CN106706590A - Portable fluorescence chip data collector - Google Patents

Portable fluorescence chip data collector Download PDF

Info

Publication number
CN106706590A
CN106706590A CN201710083505.2A CN201710083505A CN106706590A CN 106706590 A CN106706590 A CN 106706590A CN 201710083505 A CN201710083505 A CN 201710083505A CN 106706590 A CN106706590 A CN 106706590A
Authority
CN
China
Prior art keywords
light source
fluorescence
pull
chip data
portable fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710083505.2A
Other languages
Chinese (zh)
Inventor
陈华龙
蓝献泉
刘萌
姜丽君
郭杰标
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHAOGUAN FOOD AND DRUG INSPECTION INSTITUTE
Original Assignee
SHAOGUAN FOOD AND DRUG INSPECTION INSTITUTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHAOGUAN FOOD AND DRUG INSPECTION INSTITUTE filed Critical SHAOGUAN FOOD AND DRUG INSPECTION INSTITUTE
Priority to CN201710083505.2A priority Critical patent/CN106706590A/en
Publication of CN106706590A publication Critical patent/CN106706590A/en
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6402Atomic fluorescence; Laser induced fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention relates to a portable fluorescence chip data collector. The portable fluorescence chip data collector comprises a main case body and a drawing case, wherein the drawing case is movably installed in the main case body through a guide rail and can be drawn out from one side of the main case body; the top of the main case body is provided with a fluorescence light source; the top of the drawing case is provided with a first light filter; the bottom of the drawing case is provided with a chip bracket; the chip bracket is tilted to the drawing direction of the drawing case against the bottom surface of the drawing case; and a viewing port is arranged at one side in the drawing direction of the drawing case. The portable fluorescence chip data collector is convenient to carry, has no region or time limit, and is a digital portable fluorescence interpretation apparatus, thereby providing a sensitive quick specific cheap high-efficiency data collector for special anti-counterfeiting actions against illegal addition of nonsteroidal anti-inflammatory drugs and analogs thereof, and making a contribution to ensuring quality safety of food and drugs for the masses.

