CN105748029B - A kind of endoscopic imaging system - Google Patents
A kind of endoscopic imaging system Download PDFInfo
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- CN105748029B CN105748029B CN201610090949.4A CN201610090949A CN105748029B CN 105748029 B CN105748029 B CN 105748029B CN 201610090949 A CN201610090949 A CN 201610090949A CN 105748029 B CN105748029 B CN 105748029B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
Abstract
The invention discloses a kind of endoscopic imaging system, the system includes：One end of first switch is connected with red laser, and the other end is connected with the first controllable decoherence device, is used as first passage；One end of second switch is connected with green light source, and the other end is connected with the second controllable decoherence device, is used as second channel；One end of 3rd switch is connected with blue-light source, and the other end is connected with the 3rd controllable decoherence device, is used as third channel；First passage, second channel and third channel are connected with the blender, export mixed signal light；The first controllable decoherence device is not enabled described in first passage, and output signal light is imaged for laser speckle, generation laser speckle angiographic image, and the output signal light of second channel and third channel is used for arrowband photoimaging, generates arrowband light image.Endoscopic imaging system provided by the present invention, breaches narrow band light imaging depth, have detected angiemphraxis situation, improves the recognition capability of vessel depth information.
Description
Technical field
The present invention relates to endoscopic medical functional imaging technical field, more particularly to a kind of endoscopic imaging system.
Background technology
With the development of science and technology, a series of new endoscopic technics are applied to clinic.Japanese Olympus medical system
The NBI Narrow-Band Imagings of company's research and development create unprecedented advantage for the early detection of rhinopharyngeal neoplasm patient.
In human body, the primary pigments of mucous membrane tissue are hemoglobins.Hemoglobin reaches peak value to blue light absorption capability,
Relatively weak is absorbed to green glow.Compared with conventional endoscopic, NBI technologies have filtered off feux rouges using narrowband light filter, leave middle cardiac wave
Long is respectively 540nm and 415nm green glow and blue light.Because the narrow glistening light of waves is not covered with all visible lights, mucous membrane is reached
Depth is different, and the morphological image that can obtain mucous membrane different levels by green, blue sequentially imaging improves blood under mucous membrane and mucous membrane
The contrast and definition of pipe imaging, highlight the trickle change of mucous membrane construction.NBI systems are put in scope front end installation difference
The magnifying endoscope of big multiple camera lens, can make lesion details amplify 60~170 times, be beneficial to diagnosis close to microscopical multiplication factor.
NBI technical tie-ups magnifying endoscope can become apparent from, intuitively to the morphologic observation of tissue mucosa capillary and micro- glandular tube, convenient
Diagnose the illness.It is contemplated that, following NBI endoscope systems combination magnifying endoscope technology can further improve the susceptibility of diagnosis,
Clinician is helped to carry out more accurate early diagnosis.
But, the NBI technologies of the business men such as Olympus use wavelength in below 550nm, the wave band hemoglobin absorption coefficient
Very high, light projection depth as shallow can only obtain superficial layer tissue absorption characteristic, it is impossible to judge whether blood vessel blocks.
The content of the invention
It is an object of the invention to provide a kind of endoscopic imaging system, it is therefore intended that solves in existing narrow bandwidth imaging technique
Light projection depth as shallow, can only obtain superficial layer tissue absorption characteristic, it is impossible to the problem of whether blood vessel blocks judged.
In order to solve the above technical problems, the present invention provides a kind of endoscopic imaging system, including：
Red laser, green light source, blue-light source, first switch, second switch, third switch, the first controllable decoherence
Device, the second controllable decoherence device, the 3rd controllable decoherence device and blender；
Wherein, one end of the first switch is connected with the red laser, the other end and the described first controllable decoherence
Device is connected, and is used as first passage；One end of the second switch is connected with the green light source, and the other end and described second can
Control decoherence device to be connected, be used as second channel；One end of 3rd switch is connected with the blue-light source, the other end and institute
State the 3rd controllable decoherence device to be connected, be used as third channel；The first passage, the second channel and the threeway
Road is connected with the blender, exports mixed signal light；The first controllable decoherence device does not make described in the first passage
Can, output signal light is used for laser speckle and is imaged, generation laser speckle angiographic image, the second channel and described
The output signal light of third channel is used for arrowband photoimaging, generates arrowband light image.
