CN1066978A - Traditional chinese medicine immunity sweets - Google Patents

Abstract

" Traditional Chinese medicine immunity sweets " belongs to drug-preparing technology field, adopts the Chinese herbal medicine combination formula of Chinese traditional medicine, has the Chinese herbal medicine of the antagonist that can give up opiates and heroin drug dependence.Of the present invention preparing medicines handled, prepares burden, grinds, boiled and carry, lixiviate, make extractum, add an amount of excipient and deodorant tune is shaped to oral containing sugar and chewing gum, sanitary inspection, packaging and other steps make through raw material.Have with the bonded function of many types of opiate receptor and invigorating QI and tranquilization, relieving convulsionly relieve dizziness, high fever, infantile convulsions, epilepsy, etc., function such as relieving spasm to stop pain, suppress the effect of opiates and heroin medicine and opiate receptor, reach the stopping narcotic taking effect.

Description

Traditional Chinese medicine immunity sweets

Traditional Chinese medicine immunity sweets (drug rehabilitation spirit) relates to give up opioid drug dependency and help heroin addiction person with the Chinese herbal medicine of Chinese Medicine traditional remedies and removes a kind of of bad habit and prepare medicines, and the invention belongs to drug-preparing technology field.

As everyone knows, drug abuse and traffic in drugs have become big public hazards of the world today, and worldwide overflow of drugs is becoming increasingly rampant, and bring serious harm for society, economy, the public security of many countries." international cooperation is banned narcotics and psychotropic drugs illegal production, supply, needs, transported goods for sale and distribute the United Nations General Assembly's special meeting of problem " held at Headquarters of the United Nations February 20 nineteen ninety, showed the special attention of countries in the world to prohibition of drug problem.Various countries are when carrying out sweep-drug, anti-poison, multiple drug addiction treatment and work of rehabilitation plan have been carried out, different junkie for different background provide drug addiction treatment in every way, treat as the voluntary hospitalization that U.S. sanitary administration provides the voluntary out-patient treatment of methadone and U.S.'s drug rehabilitation to carry out, many again Therapeutic Method are used in medical practice, have obtained certain success.But, because the drug dependence genesis mechanism is very complicated, Therapeutic Method still lacks and improves strong theoretical direction, is still an extremely difficult and complicated problems in the research of medical skill and medicine, up to now, still there is not a kind of simple and effective drug addiction treatment medicine.

The present invention is exactly the shortcoming that exists at existing anti-additive medicament, adopts the prepared from traditional Chinese medicines of Chinese Medicine traditional remedies to become Traditional Chinese medicine immunity sweets, has produced beyond thought effect through zoopery and clinical preliminary observation.

The objective of the invention is, provide a kind of and suppress or alleviate having of withdrawal symptom to treat newly preparing medicines of opioid drug dependency and intravenous injection heroin addiction person; Second purpose of the present invention be, provides a kind of using method easy, can prepare medicines for the effective novel form sugar pill that drug dependence person and drug addiction person take like a shot; The 3rd purpose that the present invention pursues be, adopts the Chinese herbal medicine of Chinese Medicine traditional remedies, takes for a long time not have side effects, and can give therapist to feel at ease and comfortable sensation.

Main theory basis of the present invention is a receptor theory, because it is the theory that information was discerned, accepts and transmitted to the explanation cell how, the disorder of the information transfer system and obstacle can produce pathological state, adopt means of different, wherein Drug therapy accounts for special status, reach the transmission of rectification information, make it to recover or approaching the recovery normally, thereby make pathological state obtain correcting.Drug regimen preparation of the present invention, be exactly according to the reaction rule between drug molecule and the acceptor molecule, drug molecular structure and produce effect concern that on the basis, orientation designs, make the present invention prepare medicines " Fan Shi rehabilitation sugar " better therapeutic and toxic and side effects are still less arranged.Opiate receptor has pleiomorphism, has three kinds of different receptor subtypes at least, i.e. μ, δ and kappa receptor, and the μ receptor is the media that causes analgesic activity among the central nervous system, and the δ receptor also may relate to behavior effect.Be divided into two kinds of agonist and antagonisies with the bonded medicine of opiate receptor.