Description

A kind of Portable fluorescence chip data Acquisition Instrument
Technical field
The present invention relates to field of food detection, more particularly to a kind of Portable fluorescence chip data Acquisition Instrument.
Background technology
Target substance is identified using large biological molecule, is the hot technology of Safety of Food Quality detection, based on anti- The immunology detection technology of original/antibody response is main flow therein, have the advantages that it is sensitive, special, quick and cheap, extensively It is applied to the quick detection of Food and environment sample.And be capable of identify that many residual immune detections of a class material, one detected The high flux detection of the various orthogonal materials of journey Parallel testing, is the cutting edge technology neck of the complicated food safety detection task of reply Domain.
Illicit drugs phenomenon remains incessant after repeated prohibition in current food, and has the today for the trend of growing in intensity, national drug prison Pipe portion door is annual all to arrange substantial amounts of manpower and materials, carries out special detection action of cracking down on counterfeit goods.But due to HPLC, LC-MS so Instrument and equipment, the only drug inspection department of provinces and cities' one-level uses, and operating cost is high, it is difficult to extensive to carry out, and leads The batch and scope of the special detection of illegal additive is caused all to be limited to.And high-end devices as LC-ESI-MS, it is many provincial Medicine inspecting institute may not all be equipped with, therefore the non-steroidal anti-inflammatory analogue for continuously emerging, it appears helpless.
Instrument and equipment as similar HPLC, LC-MS is desk-top instrument, and desk-top fluorescence detector is typically placed in detection Interior, has some limitations in use, moves and carries very inconvenient, it is impossible to accomplishes according to demand whenever and wherever possible Site Detection.Need for detection sample to take back sensing chamber during use, then carry out Data Detection and data analysis.Therefore design A kind of Portable fluorescence chip data Acquisition Instrument is necessary.
The content of the invention
In order to solve the above-mentioned technical problem, it is convenient for carrying the invention provides a kind of, the Fluorescence chip number of convenient use According to Acquisition Instrument.
The technical solution adopted in the present invention is:A kind of Portable fluorescence chip data Acquisition Instrument, including main box and take out Draw case.The pull-out box is movably arranged in main box by guide rail, it is possible to pull out to come from main box side.The main tank Body top is provided with fluorescence light source, and the first optical filter is installed at the pull-out box top, and the pull-out box bottom is provided with chip branch Frame, the chip set favours pull-out box bottom surface towards pull-out box extraction direction, and the pull-out box extraction direction side is set There is observation port.
Further, the fluorescence light source is divided into the first light source and secondary light source, and first light source connects first switch, institute State secondary light source connection second switch.When a fluorescence light source is faulty, it is possible to use another fluorescence light source.
Further, the observation port is provided with the second optical filter.Filtering veiling glare, makes fluorescence data more accurate.
Further, it is provided with shooting fixed support by the observation port.Shooting fixed support can fix mobile phone, camera etc. Portable capture apparatus shoot to Fluorescence chip data.
Further, the fluorescence light source is ultraviolet light source.
Further, first optical filter is the optical filter for only allowing the light wave by 365nm wavelength.
Further, second optical filter is the optical filter for only allowing the light wave by 610~630nm wavelength.
The present invention is provided with chargeable storage, can support to detect work on the spot 6-8 hours in remote districts.Observation port Shooting fixed support can connect the electronic equipment with shoot function such as panel computer, mobile phone, by camera to chip clap According to mode directly the digital code information of testing result is acquired, result is divided by embedded in mobile phone picture analyzing software Analysis is processed.Can directly store and utilize network remote to send to treated data, realize the teleengineering support of information.It is pin To the special anti fake commodity campaign of illegal addition non-steroidal anti-inflammatory and the like, there is provided sensitive, quick, special, inexpensive, efficient number According to Acquisition Instrument, for the work for ensureing people's food and medicine quality safety contributes.
Brief description of the drawings
Fig. 1 is the structural representation of Portable fluorescence chip data Acquisition Instrument of the invention.
Fig. 2 is the front view of Portable fluorescence chip data Acquisition Instrument of the invention.
Fig. 3 is the top view of Portable fluorescence chip data Acquisition Instrument of the invention.
Specific embodiment
As shown in Figures 1 to 3, a kind of Portable fluorescence chip data Acquisition Instrument of the invention, including main box 1 and pull-out box 2. The pull-out box 2 is movably arranged in main box 1 by guide rail 3, it is possible to pull out to come from the side of main box 1.Will when using Pull-out box 2 is somewhat extracted out, pushes in main box 1 pull-out box 2 when not using.
The top of the main box 1 is provided with fluorescence light source 4.Specifically, 4 points of the fluorescence light source is the first light source 41 and the Two light sources 42, first light source 41 connects first switch 51, the connection second switch 52 of the secondary light source 42.When a fluorescence When light source 4 is faulty, it is possible to use another fluorescence light source 4.Specifically, shown fluorescence light source 4 is ultraviolet light source, is opened Ultraviolet can be launched after light source.
The first optical filter 6 is installed at the top of the pull-out box 2, and specifically, first optical filter 6 is only to allow to pass through The optical filter of the light wave of 365nm wavelength.The ultraviolet light that fluorescence light source 4 sends by after the first optical filter 6, only wavelength 365nm Light can pass through, be radiated in detection chip, the light wave of the wavelength can just make detection chip send fluorescence.
The bottom of the pull-out box 2 is provided with chip set 7, and the chip set 7 is favoured towards the extraction direction of pull-out box 2 The bottom surface of pull-out box 2.Chip set 7 is used to place detection chip.
The extraction direction side of the pull-out box 2 is provided with observation port 8, and further, the observation port 8 is provided with the second optical filtering Piece 9.Filtering veiling glare, makes the fluorescence data of chip more accurate.Specifically, second optical filter 9 only to allow by 610~ The optical filter of the light wave of 630nm wavelength.After chip sends fluorescence, filtered by the second optical filter 9, can only be received in observation port 8 To the light that wavelength is 610~630nm.
Further, shooting fixed support 10 is provided with by the observation port 8.Shoot fixed support 10 can fix mobile phone, The portable capture apparatus such as camera or panel computer shoot to Fluorescence chip data.
Specific explanations concrete operation method of the invention below:Sample solution and grand array films antibody chip will be detected first With reference to, then grand array films antibody chip is placed on chip set 7, chip is subject to irradiating for fluorescence light source 4. In detection process, the antibody in target inspection product array element corresponding to grand array films antibody chip in sample solution is combined, and is concentrated to Detection zone (is assembled) in array element, and the ultraviolet after fluorescence light source 4 is filtered by the first optical filter 6 excites lower generation significantly Fluorescence signal, the fluorescence signal that chip sends is can see through observation port 8.
Mobile phone or other capture apparatus are fixed on shooting fixed support 10, camera against observation panel, using taking the photograph As head shoots to the fluorescence signal of chip.Fluorescence chip photo after shooting can be carried out by embedded in mobile phone analysis software Analysis, or laboratory is sent to by network, it is analyzed using special instrument.
The present invention is convenient for carrying, and is to be adapted to the biometrics portable fluorescence that work detects in basic unit not by region and time restriction Interpretation equipment, is the special anti fake commodity campaign for illegal addition non-steroidal anti-inflammatory and the like, there is provided sensitive, quick, special, Inexpensive, efficient data collecting instrument, for the work for ensureing people's food and medicine quality safety contributes.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Scope.

