor, add water or water and second
The mixture of alcohol is decocted 1 hour as solvent, collects filtrate, and so repeatedly 3 times, merging filtrate, filtering obtains extract solution, will carry
Liquid is taken in the thick paste that relative density is 1.15-1.30 is condensed at 70-80 DEG C, activity extract is obtained.
5. compound Chinese medicinal preparation according to claim 4, it is characterised in that：The activity extract is made according to conventional method
Particle, borneol ethanol solution is configured to by borneol, is sprayed onto in above-mentioned particle, and mixing is made particle lotion.
6. compound Chinese medicinal preparation according to claim 4, it is characterised in that：Ointment base is added in the activity extract
Matter, borneol, mix according to conventional method and are made ointment.
7. compound Chinese medicinal preparation according to claim 4, it is characterised in that：Borneol is added in the activity extract, according to
Conventional method is made aerosol.
8. the compound Chinese medicinal preparation according to claim any one of 1-3 causes itch in preparation treatment hemorrhoid and perianal eczema
Medicine in application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611247178.1A CN106728236A (en) | 2016-12-29 | 2016-12-29 | It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611247178.1A CN106728236A (en) | 2016-12-29 | 2016-12-29 | It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106728236A true CN106728236A (en) | 2017-05-31 |
Family
ID=58929241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611247178.1A Pending CN106728236A (en) | 2016-12-29 | 2016-12-29 | It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106728236A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200328A (en) * | 2018-09-15 | 2019-01-15 | 高军起 | A kind of panty liner of external application safe treatment anal disease |
| CN114558067A (en) * | 2022-03-24 | 2022-05-31 | 杨坤英 | Gynecological hemostatic tissue regeneration promoting powder and application |
-
2016
- 2016-12-29 CN CN201611247178.1A patent/CN106728236A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 徐斌晖等: "痔洗消灵在肛肠术后的应用", 《人民军医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200328A (en) * | 2018-09-15 | 2019-01-15 | 高军起 | A kind of panty liner of external application safe treatment anal disease |
| CN114558067A (en) * | 2022-03-24 | 2022-05-31 | 杨坤英 | Gynecological hemostatic tissue regeneration promoting powder and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100404054C (en) | Decoction Chinese medicine sterilizing antiphlogistic, preparation and use thereof | |
| CN108514572A (en) | Chinese medicine composition, extract and preparation a kind of anti-inflammatory and that repair skin barrier | |
| CN103751663A (en) | Traditional Chinese medicine externally applied preparation for treating perianal eczema and preparation method thereof | |
| CN110292602A (en) | Yellow burn oil formula of a kind of compound five and preparation method thereof | |
| CN108938800A (en) | It is a kind of to treat skin disease painting liquid film | |
| KR101662222B1 (en) | A composition comprising medical herbs for improving respiratory diseases | |
| CN101292997A (en) | Pharmaceutical composition for treating empyrosis or gastric ulcer, and preparation method thereof | |
| CN106728236A (en) | It is a kind of to treat hemorrhoid and perianal eczema causes the compound Chinese medicinal preparation of itch | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN104771515B (en) | A kind of Wash-out medicine and preparation method thereof for treating eczema | |
| CN103721139A (en) | Traditional Chinese medicinal composition for treating balanitis and preparation method thereof | |
| CN106806758A (en) | A kind of Chinese medicine preparation for treating acne | |
| JP6590233B1 (en) | Skin disease therapeutic agent and method for producing the same | |
| CA2875908C (en) | Extracts from mother-of-thyme and the use thereof | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN110179941A (en) | A kind of Chinese medicine composition that treating eczema and its application | |
| CN106729087A (en) | A kind of Chinese medicine compound prescription external preparation for treating pruritus ani | |
| CN106963912B (en) | Dalbergia wood compound composition for treating eczema and preparation method thereof | |
| CN108853249A (en) | It is a kind of to treat dermopathic plastics | |
| CN110721274B (en) | External antipruritic and preparation method thereof | |
| KR100712659B1 (en) | Herbal composition for treatment and prevention of diabetes and diabetic complications | |
| CN103860977B (en) | A kind of pharmaceutical composition for the treatment of dermatitis | |
| CN106074994B (en) | A kind of external drug for treating psoriasis | |
| CN104971271A (en) | Medicine for treating benign prostatic hyperplasia due to damp-retained heat and preparation method thereof | |
| KR100561271B1 (en) | High consistency herb medicine extracted liquid of Artimisiawormwoodand its processed spray/aerosol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
|
| RJ01 | Rejection of invention patent application after publication |