CN106727972A - A kind of newborn piglet externally used antimicrobial drier, preparation method and applications - Google Patents
A kind of newborn piglet externally used antimicrobial drier, preparation method and applications Download PDFInfo
- Publication number
- CN106727972A CN106727972A CN201611237655.6A CN201611237655A CN106727972A CN 106727972 A CN106727972 A CN 106727972A CN 201611237655 A CN201611237655 A CN 201611237655A CN 106727972 A CN106727972 A CN 106727972A
- Authority
- CN
- China
- Prior art keywords
- drier
- piglet
- externally used
- newborn piglet
- used antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of newborn piglet externally used antimicrobial drier, preparation method and applications, described antibacterial drier includes the composition of following percentage by weight：Montmorillonite 35 45%, talcum powder 25 30%, zinc oxide 20 22%, boric acid 2 4%, borneol 1 2%, frutus cnidii 1 2%, the fruit of summer cypress 0.5 1.5%, cicada slough 0.5 1.5%, folium artemisiae argyi 2 4%, eucalyptus oil 0.5 1.5%.The present invention prevents body heat to scatter and disappear according to the proportioning and the product of processing method acquisition with quick adsorption newborn piglet body surface amniotic fluid, promotes the Wound healing of docking and disconnected navel and prevents the effect for infecting, and improves the survival rate and production performance of piglet.Antibacterial drier antibiotic-free of the invention and harmful chemical substance, drug residue free, have no toxic side effect, easy to use, safe and reliable.
Description
Technical field
The present invention relates to a kind of newborn piglet external use health agent, a kind of more particularly to green harmless type newborn piglet external application resists
Bacterium drier, preparation method and applications.
Background technology
Newborn piglet nursing is the important technical operation in large-scale pig farm delivery room.But due to newborn piglet itself body heat regulation
Ability is weak, blood sugar deposit less, the factor such as delivery room temperature is low, eat colostrum not in time, body surface amniotic fluid evaporation consumption body heat so that it is nascent
Piglet hypoglycemia turns into the key factor of influence piglet survival ratio.Additionally, newborn piglet is vulnerable, delivery room cause of disease is complicated,
Deliver a child piglet when disconnected navel, cut tail and cut the operation such as tooth and easily cause infected wound, induce dermatitis, streptococcal infection etc., cause son
Pig is dead, therefore, a kind of green, harmless quick absorption newborn piglet body surface moisture is developed, prevent the body surface antibacterial of infected wound
Drier, is the key for improving newborn piglet survival rate and individual health.
The content of the invention
In order to solve the above problems, dried it is an object of the invention to provide the green harmless type newborn piglet externally used antimicrobial of one kind
Agent, preparation method and applications.
To achieve these goals, the technical solution adopted in the present invention is：
A kind of newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite 35-45%, cunning
Stone flour 25-30%, zinc oxide 20-22%, boric acid 2-4%, borneol 1-2%, frutus cnidii 1-2%, fruit of summer cypress 0.5-1.5%, cicada
Slough off 0.5-1.5%, folium artemisiae argyi 2-4%, eucalyptus oil 0.5-1.5%.
Preferably, described newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite
40%th, talcum powder 27%, zinc oxide 21%, boric acid 3%, borneol 1.5%, frutus cnidii 1.5%, the fruit of summer cypress 1%, cicada slough 1%, Chinese mugwort
Leaf 3%, eucalyptus oil 1%.
Described montmorillonite active ingredient actual content>95%, its 10% pH value of water solution is 4.5-8.5.
Described zinc oxide active ingredient actual content>95%.
A kind of preparation method of described newborn piglet externally used antimicrobial drier, comprises the following steps：
(1) zinc oxide, boric acid and borneol were crushed to 80 mesh sieves, mixing for standby use respectively；
(2) frutus cnidii, the fruit of summer cypress, cicada slough and folium artemisiae argyi were crushed to 80 mesh sieves, mixing for standby use respectively；
(3) it is the compound and talcum powder of step (1) is well mixed, eucalyptus oil is added, it is well mixed；
(4) it is the compound and montmorillonite of step (2) is well mixed, the compound of step (3) is added, it is well mixed,
Obtain final product.
The particle diameter of described talcum powder is below 100 mesh.
Described montmorillonite is powdered, and particle diameter is below 100 mesh.