Opioid receptor agonist generally has more serious addiction effect, and they both can cause the body dependency, can cause psychologic dependence again.Opiates is very similar with the heroin chemical constitution, it is the agonist of the intravital opiate receptor of people, combine with opiate receptor, particularly repeat to cause euphoric state, Duo 10 times than opium is about, can produce lightening intensive pleasant sensation because heroin sees through blood brain barrier to opiates or heroin, comprise bask, happiness, peaceful and satisfy, conscious energetic, or be in a kind of fantasy state, can produce psychological dependence; When producing physical dependence, if there is not medicine, the people just can not carry out the functional activity of operate as normal, stops delivery time and knows from experience the generation withdrawal symptom, and is similar with serious influenza.Opiates and heroin metabolism in vivo are rapid, and the acting duration of medicine on average is 4～5 hours, and this just becomes the considerable factor that causes addiction, and the addict is 3～5 hours successive administrations at interval.

The antagonist of opiate receptor generally can make very serious withdrawal symptom be eased, and the sense of euphoria and other untoward reaction that do not have the agonist effect to produce.Antagonism is meant the disassimilation of drug interaction, it is lower than the effect that is produced when active medicine is used separately, comprise: (1) chemical antagonism, a kind of opiates and heroin that tissue or receptor is played excited effect, the medicine that has antagonism with another kind interacts, form the coordination compound of non-activity, this coordination compound no longer has the effect of irritated tissue or receptor, has offset the analeptic drug effect.(2) competitive antagonism, competitive antagonism refer to act on two kinds of opposite medicines, a kind of reversibility antagonism that carries out at same receptor or position.In this interaction, exist the competitive relation of medicine to receptor or binding site; When giving dose,equivalent, its effect performance of medicine that affinity is big is obvious, the effective relation of this effect.(3) non-equilibrium competetive antagonism, medicine produces irreversible antagonism at same acceptor site.(4) noncompetitive antagonism, two kinds of medicines of same-action not are combined in the different binding sites of same receptor simultaneously, then agonist drug has disturbed the effect of analeptic drug, and two kinds of medicines are when receptors bind, and but unwillingness is disturbed mutually, and this antagonism is not big reverse of dosage of analeptic drug.(5) physiology or functional antagonism, this antagonism are meant the antagonism that two kinds of obviously opposite medicines of effect occur.Act on the competitive antagonism of medicine and the noncompetitive antagonism of same receptor, noncompetitive antaganist does not act on the receptor of agonist, and it acts on the specific receptor of itself and produces antagonism to the agonist effect.The power of antagonist is and is directly related with the affinity between the receptor, and the present invention's " Fan Shi rehabilitation sugar " existing competitive antagonism for preparing medicines has non-competitive antagonism again; Both can act on mu opioid receptor, and can combine with delta opiate receptor again, be a kind of preparing medicines of pleiomorphism, multiple antagonism that have.

