CN106721003A - Prevent and treat the feed addictive and preparation method of animal viral disease - Google Patents

Prevent and treat the feed addictive and preparation method of animal viral disease Download PDF

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Publication number
CN106721003A
CN106721003A CN201611161829.5A CN201611161829A CN106721003A CN 106721003 A CN106721003 A CN 106721003A CN 201611161829 A CN201611161829 A CN 201611161829A CN 106721003 A CN106721003 A CN 106721003A
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parts
viral disease
feed addictive
feed
animal viral
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胡光琼
陈义娜
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Xinchang Burke Animal Feed Technology Development Co Ltd
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Xinchang Burke Animal Feed Technology Development Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Abstract

The invention discloses a kind of novel antibacterial anti-virus feed additive for livestock and poultry breeding industry, by mountain boon, kuh-seng, small cavity grass, ergosterol, Tea Saponin, spend mattress, narcissus, sophora bud powder in vain and constitute, carrier is partially aqueous alumino-silicate.Its main feature:By natural plants specific activity composition, directly or indirectly suppression is killed the virus, and antibacterial efficacy is strong, and has a broad antifungal spectrum, the activity to some bacterium is better than common medicine Berberine hydrochloride and penicillin, aureomycin etc..Feeding process can be completely free of antibiotic medicine, reduce mycotoxin, there is good treatment and preventive effect to avian pasteurella multocida, Escherichia coli, bacillus rhusiopathiae suis, cholera fowl and the white scour of piglet, white diarrhea.Resisting stress, anticoccidial, elimination heavy metal and medicament residue.

