CN101322736A - Medicament composition for preventing and treating cognitive disorder disease - Google Patents
Medicament composition for preventing and treating cognitive disorder disease Download PDFInfo
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- CN101322736A CN101322736A CNA2008101408953A CN200810140895A CN101322736A CN 101322736 A CN101322736 A CN 101322736A CN A2008101408953 A CNA2008101408953 A CN A2008101408953A CN 200810140895 A CN200810140895 A CN 200810140895A CN 101322736 A CN101322736 A CN 101322736A
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating cognitive impairment diseases and is characterized in that the pharmaceutical composition uses huperzia serrata and rhodiola root as effective medicinal components, a filler and a lubricant are added, according to weight proportion, huperzia serrata is 150-2,500g, rhodiola root is 200-3,000g, the filler is 50-500g and the lubricant is 0.2-7g. The pharmaceutical composition of the invention has the efficacies of regulating central nervous system, activating blood circulation, resisting anoxia and resisting ageing of the brain, which can be mainly used for treating cognitive impairment such as hypomnesis, unresponsiveness, vascular dementia, and the like, and has good curative effect on hypomnesis caused by brainfag.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of pharmaceutical composition that is used to prevent and treat cognitive disorder disease.
Background technology
The Cognitive function damage (cognitiveimpairments) of the various degree that cognitive dysfunction general reference a variety of causes causes, from slight Cognitive function damage to dementia.Along with China progresses into aging society, the prevalence of cognitive dysfunction increases year by year.Cognitive dysfunction has become the important diseases that influences middle-aged and elderly people Health and Living quality, the performance of cognitive dysfunction not only comprises dysmnesia, aphasia, agnosia, apraxia and visual space obstacle etc., also can follow affective behavior obstacles such as anxiety, depression, intense, impulsion, these emotions and behavior disorder equally also are the reasons that the patient is disabled, and bring white elephant for society and family.Therefore to the control of cognitive dysfunction, should adhere to the principle of early treatment and lifelong treatment.
Cognitive dysfunction is a kind of central nervous system's constitutional degenerative disease, and it is chronic, carrying out property, mental deterioration disease.The true cause of its morbidity is very complicated, analyzes from Pathophysiology and mainly contains three aspects 1, radical pair nerve cell damage, 2, neurotransmitter levels descends, 3, the circulatory disturbance of brain.Modern medicine does not still have good plan to this disease so far.In the present medicine, chemicals is more, and price is expensive, and the ubiquity toxic and side effects is big, is difficult for defectives such as life-time service.Facts have proved, Chinese medicine has the effect of many target spots such as improve neurotransmitter, microcirculation improvement, improve Radical Metabolism, anti-cell withers in control cognitive dysfunction process, evident in efficacy in the clinical practice of long-term treatment cognitive disorder disease, no obvious toxic-side effects is having special advantages aspect the treatment cognitive disorder disease.
Summary of the invention
The objective of the invention is for the patient provides a kind of determined curative effect, takes safety, stable performance, traditional Chinese compound medicine that cost is low---be a kind of pharmaceutical composition that is used to prevent and treat cognitive disorder disease.The release of this medicine is for clinical and patient provide a kind of new selection.
Purpose of the present invention can realize by following technique measures:
Pharmaceutical composition of the present invention is with Herba Lycopodii serrati, and Radix Rhodiolae is the active drug composition, is equipped with filler, lubricant, and its weight ratio is Herba Lycopodii serrati 150-2500g, Radix Rhodiolae 200-3000g, filler 50-500g, lubricant 0.2-7g.
Furtherly, preferred ingredient weight ratio of the present invention is: Herba Lycopodii serrati 500-1000g, Radix Rhodiolae 500-1500g, filler 150-400g, lubricant 0.5-6g.
Preparation of drug combination method of the present invention can adopt following step to realize: gets Herba Lycopodii serrati by weight, is ground into coarse powder, add pH and be 3 tartaric acid solution, and percolation or supersound extraction, extracting solution filters, and it is standby to be condensed into thick paste shape or crushed after being dried; Get Radix Rhodiolae by weight, add water or ethanol extraction, extracting solution filters, and it is standby to be condensed into thick paste shape or crushed after being dried; Get above-mentioned two kinds of standby materials, add filler starch, dextrin, lactose by weight, mixed pelletization, drying, granulate adds magnesium stearate lubricant by weight, and mixing is made tablet and coating or capsule.
