CN110301896A - The device and method for obtaining mechanics of biological tissue image and blood-stream image can be synchronized - Google Patents
The device and method for obtaining mechanics of biological tissue image and blood-stream image can be synchronized Download PDFInfo
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- CN110301896A CN110301896A CN201910593877.9A CN201910593877A CN110301896A CN 110301896 A CN110301896 A CN 110301896A CN 201910593877 A CN201910593877 A CN 201910593877A CN 110301896 A CN110301896 A CN 110301896A
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- 238000000034 method Methods 0.000 title claims abstract description 14
- 230000001360 synchronised effect Effects 0.000 title description 3
- 238000003384 imaging method Methods 0.000 claims abstract description 48
- 230000007246 mechanism Effects 0.000 claims abstract description 26
- 238000001914 filtration Methods 0.000 claims abstract description 20
- 230000003287 optical effect Effects 0.000 claims abstract description 16
- 230000005284 excitation Effects 0.000 claims abstract description 8
- 238000001514 detection method Methods 0.000 claims abstract description 4
- 239000004065 semiconductor Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 claims description 3
- 239000005357 flat glass Substances 0.000 claims description 2
- 239000005338 frosted glass Substances 0.000 claims description 2
- 230000005622 photoelectricity Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 14
- 230000017531 blood circulation Effects 0.000 abstract description 13
- 210000004204 blood vessel Anatomy 0.000 abstract description 4
- 238000012634 optical imaging Methods 0.000 abstract description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 3
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000006461 physiological response Effects 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
Abstract
The present invention relates to one kind can synchronize the device and method for obtaining mechanics of biological tissue image and blood-stream image, which includes light source mechanism, optical imagery mechanism and control analysis system；Light source mechanism includes laser light source and incoherent visible light source；Optical imagery mechanism includes the optical imaging lens group set gradually along light detection access, optical-filter switcher and photoelectronic imaging device, optical-filter switcher is embedded with visible filter and Excitation Filter with High, and is respectively formed visible light light-filtering channels and laser light-filtering channels；It controls analysis system and connects photoelectronic imaging device, for analyzing the mechanics of biological tissue image and blood-stream image that obtain.This can synchronize the device for obtaining mechanics of biological tissue image and blood-stream image convenient for precisely being merged the blood-stream image of biological tissue and structural images, convenient for fast implementing the INTEGRATED SIGHT analysis of the physiology courses such as distribution and variation to the blood flow, blood vessels caliber of biological tissue.
Description
Technical field
The present invention relates to one kind can synchronize the device and method for obtaining mechanics of biological tissue image and blood-stream image.
Background technique
Laser speckle blood current imaging technology be it is a kind of can quick obtaining biological tissue blood distribution and blood flow variation it is novel
Optical image technology, with it is non-contact, without contrast agent, without scanning, the whole audience imaging advantage, in recent years life science lead
Biggish popularization and application are obtained on domain.
In addition, a kind of fast laser speckle flow imaging system and method, Shen disclosed in application number 201310234441.3
It please a kind of quantitative imaging device, application number for laser speckle blood flow velocity disclosed in numbers 201510937070.4
201520414558.4 a kind of laser speckle blood current imaging device etc. laser speckle blood current imaging technology and systems are being differentiated
Rate, precision explore innovation using portable etc. progress is continuous.
However, existing laser speckle blood current imaging device can not synchronize the structural images information and blood for obtaining biological tissue
Stream picture functional information is not easy to fast implement the comprehensive analysis to physiology course.
Summary of the invention
Based on this, it is necessary to provide a kind of device and side that can be synchronized and obtain mechanics of biological tissue image and blood-stream image
Method is precisely merged convenient for blood-stream image and structural images, convenient for fast implementing blood flow to biological tissue, blood vessels caliber
The INTEGRATED SIGHT analysis of the physiology courses such as distribution and variation.
The technical scheme to solve the above technical problems is that
It is a kind of to synchronize the device for obtaining mechanics of biological tissue image and blood-stream image, including light source mechanism and optical imagery
Mechanism；
The light source mechanism includes laser light source and incoherent visible light source, the laser light source and incoherent visible light
Light source is arranged with preset oblique angle；
The optical imagery mechanism includes the optical imaging lens group set gradually along light detection path direction, optical filter
Switch and photoelectronic imaging device, the optical-filter switcher are embedded with Excitation Filter with High and visible filter, and shape respectively
At laser light-filtering channels and visible light light-filtering channels；
When for imaging in biological tissues, the laser light source, the laser light-filtering channels and the photoelectronic imaging device phase
Cooperate the blood-stream image for obtaining biological tissue, the incoherent visible light source, the visible light light-filtering channels and the light
Electrical imaging device matches the structural images for obtaining biological tissue.
