CN106699687A - 一种含硒的kga/gac和/或gdh抑制剂化合物 - Google Patents
一种含硒的kga/gac和/或gdh抑制剂化合物 Download PDFInfo
- Publication number
- CN106699687A CN106699687A CN201510789110.5A CN201510789110A CN106699687A CN 106699687 A CN106699687 A CN 106699687A CN 201510789110 A CN201510789110 A CN 201510789110A CN 106699687 A CN106699687 A CN 106699687A
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- CN
- China
- Prior art keywords
- compound
- glutaminase
- inhibitor
- atom
- allosteric site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JKCWPUDUTLRJAZ-UHFFFAOYSA-N Cc(cccc1SN2CCCCCc3nnc(NC(Cc4ccccc4)=O)[s]3)c1C2=O Chemical compound Cc(cccc1SN2CCCCCc3nnc(NC(Cc4ccccc4)=O)[s]3)c1C2=O JKCWPUDUTLRJAZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Description
Claims (9)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510789110.5A CN106699687B (zh) | 2015-11-17 | 2015-11-17 | 一种含硒的kga/gac和/或gdh抑制剂化合物 |
PCT/CN2016/106202 WO2017084598A1 (en) | 2015-11-17 | 2016-11-17 | Selenium-containing inhibitors that bind to the allosteric site of glutaminase and/or inhibit glutamate dehydrogenase and their applications |
US15/983,079 US10596152B2 (en) | 2015-11-17 | 2018-05-17 | Selenium containing KGA/GDH dual inhibitors and the applications thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510789110.5A CN106699687B (zh) | 2015-11-17 | 2015-11-17 | 一种含硒的kga/gac和/或gdh抑制剂化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106699687A true CN106699687A (zh) | 2017-05-24 |
CN106699687B CN106699687B (zh) | 2019-11-01 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510789110.5A Active CN106699687B (zh) | 2015-11-17 | 2015-11-17 | 一种含硒的kga/gac和/或gdh抑制剂化合物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10596152B2 (zh) |
CN (1) | CN106699687B (zh) |
WO (1) | WO2017084598A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019042108A1 (zh) * | 2017-08-29 | 2019-03-07 | 深圳大学 | 一种硒掺杂黑磷前药及其制备方法 |
CN109988124A (zh) * | 2017-12-29 | 2019-07-09 | 杭州健昵福生物科技有限公司 | 一种含氧族元素二唑或四氮唑结构的肾型谷氨酰胺酶变构位点的抑制剂 |
WO2021208865A1 (zh) * | 2020-04-13 | 2021-10-21 | 凯熙医药(武汉)股份有限公司 | 含四嗪取代基的芳并异硒唑类化合物及其合成方法和应用 |
CN113527329A (zh) * | 2020-04-22 | 2021-10-22 | 上海中医药大学附属龙华医院 | 含硒化合物及其医药用途 |
WO2022218345A1 (zh) * | 2021-04-13 | 2022-10-20 | 杭州汉菁生物科技有限公司 | 一种包载链状难溶药物的聚合型胶束及制备方法和应用 |
CN113527301B (zh) * | 2020-04-13 | 2024-05-17 | 凯熙医药(武汉)股份有限公司 | 含四嗪取代基的芳并异硒唑类化合物及其合成方法和应用 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200188431A1 (en) | 2017-06-09 | 2020-06-18 | Vib Vzw | Glutamine dehydrogenase inhibitors for use in muscle regeneration |
CN111138215B (zh) * | 2020-01-17 | 2023-04-25 | 湖南诺维信生物科技有限公司 | 一种培育富硒农产品的营养液 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1990475A (zh) * | 2005-12-29 | 2007-07-04 | 曾慧慧 | 取代苯并异硒唑酮类化合物及其用途 |
CN102234254A (zh) * | 2010-04-23 | 2011-11-09 | 北京大学 | 一种苯并异硒唑类化合物及其制备方法和其应用 |
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2015
- 2015-11-17 CN CN201510789110.5A patent/CN106699687B/zh active Active
-
2016
- 2016-11-17 WO PCT/CN2016/106202 patent/WO2017084598A1/en active Application Filing
-
2018
- 2018-05-17 US US15/983,079 patent/US10596152B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1990475A (zh) * | 2005-12-29 | 2007-07-04 | 曾慧慧 | 取代苯并异硒唑酮类化合物及其用途 |
CN102234254A (zh) * | 2010-04-23 | 2011-11-09 | 北京大学 | 一种苯并异硒唑类化合物及其制备方法和其应用 |
Non-Patent Citations (3)
Title |
---|
FEI MAO等: "Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
JIE HE等: "Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
M. OSAJDA等: "Bisbenzisoselenazol-3(2H)-ones, a New Group of Ebselen Analogues", 《POLISH J. CHEM.》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019042108A1 (zh) * | 2017-08-29 | 2019-03-07 | 深圳大学 | 一种硒掺杂黑磷前药及其制备方法 |
CN109988124A (zh) * | 2017-12-29 | 2019-07-09 | 杭州健昵福生物科技有限公司 | 一种含氧族元素二唑或四氮唑结构的肾型谷氨酰胺酶变构位点的抑制剂 |
CN109988124B (zh) * | 2017-12-29 | 2024-01-09 | 杭州健昵福生物科技有限公司 | 一种含氧族元素二唑或四氮唑结构的肾型谷氨酰胺酶变构位点的抑制剂 |
WO2021208865A1 (zh) * | 2020-04-13 | 2021-10-21 | 凯熙医药(武汉)股份有限公司 | 含四嗪取代基的芳并异硒唑类化合物及其合成方法和应用 |
CN113527301A (zh) * | 2020-04-13 | 2021-10-22 | 凯熙医药(武汉)股份有限公司 | 含四嗪取代基的芳并异硒唑类化合物及其合成方法和应用 |
CN113527301B (zh) * | 2020-04-13 | 2024-05-17 | 凯熙医药(武汉)股份有限公司 | 含四嗪取代基的芳并异硒唑类化合物及其合成方法和应用 |
CN113527329A (zh) * | 2020-04-22 | 2021-10-22 | 上海中医药大学附属龙华医院 | 含硒化合物及其医药用途 |
WO2022218345A1 (zh) * | 2021-04-13 | 2022-10-20 | 杭州汉菁生物科技有限公司 | 一种包载链状难溶药物的聚合型胶束及制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN106699687B (zh) | 2019-11-01 |
US20180263961A1 (en) | 2018-09-20 |
US10596152B2 (en) | 2020-03-24 |
WO2017084598A1 (en) | 2017-05-26 |
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Effective date of registration: 20201124 Address after: 310000 3rd floor, building 13, Fuchun Park, Zhigu, China, Yinhu street, Fuyang District, Hangzhou City, Zhejiang Province Patentee after: Hangzhou Hanjing Biotechnology Co., Ltd Address before: Hangzhou City, Zhejiang province 310014 City Ring Road No. 2, room 347 a tsuchiyama Patentee before: HANGZHOU GAMMA BIOTECH Co.,Ltd. |
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Effective date of registration: 20210709 Address after: Room 547, No.2, Tushan 1st lane, Huancheng East Road, Shangcheng District, Hangzhou, Zhejiang 310000 Patentee after: HANGZHOU JENNIFER BIOTECH Co.,Ltd. Address before: 310000 3rd floor, building 13, Fuchun Park, Zhongguo Zhigu, Yinhu street, Fuyang District, Hangzhou City, Zhejiang Province Patentee before: Hangzhou Hanjing Biotechnology Co., Ltd |