CN106727474A - Phenoxy acetic acid class herbicide as chemotherapeutic agent treatment disease application - Google Patents
Phenoxy acetic acid class herbicide as chemotherapeutic agent treatment disease application Download PDFInfo
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- CN106727474A CN106727474A CN201710005080.3A CN201710005080A CN106727474A CN 106727474 A CN106727474 A CN 106727474A CN 201710005080 A CN201710005080 A CN 201710005080A CN 106727474 A CN106727474 A CN 106727474A
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- acetic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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Abstract
The invention discloses phenoxy acetic acid class herbicide as the application of chemotherapeutic agent treatment disease, it is related to the new opplication of herbicide.Cancer cell is quickly to breed undifferentiated young tender cell, apical growing point of its some feature similar to plant cell, the present invention utilizes 2 accordingly, 4- dichlorphenoxyacetic acids are acted on histiocytic growth regulating at low concentrations, it is directly used in the treatment of cancer cell, control the growth and transfer of cancer cell, comprehensive injury of the containment cancer cell to histoorgan, it is also possible to as the adjuvant therapy medicaments in chemotherapy, radiotherapy, operative treatment or after treatment；In addition, the long-term chronic inflammation of body is closely related with the generation of many diseases of the mankind and progress, the present invention reaches the effect for curing the various diseases that inflammation disease and auxiliary treatment are triggered by inflammation accordingly using 2,4- dichlorphenoxyacetic acids by suppressing inflammatory reaction.
Description
Technical field
The present invention relates to the new opplication of herbicide, and in particular to phenoxy acetic acid class herbicide is used as chemotherapeutic agent treatment disease
The application of disease.
Background technology
Phenoxy acetic acid class herbicide is the hormone-type selective herbicide of first kind merchandized handling in the world, to environment friend
It is good, it is short and the features such as to people and other biological low toxicity with residual life, drug resistance is seldom produced, it is mainly used in corn, wheat etc.
Prevent and kill off broadleaf weed, nutgrass flatsedge and some malignant weeds in gramineous crop field.Because phenoxy acetic acid class herbicide belongs to sharp
Plain type selective herbicide, as herbicide when being used except high concentration, prevent and kill off 1 year and perennial broadleaf weed performance outside,
Also there is plant hormone in low concentration.
1999, the experimental study of Charles JM demonstrated 2,4- dichlorphenoxyacetic acids active compound without genetoxic.
2014, thin perfume (or spice) etc. of depositing was with reference to national standard《Agriculture chemical registration toxicology test method》The method of recommendation, is utilized respectively Ames examinations
Test, mice bone marrow micronucleus and Mouse primary spermatocyte chromosomal aberration test, to 2,4- bis-
The mutagenicity of chlorophenoxyacetic acid active compound is studied, and has obtained identical conclusion, i.e., under this experiment condition, do not find 2,
The mutagenicity of 4- dichlorphenoxyacetic acid active compounds.2,4 dichlorophenoxyacetic acid active compound rat acute LD50 666-1313mg/
Kg, this research shows that 2,4- dichlorphenoxyacetic acids belong to lower toxicity material.
Unique bioactivity and hypotoxicity of 2,4- dichlorphenoxyacetic acids, to be provided as chemotherapeutic agent treatment disease
Foundation.
Now, not yet have using phenoxy acetic acid class herbicide as the application of chemotherapeutic agent treatment disease record with grind
Study carefully.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of phenoxy acetic acid with 2,4 dichlorophenoxyacetic acid as representative
Class herbicide, as a class new chemical medicine, the application for treating some diseases.
In order to solve the above technical problems, the technical solution used in the present invention is：Phenoxy acetic acid class herbicide is used as chemistry
Therapeutic agent treats the application of disease.
Further technical scheme is that the phenoxy acetic acid class herbicide is 2,4- dichlorphenoxyacetic acids.
Further technical scheme is that the phenoxy acetic acid class herbicide is applied to treating cancer.
Further technical scheme is that the phenoxy acetic acid class herbicide is applied to the disease that treatment is triggered by inflammation
Disease.
Further technical scheme is that the phenoxy acetic acid class herbicide is applied to treatment lung cancer, stomach cancer, liver cancer, intestines
Cancer, cancer of the esophagus, lymph cancer, cancer of pancreas.
Further technical scheme is that the phenoxy acetic acid class herbicide is applied to treatment gastritis, gastric ulcer, esophagus
Inflammation, enteritis, arthritis, sphagitis, hypertension, diabetic complication.
Further technical scheme is also resided in, and the phenoxy acetic acid class herbicide dosage is in 0.01-200mg/kg.
