CN103385924A - Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof - Google Patents
Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof Download PDFInfo
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- CN103385924A CN103385924A CN2012101395803A CN201210139580A CN103385924A CN 103385924 A CN103385924 A CN 103385924A CN 2012101395803 A CN2012101395803 A CN 2012101395803A CN 201210139580 A CN201210139580 A CN 201210139580A CN 103385924 A CN103385924 A CN 103385924A
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- 239000003814 drug Substances 0.000 title claims abstract description 25
- 239000007939 sustained release tablet Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 230000000694 effects Effects 0.000 title abstract description 16
- 208000002193 Pain Diseases 0.000 title abstract description 12
- 230000036407 pain Effects 0.000 title abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 17
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 11
- 229920000178 Acrylic resin Polymers 0.000 claims abstract description 11
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 9
- 241001369613 Stephania tetrandra Species 0.000 claims abstract description 9
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 9
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 9
- 239000008101 lactose Substances 0.000 claims abstract description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000011347 resin Substances 0.000 claims abstract description 5
- 229920005989 resin Polymers 0.000 claims abstract description 5
- AEQDJSLRWYMAQI-UHFFFAOYSA-N Tetrahydropalmatine Natural products C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 26
- 230000000202 analgesic effect Effects 0.000 claims description 19
- 229920000858 Cyclodextrin Polymers 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 4
- AEQDJSLRWYMAQI-KRWDZBQOSA-N tetrahydropalmatine Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-KRWDZBQOSA-N 0.000 claims description 4
- -1 and cold drying Substances 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 238000004811 liquid chromatography Methods 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000013558 reference substance Substances 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 abstract description 6
- 206010067484 Adverse reaction Diseases 0.000 abstract description 2
- 230000006838 adverse reaction Effects 0.000 abstract description 2
- 238000005265 energy consumption Methods 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010039897 Sedation Diseases 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 4
- 230000036280 sedation Effects 0.000 description 4
- 229930013930 alkaloid Natural products 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 230000036592 analgesia Effects 0.000 description 3
- UXYJCYXWJGAKQY-HNNXBMFYSA-N (S)-stylopine Chemical compound C1C2=C3OCOC3=CC=C2C[C@@H]2N1CCC1=C2C=C(OCO2)C2=C1 UXYJCYXWJGAKQY-HNNXBMFYSA-N 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 230000035606 childbirth Effects 0.000 description 2
- VRSRXLJTYQVOHC-YEJXKQKISA-N corydaline Chemical compound C=1([C@H]2[C@H]3C)C=C(OC)C(OC)=CC=1CCN2CC1=C3C=CC(OC)=C1OC VRSRXLJTYQVOHC-YEJXKQKISA-N 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- OBVLTWCOTSTMNM-FKIZINRSSA-N (13s,13ar)-2,9,10-trimethoxy-13-methyl-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinolin-3-ol Chemical compound C1([C@@H]2C)=CC=C(OC)C(OC)=C1CN1[C@H]2C(C=C(C(=C2)O)OC)=C2CC1 OBVLTWCOTSTMNM-FKIZINRSSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- VRSRXLJTYQVOHC-UHFFFAOYSA-N Corydaline Natural products CC1C2C=3C=C(OC)C(OC)=CC=3CCN2CC2=C1C=CC(OC)=C2OC VRSRXLJTYQVOHC-UHFFFAOYSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- OBVLTWCOTSTMNM-UHFFFAOYSA-N Tetrahydrocorybulbin Natural products CC1C2=CC=C(OC)C(OC)=C2CN2C1C(C=C(C(=C1)O)OC)=C1CC2 OBVLTWCOTSTMNM-UHFFFAOYSA-N 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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Abstract
The invention provides a traditional Chinese medicine tablet with significant pain-relieving, calming, and pain-stopping effects, and a preparation method thereof. The traditional Chinese medicine sustained-release tablet comprises Kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, and magnesium stearate. The tablet provided by the invention has significant pain-relieving and pain-stopping effects, no toxicity, no addictiveness, no significant adverse reaction, and durable effect. The tablet can be applied for disease pains caused by various reasons, and for relieving pain of a patient. The adopted process method is safe, stable, and economical, and has the advantages of low loss rate and high yield. According to an extraction process, macroporous absorption resin is adopted. The material adopted during the process can be recycled and regenerated. Ethanol can be recycled and reused. Energy consumption is low, and environment pollution is prevented. During tableting, acrylic resin is adopted as a framework material. The effect of the sustained-release medicine is reliable and stable, and human body bioavailability is high.