The people that treatment relies on medicine is very difficult, because requirement and the acquisition complementary medicine of this people in order to satisfy medication tends to move towards crime.Therapeutic Method mainly contains: (1) drug dose decreasing therapy; (2) suppress with other types of drug or alleviate withdrawal symptom; (3) quit drug abuse fast with antagonist; (4) traditional medicine therapy; (5) combination therapy.Several years up to date, almost nobody thought and sucks opioid drug or intravenous injection heroin addiction person can not recover and keep normal function preferably when having medicine.Methadone is the oral active drug that suppresses withdrawal syndrome, so give methadone, just can replace any opium kind analgesics commonly used effectively, sustainable 48～72 hours of drug effect.Many countries all use the substitute of methadone as opiate, and still, methadone is oversize medicine time, takes the purpose that just can reach drug rehabilitation in six months to the time that reaches 2 years at least.Therefore, the Therapeutic Method of drug dependence also needs further research to explore.In recent years, rely on the medicine of aspects such as its Chinese herbal medicine belongs to invigorating QI and tranquilization more, relieving convulsionly relieves dizziness, high fever, infantile convulsions, epilepsy, etc., relieving spasm to stop pain with traditional medicine treatment opium in India, Malaysia, Africa and Latin America.Be to inquire into the Chinese herbal medicine mechanism of action, Hong Kong University's medical college is studied 13 flavor Chinese medicine crude extract, giving up on the rat, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, Rhizoma Et Radix Notopterygii, Rhizoma Corydalis, Radix Aconiti Lateralis Preparata can reduce significantly rock, head and extremity tremble.And Flos Daturae, the Radix Angelicae Dahuricae, Herba Houttuyniae increase the weight of, and Radix Ginseng tea, Pedicellus Melo, Radix Notoginseng, Radix Polygalae, Radix Stephaniae Tetrandrae then do not influence above-mentioned symptom, and Flos Daturae can obviously reduce limbs and stretch.Experimentation confirms that Radix Ginseng tea, Radix Aconiti Lateralis Preparata, Rhizoma Corydalis, Ramulus Uncariae Cum Uncis, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Flos Daturae have significant analgesia role.As if they think that every kind of Chinese herbal medicine is similar with the effect of psychosis haloperidol to this selection of different withdrawal symptoms.

The present invention prepares medicines " Fan Shi rehabilitation sugar " for a kind of pale brown toner end, can be made into dosage forms such as soaking with sugar cream, sugar pill and sugar-tablet.Carried out zoopery before the clinical practice, method is with 140 of Kunming mouses, male and female half and half, be divided into 4 groups at random, in 2 days, inject morphine 7 times in every mouse peritoneal, accumulated dose 375mg/kg, after the last administration, observe the present invention prepare medicines " Fan Shi rehabilitation sugar " short mice is given up jump, experimental result shows, most of mices occur uneasy after gavaging medicine of the present invention, excitation, behavior such as probe into, the symptom of withdrawal symptom occurs, show as defecation, urinate, locomotor activity increases, jump but mainly show as special mechanical formula, be used for estimating the degree that opium relies on.In 1 hour, jumping appears in 32g/kg group (n=30) 13% mice; 65g/kg group mouse jump rate is 35%.65g/kg group (n=20) jump rate is 45% in 3 hours, and average number of skips is 40.3 ± 115.88, and jump phenomena (P＜0.01) does not appear in the brinish control group mice that gavages equivalent.Another experiment, get 182 of mices, be divided into 24 groups at random, in 2 days, inject morphine 7 times in every mouse peritoneal, accumulated dose 375mg/kg, in the last administration gavaged 8,12,16 in 3 hours respectively, 32g/kg " Fan Shi rehabilitation sugar ", matched group gavages the saline of equivalent, the multiple again nalorphine of giving injection 100mg/kg is observed the Mus rate of jump in 15 minutes and the number of times of mouse jump after 1 hour." the Fan Shi rehabilitation sugar " of low dosage does not urge mice to give up jump, but can urge the antagonist nalorphine that the number of times of mouse jump is increased, and preparing medicines to the present invention has significant difference (P＜0.01) between " Fan Shi rehabilitation sugar " group and matched group.On mice, carry out the prepare medicines experimental result of " Fan Shi rehabilitation sugar " antimutagenic activity of the present invention with micronucleus test and show that the mutagenic activity to cyclophosphamide on mice has certain inhibitory action.The zoopery conclusion is, the present invention prepare medicines " Fan Shi rehabilitation sugar " have the opioid antagonist effect, be a kind of antagonist with pleiomorphism opiate receptor, be a kind of oral medicine of effective combination therapy drug rehabilitation.Clinical observation 100 examples, prove use the present invention prepare medicines " Fan Shi rehabilitation sugar " safe and effective.

The present invention with the advantage that existing anti-additive medicament is compared is:

1. " Fan Shi rehabilitation sugar " has the directed design of pleiomorphism characteristics based on Chinese herbal medicine according to opiate receptor, is a kind of pleiomorphism opiate receptor antagonist, has the combination therapy effect unique.