It is using the beneficial effect produced by above-mentioned technical proposal：The present invention treats disease to modern medicine there is provided one kind
The new way of disease, increases the New function of phenoxy acetic acid class herbicide, shows by majority of cases clinical trial, using 2,4-
Dichlorphenoxyacetic acid is acted on histiocytic growth regulating at low concentrations, is directly used in the treatment of cancer cell, and control cancer is thin
The growth and transfer of born of the same parents, comprehensive injury of the containment cancer cell to histoorgan, it is also possible to as in chemotherapy, radiotherapy, operative treatment
Or the adjuvant therapy medicaments after treatment；Using 2,4- dichlorphenoxyacetic acids by suppressing inflammatory reaction, healing inflammation can be reached
(gastritis, gastric ulcer, esophagitis, enteritis, arthritis, sphagitis, hypertension complication, diabetic complication, cancer are concurrent for disease
Disease) and the various diseases that are triggered by inflammation of auxiliary treatment.
Specific embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model of present invention protection
Enclose.
Many details are elaborated in the following description in order to fully understand the present invention, but the present invention can be with
Other manner described here is different from using other to implement, those skilled in the art can be without prejudice to intension of the present invention
In the case of do similar popularization, therefore the present invention is not limited by following public specific embodiment.
Embodiment 1：
Medically, malignant cell (also referred to as cancer cell) is body under the effect of various tumorigenesis factors, local organization
Cell loses the neoformation that the normal regulation that it grows is caused paraplasm and formed on gene level, once neoformation shape
Into, not stopped growing because the cause of disease is eliminated, normal body Physiological effect is not received in its growth, while also disturbing and destroying normal group
The operation with organ is knitted, malignant cell growth speed is fast, and wellability is strong, bleeding, necrosis, ulcer etc. easily occurs, and often have
DISTANT METASTASES IN, causes human body to become thin, powerless, anaemia, poor appetite, heating and serious organ function are impaired etc., finally makes
Into death.
Control group：Take pure lines male mice 20, every mouse inoculation S180 Ascitic Tumor Cells 1 × 106It is individual, mouse ascites
5-7 days are appeared in, 12-18 days time-to-live, Average Survival 15 days,
Experimental group：Take pure lines male mice 20, every mouse inoculation S180 Ascitic Tumor Cells 1 × 106It is individual, mouse ascites
Appear in 5-7 days, daily abdomen injection doses 2,4- dichlorphenoxyacetic acids, consumption 1-5mg/kg, time-to-live 17-
28 days, Average Survival 23 days.
Combined analysis of experimental data understands：The characteristics of young tender somatoblast of this low differentiation of malignant cell, is similar
In the shoot tip meristem of plant.Therefore, 2,4- dichlorphenoxyacetic acids are acted on into (growth regulating to the double regulation control of plant metabolism
Agent and herbicide), it is applied in the treatment of malignant cell, the metabolism of interference malignant cell is reached, excitating organism is exempted from
Epidemic disease is monitored, and prevents cancer cell division, suppresses growth and metastasis of tumours, extends the purpose of cancer patient effective life cycle.
Embodiment 2：
Chronic gastritis is the common disease and frequently-occurring disease of digestive system, and it mainly includes chronic superficial gastritis and chronic atrophy
Property gastritis.Helicobacter pylori (Hp) is the important pathogenic bacteria that it occurs.70% is up in its gastritis infection rate of developed country~
90%.
Flora in stomach is destroyed with the method for antibiotic gavage, the cleaning grade Balb/c mouse of flora imbalance in stomach are obtained, filled
Stomach method is inoculated with 1X108CFU/ml Hp in Mouse Stomach, manufactures artificial gastritis mouse 40, wherein 20 as experimental group, 20
As control group, experimental group is treated ten days with 2,4- dichlorphenoxyacetic acid 1mg/kg gavages daily, after 4 weeks, pathological tissue credit
Analysis, it is found that control group mice stomach lining chronic inflammation occurs and changes 100%, and experimental mice stomach lining chronic inflammation occurs and changes
Become 40%.
Embodiment 3
Normal living cells, after birth structural integrity can repel trypan blue, be allowed to that intracellular can not be entered；And lose and live
Property or the incomplete cell of cell membrane, the permeability of after birth increases, and can dye blueness by trypan blue.Therefore, contaminated by trypan blue
Color can simply and quickly distinguish living cells and dead cell very much.Trypan Blue is completed by only needing 3-5 minutes, and is grasped
Make very simple.
Being applied to cell in vitro to 2,4- dichlorphenoxyacetic acids carries out tumor cell in vitro experiment, shows, 2,4- dichloros
Phenoxy acetic acid has the effect of similar agglutinin, can be recognized with malignant cell surface, plays the effect of similar agglutinin,
The various cancer cells of aggegation, cancer cell after aggegation can by Trypan Blue, and under similarity condition normal live cells be not identified and
Aggegation, can not be by Trypan Blue.Speculate some specific moleculars on malignant cell surface, may look like plant point
The surface molecular of schistocyte, can occur specially identification reaction with 2,4- dichlorphenoxyacetic acids, and this identification reaction can be people
The immunosurveillance of body provides significant molecular structure, in order to nonspecific immunity cells play in human body to malignant cell
Monitoring and phagocytosis.