Description
Technical field
The present invention relates to a kind of analgesic and method for making thereof, especially a kind of Chinese medicine sustained release tablets and method for making thereof with analgesic effect.
Background technology
Chinese medicine sustained release tablets have the number of times of taking few, easy to use, keep blood drug level steadily, avoid peak valley phenomenon, the untoward reaction advantages such as minimizing relatively, avoided the Chinese medicine bioavailability low, take inconvenience, the slow shortcoming of onset.Yet at present domestic have the Chinese medicinal tablet of pain relieving effect of less types, and especially the kind of slow releasing tablet still less.
Summary of the invention
The invention provides a kind of Chinese medicine sustained release tablets and method for making thereof that obvious analgesia, calmness, analgesic effect are arranged.
Realize the Chinese medicine sustained release tablets with analgesic effect of one of the object of the invention, comprise kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, magnesium stearate.
Wherein, kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, magnesium stearate 3g.
Realize the method for making of two the Chinese medicine sustained release tablets with analgesic effect of the object of the invention, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally.
Described method for making with Chinese medicine sustained release tablets of analgesic effect also comprises step (5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.
The beneficial effect of the Chinese medicine sustained release tablets with analgesic effect of the present invention and method for making thereof is as follows:
Chinese medicine sustained release tablets and method for making thereof with analgesic effect of the present invention, have obvious analgesia, sedation, and be nontoxic, and without addiction, without obvious adverse reaction, effect is lasting.Can be applicable to the slight illness that a variety of causes causes, alleviate and alleviate patient's misery.The safe in process of taking, stable, economy, loss rate is low, and yield rate is high; Adopt macroporous adsorbent resin during extraction process, technique uses the material circular regeneration to use, and ethanol is recyclable, the low and non-environmental-pollution of energy consumption; Adopting acrylic resin during film-making is framework material, and the controlled release drug reliable effect is stable, and human bioavailability is high.
The specific embodiment
Chinese medicine sustained release tablets with analgesic effect of the present invention, comprise kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, 95% appropriate amount of ethanol, magnesium stearate 3g.
Method for making with Chinese medicine sustained release tablets of analgesic effect of the present invention, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally;
(5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.Tetrahydropalmatine is the strong alkaloid of a kind of activity,, therefore can be used as said preparation quantitative target composition,, to control quality, guarantees clinical efficacy.
The effect of the Chinese medicine sustained release tablets with analgesic effect of the present invention and method for making thereof is as follows:
1, pain relieving
Chinese medicine sustained release tablets with analgesic effect of the present invention contains multiple alkaloid, comprising corydaline, and dl-tetrahydropalmatine (dl-THP), L-Tetrahydrocoptisine, 1-tetrahydrocolumbamine and corybulbine.THP is considered to the most effective composition that eases the pain.In laboratory research, the multiple pharmacological effect that it demonstrates central nervous system (CNS), comprise analgesia and sedation.Scientist propose dl-THP may hinder some receptor site in brain (for example: dopamine) thus play sedation.In addition, menstrual pain (dysmenorrhea), childbirth postabdomen pain and headache are taken THP and have also been obtained good repercussion.Utilize THP treatment menstrual pain (dysmenorrhea), childbirth postabdomen pain and headache have also obtained good efficacy.
2, calmness
Be accompanied by analgesic effect, THP demonstrates sedation with it at experimental rat.After other human clinicals to dl-THP studies show that the dl-THP that takes 100-200mg before sleeping, it causes the effect of sleeping can be helpful to the patient.This effect also is considered to its result to the CNS effect.Human body does not find that any drug residue symptom is as unable in morning after taking this alkaloid extract, feels dizzy or dizzy.
3, to Cardiovascular
Except the central nervous system was acted on, laboratory research showed that the Chinese medicine sustained release tablets of analgesic effect of the present invention also demonstrates the effect to cardiovascular system.For example dl-THP demonstrates simultaneously to reduce PC and by reducing blood pressure, with heart rate, be protected from apoplexy and threatens in zoopery.In addition, as if it also has anti-arrhythmia effect.This effect is to be found in once to the double blinding clinical experiment of suffering from special arrhythmia (for example: upper ventricle early onset shrinks or title SVPB) patient.The patient who takes the 300-600mgdl-THP tablet every day compares with the patient who takes placebo, and obvious improvement has appearred in situation.