Alternatively, in addition to：
Fused images generation module, for the laser speckle angiographic image for generating the first passage, Yi Jisuo
The arrowband light image for stating second channel and third channel generation is merged, the blood vessel tomographic map of generation color coding
Picture.
Alternatively, in addition to：First acquisition module, believes for obtaining blood flow by the laser speckle angiographic image
Breath, and judge whether blood vessel blocks.
Alternatively, in addition to：Second acquisition module, for by the arrowband light image obtain hemoglobin concentration with
And the concentration of deoxyhemoglobin.
Alternatively, in addition to：3rd acquisition module, for the concentration by the blood flow information, the hemoglobin with
And the concentration of the deoxyhemoglobin obtains blood oxygen metabolism rate.
Alternatively, the green-light source and the blue-light source are to filter the light source obtained by white light.
Alternatively, the green light source is green laser, and the blue-light source is blue laser.
Alternatively, the green laser and the blue laser are located at the wave band corresponding to hemoglobin absorption peak.
Alternatively, the described first controllable decoherence device, the second controllable decoherence device and described 3rd controllable
Decoherence device is the device that decoherence is carried out by the way of vibration.
Alternatively, the blender is optical fiber.
Endoscopic imaging system provided by the present invention, passes through red laser, first switch, the first controllable decoherence device
Constitute first passage；Second channel is constituted by green light source, second switch, the second controllable decoherence device；Pass through blue light
Source, the 3rd switch, the 3rd controllable decoherence device composition third channel；Blue light and green glow are carried out after decoherence operation, are coupled red
The green glow and blue light signals of ray laser generation lighting source, second channel and third channel are used for arrowband photoimaging, according to
Beer-Lambert laws can obtain the information such as hemoglobin concentration；Decoherence device, output red are not enabled in first passage
Laser is imaged for laser speckle, realizes angiogram, is obtained two-dimentional blood distribution information, is realized whether blood vessel blocks judgement.
It can be seen that, endoscopic imaging system provided by the present invention is integrated arrowband photoimaging and laser speckle blood current imaging, is dashed forward
Narrow band light imaging depth has been broken, angiemphraxis situation is have detected, the recognition capability of vessel depth information is improved.
Brief description of the drawings
, below will be to embodiment or existing for the clearer explanation embodiment of the present invention or the technical scheme of prior art
The accompanying drawing used required in technology description is briefly described, it should be apparent that, drawings in the following description are only this hair
Some bright embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can be with root
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is a kind of structured flowchart of embodiment of endoscopic imaging system provided by the present invention；
Fig. 2 is the data processing schematic diagram of endoscopic imaging system provided by the present invention.
Embodiment
In order that those skilled in the art more fully understand the present invention program, with reference to the accompanying drawings and detailed description
The present invention is described in further detail.Obviously, described embodiment is only a part of embodiment of the invention, rather than
Whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creative work premise
Lower obtained every other embodiment, belongs to the scope of protection of the invention.
A kind of structured flowchart of embodiment of endoscopic imaging system provided by the present invention was as shown in figure 1, should
Device includes：
Red laser 11, green light source 21, blue-light source 31, first switch 12, second switch 22, the 3rd switch 32, the
One controllable decoherence device 13, the second controllable decoherence device 23, the 3rd controllable decoherence device 33 and blender 4；
Wherein, one end of the first switch 12 is connected with the red laser 11, and the other end controllable is gone with described first
Relevant device 13 is connected, and is used as first passage 1；One end of the second switch 22 is connected with the green light source 21, the other end
It is connected with the described second controllable decoherence device 23, is used as second channel 2；One end of 3rd switch 32 and the blue light
Source 31 is connected, and the other end is connected with the described 3rd controllable decoherence device 33, is used as third channel 3；The first passage 1, institute
State second channel 2 and the third channel 3 with the blender 4 to be connected, export mixed signal light；The first passage 1
Described in the first controllable decoherence device do not enable, output signal light for laser speckle be imaged, generation laser speckle blood vessel make
Shadow image, the output signal light of the second channel 2 and the third channel 3 is used for arrowband photoimaging, generates narrow band light figure
Picture.