Description

Prevent and treat the feed addictive and preparation method of animal viral disease
Technical field
The present invention relates to biological product technical field, particularly a kind of feed addictive for preventing and treating animal viral disease and Preparation method.
Background technology
Livestock and poultry refer to the livestock for being available for developing animal husbandry, poultry etc., are the main animal protein sources of the mankind.Livestock and poultry cultivation has There is economic worth higher, be all the time that peasant realizes agriculture dream, the important channel got rich.In the last few years, with country The popularization of preferential policy, China's livestock and poultry cultivation industry has obtained quick development, and cultivation intensive degree is also improved constantly, but The control and prevention of disease measure of the breeding way and plant of raiser does not obtain synchronous lifting but, causes China's aquaculture market Livestock birds health problem and control and prevention of disease problem it is increasingly serious.The control and prevention of disease measure in livestock and poultry cultivation is carried out to the whole poultry of China The long-term stability of poultry breeding industry long-term stability development or even entire society suffers from immeasurable effect.China's aquaculture is more closely Quickly grown over year, the number of practitioner is increased sharply, but corresponding some drawbacks also become increasingly conspicuous:On the one hand, cultivate Personnel itself cannot get position on the professional knowledge study for cultivating, and cause the understanding caused a disease to microorganism not enough, blindly wait for information the people Between so-called saying, most direct consequence is exactly that transmission of disease can not be timely and effectively controlled in outbreak of disease;The opposing party Face, due to excessively running counter to the ecological characteristic of cultivated animals, excessively pursues the maximization of interests, and raiser blindly uses hormone, wantonly Meaning abuse additive and veterinary drug, make livestock and poultry cultivation industry and animal derived food production safety be subject to serious threat and strike very To threatening people's health public safety.
Antibiotic promotes the aspect such as growth of animal and raising feed conversion to play important function in prevention livestock and poultry, but Long-term with antibiotic is largely used, and its negative effect is also increasingly revealed, such as cause pathogenic microorganism to develop immunity to drugs, The ecological balance of normal flora, reduction animal body immunologic function and medicament residue are made to the mankind and environment in destruction animal body Into harm etc..Therefore novel antibacterial, antiviral additive and its production technology of safe and effective and pollution-free noresidue are researched and developed, Basic " people's contradiction inferior to Meat Flavor demand and meat " production safety health livestock products that solve are to the modern poultry of China The development of fowl ecologic breeding industry is of great immediate significance and profound influence.
The content of the invention
A kind of feed addictive for preventing and treating animal viral disease of the present invention is made up of following raw material and weight portion:Mountain boon 5-10 parts, kuh-seng 1-15 parts, it is small cavity grass 1-15 parts of extract, ergosterol 10-15 parts, Tea Saponin 0.1-2 parts, three isooctyl acids Glyceride 0.001-0.005 parts, 0.01-0.03 parts of starch ocentyl succinic aluminium, spend mattress 10-15 parts, the sub- powder 5-20 of narcissus in vain Part, 1-6 parts of composition of sophora bud powder, carrier is partially aqueous aluminosilicate salt fines.Partially aqueous aluminosilicate salt fines can be covered in the additive Take off stone, change surname illite, clinoptilolite.
Its live pig optimal proportion is:6 parts of mountain boon, 5 parts of kuh-seng, small 5 parts of extract of cavity grass, 7 parts of ergosterol, tea soap 2 parts of element, 0.001-0.005 parts of three isooctyl acid glyceride, 0.01-0.03 parts of starch ocentyl succinic aluminium, spend 4 parts of mattress, water in vain 3 parts of fairy maiden's powder, 3 parts of sophora bud powder, partially aqueous 65 parts of aluminosilicate salt fines.Its egg fowl optimal proportion is:1 part of mountain boon, kuh-seng are extracted 7 parts of thing, small 5 parts of extract of cavity grass, 7 parts of ergosterol, 1 part of Tea Saponin, 0.001-0.005 parts of three isooctyl acid glyceride, shallow lake 0.01-0.03 parts of powder ocentyl succinic aluminium, spend in vain 2 parts of mattress, narcissus son 15 parts, 2 parts of the sophora bud, partially aqueous aluminosilicate salt fines 60 Part.
The present invention seeks to:By natural plants specific activity composition, directly or indirectly suppression is killed the virus, and antibacterial efficacy is strong, is resisted Bacterium spectrum is wide, has antibacterial activity to coccus, bacillus, Gram-positive and negative bacterium and the activity to some bacterium is better than common medicine salt Sour jamaicin and penicillin, aureomycin.Feeding process can be completely free of antibiotic medicine, mycotoxin be reduced, to fowl Pasteur Bacillus, Escherichia coli, bacillus rhusiopathiae suis, cholera fowl and the white scour of piglet, white diarrhea have good treatment and preventive effect.It is anti-to answer Sharp, anticoccidial, raising feedstuff-meat ratio and laying rate of laying hen, eliminate heavy metal and medicament residue.
