CN106727621A - A kind of Western medicine powder for treating toothache - Google Patents
A kind of Western medicine powder for treating toothache Download PDFInfo
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- CN106727621A CN106727621A CN201611032252.8A CN201611032252A CN106727621A CN 106727621 A CN106727621 A CN 106727621A CN 201611032252 A CN201611032252 A CN 201611032252A CN 106727621 A CN106727621 A CN 106727621A
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Abstract
The invention discloses a kind of Western medicine powder for treating toothache, including following weight fraction raw material：35 parts of metronidazole, 0.5 2 parts of penicillin V potassium, 13 parts of propantheline bromide, 25 parts of aliskiren, 25 parts of Tetrahydrocoptisine, 25 parts of sulfamethoxazole, 0.1 1 parts of benzyl carbinol, 13 parts of osthole, 37 parts of glucose, 0.1 1 parts of apiolin, 13 parts of ephedrine, 0.5 2 parts of loxoprofen, 0.5 1 parts of caffeine, 0.01 0.1 parts of B B-complex, 13 parts of chloperastine hydrochloride piece.The Western medicine powder is compounded by raw material and plays synergy, with anti-inflammatory analgetic, clearing lung-heat fall fire, the curative effect of clearing heat and cooling blood, can effectively treat toothache, and toxic and side effect is small；The Western medicine powder also has good effect in terms of oral peculiar smell is treated；And preparation method is simple, raw material is easy to get, and price is relatively low, reduces the financial burden of people；Simultaneously good effect, instant effect, be difficult recurrence, the effect treated both principal and secondary aspect of disease can be reached, significantly reduce the pain of patient.
Description
Technical field
The present invention relates to a kind of Western medicine compound, specifically a kind of Western medicine powder for treating toothache.
Background technology
It is a kind of common disease to have a toothache, and its clinical manifestation is：Gum is red and swollen, thermostimulation pain, swelling of cheek portion etc. to the cold.
The traditional Chinese medical science thinks that toothache is caused by the reasons such as diseases caused by external factors ailment said due to cold or exposure, exuberance of stomach fire, kidney deficiency hyperactivity of fire, worm-eaten tooth.The reason for having a toothache master
Have：Acute pulpitis, acute apical periodontitis, acute periodontitis, periodontal abscess, tooth body allergy, alveolitis, food impaction
Bitterly, gum, Jaw neoplasm and trigeminal neuralgia etc..Have a toothache mainly due to oral hygiene is not noted, tooth is subject to tooth week
The long-time stimulus caused by the dental calculus of soft tartar that the things such as swill, bacterium form and hard are enclosed, and incorrect is brushed teeth
Caused by the reasons such as custom, B B-complex shortage.
Treatment is had a toothache and mainly treated by anti-inflammatory, analgesic drug product at present, but effect on driving birds is not good, and is easily recurred, while
Side effect is larger, does not reach the effect treated both principal and secondary aspect of disease, and increased the pain of patient.
The content of the invention
It is an object of the invention to provide a kind of Western medicine powder for treating toothache, to solve what is proposed in above-mentioned background technology
Problem.
To achieve the above object, the present invention provides following technical scheme：
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：Metronidazole 3-5 parts, penicillin V potassium
0.5-2 parts, propantheline bromide 1-3 parts, aliskiren 2-5 parts, Tetrahydrocoptisine 2-5 parts, sulfamethoxazole 2-5 parts, benzene
Ethanol 0.1-1 parts, osthole 1-3 parts, glucose 3-7 parts, apiolin 0.1-1 parts, ephedrine 1-3 parts, loxoprofen
0.5-2 parts, caffeine 0.5-1 parts, B B-complex 0.01-0.1 parts, 1-3 parts of chloperastine hydrochloride piece.
As further scheme of the invention：Raw material including following weight fraction：Metronidazole 3.5-4 parts, ospeneff
Piece 0.8-1.5 parts, propantheline bromide 1.5-2.5 parts, aliskiren 3-5 parts, Tetrahydrocoptisine 3-4 parts, sulfamethoxazole
2.5-3 parts, benzyl carbinol 0.5-0.8 parts, osthole 1.5-2 parts, glucose 4-6 parts, apiolin 0.5-1 parts, ephedrine
1.5-2.5 parts, loxoprofen 0.5-1 parts, caffeine 0.6-0.9 parts, B B-complex 0.03-0.08 parts, chloperastine hydrochloride piece
1.8-2.5 parts.