Herba Lycopodii serrati described in the present invention is the herb of Huperziaceae plants of Huperzia Herba Lycopodii serrati Lycopodiumserratum Thunb., has benefiting QI for activating blood circulation, dissipating blood stasis for subsidence of swelling, detoxifcation, analgesic effect.The chemistry and the pharmacology of Herba Lycopodii serrati have been carried out detailed further investigation both at home and abroad, the active component huperzine A of proof Herba Lycopodii serrati, it is a kind of reversibility cholinesterase inhibitor to true cholinesterase tool high selectivity, it can see through blood brain barrier and enter maincenter, and be distributed in the brain district that close ties are arranged with learning and memory, be combined into complex with acetylcholinesterase, acetylcholine esterase inhibition decomposes the effect of acetylcholine, improve the content of acetylcholine in the brain rapidly, thereby directly activate the cranial nerve conduction function, improve information transmission speed, and long action time, toxicity is low.Animal experiment shows that huperzine A is to the effect that all has clear improvement of the kinds of experiments dysmnesia of animals such as mice; further discover; huperzine A can also be resisted the toxic action of some neurotoxins to neurocyte; the expression of regulating cell apoptogene realizes the protection to neurocyte, illustrates to take huperzine A has treating both the principal and secondary aspects of a disease to alzheimer disease effect for a long time.
Radix Rhodiolae mainly contains rhodioside, butyl alcohol, flavone, aminoacid, trace element, coumarin etc., sweet in the mouth, hardship, puckery, warm in nature, having enriches blood invigorates blood circulation, the function of the kidney invigorating, clearing heat and moistening lung, modern pharmacological research proof Radix Rhodiolae (1) has obvious body oxygen supply, the improving memory of improving; (2) increase blood glucose, liver glycogen content, for brain provides many energy; (3) central nervous system is had dual regulation, and can improve neural some the mediator imbalance of mouse brain; (4) to central nervous system's aging resistance effect, can remove interior free yl, the inhibitory cell degeneration changes.(5) blood vessel dilating effect improves effects such as blood supply in brain.Clinical proof, take obviously hypermnesis ability of rhodiola rosea formulated product, improve mental and blue-collar work efficiency, the adaptive capacity of enhancing body, improve feeling after the long-term work, improve energy metabolism, promote the resynthesis of ATP, the excitation of similar Radix Ginseng to brain and spinal function arranged, and some anesthetis, hypnotic, organic phosphorus compound etc. are had Detoxication.Current the world of medicine both at home and abroad has been decided to be Radix Rhodiolae the new drug that a new generation has after Radix Ginseng " strengthening healthy qi " acts on, and its nourishing and fit keeping function and immunization are better than Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi.
The present invention utilizes the inhibition nervus centralis acetylcholinesterase of active ingredient huperzine A in the Herba Lycopodii serrati, excited cholinergic pharmacological action, mix the Radix Rhodiolae that has enhancement central nervous system activity, improves the merit of cerebral blood circulation, anti-hypoxia, removing free radical, play the effect that improves memory, improves cognitive function.
Medicine of the present invention is to develop summing up on the basis of clinical experience for many years, and still being difficult Herba Lycopodii serrati and Radix Rhodiolae at present is that raw material is united the relevant report of using the treatment cognitive disorder disease.
Beneficial effect of the present invention is as follows:
Pharmaceutical composition of the present invention have regulate the central nervous system, invigorate blood circulation, the effect of anti-hypoxia, antibrain senile.Can be used for the treatment of cognitive dysfunction, be mainly used in hypomnesis, react pure late, vascular dementia etc. also have therapeutical effect preferably to the hypomnesis that brain fag causes simultaneously.
The specific embodiment
The present invention is further described below with reference to embodiment, but this should be interpreted as that scope of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1:
Get Herba Lycopodii serrati 1000g by weight, be ground into coarse powder, add pH and be 3 tartaric acid solution (feed liquid weight ratio 1: 35), percolation is collected percolate, and it is standby to be condensed into thick paste; Get Radix Rhodiolae 800g, add the water of 10 times of weight ratios, decoct 3 times, each 1 hour, decoction liquor filter to merge, and it is standby to be condensed into thick paste; Get above-mentioned two kinds of thick pastes, add filler starch 220g, dextrin 50g, mixed pelletization, drying, granulate adds magnesium stearate lubricant 4.0g, and mixing is made tablet and the coating or the capsule of 1000 preparation units.
Embodiment 2:
Get Herba Lycopodii serrati 500g by weight, be ground into coarse powder, add pH and be 3 tartaric acid solution (feed liquid weight ratio 1: 35), percolation is collected percolate, and it is standby to be condensed into thick paste; Get Radix Rhodiolae 1000g, add the water of 10 times of weight ratios, decoct 3 times, each 1 hour, decoction liquor filter to merge, and it is standby to be condensed into thick paste; Get above-mentioned two kinds of thick pastes, add filler starch 180g, dextrin 60g, lactose 20g, mixed pelletization, drying, granulate adds magnesium stearate lubricant 3.0g, and mixing is made tablet and the coating or the capsule of 1000 preparation units.