Further, synchronize the acquisition mechanics of biological tissue image and the device of blood-stream image further include light uniforming device
Part, the light balancing device is set to the front end of the laser light source, further to solve semiconductor laser divergence angle degree and outgoing
Hot spot major and minor axis is inconsistent and the non-uniform problem of hot spot, improves imaging effect.
Preferably, the light balancing device is cylindrical mirror, diffusion sheet or frosted glass.
The light source mechanism further includes thermostatic chamber and constant-temperature constant-current controller in one of the embodiments, described to swash
Radiant is semiconductor laser, and the semiconductor laser is set in the thermostatic chamber, the thermostatic chamber and the perseverance
Warm constant-current controller connection, guarantees the consistency of light-out effect.
Preferably, the laser light source is 785nm semiconductor laser, and the Excitation Filter with High is 785nm bandpass filter
Piece.
Preferably, the incoherent visible light source is LED light source, for example, monochromatic LED light source or wide spectrum white
LED light source, wave-length coverage are visible light wave range.
The incoherent visible light source is arranged in a ring in one of the embodiments, the incoherent visible light light
Source and laser light source coaxial arrangement, further compact device volume.
The optical imagery mechanism includes stereomicroscope in one of the embodiments, and the stereomicroscope is embedded
The optical-filter switcher.Using the stereomicroscope of embedded double optical-filter switchers, it is easy to implement to the fine of biological tissue
The micro-imaging of structure.
Preferably, the photoelectronic imaging device is face battle array Digital CCD Camera, face battle array digital CCD camera, face battle array number
CMOS camera or face battle array cmos digital video camera, analog-to-digital conversion digit are not less than 12.
It is a kind of to synchronize the method for obtaining mechanics of biological tissue image and blood-stream image, using device described above, packet
Include following steps:
Biological tissue samples to be checked are placed, incoherent visible light source is lighted, switch to visible filter, are focused to clear
It is clear, obtain the structural images of biological tissue；
Laser light source is lighted, Excitation Filter with High is switched to, obtains the blood-stream image of biological tissue.
The beneficial effects of the present invention are:
The present invention by include laser light source and incoherent visible light source light source mechanism including optical-filter switcher and
Optical imagery mechanism of photoelectronic imaging device etc. matches setting, can synchronize the structural images and rheography for obtaining biological tissue
On the one hand picture is easy to implement blood-stream image and merges with structural images progress the accurate of Pixel-level, is on the other hand also convenient for the life
The functional informations relevant to physiological responses such as blood distribution, blood flow variation, the blood vessels caliber shrinkage expansion of object tissue are observed
And quantitative analysis, it is swift to operate without adjusting imaged viewing angle.
Detailed description of the invention
Fig. 1 is the apparatus structure signal for synchronizing the imaging of acquisition mechanics of biological tissue with blood flow imaging of an embodiment
Figure；
Fig. 2 shows for the apparatus structure for synchronizing the imaging of acquisition mechanics of biological tissue and blood flow imaging of another embodiment
It is intended to；
Fig. 3 is the method and step schematic diagram for synchronizing acquisition mechanics of biological tissue imaging and blood flow imaging of the invention.
In attached drawing, parts list represented by the reference numerals are as follows:
110, laser light source, 120, incoherent visible light source, 200, optical imagery mechanism, 210, optical imaging lens
Group, 220, optical-filter switcher, 230, photoelectronic imaging device, 300, control analysis system.
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.It should be noted that when an element is considered as " connection " another element, it can be with
It is directly to another element or may be simultaneously present centering elements.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
Incorporated by reference to Fig. 1, the device for synchronizing acquisition mechanics of biological tissue image and blood-stream image of an embodiment, including
Light source mechanism, optical imagery mechanism 200 and control analysis system 300.
In the present embodiment, light source mechanism includes laser light source 110 and incoherent visible light source 120.
Wherein, laser light source 110 be preferably 785nm semiconductor laser, be near-infrared light source, line width stability be less than ±
785nm bandpass filter can be used in 0.02nm, Excitation Filter with High.
Further, light source mechanism further includes thermostatic chamber and constant-temperature constant-current controller.Semiconductor laser installing is in perseverance
In warm chamber, thermostatic chamber is connected with constant-temperature constant-current (driving current) controller, temperature-monitoring element in thermostatic chamber plus
But element etc. is connected with constant temperature controller hot and cold respectively, realizes constant temperature regulation, improves the consistency and stabilization of blood flow imaging
Property.
Incoherent visible light source 120 preferably uses LED light source, such as monochromatic LED light source or wide spectrum White LED light
Source, wave-length coverage are visible light wave range, preferably the visible light wave range of 400-650nm.
In the present embodiment, laser light source 110 and incoherent visible light source 120 are set by the way of relative tilt
It sets, is irradiated in the inclination angle (such as 55 °) set convenient for incoherent visible light source 120 and the realization of laser light source 110 and is observed object,
When biological tissue samples to be checked (being observed object) are by shape library, light source irradiation center is overlapped just with central region, can be kept away
Exempt from the process of adjustable visual angle.
Please further combined with Fig. 2, in other embodiments, it is preferable that incoherent visible light source 120 is arranged in a ring
Coaxial tilt setting can also be used in cloth, incoherent visible light source 120 and laser light source 110, is convenient for compact device volume.
By making laser light source 110 and incoherent visible light source 120 with the setting of preset oblique angle, it is convenient for laser
Light source 110 and the realization of incoherent visible light source 120 are irradiated in the inclination angle set and are observed object, when biological tissue samples to be checked
When (being observed object) is by shape library, light source irradiation center is overlapped just with central region, be can avoid the process of adjustable visual angle, is mentioned
High imaging efficiency.
Further, synchronizing for present embodiment obtains the device of mechanics of biological tissue image and blood-stream image and further includes
Light balancing device set on the front end of laser light source 110 can synchronize and solve semiconductor laser divergence angle degree and emergent light spot length
Axis is inconsistent and leads to the non-uniform problem of hot spot.Light balancing device is preferably cylindrical mirror.For example, can be special before laser light source 110
The cylindrical mirror of F=50 is used at set a distance.In addition, light balancing device is nonessential and is not limited to cylindrical mirror, but also diffusion sheet, hair glass
Glass etc. has the device of even light action.
In the present embodiment, optical imagery mechanism 200 include the optics that is set gradually along light detection path direction at
As lens group 210, optical-filter switcher 220 and photoelectronic imaging device 230.Optical imaging lens group 210 is for treating life to be checked
Object tissue sample is amplified, is focused.Optical-filter switcher 220 is using the double optical-filter switchers for being mounted with two tablet filters
(IRCUT), it is embedded with visible filter and Excitation Filter with High, and forms visible light light-filtering channels and laser light-filtering channels.It is excellent
Selection of land, double optical-filter switchers use automatically controlled switching mode, are easy to use serial communication protocol by control analysis system control
The cooperation of light source igniting and IRCUT switching, improves the efficiency of switching imaging pattern.Incoherent visible light source 120, visible light filter
Channel (for example, by using the visible light light-filtering channels of 400-650nm) and photoelectronic imaging device 230 are matched for obtaining biological group
The structural images knitted.Laser light source 110, laser light-filtering channels and photoelectronic imaging device 230 are matched for obtaining biological tissue
Blood-stream image.
Preferably, optical imagery mechanism includes stereomicroscope, embedding double optical-filter switchers in stereomicroscope.This
When, according to the operating distance of stereomicroscope, laser light source 110 and incoherent visible light source 120 can be arranged with 55 ° of inclination angles.
It is convenient for carrying out micro-imaging to biological tissue's fine structure using stereomicroscope.
Preferably, photoelectronic imaging device is using face battle array Digital CCD Camera, face battle array digital CCD camera, face battle array digital CMOS
Camera or face battle array cmos digital video camera, analog-to-digital conversion digit are not less than 12.
In the present embodiment, control analysis system 300 connects photoelectronic imaging device 230, for analyzing the biology obtained
The structural images and blood-stream image of tissue.Preferably, control analysis system 300 can also directly control light source mechanism and optical filtering
The switching of piece switch 220 cooperates.
Please further combined with Fig. 3, mechanics of biological tissue image and blood-stream image are obtained using synchronizing for present embodiment
The method that is imaged of device, include the following steps:
(1), biological tissue samples to be checked are placed, device for opening carries out image preview, and laser light source 110 is lit at this time,
Carry out imaging pattern selection.
(2), when selecting structure imaging mode, incoherent visible light source 120 is lighted, visible light is switched to and filters and lead to
Road obtains the structural images of biological tissue, is sent to control analysis system 300.
When selecting blood flow imaging mode, incoherent visible light source 120 is closed, switches to laser light-filtering channels, is used
Laser speckle blood flow computational algorithm, obtains the blood-stream image of biological tissue, is sent to control analysis system 300.
(3), the imaging that selection (1) and (2) carries out different mode is repeated, or repeats step (1) and (2), is carried out next
The structural images and blood-stream image imaging operation of a test serum sample.
(4), imaging terminates, and closes all light sources.
In synchronizing in the device for obtaining mechanics of biological tissue image and blood-stream image for present embodiment, two kinds of light sources
Radiation modality, which is passed through, to be built in entire imaging process with specific inclination angle design group and need not be adjusted, and the lighting mode of two kinds of light sources (swashs
Lighted when radiant is long, incoherent visible light source is lighted immediately) and its cooperation with light imaging lens group, double optical-filter switchers
So that neither mutual crosstalk is imaged, also not by ambient light interference.When acquiring the structural images of biological tissue, rear orientation light
It is optically imaged collect and images in photoelectronic imaging device through visible light light-filtering channels；When the rheography of acquisition biological tissue
When picture, backward scattering laser is optically imaged collect and images in light through laser light-filtering channels (near infrared filter channel)
Electrical imaging device；Acquisition image is sent to control analysis system (module) and carries out calculating analysis by photoelectronic imaging device.
Using the device for synchronizing acquisition mechanics of biological tissue image and blood-stream image of present embodiment, on the one hand it is convenient for
It realizes that blood-stream image carries out the accurate of Pixel-level with structural images and merges, is on the other hand also convenient for the blood flow point to the biological tissue
The functional informations relevant to physiological responses such as cloth, blood flow variation, blood vessels caliber shrinkage expansion are observed and quantitative analysis, operation
Fast.
Each technical characteristic of above embodiments can be combined arbitrarily, for simplicity of description, not to above-described embodiment
In each technical characteristic it is all possible combination be all described, as long as however, the combination of these technical characteristics be not present lance
Shield all should be considered as described in this specification.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. one kind can synchronize the device for obtaining mechanics of biological tissue image and blood-stream image, which is characterized in that including light source mechanism
With optical imagery mechanism；
The light source mechanism includes laser light source and incoherent visible light source, the laser light source and incoherent visible light source
With the setting of preset oblique angle；
The optical imagery mechanism includes the optical-filter switcher set gradually along light detection path direction and photoelectronic imaging device
Part, the optical-filter switcher are embedded with Excitation Filter with High and visible filter, and are respectively formed laser light-filtering channels and can
Light-exposed light-filtering channels；
When for imaging in biological tissues, the laser light source, the laser light-filtering channels and the photoelectronic imaging device are matched
For obtaining the blood-stream image of biological tissue, the incoherent visible light source, the visible light light-filtering channels and the photoelectricity at
As device matches the structural images for obtaining biological tissue.
2. according to claim 1 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image, feature exists
In, further include light balancing device, the light balancing device be set to the laser light source front end.
3. according to claim 2 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image, feature exists
In the light balancing device is cylindrical mirror, diffusion sheet or frosted glass.
4. according to any one of claims 1 to 3 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image,
It is characterized in that, the light source mechanism further includes thermostatic chamber and constant-temperature constant-current controller, the laser light source swashs for semiconductor
Light device, the semiconductor laser are set in the thermostatic chamber, and the thermostatic chamber is connect with the constant-temperature constant-current controller.
5. according to claim 4 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image, feature exists
In the laser light source is 785nm semiconductor laser, and the Excitation Filter with High is 785nm bandpass filter.
6. according to any one of claims 1 to 3 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image,
It is characterized in that, the incoherent visible light source is LED light source.
7. according to any one of claims 1 to 3 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image,
It is characterized in that, the incoherent visible light source is arranged in a ring, the incoherent visible light source and the laser light source
Coaxial arrangement.
8. according to any one of claims 1 to 3 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image,
It is characterized in that, the optical imagery mechanism includes stereomicroscope, the stereomicroscope embeds the optical-filter switcher.
9. according to any one of claims 1 to 3 synchronize the device for obtaining mechanics of biological tissue image and blood-stream image,
It is characterized in that, the photoelectronic imaging device is face battle array Digital CCD Camera, face battle array digital CCD camera, face battle array digital CMOS phase
Machine or face battle array cmos digital video camera, analog-to-digital conversion digit are not less than 12.
10. one kind can synchronize the method for obtaining mechanics of biological tissue image and blood-stream image, which is characterized in that use claim
1 to 9 described in any item devices, include the following steps:
Place biological tissue samples to be checked, light incoherent visible light source, switch to visible light light-filtering channels, focusing to clear,
Obtain the structural images of biological tissue.
Laser light source is lighted, laser light-filtering channels are switched to, obtains the blood-stream image of biological tissue.
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| CN201910593877.9A CN110301896B (en) | 2019-07-03 | 2019-07-03 | Device and method capable of synchronously acquiring biological tissue structure image and blood flow image |
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| CN201910593877.9A CN110301896B (en) | 2019-07-03 | 2019-07-03 | Device and method capable of synchronously acquiring biological tissue structure image and blood flow image |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115670391A (en) * | 2023-01-03 | 2023-02-03 | 中国科学技术大学 | Coaxial intelligent image system for biological tissue diagnosis |
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