CN103385924A - Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof - Google Patents
Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof Download PDFInfo
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- CN103385924A CN103385924A CN2012101395803A CN201210139580A CN103385924A CN 103385924 A CN103385924 A CN 103385924A CN 2012101395803 A CN2012101395803 A CN 2012101395803A CN 201210139580 A CN201210139580 A CN 201210139580A CN 103385924 A CN103385924 A CN 103385924A
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Abstract
The invention provides a traditional Chinese medicine tablet with significant pain-relieving, calming, and pain-stopping effects, and a preparation method thereof. The traditional Chinese medicine sustained-release tablet comprises Kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, and magnesium stearate. The tablet provided by the invention has significant pain-relieving and pain-stopping effects, no toxicity, no addictiveness, no significant adverse reaction, and durable effect. The tablet can be applied for disease pains caused by various reasons, and for relieving pain of a patient. The adopted process method is safe, stable, and economical, and has the advantages of low loss rate and high yield. According to an extraction process, macroporous absorption resin is adopted. The material adopted during the process can be recycled and regenerated. Ethanol can be recycled and reused. Energy consumption is low, and environment pollution is prevented. During tableting, acrylic resin is adopted as a framework material. The effect of the sustained-release medicine is reliable and stable, and human body bioavailability is high.
Description
Technical field
The present invention relates to a kind of analgesic and method for making thereof, especially a kind of Chinese medicine sustained release tablets and method for making thereof with analgesic effect.
Background technology
Chinese medicine sustained release tablets have the number of times of taking few, easy to use, keep blood drug level steadily, avoid peak valley phenomenon, the untoward reaction advantages such as minimizing relatively, avoided the Chinese medicine bioavailability low, take inconvenience, the slow shortcoming of onset.Yet at present domestic have the Chinese medicinal tablet of pain relieving effect of less types, and especially the kind of slow releasing tablet still less.
Summary of the invention
The invention provides a kind of Chinese medicine sustained release tablets and method for making thereof that obvious analgesia, calmness, analgesic effect are arranged.
Realize the Chinese medicine sustained release tablets with analgesic effect of one of the object of the invention, comprise kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, magnesium stearate.
Wherein, kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, magnesium stearate 3g.
Realize the method for making of two the Chinese medicine sustained release tablets with analgesic effect of the object of the invention, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally.
Described method for making with Chinese medicine sustained release tablets of analgesic effect also comprises step (5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.
The beneficial effect of the Chinese medicine sustained release tablets with analgesic effect of the present invention and method for making thereof is as follows:
Chinese medicine sustained release tablets and method for making thereof with analgesic effect of the present invention, have obvious analgesia, sedation, and be nontoxic, and without addiction, without obvious adverse reaction, effect is lasting.Can be applicable to the slight illness that a variety of causes causes, alleviate and alleviate patient's misery.The safe in process of taking, stable, economy, loss rate is low, and yield rate is high; Adopt macroporous adsorbent resin during extraction process, technique uses the material circular regeneration to use, and ethanol is recyclable, the low and non-environmental-pollution of energy consumption; Adopting acrylic resin during film-making is framework material, and the controlled release drug reliable effect is stable, and human bioavailability is high.
The specific embodiment
Chinese medicine sustained release tablets with analgesic effect of the present invention, comprise kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, 95% appropriate amount of ethanol, magnesium stearate 3g.
Method for making with Chinese medicine sustained release tablets of analgesic effect of the present invention, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally;
(5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.Tetrahydropalmatine is the strong alkaloid of a kind of activity,, therefore can be used as said preparation quantitative target composition,, to control quality, guarantees clinical efficacy.
The effect of the Chinese medicine sustained release tablets with analgesic effect of the present invention and method for making thereof is as follows:
1, pain relieving
Chinese medicine sustained release tablets with analgesic effect of the present invention contains multiple alkaloid, comprising corydaline, and dl-tetrahydropalmatine (dl-THP), L-Tetrahydrocoptisine, 1-tetrahydrocolumbamine and corybulbine.THP is considered to the most effective composition that eases the pain.In laboratory research, the multiple pharmacological effect that it demonstrates central nervous system (CNS), comprise analgesia and sedation.Scientist propose dl-THP may hinder some receptor site in brain (for example: dopamine) thus play sedation.In addition, menstrual pain (dysmenorrhea), childbirth postabdomen pain and headache are taken THP and have also been obtained good repercussion.Utilize THP treatment menstrual pain (dysmenorrhea), childbirth postabdomen pain and headache have also obtained good efficacy.
2, calmness
Be accompanied by analgesic effect, THP demonstrates sedation with it at experimental rat.After other human clinicals to dl-THP studies show that the dl-THP that takes 100-200mg before sleeping, it causes the effect of sleeping can be helpful to the patient.This effect also is considered to its result to the CNS effect.Human body does not find that any drug residue symptom is as unable in morning after taking this alkaloid extract, feels dizzy or dizzy.