Action function of each component feed addictive of the present invention to livestock and poultry:
The antivirus action of additive of the present invention:Mainly directly suppression is killed and kills two aspects with suppression indirectly.Directly suppression is killed mainly Virus is directly acted on by natural plants specific activity composition, suppresses the biosynthesis of virus, prevent virus from penetrating host thin Born of the same parents suppress virus release.Suppression indirectly is killed and mainly played a role by increasing and adjusting immunity of organisms, so as to improve foster Bad border is grown, animal and bird intestines colony balance is maintained, the resolution ratio of organic matter is improved, the concentration of ammonia in poultry house air is reduced.Grind Study carefully and show, the safe additive for farm animal feed of addition 3-5g/kg can improve pig and be immunized and antiviral functions in Diet For Finishing Pig.
Additive of the present invention has the effect for improving liver function, can significantly reduce serum lactic deaminase (LDH) level, Mortality of animals is reduced, the ratio of seralbumin/globulin (A/G) is improved, liver plasma membrane is effectively protected, suppresses hepatic fibrosis Change it has good treatment and preventive effect to poultry dieases such as common cholera fowl, white diarrhea, typhoid fever diarrheas, to follow-up study 2312 local hybridization chickens, duck cure rates are respectively 93.1%, 93.1% and 91.7%.
Additive of the present invention can not only reduce the concentration of ammonia and hydrogen sulfide in animal house.Can reduce in animal house simultaneously air and The humidity of excrement, reduces the generation of the pernicious gases such as ammonia, so as to reach deodorant purpose.Added in egg feedstuff 0.2%~0.5% additive, can make excrement water content reduction by 5%, and foul smell is reduced.The addition of addition 0.5% in the daily ration of pig Agent, can make the content of ammonia in excreta decline 21%.0.4kg additives are added in the mixed feed of 48.5kg chickens to be used to feed Chicken, observes through 21~47d, and hen house ammonia declines 45%~78%.
This additive has repairs and improves defense function of the gastrointestinal mucosa to virulence factor, especially fowl poultry kind is suffered from diarrhoea, Dysentery has the effect of uniqueness, while the pathogenic microorganism of livestock and poultry alimentary tract mucous membrane can be fixed, makes its rupture, is dehydrated so that inactivating.
Specific embodiment
The present invention is described in detail with reference to specific embodiment, it should be appreciated that embodiment is served only for illustrating this hair Bright, rather than for limiting the invention, any modification made on the basis of the present invention, equivalent etc. are in this hair In bright protection domain.
Embodiment 1
A kind of feed addictive for preventing and treating animal viral disease is made up of following weight portion:It is 10 parts of mountain boon, 15 parts of kuh-seng, small Empty 15 parts of extract of grass, 10 parts of ergosterol, 0.1 part of Tea Saponin, 0.005 part of three isooctyl acid glyceride, starch octenyl amber Amber acid 0.01 part of aluminium, spend 10 parts of the sub- powder of 15 parts of mattress, narcissus, 6 parts of sophora bud powder in vain, carrier be partially aqueous aluminosilicate salt fines, by weight Compare additive:Carrier=1-2:1-10 is mixed.Partially aqueous aluminosilicate salt fines can be montmorillonites, change surname Yi in the additive Sharp stone, clinoptilolite.
The feed addictive preparation method is completed by following operating procedure:
In proportion by mountain boon seed, kuh-seng, small empty grass seed, ergosterol, spend the cleaned machine flow fluid of mattress in vain and rinse;Will The material for cleaning is dried, and by pulverizer, is crushed to 10-30 mesh, is placed in tank by solid-to-liquid ratio 1:9~15 times of amounts are added, leaching Bubble 1-2 hours, after being heated to reflux 2-2.5 hours, leaches first time extract solution;Then solid-to-liquid ratio 1 is pressed:8~13 amounts are leaving Add ethanol in hybrid solid thing, after being heated to reflux 1-2.5 hours, leach second extract solution, solid-to-liquid ratio 1 is then pressed again:5- 10 amounts are in the mixing solid-liquid for leaving plus ethanol is after being heated to reflux 2-2.5 hours, leach third time extract solution.By three extractions Liquid merging reclaims ethanol in putting evaporator, every milliliter of extract solution is concentrated to, equivalent to the 10% of mixed biologic alkali raw material;Extracting Tea Saponin, three isooctyl acid glyceride, starch ocentyl succinic aluminium, the sub- powder of narcissus, sophora bud powder are proportionally added into liquid while hot fast Speed stirs, and dries, crushes.It is proportionally added into that partially aqueous aluminosilicate salt fines are well mixed to be made the antiviral feeding of novel antibacterial again Feed additives finished product, checks qualified packaging and storage.