A kind of application of described antibacterial drier, piglet is practiced midwifery after the completion of operation, 60-80g antibacterials drier is smeared
The wound of body surface of piglet, the piglet umbilical cord wound sterilized and tail end, is put into incubator.
Beneficial effects of the present invention：
Antibacterial drier of the invention is by montmorillonite, talcum powder, zinc oxide, boric acid, borneol, frutus cnidii, the fruit of summer cypress, cicada
Slough off, folium artemisiae argyi and eucalyptus oil are combined, formula is reasonable, effect is complementary.Wherein, montmorillonite, talcum powder have good hygroscopicity；Oxygen
Changing zinc, boric acid and borneol has the effect of good convergence, anti-inflammation；Cnidium Monnieri, the fruit of summer cypress, cicada slough, folium artemisiae argyi and eucalyptus
Leaf oil has functions that clearing heat and detoxicating, analgesic is sterilized.The product that above-mentioned raw materials are obtained by proportioning of the present invention and processing method,
Prevent body heat to scatter and disappear with quick adsorption newborn piglet body surface amniotic fluid, promote the Wound healing of docking and disconnected navel and prevent infection
Effect, improves the survival rate and production performance of piglet.Antibacterial drier antibiotic-free of the invention and harmful chemical substance,
Drug residue free, has no toxic side effect, easy to use, safe and reliable.
Specific embodiment
Specific embodiment of the invention is described in further detail with reference to embodiments.
Montmorillonite active ingredient actual content of the invention>95%, its 10% pH value of water solution is 4.5-8.5.
Zinc oxide active ingredient actual content of the invention>95%.
Embodiment 1
A kind of newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite 40%, talcum powder
27%th, zinc oxide 21%, boric acid 3%, borneol 1.5%, frutus cnidii 1.5%, the fruit of summer cypress 1%, cicada slough 1%, folium artemisiae argyi 3%, folium eucalypti
Oil 1%.
The preparation method of described newborn piglet externally used antimicrobial drier, comprises the following steps：
(1) zinc oxide, boric acid and borneol were crushed to 80 mesh sieves, mixing for standby use respectively；
(2) frutus cnidii, the fruit of summer cypress, cicada slough and folium artemisiae argyi were crushed to 80 mesh sieves, mixing for standby use respectively；
(3) it is the compound and talcum powder of step (1) is well mixed, eucalyptus oil is added, it is well mixed；
(4) it is the compound and montmorillonite of step (2) is well mixed, the compound of step (3) is added, it is well mixed,
Obtain final product.
The particle diameter of described talcum powder is below 100 mesh.
Described montmorillonite is powdered, and particle diameter is below 100 mesh.
Embodiment 2
A kind of newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite 35%, talcum powder
34%th, zinc oxide 20%, boric acid 4%, borneol 1%, frutus cnidii 1%, the fruit of summer cypress 0.5%, cicada slough 1.5%, folium artemisiae argyi 2%, folium eucalypti
Oil 1%.
The preparation method of described newborn piglet externally used antimicrobial drier is with embodiment 1.
Embodiment 3
A kind of newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite 45%, talcum powder
25%th, zinc oxide 20%, boric acid 2%, borneol 1%, frutus cnidii 1%, the fruit of summer cypress 1%, cicada slough 0.5%, folium artemisiae argyi 4%, eucalyptus oil
0.5%.
The preparation method of described newborn piglet externally used antimicrobial drier is with embodiment 1.
Embodiment 4
A kind of newborn piglet externally used antimicrobial drier, including following percentage by weight composition：Montmorillonite 35%, talcum powder
30%th, zinc oxide 22%, boric acid 3%, borneol 2%, frutus cnidii 2%, the fruit of summer cypress 1.5%, cicada slough 1%, folium artemisiae argyi 2%, eucalyptus oil
1.5%.
The preparation method of described newborn piglet externally used antimicrobial drier is with embodiment 1.
Using effect of the invention
Experiment one：Certain pig farm, the numerous sow 3500 of energy, delivers market pig 55000 or so year for sale.Choose adjacent 2 units
Parturient sow in delivery room is experiment colony, and milking sow 28 is raised per unit, and sow is transferred to delivery room on the 107th day in gestation,
When piglet is born, operation of practicing midwifery is：
Unit 1：Every piglet is practiced midwifery after end of operation, and 80g newborn piglet body surface antibacterial drier of the present invention is used in 10min
(embodiment 1) smears the wound of body surface, the umbilical cord sterilized and tail end, and then at once light and slow hand removes body surface and inhaled
Enter the drier of moisture, place into incubator.