As further scheme of the invention：Raw material including following weight fraction：3.6 parts of metronidazole, ospeneff
1 part of piece, 2.3 parts of propantheline bromide, 4.1 parts of aliskiren, 3.5 parts of Tetrahydrocoptisine, 2.6 parts of sulfamethoxazole, benzene second
0.6 part of alcohol, 1.8 parts of osthole, 5 parts of glucose, 0.6 part of apiolin, 2 parts of ephedrine, 0.8 part of loxoprofen, caffeine
0.8 part, 0.05 part of B B-complex, 2 parts of chloperastine hydrochloride piece.
As further scheme of the invention：The B B-complex include vitamin A, vitamin B1, vitamin B2,
Vitamin D and nicotinic acid.
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, aliskiren, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthenol
Methyl ether, glucose, apiolin, ephedrine, loxoprofen, caffeine, chloperastine hydrochloride piece and B B-complex, it is standby；(2) will
Metronidazole, penicillin V potassium, propantheline bromide, sulfamethoxazole, aliskiren, loxoprofen, apiolin, compound dimension
Raw element, caffeine, osthole, chloperastine hydrochloride piece difference grind into powder, are then well mixed, and obtain mixed-powder；
(3) Tetrahydrocoptisine, glucose, benzyl carbinol are well mixed, obtain mixture；(4) by step (2) gained mixed-powder and step
Suddenly (3) gained mixture is both placed in container, is stirred；(5) 100-120 is ground to form after step (4) gains are dried
Purpose powder, obtains final product the Western medicine powder for the treatment of toothache.
Compared with prior art, the beneficial effects of the invention are as follows：
The Western medicine powder by raw material compound play synergy, with anti-inflammatory analgetic, clearing lung-heat fall fire, clearing heat and cooling blood treatment
Effect, can effectively treat toothache, and toxic and side effect is small；The Western medicine powder also has good effect in terms of oral peculiar smell is treated；
And preparation method is simple, raw material is easy to get, and price is relatively low, reduces the financial burden of people；Good effect, instant effect, no simultaneously
Easily recurrence, can reach the effect treated both principal and secondary aspect of disease, and significantly reduce the pain of patient.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：3 parts of metronidazole, penicillin V potassium
0.5 part, 1 part of propantheline bromide, 2 parts of aliskiren, 2 parts of Tetrahydrocoptisine, 2 parts of sulfamethoxazole, 0.1 part of benzyl carbinol,
It is 1 part of osthole, 3 parts of glucose, 0.1 part of apiolin, 1 part of ephedrine, 0.5 part of loxoprofen, 0.5 part of caffeine, compound
0.01 part of vitamin, 1 part of chloperastine hydrochloride piece；The B B-complex includes vitamin A, vitamin B1, vitamin B2, dimension life
Plain D and nicotinic acid.
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, aliskiren, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthenol
Methyl ether, glucose, apiolin, ephedrine, loxoprofen, caffeine, chloperastine hydrochloride piece and B B-complex, it is standby；(2) will
Metronidazole, penicillin V potassium, propantheline bromide, sulfamethoxazole, aliskiren, loxoprofen, apiolin, compound dimension
Raw element, caffeine, osthole, chloperastine hydrochloride piece difference grind into powder, are then well mixed, and obtain mixed-powder；
(3) Tetrahydrocoptisine, glucose, benzyl carbinol are well mixed, obtain mixture；(4) by step (2) gained mixed-powder and step
Suddenly (3) gained mixture is both placed in container, is stirred；(5) 100 purposes are ground to form after step (4) gains are dried
Powder, obtains final product the Western medicine powder for the treatment of toothache.
