CN106725349A - A kind of dermoscopy of detectable blood flow - Google Patents
A kind of dermoscopy of detectable blood flow Download PDFInfo
- Publication number
- CN106725349A CN106725349A CN201710110657.7A CN201710110657A CN106725349A CN 106725349 A CN106725349 A CN 106725349A CN 201710110657 A CN201710110657 A CN 201710110657A CN 106725349 A CN106725349 A CN 106725349A
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- Prior art keywords
- light source
- dermoscopy
- probe
- information
- skin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
Abstract
The invention provides a kind of dermoscopy of detectable blood flow,The processing unit popped one's head in including dermoscopy and be connected with dermoscopy probe,The dermoscopy probe includes light source part,The first polarizer in front of the light source part,The imaging optical path being disposed adjacent with light source part,The imaging optical path includes the second polarizer,Image-forming assembly,The image-forming assembly includes imaging len,Optical-filter switcher part and Photoelectric Detection chip,The light source part includes two kinds of light sources of broad spectrum light source and LASER Light Source,The broad spectrum light source is used for dermoscopy probe and obtains skin molds information,The LASER Light Source is used for dermoscopy probe and obtains laser speckle image to detect SkBF information,The two information combination can simultaneously provide the structural information and function information of skin,It is not only applicable to disease of skin diagnosis,Also there is important function to curative effect evaluation.
Description
Technical field
The present invention relates to a kind of dermoscopy, more particularly to a kind of dermoscopy of detectable blood flow.
Background technology
Skin is first of human body defence, protect in-vivo tissue and organ from various mechanicalnesses, chemically, cause of disease it is micro-
The invasion of the harm such as biological.In recent years, with the continuous upgrading of food security and environmental problem etc., it is strong that skin disease triggers
Health, life security and patients ' psychological problem are more subject to social concerns；Disease of skin is also the disease of most species simultaneously；And mesh
Preceding dermopathic diagnosis Main Basiss clinical manifestation and tissue pathology checking, the former depends on the clinical experience of doctor and there is master
Composition is seen, the latter belongs to invasive detection, can cause chromoma that the serious consequences such as transfer occur when serious.The new use of research
It is very necessary and is badly in need of in effective, the noninvasive instrument of skin disease detection, diagnosis.
Dermoscopy also known as epidermis printing opacity microscope, because it can quickly, non-invasively observe skin focus surface and following aobvious
Micro-structural, so as to improve the accuracy rate of the diagnosis of skin disease, especially pigmented dermatosis, the use of dermoscopy in recent years is obtained
Greatly promote.But dermoscopy is when disease of skin auxiliary diagnosis are carried out, its indication (such as Magnifying chromoscopy shape, color) category form
Detection, though it is right to propose to have various ways (type method, ABCD methods, detection table method etc.) to belong to the etiologic diagnosis of disease at 3 points
The combined chance analysis of variform indication, it can not negates diagnosis to lack a certain bar indication, and only possessing a certain bar indication can not
Certainly diagnose, i.e. the diagnosis of dermoscopy can not also completely replace existing tissue pathology checking because lacking specific indicators, skin
Skin mirror also needs to be improved further combined with other diagnostic techniques or Diagnostic parameters in itself the accuracy rate and validity of its diagnosis.
Blood flow is the important physiological characteristic of viable organism, focal area big city raised with blood flow or blood flow reduction it is different
Often characterize, and blood flow signal function of dominant information, the information that structure/form signals cannot be showed can be embodied.For example it is similarly pigment
Property disease of skin, mole is only pigment aggregation and without specific blood flow signal, and melanoma then generally entails that blood flow signal strengthens；It is fresh
The optical dynamic therapy of erythema mole is the blood vessel by blocking paraplasm so that whether focus is from row degradation, and treat and effectively lead to
Form is crossed to be difficult to judge, and blood flow signal can intuitively react, if closure is effective, the blood flow signal of affected area can be remarkably decreased.Swash
Light speckle blood flow imaging technology or laser doppler technique are detection and the imaging means of blood flow signal emerging in recent years, are had
There are noncontact, advantage noninvasive, without contrast agent, the limitation that the former can also depart from mechanical scanning carries out the blood flow imaging of the whole audience,
Temporal resolution can reach several ms magnitude, spatial resolution up to micron dimension, because its is non-invasive and real-time, in recent years
It is deep to be welcome by clinical detection, but the skin lens device with blood flow detection function is there is no at present, for example：Application number
201010178190.8 patent of invention " polarized skin lens ", is only the fine structure information for observing skin lesion sites；Application
Number observed using different methods for a kind of 201410475367.9 patent of invention " skin lens image harvester and method "
Structural information below skin surface and skin keratin, above-mentioned patent is all only observation structure information without possessing observation blood flow
Function information.