Endoscopic imaging system provided by the present invention, passes through red laser, first switch, the first controllable decoherence device
Constitute first passage；Second channel is constituted by green light source, second switch, the second controllable decoherence device；Pass through blue light
Source, the 3rd switch, the 3rd controllable decoherence device composition third channel；Blue light and green glow are carried out after decoherence operation, are coupled red
The green glow and blue light signals of ray laser generation lighting source, second channel and third channel are used for arrowband photoimaging, according to
Beer-Lambert laws can obtain the information such as hemoglobin concentration；Decoherence device, output red are not enabled in first passage
Laser is imaged for laser speckle, realizes angiogram, is obtained two-dimentional blood distribution information, is realized whether blood vessel blocks judgement.
It can be seen that, endoscopic imaging system provided by the present invention is integrated arrowband photoimaging and laser speckle blood current imaging, is dashed forward
Narrow band light imaging depth has been broken, angiemphraxis situation is have detected, the recognition capability of vessel depth information is improved.
Above-mentioned green-light source and the blue-light source can filter the light obtained specifically by white light in the present embodiment
Source, certainly, green light source and blue-light source can also use laser.Narrow band light is generated using laser decoherence, and illumination is high, energy
The quality of enough lifting imagings, it is to avoid in existing NBI technologies, due to the addition of narrow band pass filter, reduction mirror body output end arrowband
Light energy, causes the problem of final image is partially dark.
When light source selection is laser, the red laser light source of any wavelength of red spectral band according to actual conditions, can be selected.
Preferably, blue light and green glow can select the wave band corresponding to hemoglobin absorption peak.In the present invention to the type of laser not
Limit, this does not influence the realization of the present invention.
As a kind of embodiment, the first controllable decoherence device, the second controllable decoherence device with
And the 3rd controllable decoherence device can be the device that decoherence is carried out by the way of vibration, blender can be specially
Optical fiber.
Endoscopic imaging system provided by the present invention not only realizes narrow band light and laser speckle fusion of imaging, can be with
Multi-modal endoscopic imaging is realized, is fused into comprising white light imaging, arrowband photoimaging, laser speckle blood current imaging and laser speckle
As multiple modalities.Below so that green-light source and blue-light source are LASER Light Source as an example, to endoscope provided by the present invention
The various modes of imaging system are explained in further detail.
Conventional white is illuminated：First switch, second switch and the 3rd switch are in closure state, the road laser of Bing Dui tri-
Decoherence operation is carried out, the irrelevant light in the road of RGB three is mixed into white light, realizes white-light illuminating.
Arrowband photoimaging：First switch, closure second switch and the 3rd switch are disconnected, and blue light and green glow are gone
Coherent operations, realize arrowband photoimaging.
Laser speckle blood current imaging：Second switch and the 3rd switch are disconnected, first switch is closed, is shone using red laser
It is bright, the R signal in sensor is taken, the two-dimentional blood flow imaging of laser speckle is realized.It is imaged by coherent light illumination, obtains imaging object
The movable information of middle scattering particles.In laser speckle blood current imaging, because the hemoglobin movement velocity in blood vessel is far above it
Hetero-organization, therefore the blood vessel network image of high-contrast can be generated.This pattern breaking narrow band light imaging depth, can be obtained
More blood vessel network information.
Joint imaging：First switch, second switch and the 3rd switch are closed, blue light and green glow carry out decoherence behaviour
Make, coupling red laser generation lighting source.G and B signal in Sensor are used for arrowband photoimaging, according to Beer-Lambert
Law can obtain the information such as hemoglobin concentration；R signal is used for laser speckle blood current imaging, realizes angiogram, obtains two
Blood distribution information is tieed up, realizes whether blood vessel blocks judgement.
Specifically, in laser speckle angiogram and narrow band light image co-registration, R signal is set to laser speckle blood vessel
Contrastographic picture, G and B signal are respectively set to green glow and blue light images in narrow band light.In image after fusion, vascular surface is
Blueness, deep-level blood vessel is red, the blood vessel tomography of color coding is realized, so as to provide more vessel depths for clinician
Identification information.
On the basis of above-described embodiment, endoscopic imaging system provided by the present invention can further include：
Fused images generation module, for the laser speckle angiographic image for generating the first passage, Yi Jisuo
The arrowband light image for stating second channel and third channel generation is merged, the blood vessel tomographic map of generation color coding
Picture；
First acquisition module, for obtaining blood flow information by the laser speckle angiographic image, and be to blood vessel
No obstruction is judged；
By judging whether blood vessel blocks, angiemphraxis situation, infringement of the reduction operation to blood vessel can be monitored.