Embodiment 2
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：5 parts of metronidazole, penicillin V potassium 2
Part, 3 parts of propantheline bromide, 5 parts of aliskiren, 5 parts of Tetrahydrocoptisine, 5 parts of sulfamethoxazole, 1 part of benzyl carbinol, osthenol
3 parts of methyl ether, 7 parts of glucose, 1 part of apiolin, 3 parts of ephedrine, 2 parts of loxoprofen, 1 part of caffeine, 0.1 part of B B-complex,
3 parts of chloperastine hydrochloride piece；The B B-complex includes vitamin A, vitamin B1, vitamin B2, vitamin D and vitamin
PP。
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, aliskiren, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthenol
Methyl ether, glucose, apiolin, ephedrine, loxoprofen, caffeine, chloperastine hydrochloride piece and B B-complex, it is standby；(2) will
Metronidazole, penicillin V potassium, propantheline bromide, sulfamethoxazole, aliskiren, loxoprofen, apiolin, compound dimension
Raw element, caffeine, osthole, chloperastine hydrochloride piece difference grind into powder, are then well mixed, and obtain mixed-powder；
(3) Tetrahydrocoptisine, glucose, benzyl carbinol are well mixed, obtain mixture；(4) by step (2) gained mixed-powder and step
Suddenly (3) gained mixture is both placed in container, is stirred；(5) 120 purposes are ground to form after step (4) gains are dried
Powder, obtains final product the Western medicine powder for the treatment of toothache.
Embodiment 3
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：3.6 parts of metronidazole, penicillin V potassium
1 part, 2.3 parts of propantheline bromide, 4.1 parts of aliskiren, 3.5 parts of Tetrahydrocoptisine, 2.6 parts of sulfamethoxazole, benzyl carbinol
0.6 part, 1.8 parts of osthole, 5 parts of glucose, 0.6 part of apiolin, 2 parts of ephedrine, 0.8 part of loxoprofen, caffeine 0.8
Part, 0.05 part of B B-complex, 2 parts of chloperastine hydrochloride piece；The B B-complex includes vitamin A, vitamin B1, vitamin
B2, vitamin D and nicotinic acid.
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, aliskiren, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthenol
Methyl ether, glucose, apiolin, ephedrine, loxoprofen, caffeine, chloperastine hydrochloride piece and B B-complex, it is standby；(2) will
Metronidazole, penicillin V potassium, propantheline bromide, sulfamethoxazole, aliskiren, loxoprofen, apiolin, compound dimension
Raw element, caffeine, osthole, chloperastine hydrochloride piece difference grind into powder, are then well mixed, and obtain mixed-powder；
(3) Tetrahydrocoptisine, glucose, benzyl carbinol are well mixed, obtain mixture；(4) by step (2) gained mixed-powder and step
Suddenly (3) gained mixture is both placed in container, is stirred；(5) 110 purposes are ground to form after step (4) gains are dried
Powder, obtains final product the Western medicine powder for the treatment of toothache.
Comparative example 1
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：3.6 parts of metronidazole, penicillin V potassium
1 part, 2.3 parts of propantheline bromide, 3.5 parts of Tetrahydrocoptisine, 2.6 parts of sulfamethoxazole, 0.6 part of benzyl carbinol, osthenol first
1.8 parts of ether, 5 parts of glucose, 0.6 part of apiolin, 2 parts of ephedrine, 0.8 part of loxoprofen, 0.8 part of caffeine, B B-complex
0.05 part, 2 parts of chloperastine hydrochloride piece；The B B-complex include vitamin A, vitamin B1, vitamin B2, vitamin D and
Nicotinic acid.
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthole, grape
Sugar, apiolin, ephedrine, loxoprofen, caffeine, chloperastine hydrochloride piece and B B-complex, it is standby；(2) by metronidazole, green grass or young crops
Mycin V potassium piece, propantheline bromide, sulfamethoxazole, loxoprofen, apiolin, B B-complex, caffeine, osthenol
Methyl ether, chloperastine hydrochloride piece difference grind into powder, are then well mixed, and obtain mixed-powder；(3) by Tetrahydrocoptisine, Portugal
Grape sugar, benzyl carbinol are well mixed, and obtain mixture；(4) it is step (2) gained mixed-powder is equal with step (3) gained mixture
Place in a reservoir, stir；(5) powder of 110 mesh is ground to form after step (4) gains are dried, treatment toothache is obtained final product
Western medicine powder.Aliskiren is not added with comparative example 1.