The content of the invention
In order to solve the defect of above-mentioned deficiency, the invention provides a kind of dermoscopy of detectable blood flow, by being provided with skin
The processing unit that skin mirror is popped one's head in and is connected with dermoscopy probe, and dermoscopy probe includes broad spectrum light source and LASER Light Source
Two kinds of light sources, processing unit obtains skin molds information using the skin image of wide spectrum illumination, is examined using laser speckle blood flow
Gained laser speckle image under laser lighting is converted to SkBF information by survey method or laser-Doppler blood flow detection method.
Pop one's head in and popped one's head in the dermoscopy and connect the invention provides a kind of dermoscopy of detectable blood flow, including dermoscopy
The processing unit for connecing, the dermoscopy probe includes light source part, the first polarizer and light in front of the light source part
The imaging optical path that source block is disposed adjacent, the imaging optical path includes the second polarizer, image-forming assembly, and the image-forming assembly includes
Imaging len, optical-filter switcher part and Photoelectric Detection chip, the light source part include broad spectrum light source and LASER Light Source, institute
State broad spectrum light source and obtain skin molds image for dermoscopy probe, the LASER Light Source is used for dermoscopy probe and obtains laser
Speckle image is detecting SkBF information.
The present invention has advantages below：Can be to naked eyes such as the epidermis bottom of skin, the connection of table corium and papillaris pars corium
Sightless skin carries out micro-imaging, and skin is obtained using dermoscopy indication (pigment net, pigment line, lobate area, bluish grey area etc.)
The Morphology observation information of skin；On the other hand obtained using laser speckle blood flow detection technology or laser-Doppler blood flow detection method
The blood flow information of skin at this, obtains the Two dimensional Distribution information of blood flow or the quantitative information of the front and rear blood flow change for the treatment of；And then will
The two information carries out comprehensive analysis or the two image carries out fusion ratio pair, obtains the diagnostic message to the skin.The two information knot
Conjunction can simultaneously provide the structural information and function information of skin focus, be not only applicable to disease of skin diagnosis, improve the standard of diagnosis
True rate, also has important function, there is provided cure rate to curative effect evaluation.
Brief description of the drawings
By the detailed description made to non-limiting example with reference to the following drawings of reading, the present invention and its feature, outward
Shape and advantage will become more apparent upon.Identical mark indicates identical part in whole accompanying drawings.Not deliberately proportionally
Draw accompanying drawing, it is preferred that emphasis is purport of the invention is shown.
Fig. 1 is a kind of structural representation of the dermoscopy of detectable blood flow of the invention.
Fig. 2 is the structural representation that one of which of the present invention implements example.
Fig. 3 a- Fig. 3 d are one of which Application Example of the invention.
Specific embodiment
In the following description, a large amount of concrete details are given to provide more thorough understanding of the invention.So
And, it is obvious to the skilled person that the present invention can be able to without one or more of these details
Implement.In other examples, in order to avoid obscuring with the present invention, do not enter for some technical characteristics well known in the art
Row description.
In order to thoroughly understand the present invention, detailed step and detailed structure will be proposed in following description, so as to
Explaination technical scheme.Presently preferred embodiments of the present invention is described in detail as follows, but in addition to these detailed descriptions, this
Invention can also have other embodiment.
Shown in reference picture 1, Fig. 2, the invention provides a kind of dermoscopy of detectable blood flow, including dermoscopy probe 6 with
And with the processing units 8 that be connecteds of dermoscopy probe 6, wherein processing unit 8 for Data Collection, process, show, preserving, going out
Have a work station composition of report, dermoscopy probe 6 include light source part 1, the first polarizer 2 positioned at the front of light source part 1 and
The imaging optical path that light source part 1 is disposed adjacent, wherein the first polarizer 2 is the polarizer, it is ensured that the light for being irradiated in tissue surface is
Polarised light, imaging optical path includes the second polarizer 4, image-forming assembly 5, and image-forming assembly 5 switches including imaging lens group 51, optical filter
Device 52 and Photoelectric Detection chip 53, wherein light source part 1 include broad spectrum light source and LASER Light Source, and broad spectrum light source is used for skin
Skin mirror probe obtains skin molds image, and LASER Light Source is used for dermoscopy probe and obtains laser speckle image.Work of the invention
Principle is：The skin image illuminated using wide spectrum obtains skin molds information；Using laser speckle blood flow detection method or sharp
Gained laser speckle image under laser lighting is converted to SkBF information by light doppler flow inaging detection method, obtains blood flow
The quantitative information of blood flow change before and after Two dimensional Distribution information or treatment；And then form and blood flow information are carried out into comprehensive analysis or two
Person's image carries out fusion ratio pair, obtains the diagnostic message to the skin focus.When dermoscopy probe is detected or is imaged, into
As the polarization direction of light path and the polarization direction of illumination path are orthogonal, to obtain the information under skin surface.Wherein
Laser speckle blood flow detection method is similar to the operation principle of laser speckle blood flow detection instrument, is that those skilled in the art can manage
The technical scheme of solution.Key point of the invention is can be while obtain skin molds image and laser by being provided with light source part
Speckle image.
Preferably and in non-limiting embodiment, imaging lens group 51 at least includes what is be made up of two lens to the present invention one
Lens group, for object of observation to be imaged in into Photoelectric Detection chip, optical-filter switcher part 52 includes containing two optical filters
Switching device, for pop one's head in carry out morphological image gather when be switched to the optical filter of visible light wave range to filter Laser interferometers,
Further preferably, switch is optical filter runner switching device or IRCUT optical-filter switcher parts, and the Photoelectric Detection chip is
CCD or cmos image acquisition chip.That is, in the present invention, imaging lens group 51 is by being not limited to two lens of lens
Group composition, object of observation is imaged on Photoelectric Detection chip.Optical-filter switcher part 52 is comprising two switchings of optical filter
Device, the device can carry out being switched to the optical filter of visible light wave range to filter Laser interferometers when morphological image is gathered in probe,
Carry out being switched to bandpass filter with the interference of other wave band light sources beyond filtering laser when blood-stream image is gathered in probe.The filter
Mating plate switch is not limited to the optical-filter switcher part such as optical filter runner, IRCUT, and optical filter quantity is not limited to two panels, according to reality
Border application can be one or more pieces.Photoelectric Detection chip 53 carries out Treatment Analysis in being sent to 8 after picture signal is digitized, should
Photoelectric Detection chip is not limited to CCD or cmos image acquisition chip.
Preferably and in non-limiting embodiment, imaging optical path is additionally provided with an optics window to the present invention one, for preventing ash
Dirt, skin infiltration liquid enter in dermoscopy probe.
Of the invention one preferably and in non-limiting embodiment, wherein broad spectrum light source, preferably comprises for form inspection
Survey the LED white light sources of imaging；LASER Light Source, is preferably used for the laser diode of laser speckle blood current imaging, the pole of laser two
The centre wavelength of pipe is 785nm, that is to say, that the light source is not only useful for the LED white light sources of Morphology observation imaging, Er Qieyou
For the laser diode (LD light sources) of laser speckle blood current imaging, light source casts oblique rays in positioned at center probe lower section at an angle
Focal area, and the light that light source sends will not enter imaging optical path.Wherein broad spectrum light source is not limited to LED white light sources, swashs
Radiant is not limited to laser diode (LD), and the centre wavelength of LASER Light Source is not limited to 785nm.
Preferably and in non-limiting embodiment, shown in reference picture 2,6 front ends of dermoscopy probe are provided with a guarantor to the present invention one
Shield 9, dermoscopy probe is connected by data transmission cable 7 with processing unit 8, detachably, when focal area is little, be can be used
Protective cover, is easy to dermoscopy probe placement in skin surface and does not block, presses focal area；When focal area is excessive, can
Dismounting protective cover, increases the investigative range of dermoscopy.
It is one of the invention specific Application Example shown in reference picture 3a- Fig. 3 d.Wherein Fig. 3 a and Fig. 3 c are respectively
Wide spectrum photo after nevus flammeus treatment and when flat wart is diagnosed, Fig. 3 b and Fig. 3 d be respectively the two blood-stream image (blood flow from
Low to high correspondence image color is from Blue-Green-red).Hyperplasia blood after the treatment of identification nevus flammeus region is difficult to from Fig. 3 a
The effect that pipe is blocked, is difficult to determine the border and infected zone of flat wart on Fig. 3 c, on the other side, by acquiring
Blood-stream image, respectively Fig. 3 b and Fig. 3 d, wherein, on Fig. 3 b blood vessel hyperplasia focal area (red) in black circles table
The blue region for showing represents that blood flow information is decreased obviously at this, i.e., blood vessel is effectively blocked；Red area on Fig. 3 d is
Be the focal area of flat wart, clear positioning can be carried out and delimited with border, so as to by the two information carry out comprehensive analysis or the two
Image carries out fusion ratio pair, obtains the diagnostic message to the skin.
Presently preferred embodiments of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, wherein the equipment and structure that do not describe in detail to the greatest extent are construed as giving reality with the common mode in this area
Apply；Any those of ordinary skill in the art, in the case where technical solution of the present invention ambit is not departed from, all using the disclosure above
Methods and techniques content make many possible variations and modification to technical solution of the present invention, or be revised as equivalent variations etc.
Effect embodiment, this has no effect on substance of the invention.Therefore, every content without departing from technical solution of the present invention, foundation
Technical spirit of the invention still falls within the present invention to any simple modification, equivalent variation and modification made for any of the above embodiments
In the range of technical scheme protection.
Claims (1)
1. the processing unit that a kind of dermoscopy of detectable blood flow, including dermoscopy is popped one's head in and is connected with dermoscopy probe,
Dermoscopy probe includes light source part, the first polarizer in front of the light source part is adjacent with light source part sets
The imaging optical path put, the imaging optical path includes the second polarizer, image-forming assembly, and the image-forming assembly includes imaging len, filter
Mating plate switching device and Photoelectric Detection chip, it is characterised in that the light source part includes broad spectrum light source and LASER Light Source two
Light source is planted, the broad spectrum light source is used for dermoscopy probe and obtains skin molds information, and the LASER Light Source is visited for dermoscopy
Head obtains laser speckle image to detect SkBF information.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710110657.7A CN106725349A (en) | 2017-02-28 | 2017-02-28 | A kind of dermoscopy of detectable blood flow |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710110657.7A CN106725349A (en) | 2017-02-28 | 2017-02-28 | A kind of dermoscopy of detectable blood flow |
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| CN106725349A true CN106725349A (en) | 2017-05-31 |
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| CN201710110657.7A Pending CN106725349A (en) | 2017-02-28 | 2017-02-28 | A kind of dermoscopy of detectable blood flow |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309237A (en) * | 2018-01-29 | 2018-07-24 | 杭州美界科技有限公司 | A kind of intelligence skin detection mirror |
| CN108681056A (en) * | 2018-06-26 | 2018-10-19 | 深圳市吉斯迪科技有限公司 | Multi-wavelength polarised light biomedicine microscopic imaging device towards live body |
| CN109752377A (en) * | 2019-02-02 | 2019-05-14 | 佛山科学技术学院 | A kind of beam splitting type bimodal projection chromatography tissue blood vessel imaging device and method |
| CN110301896A (en) * | 2019-07-03 | 2019-10-08 | 武汉迅微光电技术有限公司 | The device and method for obtaining mechanics of biological tissue image and blood-stream image can be synchronized |
| CN110338814A (en) * | 2019-07-03 | 2019-10-18 | 武汉迅微光电技术有限公司 | The device and method for obtaining a variety of images of biological tissue can be synchronized |
| CN110786833A (en) * | 2019-12-03 | 2020-02-14 | 南昌航空大学 | Device for detecting and projecting skin tissue wound in real time by laser speckle |
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| CN207341746U (en) * | 2017-02-28 | 2018-05-11 | 武汉迅微光电技术有限公司 | A kind of dermoscopy of detectable blood flow |
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| CN102240205A (en) * | 2010-05-14 | 2011-11-16 | 北京大学 | Polarized skin lens |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309237A (en) * | 2018-01-29 | 2018-07-24 | 杭州美界科技有限公司 | A kind of intelligence skin detection mirror |
| CN108681056A (en) * | 2018-06-26 | 2018-10-19 | 深圳市吉斯迪科技有限公司 | Multi-wavelength polarised light biomedicine microscopic imaging device towards live body |
| CN109752377A (en) * | 2019-02-02 | 2019-05-14 | 佛山科学技术学院 | A kind of beam splitting type bimodal projection chromatography tissue blood vessel imaging device and method |
| CN109752377B (en) * | 2019-02-02 | 2024-02-13 | 佛山科学技术学院 | Spectroscopic bimodal projection tomography tissue blood vessel imaging device and method |
| CN110301896A (en) * | 2019-07-03 | 2019-10-08 | 武汉迅微光电技术有限公司 | The device and method for obtaining mechanics of biological tissue image and blood-stream image can be synchronized |
| CN110338814A (en) * | 2019-07-03 | 2019-10-18 | 武汉迅微光电技术有限公司 | The device and method for obtaining a variety of images of biological tissue can be synchronized |
| CN110301896B (en) * | 2019-07-03 | 2024-01-02 | 武汉迅微光电技术有限公司 | Device and method capable of synchronously acquiring biological tissue structure image and blood flow image |
| CN110786833A (en) * | 2019-12-03 | 2020-02-14 | 南昌航空大学 | Device for detecting and projecting skin tissue wound in real time by laser speckle |
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