Claims (7)

1. a kind of Portable fluorescence chip data Acquisition Instrument, it is characterised in that:Including main box and pull-out box, the pull-out box leads to Cross guide rail to be movably arranged in main box, it is possible to pull out to come from main box side;The main box top is provided with fluorescence The first optical filter is installed at light source, the pull-out box top, and the pull-out box bottom is provided with chip set, the chip set court Pull-out box extraction direction and favour pull-out box bottom surface, the pull-out box extraction direction side is provided with observation port.
2. Portable fluorescence chip data Acquisition Instrument according to claim 1, it is characterised in that:The fluorescence light source is divided into First light source and secondary light source, first light source connect first switch, and the secondary light source connects second switch.
3. Portable fluorescence chip data Acquisition Instrument according to claim 1, it is characterised in that:The observation port is provided with Second optical filter.
4. Portable fluorescence chip data Acquisition Instrument according to claim 1, it is characterised in that:The observation port side is set There is shooting fixed support.
5. Portable fluorescence chip data Acquisition Instrument according to claim 1, it is characterised in that:The fluorescence light source is purple Outer line source.
6. Portable fluorescence chip data Acquisition Instrument according to claim 1, it is characterised in that:First optical filter is Only allow the optical filter of the light wave by 365nm wavelength.
7. Portable fluorescence chip data Acquisition Instrument according to claim 3, it is characterised in that:Second optical filter is Only allow the optical filter of the light wave by 610~630nm wavelength.
CN201710083505.2A 2017-02-16 2017-02-16 Portable fluorescence chip data collector Pending CN106706590A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710083505.2A CN106706590A (en) 2017-02-16 2017-02-16 Portable fluorescence chip data collector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710083505.2A CN106706590A (en) 2017-02-16 2017-02-16 Portable fluorescence chip data collector

Publications (1)

Publication Number Publication Date
CN106706590A true CN106706590A (en) 2017-05-24

Family

ID=58909339

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710083505.2A Pending CN106706590A (en) 2017-02-16 2017-02-16 Portable fluorescence chip data collector

Country Status (1)