Experiment in vitro is also shown that 2,4- dichlorphenoxyacetic acids have functions that to eliminate various tissue inflammations, can be as sense
Metachromia or the antiphlogistic without infection inflammation, for alleviating the disease triggered due to various inflammation.
In vitro cell experiment shows that 2,4- dichlorphenoxyacetic acids have the effect of agglutinin, can aggegation cancer cell, and
Aggegation normal cell is not acted on, and this cancer cell by aggegation can show that 2,4- dichlorphenoxyacetic acids exist by Trypan Blue
It is external that there is the effect for killing cancer cell.
For above-mentioned experiment, the best results when 2,4- dichlorphenoxyacetic acids dosage is in 0.01-200mg/kg.
Before making the present invention, 2,4- dichlorphenoxyacetic acids are plant growth regulator and herbicide.The 2,4- of low concentration
Dichlorphenoxyacetic acid has promotion crop growth, prevents young fruit from coming off and improves the effect of percentage of fertile fruit；It is also simultaneously extensive use
Fruit antistaling agent, be mainly used in enhancing fruit premunition, delayed fruit aging, extension fruit storage phase；When high concentration is used
As herbicide, 1 year and perennial broadleaf weed are prevented and kill off.
After the present invention, cancer cell is quickly to breed undifferentiated young tender cell, and its some feature is thin similar to plant
The apical growing point of born of the same parents, is acted on histiocytic growth regulating at low concentrations using 2,4- dichlorphenoxyacetic acids, is directly used
In the treatment of cancer cell, the growth and transfer of cancer cell, comprehensive injury of the containment cancer cell to histoorgan, it is also possible to make are controlled
It is the adjuvant therapy medicaments in chemotherapy, radiotherapy, operative treatment or after treatment.
Increasing experimental evidence shows, generation of the long-term chronic inflammation of body with many diseases of the mankind and progress
It is closely related, for example：Obesity, cancer, diabetes, hypertension, coronary heart disease, 2,4- dichlorphenoxyacetic acids are anti-by suppressing inflammation
Should, disease (gastritis, gastric ulcer, the esophagitis, enteritis, arthritis, sphagitis, hypertension cured and triggered by inflammation can be reached
Complication, diabetic complication, cancer complication) and the various diseases that are triggered by inflammation of auxiliary treatment.
2,4- dichlorphenoxyacetic acid sterlings are white crystals, and odorless, tasteless is non-hygroscopic, is insoluble in water, can be dissolved in ethanol,
First 2,4- dichlorphenoxyacetic acids are dissolved in ethanol when can prepare, are added water and is diluted to preferable concentration and uses；Such as, first
1 gram of 2,4- dichlorphenoxyacetic acid is dissolved in 10 grams of ethanol, is added water and is diluted to 1 liter, the concentration for being made 1000mg/L is used,
As long as dosage is in 0.01-200mg/kg, effect is all preferable.
Claims (7)
1. phenoxy acetic acid class herbicide as chemotherapeutic agent treatment disease application.
2. application as claimed in claim 1, the phenoxy acetic acid class herbicide is 2,4- dichlorphenoxyacetic acids.
3. application as claimed in claim 1 or 2, the phenoxy acetic acid class herbicide is applied to treating cancer.
4. application as claimed in claim 1 or 2, the phenoxy acetic acid class herbicide is applied to the disease that treatment is triggered by inflammation
Disease.
5. application as claimed in claim 3, the phenoxy acetic acid class herbicide is applied to treatment lung cancer, stomach cancer, liver cancer, intestines
Cancer, cancer of the esophagus, lymph cancer, cancer of pancreas.
6. application as claimed in claim 4, the phenoxy acetic acid class herbicide is applied to treatment gastritis, gastric ulcer, esophagitis,
Enteritis, arthritis, sphagitis, hypertension, diabetic complication.
7. application as claimed in claim 1 or 2, the phenoxy acetic acid class herbicide dosage is in 0.01-200mg/kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710005080.3A CN106727474A (en) | 2017-01-04 | 2017-01-04 | Phenoxy acetic acid class herbicide as chemotherapeutic agent treatment disease application |
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| CN201710005080.3A CN106727474A (en) | 2017-01-04 | 2017-01-04 | Phenoxy acetic acid class herbicide as chemotherapeutic agent treatment disease application |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101573363A (en) * | 2006-10-04 | 2009-11-04 | 先灵公司 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| CN102283825A (en) * | 2011-07-28 | 2011-12-21 | 张克军 | Medicament with broad-spectrum bactericidal effect |
-
2017
- 2017-01-04 CN CN201710005080.3A patent/CN106727474A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101573363A (en) * | 2006-10-04 | 2009-11-04 | 先灵公司 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| CN102283825A (en) * | 2011-07-28 | 2011-12-21 | 张克军 | Medicament with broad-spectrum bactericidal effect |
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