3, to Cardiovascular
Except the central nervous system was acted on, laboratory research showed that the Chinese medicine sustained release tablets of analgesic effect of the present invention also demonstrates the effect to cardiovascular system.For example dl-THP demonstrates simultaneously to reduce PC and by reducing blood pressure, with heart rate, be protected from apoplexy and threatens in zoopery.In addition, as if it also has anti-arrhythmia effect.This effect is to be found in once to the double blinding clinical experiment of suffering from special arrhythmia (for example: upper ventricle early onset shrinks or title SVPB) patient.The patient who takes the 300-600mgdl-THP tablet every day compares with the patient who takes placebo, and obvious improvement has appearred in situation.
Embodiment recited above is described the preferred embodiment of the present invention; not scope of the present invention is limited; design under spiritual prerequisite not breaking away from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical solution of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (4)
1. the Chinese medicine sustained release tablets with analgesic effect, comprise kwangsi stephania root, HPMC, acrylic resin, lactose, 95% ethanol, magnesium stearate.
2. the Chinese medicine sustained release tablets with analgesic effect according to claim 1, is characterized in that: kwangsi stephania root 100g, HPMC 30g, acrylic resin 30g, lactose 40g, magnesium stearate 3g.
3. the method for making with Chinese medicine sustained release tablets of analgesic effect, comprise the steps:
(1) kwangsi stephania root is first passed through water extract-alcohol precipitation, ethanol is filtered, filtrate is processed through macroporous adsorbent resin AB-8, uses the hydrochloric acid solution eluting, collects last eluent, gets dry extract after concentrate drying standby.
(2) dry extract and the cyclodextrin ratio of 1: 1 that step (1) are obtained are carried out enclose: first make cyclodextrin water saturation solution, more dried cream fine powder is added, fully be ground to into pastel, cold drying, obtain cyclodextrin clathrate;
(3) be framework material with HPMC and acrylic resin, add PVP to make binding agent, make soft material after mixing with cyclodextrin;
(4) the soft material cold drying that step (3) is obtained, pulverize to obtain fine powder, then get fine powder and add lactose as diluent, granulate take 95% ethanol as wetting agent, and cold drying, granulate, add magnesium stearate as lubricant, tabletting finally.
4. the method for making with Chinese medicine sustained release tablets of analgesic effect according to claim 3, it is characterized in that: also comprise step (5) quality inspection: use the tetrahydropalmatine reference substance solution as external standard, adopt Content determination of dl-tetrahydropalmatine in the high effective liquid chromatography for measuring said preparation.
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| CN2012101395803A CN103385924A (en) | 2012-05-08 | 2012-05-08 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
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| CN2012101395803A CN103385924A (en) | 2012-05-08 | 2012-05-08 | Traditional Chinese medicine sustained-release tablet with pain relieving effect, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727621A (en) * | 2016-11-22 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of Western medicine powder for treating toothache |
| CN107854632A (en) * | 2017-11-14 | 2018-03-30 | 青岛卓森纳生物工程有限公司 | A kind of slow releasing drugs of tcm for treating peptic ulcer |
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| CN1562019A (en) * | 2004-04-05 | 2005-01-12 | 孟繁浩 | Corydalis B long-acting preparation and its preparing method |
| CN101234141A (en) * | 2008-01-14 | 2008-08-06 | 马仁强 | Total alkaloid of stephania delavayi and preparation and application thereof |
| WO2011149575A1 (en) * | 2010-05-28 | 2011-12-01 | Nexgen Dermatologics, Inc. | Compositions and methods for treating bruises |
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2012
- 2012-05-08 CN CN2012101395803A patent/CN103385924A/en active Pending
Patent Citations (4)
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| CN1481854A (en) * | 2003-05-13 | 2004-03-17 | 沈阳药科大学 | Delay, control release drug of prepared aconite root which can regulate the function of middle-warmer, and its preparation method |
| CN1562019A (en) * | 2004-04-05 | 2005-01-12 | 孟繁浩 | Corydalis B long-acting preparation and its preparing method |
| CN101234141A (en) * | 2008-01-14 | 2008-08-06 | 马仁强 | Total alkaloid of stephania delavayi and preparation and application thereof |
| WO2011149575A1 (en) * | 2010-05-28 | 2011-12-01 | Nexgen Dermatologics, Inc. | Compositions and methods for treating bruises |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727621A (en) * | 2016-11-22 | 2017-05-31 | 郑州仁宏医药科技有限公司 | A kind of Western medicine powder for treating toothache |
| CN107854632A (en) * | 2017-11-14 | 2018-03-30 | 青岛卓森纳生物工程有限公司 | A kind of slow releasing drugs of tcm for treating peptic ulcer |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Jie Inventor after: Xu Liba Inventor after: Jiang Weizhe Inventor after: Long Yu Inventor after: Wei Jinbin Inventor after: Huang Zengqiong Inventor after: Jiao Aijun Inventor after: Chen Rong Inventor after: Li Rumin Inventor after: Huang Seping Inventor before: Wang Jie Inventor before: Long Yu Inventor before: Wei Jinbin Inventor before: Li Yuanhong Inventor before: Liu Yingxin |
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| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20151204 Address after: Support 530021 Nanning Road, the Guangxi Zhuang Autonomous Region No. 22 Applicant after: Guangxi Medical Univ. Pharmaceutical Plant Address before: Support 530021 Nanning Road, the Guangxi Zhuang Autonomous Region No. 22 Applicant before: Wang Jie |
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| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131113 |