Embodiment 3:
Get Herba Lycopodii serrati 800g by weight, be ground into coarse powder, add pH and be 3 tartaric acid solution (feed liquid weight ratio 1: 35), percolation is collected percolate, and it is standby to be condensed into thick paste; Get Radix Rhodiolae 800g, add the water of 10 times of weight ratios, decoct 3 times, each 1 hour, decoction liquor filter to merge, and it is standby to be condensed into thick paste; Get above-mentioned two kinds of thick pastes, add filler starch 200g, dextrin 40g, lactose 30g, mixed pelletization, drying, granulate adds magnesium stearate lubricant 5.0g, and mixing is made tablet and the coating or the capsule of 1000 preparation units.
Embodiment 4:
Get Herba Lycopodii serrati 1000g by weight, be ground into coarse powder, add pH and be 3 tartaric acid solution (feed liquid weight ratio 1: 20), flooded after 24 hours supersound extraction 30 minutes, filter, concentrate, precipitate with ethanol is received alcohol and is condensed into thick paste, vacuum microwave drying is ground into 100 order fine powders, and is standby; Get Radix Rhodiolae 1500g, add 8 times of weight ratio ethanol (ethanol content is 70%) reflux, extract, 2 times, per 1 hour, filter, reclaim ethanol and be condensed into thick paste, vacuum microwave drying is ground into 100 order fine powders, and is standby; Get two kinds of fine powders and add filler starch 200g, dextrin 30g, lactose 20g, add alcohol granulation behind the mixing, drying, granulate adds magnesium stearate lubricant 2.5g, and mixing is made tablet and the coating or the capsule of 1000 preparation units.
Embodiment 5:
Get Herba Lycopodii serrati 1000g by weight, be ground into coarse powder, add pH and be 3 tartaric acid solution (feed liquid weight ratio 1: 20), flooded after 24 hours supersound extraction 30 minutes, filter, concentrate, precipitate with ethanol is received alcohol and is condensed into thick paste, vacuum microwave drying is ground into 100 order fine powders, and is standby; Get Radix Rhodiolae 1000g, add ethanol (ethanol content the is 70%) reflux, extract, 2 times of 8 times of weight ratios, per 1 hour, filter, reclaim ethanol and also be condensed into thick paste, vacuum microwave drying is ground into 100 order fine powders, and is standby; Get above-mentioned two kinds of fine powders and add filler starch 200g, dextrin 20g, lactose 40g, add alcohol granulation behind the mixing, drying, granulate adds magnesium stearate lubricant 2.0g, and mixing is made tablet and the coating or the capsule of 1000 preparation units.
Claims (2)
1. pharmaceutical composition that is used to prevent and treat cognitive disorder disease, it is characterized in that: described pharmaceutical composition is with Herba Lycopodii serrati, and Radix Rhodiolae is the active drug composition, is equipped with filler, lubricant; Its weight ratio is Herba Lycopodii serrati 150-2500g, Radix Rhodiolae 200-3000g, filler 50-500g, lubricant 0.2-7g.
2. pharmaceutical composition according to claim 1 is characterized in that: its weight ratio is: Herba Lycopodii serrati 500-1000g, Radix Rhodiolae 500-1500g, filler 150-400g, lubricant 0.5-6g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101408953A CN101322736A (en) | 2008-08-04 | 2008-08-04 | Medicament composition for preventing and treating cognitive disorder disease |
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| CNA2008101408953A CN101322736A (en) | 2008-08-04 | 2008-08-04 | Medicament composition for preventing and treating cognitive disorder disease |
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| CN101322736A true CN101322736A (en) | 2008-12-17 |
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| CNA2008101408953A Pending CN101322736A (en) | 2008-08-04 | 2008-08-04 | Medicament composition for preventing and treating cognitive disorder disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445148A (en) * | 2012-06-04 | 2013-12-18 | 孔徐生 | Composition capable of improving memory and preparation method of composition |
| CN105902608A (en) * | 2015-08-30 | 2016-08-31 | 王六生 | Preparation method and use of traditional Chinese medicine rhodiola solution for improving memory |
| CN106074668A (en) * | 2016-08-03 | 2016-11-09 | 刘石磊 | For neurodegenerative diseases or the Chinese medicine preparation of neuranagenesis |
-
2008
- 2008-08-04 CN CNA2008101408953A patent/CN101322736A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445148A (en) * | 2012-06-04 | 2013-12-18 | 孔徐生 | Composition capable of improving memory and preparation method of composition |
| CN105902608A (en) * | 2015-08-30 | 2016-08-31 | 王六生 | Preparation method and use of traditional Chinese medicine rhodiola solution for improving memory |
| CN106074668A (en) * | 2016-08-03 | 2016-11-09 | 刘石磊 | For neurodegenerative diseases or the Chinese medicine preparation of neuranagenesis |
| CN106074668B (en) * | 2016-08-03 | 2019-09-27 | 黑龙江中医药大学 | For neurodegenerative disease or the Chinese materia medica preparation of nerve regneration |
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Open date: 20081217 |