Unit 2：Every piglet is practiced midwifery after end of operation, and with sterilization towel body surface of piglet, (scale pig farm is normal in 10min
With method 1), it is put into incubator.
Index determining：Compared with sterilization towel body surface of piglet (scale pig farm common method 1), after piglet birth
Complete to cut tooth, docking, disconnected navel in 10min, and smear antibacterial drier of the present invention, piglet omphalitis rate reduction by 75%, weaned piglet
When the death rate reduction by 3.4%, 21 age in days weaning weights improve 0.2kg, in nursing period diarrhea rate reduction by 12%, skin disease incidence subtracts
Few 32%.
Experiment two：Certain pig farm, the numerous sow 800 of energy, delivers market pig 12000 or so year for sale.Adjacent 2 units are chosen to produce
Parturient sow in room is experiment colony, and milking sow 24 is raised per unit, and sow is transferred to delivery room on the 107th day in gestation, young
When pig is born, operation of practicing midwifery is：
Unit 1：Every piglet is practiced midwifery after end of operation, in 10min, is dried with 80g newborn piglet body surface antibacterials of the present invention
The wound of body surface, the umbilical cord sterilized and tail end is smeared in agent (embodiment 1), and then at once light and slow hand has removed body surface
The drier of moisture is sucked, incubator is placed into.
Unit 2：Every piglet is practiced midwifery after end of operation, smears young with enough wheat brans dry after being exposed to the sun in 10min
Pig body surface (scale pig farm common method 2), it is then at once light and slow with hand removing body surface wheat bran, place into incubator.
Index determining：Body surface of piglet (scale pig farm common method 2) is smeared with dry wheat bran to compare, after piglet birth
Complete to cut tooth, docking, disconnected navel in 10min, and smear antibacterial drier of the present invention, piglet omphalitis rate reduction by 85%, weaned piglet
When the death rate reduction by 3.1%, 21 age in days weaning weights improve 0.15kg, in nursing period diarrhea rate reduction by 8.5%, skin disease incidence
Reduce 25%.
Claims (8)
1. a kind of newborn piglet externally used antimicrobial drier, it is characterised in that the composition including following percentage by weight：Montmorillonite
35-45%, talcum powder 25-30%, zinc oxide 20-22%, boric acid 2-4%, borneol 1-2%, frutus cnidii 1-2%, the fruit of summer cypress
0.5-1.5%, cicada slough 0.5-1.5%, folium artemisiae argyi 2-4%, eucalyptus oil 0.5-1.5%.
2. newborn piglet externally used antimicrobial drier according to claim 1, it is characterised in that including following percentage by weight
Composition：Montmorillonite 40%, talcum powder 27%, zinc oxide 21%, boric acid 3%, borneol 1.5%, the frutus cnidii 1.5%, fruit of summer cypress
1%th, cicada slough 1%, folium artemisiae argyi 3%, eucalyptus oil 1%.
3. the newborn piglet externally used antimicrobial drier according to claim any one of 1-2, it is characterised in that described illiteracy takes off
Stone active ingredient actual content>95%, its 10% pH value of water solution is 4.5-8.5.
4. the newborn piglet externally used antimicrobial drier according to claim any one of 1-2, it is characterised in that described oxidation
Zinc active ingredient actual content>95%.
5. a kind of preparation method of newborn piglet externally used antimicrobial drier as claimed in claim 3, it is characterised in that including with
Lower step：
(1) zinc oxide, boric acid and borneol were crushed to 80 mesh sieves, mixing for standby use respectively；
(2) frutus cnidii, the fruit of summer cypress, cicada slough and folium artemisiae argyi were crushed to 80 mesh sieves, mixing for standby use respectively；
(3) it is the compound and talcum powder of step (1) is well mixed, eucalyptus oil is added, it is well mixed；
(4) it is the compound and montmorillonite of step (2) is well mixed, the compound of step (3) is added, it is well mixed, obtain final product.
6. the preparation method of newborn piglet externally used antimicrobial drier according to claim 5, it is characterised in that described cunning
The particle diameter of stone flour is below 100 mesh.
7. the preparation method of newborn piglet externally used antimicrobial drier according to claim 5, it is characterised in that described illiteracy
De- stone is powdered, and particle diameter is below 100 mesh.