Comparative example 2
A kind of Western medicine powder for treating toothache, including following weight fraction raw material：3.6 parts of metronidazole, penicillin V potassium
1 part, 2.3 parts of propantheline bromide, 4.1 parts of aliskiren, 3.5 parts of Tetrahydrocoptisine, 2.6 parts of sulfamethoxazole, benzyl carbinol
0.6 part, 1.8 parts of osthole, 5 parts of glucose, 0.6 part of apiolin, 2 parts of ephedrine, 0.8 part of loxoprofen, caffeine 0.8
Part, 0.05 part of B B-complex；The B B-complex includes vitamin A, vitamin B1, vitamin B2, vitamin D and Wei Sheng
Plain PP.
A kind of preparation method of the Western medicine powder for treating toothache, concretely comprises the following steps：(1) it is first according to weight fraction and weighs first
Nitre azoles, penicillin V potassium, propantheline bromide, aliskiren, Tetrahydrocoptisine, sulfamethoxazole, benzyl carbinol, osthenol
Methyl ether, glucose, apiolin, ephedrine, loxoprofen, caffeine and B B-complex, it is standby；(2) by metronidazole, penicillin
V potassium piece, propantheline bromide, sulfamethoxazole, aliskiren, loxoprofen, apiolin, B B-complex, caffeine, Europe
Celery phenol methyl ether distinguishes grind into powder, is then well mixed, and obtains mixed-powder；(3) by Tetrahydrocoptisine, glucose, benzene second
Alcohol is well mixed, and obtains mixture；(4) step (2) gained mixed-powder is both placed in container with step (3) gained mixture
In, stir；(5) powder of 110 mesh is ground to form after step (4) gains are dried, the Western medicine powder for the treatment of toothache is obtained final product.
Chloperastine hydrochloride piece is not added with comparative example 2.
Clinical test
1. case is originated
Screening outpatient service of the present invention is had a toothache patient 250；It is wherein male 130, female 120；Age 10-60 Sui；Wherein
Fiery tooth patient 120, eurodonticus 50, periodontitis 30, pulpitis 30, hypersensitive dentin 20.Have a toothache and show as：Hold
Continue property or intermittent pain, gum is red and swollen, partly have bleeding, all patients are equally divided into four groups, and experiment 1 group, reality
2 groups are tested, 3 groups is tested, is tested 4 groups and 5 groups of experiment, every group 50, each group patient's no difference of science of statistics.
2. application process
1 group of Western medicine powder prepared using the embodiment of the present invention 1 is tested, what 2 groups of experiment was prepared using the embodiment of the present invention 2
Western medicine powder, tests 3 groups of Western medicine powders prepared using the embodiment of the present invention 3, and 4 groups of experiment is prepared using comparative example of the present invention 1
Western medicine powder, test 5 groups using comparative examples 2 of the present invention prepare Western medicine powders, each group often daily cotton swab pick Western medicine powder
It is applied on the tooth of pain, three times per day, half an hour smearing, 2 days is a course for the treatment of after meal.
3. criterion of therapeutical effect is treated：It is effective, effective and invalid.
It is effective：After taking the latter course for the treatment of, dental pain, red and swollen bleeding are wholly absent, and masticatory function recovers normal.
Effectively：After taking latter two course for the treatment of, dental pain, red and swollen bleeding are clearly better, and dental pain number of times is reduced, pain
The reduction of pain degree, can normally have a meal.
It is invalid：After clothes after three courses for the treatment of, symptom of having a toothache is without improvement or aggravates.
4. clinical treatment outcome
Clinical treatment outcome is shown in Table 1：
The efficacy result of the Western medicine powder treatment toothache of table 1
| Project | Effective/example | Effectively/example | Invalid/example | Effective percentage/% |
| Test 1 group | 25 | 49 | 1 | 98 |
| Test 2 groups | 22 | 48 | 2 | 96 |
| Test 3 groups | 28 | 50 | 0 | 100 |
| Test 4 groups | 10 | 32 | 18 | 64 |
| Test 5 groups | 12 | 34 | 16 | 68 |
As it can be seen from table 11 group of experiment, the average clinical effective rate of 3 groups of 2 combination experiment of experiment are 98%, it is average clinical
Inefficiency accounts for 2%；The clinical effective rate for testing 5 groups of 4 combination experiment is below 70%, and inefficiency is all higher than 30%；Therefore pass through
Chloperastine hydrochloride piece is added in the Western medicine powder and aliskiren has played synergy, effectively enhance the Western medicine powder and control
Treat the effective percentage of toothache.