Feed addictive is added by the 0.3%-0.5% of complete feed per ton.
Embodiment 2
A kind of feed addictive for preventing and treating animal viral disease is made up of following weight portion:5 parts of mountain boon, 1 part of kuh-seng, small sky Careless 15 parts of the extract in hole, 15 parts of ergosterol, 2 parts of Tea Saponin, 0.003 part of three isooctyl acid glyceride, starch ocentyl succinic 0.02 part of aluminium, spend 10 parts of the sub- powder of 15 parts of mattress, narcissus, 6 parts of sophora bud powder in vain, carrier is partially aqueous aluminosilicate salt fines, is added by weight Plus agent:Carrier=1-2:1-10 is mixed.In the additive partially aqueous aluminosilicate salt fines can be montmorillonite, change surname illite, Clinoptilolite.A small amount of three isooctyl acid glyceride, starch ocentyl succinic aluminium composition, can be with sophora bud powder, partially aqueous sial The component substances such as hydrochlorate are combined, and can in vivo form stimulation, and enhance immunity, anti-inflammation, reduction are ill.
The feed addictive preparation method is completed by following operating procedure:
In proportion by mountain boon seed, kuh-seng, small empty grass seed, ergosterol, spend the cleaned machine flow fluid of mattress in vain and rinse;Will The material for cleaning is dried, and by pulverizer, is crushed to 10-30 mesh, is placed in tank by solid-to-liquid ratio 1:9~15 times of amounts are added, leaching Bubble 1-2 hours, after being heated to reflux 2-2.5 hours, leaches first time extract solution;Then solid-to-liquid ratio 1 is pressed:8~13 amounts are leaving Add ethanol in hybrid solid thing, after being heated to reflux 1-2.5 hours, leach second extract solution, solid-to-liquid ratio 1 is then pressed again:5- 10 amounts are in the mixing solid-liquid for leaving plus ethanol is after being heated to reflux 2-2.5 hours, leach third time extract solution.By three extractions Liquid merging reclaims ethanol in putting evaporator, every milliliter of extract solution is concentrated to, equivalent to the 10% of mixed biologic alkali raw material;Extracting Tea Saponin, three isooctyl acid glyceride, starch ocentyl succinic aluminium, the sub- powder of narcissus, sophora bud powder are proportionally added into liquid while hot fast Speed stirs, and dries, crushes.It is proportionally added into that partially aqueous aluminosilicate salt fines are well mixed to be made the antiviral feeding of novel antibacterial again Feed additives finished product, checks qualified packaging and storage.
Feed addictive is added by the 0.3%-0.5% of complete feed per ton.
Embodiment 3
A kind of feed addictive for preventing and treating animal viral disease is made up of following weight portion:It is 10 parts of mountain boon, 15 parts of kuh-seng, small Empty 1 part of extract of grass, 15 parts of ergosterol, 2 parts of Tea Saponin, 0.003 part of three isooctyl acid glyceride, starch ocentyl succinic 0.02 part of aluminium, 5 parts of the sub- powder of 10 parts of mattress, narcissus, 1 part of sophora bud powder are spent in vain, carrier is partially aqueous aluminosilicate salt fines, by weight adding Agent:Carrier=1-2:1-10 is mixed.In the additive partially aqueous aluminosilicate salt fines can be montmorillonite, change surname illite, tiltedly Ptilolite.
The feed addictive preparation method is completed by following operating procedure:
In proportion by mountain boon seed, kuh-seng, small empty grass seed, ergosterol, spend the cleaned machine flow fluid of mattress in vain and rinse;Will The material for cleaning is dried, and by pulverizer, is crushed to 10-30 mesh, is placed in tank by solid-to-liquid ratio 1:9~15 times of amounts are added, leaching Bubble 1-2 hours, after being heated to reflux 2-2.5 hours, leaches first time extract solution;Then solid-to-liquid ratio 1 is pressed:8~13 amounts are leaving Add ethanol in hybrid solid thing, after being heated to reflux 1-2.5 hours, leach second extract solution, solid-to-liquid ratio 1 is then pressed again:5- 10 amounts are in the mixing solid-liquid for leaving plus ethanol is after being heated to reflux 2-2.5 hours, leach third time extract solution.By three extractions Liquid merging reclaims ethanol in putting evaporator, every milliliter of extract solution is concentrated to, equivalent to the 10% of mixed biologic alkali raw material;Extracting Tea Saponin, three isooctyl acid glyceride, starch ocentyl succinic aluminium, the sub- powder of narcissus, sophora bud powder are proportionally added into liquid while hot fast Speed stirs, and dries, crushes.It is proportionally added into that partially aqueous aluminosilicate salt fines are well mixed to be made the antiviral feeding of novel antibacterial again Feed additives finished product, checks qualified packaging and storage.
Feed addictive is added by the 0.3%-0.5% of complete feed per ton.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to compared with Good embodiment has been described in detail to the present invention, it will be understood by those within the art that, can be to skill of the invention Art scheme is modified or equivalent, and without deviating from the objective and scope of technical solution of the present invention, it all should cover at this In the middle of the right of invention.