Second acquisition module, concentration and deoxyhemoglobin for obtaining hemoglobin by the arrowband light image
Concentration；
3rd acquisition module, for passing through the dense of the blood flow information, the concentration of hemoglobin and deoxyhemoglobin
Degree obtains blood oxygen metabolism rate.
As shown in the data processing schematic diagram of Fig. 2 endoscopic imaging systems provided by the present invention, by laser original image
Using laser speckle imaging technology, blood-stream image is generated；Green glow image and blue light images are generated by NBI technologies；By blood flow
After image and narrow band light image co-registration, fused images are generated.In addition, the dense of hemoglobin can be obtained by arrowband light image
Information is spent, blood oxygen metabolism rate information can be obtained with reference to the information of blood-stream image.
Specifically, VPV, hemoglobin concentration and deoxy-hemoglobin concentrations can be obtained using following formula：
Log (I)=(εHbO(λ)CHbO+εHb(λ)CHb)D(λ)
CMRO2=CBF × Hb/ (HbO+Hb)
Wherein, VPV is the ratio of variance and average during CBF is single pixel value spatial domain window or time window；Blood
Lactoferrin HbO and deoxy-hemoglobin concentrations Hb, is obtained by Beer-Lambert laws, and wherein ε is corresponding mole of narrow band light
Extinction coefficient, D is the corresponding optical path of narrow band light.Hemoglobin concentration and above-mentioned blood flow information can be used for calculating blood oxygen metabolism
Rate two-dimensional distribution.Specifically, blood oxygen metabolism rate is by VPV, deoxy-hemoglobin concentrations and hemoglobin concentration inverse
Product is obtained.Blood oxygen metabolism rate two-dimensional distribution in the present invention can provide further diagnostic message for clinician.
To sum up shown, the present invention realizes multi-modal endoscopic imaging system, comprising white light imaging, arrowband photoimaging, swashs
Light speckle blood flow imaging, narrow band light and laser speckle fusion of imaging.The present invention can also detect hemoglobin concentration, key simultaneously
The parameters such as region blood flow relative velocity, blood oxygen metabolism rate.The present invention can provide more abundant blood for endoscopic medical doctor
Pipe morphology and histophysiology information, improve the accuracy rate of focus diagnosis.
The embodiment of each in this specification is described by the way of progressive, what each embodiment was stressed be with it is other
Between the difference of embodiment, each embodiment same or similar part mutually referring to.For being filled disclosed in embodiment
For putting, because it is corresponded to the method disclosed in Example, so description is fairly simple, related part is referring to method part
Explanation.
Professional further appreciates that, with reference to the unit of each example of the embodiments described herein description
And algorithm steps, can be realized with electronic hardware, computer software or the combination of the two, in order to clearly demonstrate hardware and
The interchangeability of software, generally describes the composition and step of each example according to function in the above description.These
Function is performed with hardware or software mode actually, depending on the application-specific and design constraint of technical scheme.Specialty
Technical staff can realize described function to each specific application using distinct methods, but this realization should not
Think beyond the scope of this invention.
Directly it can be held with reference to the step of the method or algorithm that the embodiments described herein is described with hardware, processor
Capable software module, or the two combination are implemented.Software module can be placed in random access memory (RAM), internal memory, read-only deposit
Reservoir (ROM), electrically programmable ROM, electrically erasable ROM, register, hard disk, moveable magnetic disc, CD-ROM or technology
In any other form of storage medium well known in field.
Endoscopic imaging system provided by the present invention is described in detail above.Specific case used herein
Principle and embodiment to the present invention are set forth, and the explanation of above example is only intended to the side for helping to understand the present invention
Method and its core concept.It should be pointed out that for those skilled in the art, not departing from the principle of the invention
Under the premise of, some improvement and modification can also be carried out to the present invention, these are improved and modification also falls into the claims in the present invention
In protection domain.
Claims (10)
1. a kind of endoscopic imaging system, it is characterised in that including：
Red laser, green light source, blue-light source, first switch, second switch, third switch, the first controllable decoherence device,
Second controllable decoherence device, the 3rd controllable decoherence device and blender；
Wherein, one end of the first switch is connected with the red laser, the other end and the described first controllable decoherence device
It is connected, is used as first passage；One end of the second switch is connected with the green light source, and the other end controllable is gone with described second
Relevant device is connected, and is used as second channel；One end of 3rd switch is connected with the blue-light source, the other end and described the
Three controllable decoherence devices are connected, and are used as third channel；The first passage, the second channel and the third channel are equal
It is connected with the blender, exports mixed signal light；The first controllable decoherence device is not enabled described in the first passage, defeated
Go out flashlight to be imaged for laser speckle, generate laser speckle angiographic image, the second channel and the threeway
The output signal light in road is used for arrowband photoimaging, generates arrowband light image.