Country Link
CN (1) CN106706590A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113533269A (en) * 2021-06-08 2021-10-22 东南大学 Portable urine glucose meter and detection method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101281120A (en) * 2008-05-29 2008-10-08 夏云厚 Rock debris fluorescent / general light digitization imaging acquiring instrument and analyze management system
CN104237210A (en) * 2013-06-08 2014-12-24 北京百康芯生物科技有限公司 Portable detection device
CN105388131A (en) * 2014-09-09 2016-03-09 国家纳米科学中心 Fluorescence detection instrument and system based on micro-fluidic chip
CN105842217A (en) * 2016-05-19 2016-08-10 西安交通大学 Up-conversion fluorescence tomography test paper detection result reading device based on mobile terminal
CN106404733A (en) * 2016-09-18 2017-02-15 天津博硕东创科技发展有限公司 Mobile intelligent terminal-based food safety detection device and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101281120A (en) * 2008-05-29 2008-10-08 夏云厚 Rock debris fluorescent / general light digitization imaging acquiring instrument and analyze management system
CN104237210A (en) * 2013-06-08 2014-12-24 北京百康芯生物科技有限公司 Portable detection device
CN105388131A (en) * 2014-09-09 2016-03-09 国家纳米科学中心 Fluorescence detection instrument and system based on micro-fluidic chip
CN105842217A (en) * 2016-05-19 2016-08-10 西安交通大学 Up-conversion fluorescence tomography test paper detection result reading device based on mobile terminal
CN106404733A (en) * 2016-09-18 2017-02-15 天津博硕东创科技发展有限公司 Mobile intelligent terminal-based food safety detection device and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113533269A (en) * 2021-06-08 2021-10-22 东南大学 Portable urine glucose meter and detection method thereof

Similar Documents

Publication Publication Date Title
US9625370B2 (en) Microscope with spectroscopic capability
US20130321792A1 (en) Universal tool for automated gem and mineral identification and measurement
WO2007130522A3 (en) Integrated mold detector
CN104569379A (en) Intelligent mobile phone type rapid detection device matched with immunochromatographic test strip
CN104634789A (en) System and method for performing foreign matter inspection on upper surface of ultrathin glass substrate
US6995839B1 (en) Automated Raman scanner for documents and materials
CN108051595A (en) A kind of Portable fluorescence immunity-chromatography test strip image-forming detecting system
CN106706590A (en) Portable fluorescence chip data collector
Kukkola et al. Easy and accessible way to calibrate a fluorescence microscope and to create a microplastic identification key
WO2011030156A3 (en) Collection of electromagnetic radiation emitted from particle-irradiated samples
Ceco et al. Stand-off imaging Raman spectroscopy for forensic analysis of post-blast scenes: trace detection of ammonium nitrate and 2, 4, 6-trinitrotoluene
CN104212706B (en) A kind of cell microfluidic image capturing system based on phase lock amplifying technology
CN206440615U (en) A kind of Portable fluorescence chip data Acquisition Instrument
US20150109430A1 (en) Digital imaging system for biopsy inspection
US20110095898A1 (en) Interactive Security Screening System
CN205333509U (en) Polymorphic type hyperspectral imager integrated device and system
CN104212705B (en) A kind of two channels cell microfluidic image capturing system based on impulse detection technique
CN114252421B (en) Handheld fluorescence detector
CN205941370U (en) Explosive identification apparatus based on raman spectroscopy technique
CN207882283U (en) A kind of Portable fluorescence immunity-chromatography test strip image-forming detecting system
CN209764705U (en) infrared spectrum imaging system for detecting shooting residues
Huang et al. Detection of latent fingerprints by ultraviolet spectral imaging
CN211061423U (en) Explosive rapid detection equipment
Mai et al. Flow cytometry visualization and real-time processing with a CMOS SPAD array and high-speed hardware implementation algorithm
Wilcox et al. Comparison of handheld Raman sensors through opaque containers

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination