CN106727884A - Purposes of the Yupingfeng San in anti-aging or senile dementia disease drug is prepared - Google Patents
Purposes of the Yupingfeng San in anti-aging or senile dementia disease drug is prepared Download PDFInfo
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- CN106727884A CN106727884A CN201611203552.8A CN201611203552A CN106727884A CN 106727884 A CN106727884 A CN 106727884A CN 201611203552 A CN201611203552 A CN 201611203552A CN 106727884 A CN106727884 A CN 106727884A
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- yupingfeng san
- aging
- senile dementia
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- yupingfeng
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
Abstract
The present invention relates to application in TCM technical field, and in particular to purposes of the Yupingfeng San in anti-aging or senile dementia disease drug is prepared；Yupingfeng San of the present invention is the classics recipe for consolidating, experiments verify that, Yupingfeng San has growth promoting function to senescent fibroblast, there is good activation to Telomerase, there is obvious extension to act on to life span of drosophila melanogaster, the level of CAT and SOD in fruit bat body can be improved, the content of the catabolite MDA of MDA is reduced；Yupingfeng San is traditional Chinese medicine, is recorded with long-term Clinical practice, and safely and effectively, obvious side effect does not occur in long-term use, can be used for preparing anti-aging and anti-senile dementia disease drug.
Description
Technical field
The present invention relates to application in TCM technical field, and in particular to Yupingfeng San is preparing anti-aging or senile dementia
Purposes in medicine.
Background technology
Aging is the inexorable law during human life, and the number of the neuron of brain can be caused to gradually decrease, or even
Produce the nerve degenerative diseases closely related with aging such as senile dementia.Aging is probably the nerveous systems such as senile dementia
The initial stage stage of system degenerative change.Aging is the functional deterioration of whole body, many aspects, this just with the effect of traditional Chinese medicine
Feature is mutually agreed with, and deeply excavates traditional traditional tonic medicine, and traditional anti-aging is theoretical with the organic knot of modern medicine and pharmacology means of testing
Close, it will help find preferable anti-ageing out-of-date methods（In Song dynasty's spring, wait the progress China of agings and antiaging agent raw
Chemical drug thing magazine, 2015,35 (1): 163-170）.
Senile dementia system betides a kind of chronic progressive mental deterioration disease of senescence phase or presenium, disease
It is that pathogenesis is complicated based on the atrophy of brain and denaturation that reason changes, and pathogenic process is related to link more.The eighties in 20th century
Started the research of traditional Chinese medicine prevention senile dementia, obtained remarkable progress, senile dementia cause of disease pathology has been reached compared with
It is consistent viewpoint：In brain, characteristic of disease belongs to asthenia in origin and asthenia in superficiality for dementia position.The traditional Chinese medical science thinks that the senile dementia cause of disease is renal failure with age,
The five internal organs laboured breathing loses to marrow eventually, and marrow loses consumption and kidney essense, and then " kidney deficiency marrow loses " falls ill.Kidney deficiency water without leading, spleen insufficiency water
Wet, wet consor phlegm, phlegm is disturbed clear spirit and then covers slow-witted blunt dusk.Therefore, the Chinese medicine of kidney tonifying, essence replenishing benefit marrow effect can be with postpone aging and prolong life；By the stasis of blood
Phlegm, promotion of blood circulation abolishes phlegm and blood stasis with the method for eliminating evil, is able to clear key and calms the nerves（Su Rui, waits the traditional Chinese medical science to the senile dementia cause of disease
The interpretation of the cause, onset and process of an illness and treatment by Chinese herbs research China traditional Chinese medicine magazine, 2011,26 (9): 1917-1920.）.
The classics recipe that the Yupingfeng San system traditional Chinese medical science is strengthened the body resistance to consolidate the constitution, firstly appears in the Yuan Dynasty, though the taste of medicine three, right medicine letter effect is grand, and collection is controlled
Treat and praised highly with prevention and one, extremely successive dynasties medicine scholar.Yupingfeng San has QI invigorating, Gu the effect of table, hidroschesis, for exterior deficiency
Not solid, spontaneous perspiration foul wind, complexion white, or physically weak susceptible ailment said due to cold or exposure person can also be used to prevent and treat allergic rhinitis, the infection of the upper respiratory tract
Etc. disease, clinical efficacy is notable（Chinese Pharmacopoeia（Version in 2015, one）, 2015：743-746）.The Radix Astragali has tonifying Qi and lifting yang, raw
The effect of Tianjin blood-nourishing；Bighead atractylodes rhizome strengthening the spleen and replenishing qi.Windproof expelling wind and clearing away cold, strengthens the penetration of prescription, with the jade screen that this three tastes medicine is constituted
Wind dissipates the effect of having air making-up and spleen enlivening.For the disease sheet that the kidney deficiency marrow of senile dementia loses, Yupingfeng San can be special by tonifying Qi
It is to supplement the vigour of human body and act the physiological activity for exciting whole body zang-fu differentiation body official's key；The spleen has the function to transport and transform nutrients essence of water and grain, in kidney
Vital essence depend on essence of water and grain and constantly supplement nutrition, and marrow, by kidney essense institute metaplasia, transporting and transforming nutrients from foodstuff is precise and tiny by invigorating the spleen for jade screen wind energy,
The vital essence allowed in kidney fills Sheng, and brains are also supplemented nutrition.Yupingfeng can lose to play and control in terms of material with function two to kidney deficiency marrow
Treatment is acted on.And the table of the phlegm-blood stasis retardance for senile dementia, jade screen wind energy by invigorating the spleen tonifying Qi play spleen transport water paddy, make in vivo
Water is not poly- to form humidogene phlegm, and arrogant blood does not stay the stasis of blood." kidney tonifying, essence replenishing benefit marrow " according to Traditional Chinese Medicine is theoretical, and Yupingfeng has base
In tonifying speen and tonifying kidney, the anti-aging of production of sperm mends marrow mechanism and prevent and treat the potentiality of senile dementia.
Telomerase（Telomerase）It is a kind of nucleic acid-protein complex, is a kind of special necessary to telomere is replicated
Archaeal dna polymerase, if activation Telomerase, it is possible to increase frequency dividing cell, so as to extend the life-span.In senile dementia
（Alzheimer ' s Disease, AD）Found in patient and experimental model, it is to trigger amyloid that telomere shortens（Aβ）Aggregation
With Tau protein hyperphosphorylations and the key factor of cognition dysfunction, by remove oxidative stress and neuroinflamation and
The means such as activation Telomerase, extend telomere length or delay the speed of telomere shortening, it is possible to preventing and treating senile dementia tool
It is significant（Jaskelioff et al., Telomerase reactivation reverses tissue
degeneration in aged telomerase-deficient mice, Nature, 2010, 469, 102–106 ;
Cai et al., Telomere Shortening and Alzheimer’s Disease, Neuromol Med, 2013,
15: 25–48）.
Therefore, Yupingfeng San provided herein is preparing anti-aging and Anti-alzheimer's disease based on telomere enzyme mechanism
Application in disease drug.
The content of the invention
It is an object of the invention to overcome defect of the prior art, there is provided Yupingfeng San is used for anti-aging and preventing and treating is old
The new medical use of dementia, for clinical application provides accurately foundation.
Raw material of the Yupingfeng San of the present invention comprising following weight portion：The 1-3 parts of Radix Astragali, the 1-3 parts of bighead atractylodes rhizome, 1-2 parts is prevented
Wind.
Yupingfeng San of the present invention can be made several formulations：Such as oral liquid, granule, tablet, capsule.
Described pharmaceutical preparation includes pharmaceutically acceptable carrier or auxiliary material, and the carrier and/or auxiliary material are this area
Technical staff is known, will not be described here.
Yupingfeng San of the present invention, its technology of preparing belongs to prior art, can be from existing patent publication us
Obtain or prepared according to the disclosed drug standards.
New application of the Yupingfeng San in terms of anti-aging and senile dementia that the present invention is provided, be based on Telomerase and
The oxidative stress related to Telomerase and neuroinflamation mechanism, with gentle effective activation Telomerase effect, in anti-aging and
Anti-alzheimer's disease aspect has good application potential.Yupingfeng San is traditional Chinese medicine, is recorded with long-term Clinical practice,
Safely and effectively, there is not obvious side effect in long-term use.
Brief description of the drawings
Fig. 1 is facilitation result of the Yupingfeng San to BJ fibroblastic growths；Left figure is the BJ cells to 22PD（BJ
22PD）Cell growth rate influence；Right figure is the BJ cells to 27PD（BJ 27PD）Cell growth rate influence.
Fig. 2 is influence result of the Yupingfeng San to telomerase activation, and in figure, A is the result of gel imaging；B is Yupingfeng
Dissipate the data audio-visual picture on Activation of Telomerase influence.
Specific embodiment
Technical scheme is described with reference to specific embodiment and accompanying drawing, so that the technology of the present invention
Personnel are better understood from, and the following example is used for illustrating the present invention, but does not limit the scope of the invention.
The medicinal material being related in the present invention is purchased from medicinal material company, meets through professional pharmacist identification《The People's Republic of China (PRC)
Pharmacopeia》Standard.
BJ fibroblasts are purchased from U.S. ATCC；
TRAPEZE®Telomere enzyme reagent kit is purchased from U.S. EMD millipore；
Drosophila melanogaster is purchased from The 2nd Army Medical College；
CAT, SOD and MDA kit build up Bioengineering Research Institute purchased from Nanjing.
Embodiment 1：
By the Radix Astragali, rhizoma atractylodis macrocephalae, windproof by mass fraction 1:1:The 1 Yupingfeng San prescription being formulated, crushed after being dried to 20
Mesh, by 3 kg, the prescription medicinal material is soaked in 30 L distilled water, the h of refluxing extraction 2, and the dregs of a decoction add 30 L distillations after suction filtration
Water, refluxing extraction 2h suction filtrations.Filtrate merging twice is concentrated into thick paste.The thick paste is through vacuum decompression drying machine (60 DEG C, -0.06
MPa) crush afterwards, cross 100 mesh sieves, obtain final product Yupingfeng San prescription extract.
Embodiment 2：
Take the prescription extract in above-described embodiment 1 and prepare piece agent, including step in detail below：It is added in prescription extract
3% dextrin of quality, 3% starch, with the ethanol that volumetric concentration is 60-70% are adhesive after being well mixed, successively through height
Fast mixer-granulator granulation, boiling drier are dried, shaking screen whole grain, and add 0.1% talcum of prescription extract quality
Powder, tabletting machine is used after being well mixed, and obtains final product Yupingfeng San tablet.Embodiment 3：
Take the prescription extract in above-described embodiment 1 and be prepared into capsule, including step in detail below：60 g prescription extracts
Dried powder, adds 30 g soluble starches and the ethanol of 90 mL 70%, mixes, 60 DEG C of drying, crushes.By every 0.45 g system
Into capsule.
Embodiment 4：
The preparation of Yupingfeng San oral liquid, specific steps：The mL of filtrate 500 after merging in embodiment 1, after being concentrated into 100 mL,
Centrifugation, adds sucrose syrup appropriate in supernatant, canned, sterilizing is obtained final product.
Embodiment 5：
By the Radix Astragali, rhizoma atractylodis macrocephalae and windproof press 3:1:1 ratio compatibility.Windproof independent extraction volatile oil, the gained dregs of a decoction and the Radix Astragali and
Rhizoma atractylodis macrocephalae adds 10 times of distilled water of quality to decoct, and decocts twice, and the time is respectively 1.5 h and 1 h, collecting decoction.It is dense after filtering
Contracting, plus ethanol is to 70%, stands, filtering, decompression filtrate recycling ethanol, gained concentrate reveals mixing with windproof water, stands, and takes
Supernatant, is concentrated into relative density 1.30-1.33（70℃）, plus appropriate amount of auxiliary materials is made particle, and above-mentioned windproof volatilization is sprayed after cooling
Oil, obtains final product after mixing.
Embodiment 6：
Facilitation of the Yupingfeng San to BJ fibroblastic growths：BJ fibroblasts are a kind of cells of rapid senescence, warp
It is commonly used to as a kind of cell model of screening, evaluates anti-aging material, therefore the present embodiment determines beautiful from BJ cell models
The scattered anti-aging effects of screen.
BJ fibroblasts（20-25 PD）It is inoculated in 12 orifice plates, is placed in 37 DEG C, 5% CO2The h of incubator culture 36,
The Yupingfeng San prepared in embodiment 1 is added, concentration is 0.01,0.1,1.0,10,100 μ g/mL, and blank group is 0.1%
DMSO, multiple holes.Continue to determine its absorbance with mtt assay after being incubated 36 h, as a result as shown in Figure 1, it is seen that, Yupingfeng San is to 22PD
BJ cells（BJ 22PD）Cell growth rate be respectively with respect to blank control group：- 1.6%, 4.8%, 0%, 5.1% and -3.3%
（Figure 1A）, illustrate that Yupingfeng San has faint growth promoting function in the range of 0.1-10 μ g/mL to BJ 22PD cells；It is right
The BJ cells of 27PD（BJ 27PD）Cell growth rate be respectively with respect to blank control group：2.7%, 12.0%, 11.4%, 14.4%
With 14.4%（Figure 1B）, illustrate that there is gentle growth promoting function to BJ 27PD cells in the range of 0.01-100 μ g/mL.
Influence using TRAP experimental evaluations Yupingfeng San to telomerase activation：BJ fibroblasts（30-35 PD）Connect
Plant in 12 orifice plates, be separately added into the Yupingfeng San for adding and being prepared in embodiment 1（0.01,0.1,1,10,100 μ g/mL）,
5% CO2 incubator cultures at 37 DEG C, every 24 h changes the culture medium of half drug containing.Cell collects thin when increasing to 75%
Born of the same parents, are centrifuged off nutrient solution, and PBS washings, Chaps cracking, centrifugation takes supernatant, with reference to TRAPEZE®Telomere enzyme reagent kit
Operating instruction, gel is scanned in Storm imaging systems, and Yupingfeng San opposite end is calculated using ImageQuant TL softwares
The influence of granzyme activation, blank group is 0.1 % DMSO, as a result sees Fig. 2A.
Under 0.01,0.1,1.0,10 and 100 μ g/mL concentration, telomerase activation increases by 14.9%, 42.3% respectively,
43.4%, -11.4% and -16.0%（Fig. 2 B）.Illustrate that Yupingfeng San has under 0.01 μ g/mL-1.0 μ g/mL concentration significant
The effect of Telomerase is activated, but at higher concentrations（10 μ g/mL and 100 μ g/mL）Performance on the contrary suppresses the work of Telomerase
With.The above results show Yupingfeng San in suitable concentration range have based on telomere enzyme mechanism anti-nerve cell aging and
Preventing and treating aging and the potentiality of the disease related to aging.
Embodiment 7：
Influence using fruit bat experimental evaluation Yupingfeng San to oxidative stress effect：Using Drosophila medium（HB8590）Feeding black
Abdomen fruit bat；Blank group, medicine group are set（Yupingfeng San group）：Addition concentration is 100 mg/L and 30 mg/ respectively in the medium
The Yupingfeng San of L.