2. endoscopic imaging system as claimed in claim 1, it is characterised in that also include：
Fused images generation module, for the laser speckle angiographic image for generating the first passage, and described
The arrowband light image of two passages and third channel generation is merged, the blood vessel tomographic map of generation color coding.
3. endoscopic imaging system as claimed in claim 2, it is characterised in that also include：First acquisition module, for passing through
The laser speckle angiographic image obtains blood flow information, and judges whether blood vessel blocks.
4. endoscopic imaging system as claimed in claim 3, it is characterised in that also include：Second acquisition module, for passing through
The arrowband light image obtains the concentration of hemoglobin and the concentration of deoxyhemoglobin.
5. endoscopic imaging system as claimed in claim 4, it is characterised in that also include：3rd acquisition module, for passing through
The concentration of the blood flow information, the concentration of the hemoglobin and the deoxyhemoglobin obtains blood oxygen metabolism rate.
6. the endoscopic imaging system as described in any one of claim 1 to 5, it is characterised in that the green light source and institute
It is to filter the light source obtained by white light to state blue-light source.
7. the endoscopic imaging system as described in any one of claim 1 to 5, it is characterised in that the green light source is green
Laser, the blue-light source is blue laser.
8. endoscopic imaging system as claimed in claim 7, it is characterised in that the green laser and the blue laser
Positioned at the wave band corresponding to hemoglobin absorption peak.
9. endoscopic imaging system as claimed in claim 8, it is characterised in that the first controllable decoherence device, described
Second controllable decoherence device and the 3rd controllable decoherence device are the device that decoherence is carried out by the way of vibration.
10. endoscopic imaging system as claimed in claim 9, it is characterised in that the blender is optical fiber.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106264453B (en) * | 2016-07-25 | 2018-10-16 | 深圳先进技术研究院 | Endoscopic imaging and laser speckle imaging fusion imaging system |
| JP6812692B2 (en) * | 2016-07-27 | 2021-01-13 | 富士ゼロックス株式会社 | Laser components, laser light generators and optical coherence tomography |
| CN106842195B (en) * | 2016-12-26 | 2020-12-25 | 中国科学院合肥物质科学研究院 | Multi-object simultaneous imaging and encryption method based on calculation correlation imaging |
| CN106955085A (en) * | 2017-04-28 | 2017-07-18 | 浙江大学 | Structural light three-dimensional endoscope apparatus |
| CN107854116A (en) * | 2017-11-15 | 2018-03-30 | 上海交通大学 | A kind of oral soft tissue metabolism monitoring system and method |
| CN108335270A (en) * | 2018-01-19 | 2018-07-27 | 重庆大学 | A kind of multiple image blood vessel feature recognition and the color coding approach of information fusion |
| CN110389438A (en) * | 2018-04-23 | 2019-10-29 | 新视电科技有限公司 | Endoscope system and its light source machine |
| CN109009060B (en) * | 2018-06-19 | 2021-04-06 | 南京航空航天大学 | Endoscopic laser speckle blood flow imaging probe |
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| JP2007275243A (en) * | 2006-04-05 | 2007-10-25 | Media Technology:Kk | Field sequential type electronic endoscope system |
| JP5582948B2 (en) * | 2010-09-29 | 2014-09-03 | 富士フイルム株式会社 | Endoscope device |
| CN102499615A (en) * | 2011-09-26 | 2012-06-20 | 首都医科大学 | Illuminating light source device and sampling and controlling method |
| WO2013084566A1 (en) * | 2011-12-07 | 2013-06-13 | オリンパスメディカルシステムズ株式会社 | Endoscope device |
| WO2013164962A1 (en) * | 2012-05-01 | 2013-11-07 | オリンパスメディカルシステムズ株式会社 | Endoscope device |
| CN103431833A (en) * | 2013-05-24 | 2013-12-11 | 中国科学院苏州生物医学工程技术研究所 | Medical multiband narrow band imaging system |
| CN204379226U (en) * | 2014-12-19 | 2015-06-10 | 佛山市南海区欧谱曼迪科技有限责任公司 | A kind of Narrow-Band Imaging endoscope apparatus |
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