8. the application of a kind of antibacterial drier as described in claim any one of 1-2, it is characterised in that piglet is practiced midwifery and operated
Cheng Hou, the piglet umbilical cord wound and the wound of tail end for 60-80g antibacterials drier is smeared into body surface of piglet, having sterilized, is put into
Incubator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611237655.6A CN106727972A (en) | 2016-12-28 | 2016-12-28 | A kind of newborn piglet externally used antimicrobial drier, preparation method and applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611237655.6A CN106727972A (en) | 2016-12-28 | 2016-12-28 | A kind of newborn piglet externally used antimicrobial drier, preparation method and applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727972A true CN106727972A (en) | 2017-05-31 |
Family
ID=58925010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611237655.6A Pending CN106727972A (en) | 2016-12-28 | 2016-12-28 | A kind of newborn piglet externally used antimicrobial drier, preparation method and applications |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106727972A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044866A (en) * | 2018-09-28 | 2018-12-21 | 佛山市正典生物技术有限公司 | One boar talcum powder and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102423692A (en) * | 2011-11-07 | 2012-04-25 | 齐鲁动物保健品有限公司 | Piglet and calf amniotic fluid adsorbent and preparation method thereof |
| CN103054734A (en) * | 2012-12-14 | 2013-04-24 | 漳州傲农牧业科技有限公司 | Porcine body powder and preparation method thereof |
-
2016
- 2016-12-28 CN CN201611237655.6A patent/CN106727972A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102423692A (en) * | 2011-11-07 | 2012-04-25 | 齐鲁动物保健品有限公司 | Piglet and calf amniotic fluid adsorbent and preparation method thereof |
| CN103054734A (en) * | 2012-12-14 | 2013-04-24 | 漳州傲农牧业科技有限公司 | Porcine body powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 尚恩锰: "新生仔猪皮肤病的中西药疗法", 《中兽医医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044866A (en) * | 2018-09-28 | 2018-12-21 | 佛山市正典生物技术有限公司 | One boar talcum powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101703072A (en) | Environment modifier for disinfection with dry powder | |
| CN103054734B (en) | The refreshing body agent and preparation method thereof of one boar | |
| CN102727751B (en) | Swine mineral powder for external use and preparation method thereof | |
| CN108553355A (en) | A kind of compound houttuynin oral bacteriostasis fresh and cool spray and preparation method thereof | |
| CN104095999A (en) | Ozonized borneol tea oil | |
| CN106265276A (en) | One boar talcum powder and preparation method thereof | |
| CN100588455C (en) | Drying agent for absorbing ammonia | |
| CN101543658B (en) | Cervical cap for preventing and treating cervical erosion and preparation method thereof | |
| CN111109304B (en) | Disinfectant composition for improving pig immunity and antiviral ability and application method thereof | |
| CN108013073A (en) | A kind of hog house disinfectant | |
| CN113273646B (en) | Powder for sow parturition and inoculation as well as preparation method and application thereof | |
| CN106727972A (en) | A kind of newborn piglet externally used antimicrobial drier, preparation method and applications | |
| CN102973690A (en) | Chinese herbal medicine preparation for treating pig gastroenteritis | |
| CN103417746A (en) | Chinese-western compound pharmaceutical composition for treatment of bacterial gill-rot disease in Macrobrachium nipponense | |
| CN102614294A (en) | Compound amoxicillin suspension injection and preparation method thereof | |
| CN112586441A (en) | African swine fever prevention and control method and application thereof | |
| CN101390965A (en) | Veterinary traditional Chinese herb medicine for treating livestock and poultry bacterial and viral infectious diseases and preparation method thereof | |
| CN102846893B (en) | Chinese medicine composition for expelling parasite in animal and preparation method thereof | |
| CN101732289B (en) | External tincture for treating rabbit sarcoptidosis | |
| CN111956510B (en) | Talcum powder for animals and preparation method thereof | |
| CN115777725B (en) | Nano silver disinfectant and preparation method thereof | |
| CN105053655B (en) | It is a kind of that a kind feed for duck brood time survival rate can be improved | |
| CN102698302B (en) | Dedicated vegetal air disinfectant for medical institution | |
| CN101406660A (en) | Medicament for improving organism immunity of aquatic livestock | |
| CN102397330B (en) | Compound oil-in-water schizonepeta spike oil nanoemulsion composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
|
| RJ01 | Rejection of invention patent application after publication |