The Western medicine powder by raw material compound play synergy, with anti-inflammatory analgetic, clearing lung-heat fall fire, clearing heat and cooling blood treatment
Effect, can effectively treat toothache, and toxic and side effect is small；The Western medicine powder also has good effect in terms of oral peculiar smell is treated；
And preparation method is simple, raw material is easy to get, and price is relatively low, reduces the financial burden of people；Good effect, instant effect, no simultaneously
Easily recurrence, can reach the effect treated both principal and secondary aspect of disease, and significantly reduce the pain of patient.
The better embodiment to this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, in the ken that one skilled in the relevant art possesses, can also be on the premise of this patent objective not be departed from
Make a variety of changes.
Claims (5)
1. a kind of Western medicine powder for treating toothache, it is characterised in that the raw material including following weight fraction：Metronidazole 3-5 parts, green grass or young crops
0.5-2 parts of mycin V potassium pieces, propantheline bromide 1-3 parts, aliskiren 2-5 parts, Tetrahydrocoptisine 2-5 parts, sulfamethoxazole
2-5 parts, benzyl carbinol 0.1-1 parts, osthole 1-3 parts, glucose 3-7 parts, apiolin 0.1-1 parts, ephedrine 1-3 parts, Lip river
Suo Luofen 0.5-2 parts, caffeine 0.5-1 parts, B B-complex 0.01-0.1 parts, 1-3 parts of chloperastine hydrochloride piece.
2. the Western medicine powder that treatment according to claim 1 is had a toothache, it is characterised in that the original including following weight fraction
Material：Metronidazole 3.5-4 parts, penicillin V potassium 0.8-1.5 parts, propantheline bromide 1.5-2.5 parts, aliskiren 3-5 parts, tetrahydrochysene
Coptisine 3-4 parts, sulfamethoxazole 2.5-3 parts, benzyl carbinol 0.5-0.8 parts, osthole 1.5-2 parts, glucose 4-6
Part, apiolin 0.5-1 parts, ephedrine 1.5-2.5 parts, loxoprofen 0.5-1 parts, caffeine 0.6-0.9 parts, B B-complex
0.03-0.08 parts, 1.8-2.5 parts of chloperastine hydrochloride piece.
3. the Western medicine powder that treatment according to claim 1 is had a toothache, it is characterised in that the original including following weight fraction
Material：3.6 parts of metronidazole, 1 part of penicillin V potassium, 2.3 parts of propantheline bromide, 4.1 parts of aliskiren, 3.5 parts of Tetrahydrocoptisine,
2.6 parts of sulfamethoxazole, 0.6 part of benzyl carbinol, 1.8 parts of osthole, 5 parts of glucose, 0.6 part of apiolin, ephedrine 2
Part, 0.8 part of loxoprofen, 0.8 part of caffeine, 0.05 part of B B-complex, 2 parts of chloperastine hydrochloride piece.
4. according to the Western medicine powder of any described treatment toothache of claim 1-3, it is characterised in that the B B-complex bag
Include vitamin A, vitamin B1, vitamin B2, vitamin D and nicotinic acid.