Claims (6)

1. it is a kind of prevent and treat animal viral disease feed addictive, it is characterised in that:It is made up of following raw material and weight portion:By 5-10 parts of mountain boon, kuh-seng 1-15 parts, it is small cavity grass 1-15 parts of extract, ergosterol 10-15 parts, Tea Saponin 0.1-2 parts, three 0.001-0.005 parts of isooctyl acid glyceride, 0.01-0.03 parts of starch ocentyl succinic aluminium, spend in vain mattress 10-15 parts, narcissus son Powder 5-10 parts, 1-6 parts of sophora bud powder.
2. according to a kind of feed addictive for preventing and treating animal viral disease of claim 1, it is characterised in that:The feed addition The carrier of agent is the partially aqueous aluminosilicate salt fines of 300-500 mesh, by weight additive:Carrier=1-2:1-10 is mixed.
3. according to a kind of feed addictive for preventing and treating animal viral disease of claim 1, it is characterised in that:In the additive partially Aqueous aluminosilicate salt fines can be montmorillonites, change surname illite, clinoptilolite.
4. according to a kind of feed addictives for preventing and treating animal viral disease of claim 1-4, it is characterised in that:The feed is added Agent preparation method is completed by following operating procedure:
In proportion by mountain boon branches and leaves or seed, kuh-seng, small cavity grass branches and leaves or seed, ergosterol, spend mattress in vain, cleaned get rid of Dry grinding, immersion, boiling, solvent refluxing, filtering, collect mother liquor repeatedly for three times;In proportion by Tea Saponin, three isooctyl acid glycerine Ester, starch ocentyl succinic aluminium, the sub- powder of narcissus, sophora bud powder quickly stir in being added to recovery mother liquor, dry, crush.
5. according to a kind of feed addictive for preventing and treating animal viral disease of claim 5, it is characterised in that:It is proportionally added into partially Aqueous aluminosilicate salt fines are mixed, and check qualified packaging and storage.
6. according to a kind of feed addictive for preventing and treating animal viral disease of claim 1, it is characterised in that:Feed addictive is pressed The 0.3%-0.5% of complete feed per ton is added.
CN201611161829.5A 2016-12-15 2016-12-15 Prevent and treat the feed addictive and preparation method of animal viral disease Pending CN106721003A (en)

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CN111068039A (en) * 2020-02-18 2020-04-28 江苏周春祥生物科技有限公司 Poultry drinking water additive composition for preventing and treating viral diseases of livestock and poultry

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CN101637220A (en) * 2008-07-29 2010-02-03 张起凡 Anti-virus feed additive for reducing cholesterol, production process thereof and application
CN102845607A (en) * 2012-08-06 2013-01-02 王茜 Novel antibacterial antiviral feed additive
CN106173257A (en) * 2016-08-29 2016-12-07 广西大学 A kind of Chinese medicine feed additive preventing and treating animal viral disease and preparation method thereof

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CN101543589A (en) * 2008-03-26 2009-09-30 北京大北农动物保健科技有限责任公司 Compound pharmaceutical composition for curing virus diseases of animals and preparation method thereof
CN101637220A (en) * 2008-07-29 2010-02-03 张起凡 Anti-virus feed additive for reducing cholesterol, production process thereof and application
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CN109820111A (en) * 2019-03-25 2019-05-31 和县世宏肉鸽养殖家庭农场 A kind of anti-virus feed additive and preparation method thereof of childhood pigeon for meat
CN111068039A (en) * 2020-02-18 2020-04-28 江苏周春祥生物科技有限公司 Poultry drinking water additive composition for preventing and treating viral diseases of livestock and poultry

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