48 h emergence Drosophila melanogaster adults are collected in life span of drosophila melanogaster experiment, random to be grouped, every group of fruit bat 400, and male and female are each
Half.Every 96 h changes fresh culture.After experiment starts, daily fixed point observation records fruit bat death toll, until each group fruit bat is complete
Untill portion's death.Half death time, maximum life span, average life span and the rate of averagely lengthening the life of fruit bat are calculated, wherein averagely lengthening the life
Rate (%)=(administration group average life span-control group average life span)/control group average life span × 100%.Experimental data is shown in Table 1,
Illustrate that Yupingfeng San has the effect of good extension life span of drosophila melanogaster.
Influence of the Yupingfeng San of table 1. to life span of drosophila melanogaster
**Compare with control group, p<0.01,*Compare with control group, p<0.05
Catalase（Catalase, CAT）, erythrocuprein（Superoxide dismutase, SOD）And MDA
（Malondialdehvde, MDA）Measure：Collect 48 h emergence Drosophila melanogaster adults, random group experiment.Every group of fruit bat 200
Only, male and female half and half.Every 96 h changes fresh culture.Upon administration the 30th day when, be made of physiological saline 8% tissue homogenate；
With 4000 rpm be centrifuged 10 min, according to CAT, SOD and MDA kit explanation determine respectively every group of supernatant C AT, SOD and
MDA levels, experimental data is shown in Table 2.
Influence of the Yupingfeng San of table 2. to CAT, SOD and MDA in fruit bat
**It is to compare with control group, p<0.01；*It is to compare with control group, p<0.05.
From table 1 and 2, Yupingfeng San can extend life span of drosophila melanogaster, can improve the level of CAT and SOD in fruit bat body,
The content of the catabolite MDA of MDA is reduced, shows that Yupingfeng San there are preferable anti-ROS abilities.
Above experimental result explanation Yupingfeng San has good activation Telomerase and antibody internal oxidition stress ability, anti-
Aging and senile dementia prevention and cure aspect have good application potential.
Claims (6)
1. Yupingfeng San is preparing treatment or prevention based on Telomerase and the oxidative stress and neuroinflamation related to Telomerase
Application in the medicine of the disease that mechanism causes.
2. application according to claim 1, it is characterised in that the application is the application in antiaging agent is prepared.
3. application according to claim 1, it is characterised in that the application is in the medicine for preparing anti-senile dementia disease
Application.
4. the application according to claim any one of 1-3, it is characterised in that original of the medicine comprising following weight portion
Material：The 1-3 parts of Radix Astragali, the 1-3 parts of bighead atractylodes rhizome, 1-2 parts is windproof.
5. the application according to claim any one of 1-4, it is characterised in that the medicine includes pharmaceutically acceptable load
Body or auxiliary material.
6. the application according to claim any one of 1-5, it is characterised in that the formulation of the medicine is oral liquid, particle
Agent, tablet or capsule.
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| CN201611203552.8A CN106727884A (en) | 2016-12-23 | 2016-12-23 | Purposes of the Yupingfeng San in anti-aging or senile dementia disease drug is prepared |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110604823A (en) * | 2019-10-21 | 2019-12-24 | 兰州大学 | Method for rapidly screening anti-saccharification and/or anti-aging substances |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491003A (en) * | 2015-01-23 | 2015-04-08 | 天津市南开医院 | Jiawei Yupingfeng gel, preparation method and purpose thereof |
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2016
- 2016-12-23 CN CN201611203552.8A patent/CN106727884A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491003A (en) * | 2015-01-23 | 2015-04-08 | 天津市南开医院 | Jiawei Yupingfeng gel, preparation method and purpose thereof |
Non-Patent Citations (1)
| Title |
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| 秦霖 等: "玉屏风散抗衰老蒺藜的中西医研究", 《福建中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110604823A (en) * | 2019-10-21 | 2019-12-24 | 兰州大学 | Method for rapidly screening anti-saccharification and/or anti-aging substances |
| CN110604823B (en) * | 2019-10-21 | 2020-10-20 | 兰州大学 | Method for rapidly screening anti-saccharification and/or anti-aging substances |
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Application publication date: 20170531 |