Embodiment recited above is described the preferred embodiment of the present invention; not scope of the present invention is limited; design under spiritual prerequisite not breaking away from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical solution of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (4)
1. the Chinese medicine sustained release tablets with analgesic effect, comprise kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, magnesium stearate.
2. the Chinese medicine sustained release tablets with analgesic effect according to claim 1, is characterized in that: kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, magnesium stearate 3g.
3. the method for making with Chinese medicine sustained release tablets of analgesic effect, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally.
4. the method for making with Chinese medicine sustained release tablets of analgesic effect according to claim 3, it is characterized in that: also comprise step (5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101395803A CN103385924A (en) | 2012-05-08 | 2012-05-08 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101395803A CN103385924A (en) | 2012-05-08 | 2012-05-08 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
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| CN103385924A true CN103385924A (en) | 2013-11-13 |
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| CN2012101395803A Pending CN103385924A (en) | 2012-05-08 | 2012-05-08 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727621A (en) * | 2016-11-22 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of Western medicine powder for treating toothache |
| CN107854632A (en) * | 2017-11-14 | 2018-03-30 | 青岛卓森纳生物工程有限公司 | A kind of slow releasing drugs of tcm for treating peptic ulcer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481854A (en) * | 2003-05-13 | 2004-03-17 | 沈阳药科大学 | Delay, control release drug of prepared aconite root which can regulate the function of middle-warmer, and its preparation method |
| CN1562019A (en) * | 2004-04-05 | 2005-01-12 | 孟繁浩 | Corydalis B long-acting preparation and its preparing method |
| CN101234141A (en) * | 2008-01-14 | 2008-08-06 | 马仁强 | Total alkaloid of stephania delavayi and preparation and application thereof |
| WO2011149575A1 (en) * | 2010-05-28 | 2011-12-01 | Nexgen Dermatologics, Inc. | Compositions and methods for treating bruises |
-
2012
- 2012-05-08 CN CN2012101395803A patent/CN103385924A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481854A (en) * | 2003-05-13 | 2004-03-17 | 沈阳药科大学 | Delay, control release drug of prepared aconite root which can regulate the function of middle-warmer, and its preparation method |
| CN1562019A (en) * | 2004-04-05 | 2005-01-12 | 孟繁浩 | Corydalis B long-acting preparation and its preparing method |
| CN101234141A (en) * | 2008-01-14 | 2008-08-06 | 马仁强 | Total alkaloid of stephania delavayi and preparation and application thereof |
| WO2011149575A1 (en) * | 2010-05-28 | 2011-12-01 | Nexgen Dermatologics, Inc. | Compositions and methods for treating bruises |
Non-Patent Citations (1)
| Title |
|---|
| 马仁强等: "金不换药材质量标准研究", 《中成药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727621A (en) * | 2016-11-22 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of Western medicine powder for treating toothache |
| CN107854632A (en) * | 2017-11-14 | 2018-03-30 | 青岛卓森纳生物工程有限公司 | A kind of slow releasing drugs of tcm for treating peptic ulcer |
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| CB03 | Change of inventor or designer information |
Inventor after: Wang Jie Inventor after: Xu Liba Inventor after: Jiang Weizhe Inventor after: Long Yu Inventor after: Wei Jinbin Inventor after: Huang Zengqiong Inventor after: Jiao Aijun Inventor after: Chen Rong Inventor after: Li Rumin Inventor after: Huang Seping Inventor before: Wang Jie Inventor before: Long Yu Inventor before: Wei Jinbin Inventor before: Li Yuanhong Inventor before: Liu Yingxin |
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Effective date of registration: 20151204 Address after: Support 530021 Nanning Road, the Guangxi Zhuang Autonomous Region No. 22 Applicant after: Guangxi Medical Univ. Pharmaceutical Plant Address before: Support 530021 Nanning Road, the Guangxi Zhuang Autonomous Region No. 22 Applicant before: Wang Jie |
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| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20131113 |