5. the preparation method of the Western medicine powder of a kind for the treatment of toothache as described in claim 1-3 is any, it is characterised in that specific
Step is：(1) it is first according to weight fraction and weighs metronidazole, penicillin V potassium, propantheline bromide, aliskiren, the tetrahydrochysene coptis
Alkali, sulfamethoxazole, benzyl carbinol, osthole, glucose, apiolin, ephedrine, loxoprofen, caffeine, hydrochloric acid
Cloperastine piece and B B-complex, it is standby；(2) by metronidazole, penicillin V potassium, propantheline bromide, sulfamethoxazole,
Aliskiren, loxoprofen, apiolin, B B-complex, caffeine, osthole, chloperastine hydrochloride piece grind to form respectively
Powder, is then well mixed, and obtains mixed-powder；(3) Tetrahydrocoptisine, glucose, benzyl carbinol are well mixed, are mixed
Thing；(4) step (2) gained mixed-powder is both placed in container with step (3) gained mixture, is stirred；(5) will step
Suddenly (4) gains grind to form the powder of 100-120 mesh after drying, and obtain final product the Western medicine powder for the treatment of toothache.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288878A (en) * | 2021-04-15 | 2021-08-24 | 地奥集团成都药业股份有限公司 | Cloperidine hydrochloride tablet and preparation method thereof |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357324A (en) * | 2001-12-18 | 2002-07-10 | 复旦大学 | Loselofen sodium injection and its prepn |
| CN1638749A (en) * | 2002-02-27 | 2005-07-13 | 贝林格尔英格海姆法玛两合公司 | Ambroxol for treating painful conditions in the mouth and pharyngeal cavity |
| CN1954833A (en) * | 2005-10-24 | 2007-05-02 | 王明贤 | Medicine for treating toothache |
| CN101062054A (en) * | 2007-06-08 | 2007-10-31 | 郑淑芬 | Medicine for curing wound |
| CN101322683A (en) * | 2008-07-30 | 2008-12-17 | 宛六一 | Gel for eye containing bromfenac sodium hydrate and preparation thereof |
| CN101623394A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Nakedflower beautyberry extract as well as preparation method, preparation and application thereof |
| CN102178844A (en) * | 2011-04-28 | 2011-09-14 | 孔建 | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof |
| CN102266563A (en) * | 2011-07-13 | 2011-12-07 | 赵磊 | Compound analgesic composition and preparation method thereof |
| CN103385924A (en) * | 2012-05-08 | 2013-11-13 | 王捷 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
| CN103450140A (en) * | 2013-09-11 | 2013-12-18 | 南京泽朗农业发展有限公司 | Purification method of osthole |
| CN104107379A (en) * | 2014-07-03 | 2014-10-22 | 河南科技大学第一附属医院 | Toothache-relieving and inflammation-diminishing tablet and preparation method thereof |
| CN104721295A (en) * | 2015-03-02 | 2015-06-24 | 张小安 | Chinese and western medicine composition for treating various kinds of wind fire toothache and preparation method thereof |
-
2016
- 2016-11-22 CN CN201611032252.8A patent/CN106727621A/en not_active Withdrawn
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357324A (en) * | 2001-12-18 | 2002-07-10 | 复旦大学 | Loselofen sodium injection and its prepn |
| CN1638749A (en) * | 2002-02-27 | 2005-07-13 | 贝林格尔英格海姆法玛两合公司 | Ambroxol for treating painful conditions in the mouth and pharyngeal cavity |
| CN1954833A (en) * | 2005-10-24 | 2007-05-02 | 王明贤 | Medicine for treating toothache |
| CN101062054A (en) * | 2007-06-08 | 2007-10-31 | 郑淑芬 | Medicine for curing wound |
| CN101322683A (en) * | 2008-07-30 | 2008-12-17 | 宛六一 | Gel for eye containing bromfenac sodium hydrate and preparation thereof |
| CN101623394A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Nakedflower beautyberry extract as well as preparation method, preparation and application thereof |
| CN102178844A (en) * | 2011-04-28 | 2011-09-14 | 孔建 | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof |
| CN102266563A (en) * | 2011-07-13 | 2011-12-07 | 赵磊 | Compound analgesic composition and preparation method thereof |
| CN103385924A (en) * | 2012-05-08 | 2013-11-13 | 王捷 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
| CN103450140A (en) * | 2013-09-11 | 2013-12-18 | 南京泽朗农业发展有限公司 | Purification method of osthole |
| CN104107379A (en) * | 2014-07-03 | 2014-10-22 | 河南科技大学第一附属医院 | Toothache-relieving and inflammation-diminishing tablet and preparation method thereof |
| CN104721295A (en) * | 2015-03-02 | 2015-06-24 | 张小安 | Chinese and western medicine composition for treating various kinds of wind fire toothache and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288878A (en) * | 2021-04-15 | 2021-08-24 | 地奥集团成都药业股份有限公司 | Cloperidine hydrochloride tablet and preparation method thereof |
| CN113288878B (en) * | 2021-04-15 | 2023-03-17 | 地奥集团成都药业股份有限公司 | Cloperidine hydrochloride tablet and preparation method thereof |
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