2. " Fan Shi rehabilitation sugar " can suppress or alleviate withdrawal symptom, takes for a long time and does not produce dependency and toxic and side effects.

3. " Fan Shi rehabilitation sugar " is simple for production, can be made into multiple peroral dosage form, has exempted painful and the complicated formality of having an injection of some drug-breaking medicine.Wherein the chewing gum type is easy to carry, and can take at any time.

The present invention prepare medicines " Fan Shi rehabilitation sugar " concentrated the advantage of Chinese medicine therapy, have invigorating QI and tranquilization, relieving convulsionly relieve dizziness, high fever, infantile convulsions, epilepsy, etc., effect such as relieving spasm to stop pain, treat from physiological function.

5. the present invention prepares medicines and interacts between the medicine of " Fan Shi rehabilitation sugar ", has significantly compound and synergism, has combined therapy effect.

The prepare medicines prescription of " Fan Shi rehabilitation sugar " of the present invention is made up of following medicine:

Flos Daturae 1g Radix Ginseng 6g Rhizoma Atractylodis Macrocephalae 10g Poria 10g Rhizoma Corydalis 2g Rhizoma Coptidis 1g Ramulus Cinnamomi 1g crust halberd 1g Fructus Corni 1g Cornu Cervi Pantotrichum 2g Semen Ziziphi Spinosae 1g Herba Cynomorii 2g Caulis Spatholobi 5g Colla Corii Asini 5g Radix Notoginseng 2g Radix Salviae Miltiorrhizae 5g Rhizoma Chuanxiong 1g Ramulus Uncariae Cum Uncis 1g Radix Angelicae Dahuricae 1g Rhizoma Et Radix Notopterygii 1g starch 19g sugar 20g Cordyceps 2g

The following example is described further invention, but is not construed as limiting.

Embodiment

Flos Daturae 1g, the Radix Ginseng 6g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Rhizoma Corydalis 2g, Rhizoma Coptidis 1g, Ramulus Cinnamomi 1g, crust halberd 1g, Fructus Corni 1g, Cornu Cervi Pantotrichum 2g, Semen Ziziphi Spinosae 1g, Herba Cynomorii 2g, Caulis Spatholobi 5g, Colla Corii Asini 5g, Radix Notoginseng 2g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 1g, Ramulus Uncariae Cum Uncis 1g, Radix Angelicae Dahuricae 1g, Rhizoma Et Radix Notopterygii 1g, Cordyceps 2g, starch 19g, the sugared 20g etc. that cook are handled through (1) raw material, remove foreign material, undesirable root and the base of a fruit, sieve dedust bits, clean dry; (2) batching is as follows by weight percentage: 1%, 6%, 10%, 10%, 2%, 1%, 1%, 1%, 1%, 2%, 1%, 2%, 5%, 5%, 2%, 5%, 1%, 1%, 1%, 1%, 2%, 19%, 20%; (3) grind, powdered; (4) make extractum; (5) add an amount of excipient and deodorant tune, excipient is pectin, Mel, white sugar, and deodorant tune can be cream flavour, Herba Menthae essence etc., selects for use according to user's taste, and content is 0.1～2%; (6) dosage form can be made into oral containing sugar or chewing gum, obeys every day 4 times, each a slice; (7) sanitary standard, by People's Republic of China's " Medicine Act " and " food hygiene law " regulation, assorted bacterium＜100/ml, pathogenic bacterium must not detect; (8) packing.

Claims (4)

1, " Traditional Chinese medicine immunity sweets ", the Chinese herbal medicine that contains multiple Chinese traditional medicine, it is characterized in that sugared body contains invigorating QI and tranquilization, relieving convulsionly relieves dizziness, high fever, infantile convulsions, epilepsy, etc., relieving spasm to stop pain and have Chinese medicine with many types of opiate receptor competition and the bonded antagonist of noncompetitive, it is a kind of Chinese drug-treated group mixture that can give up drug dependence such as opiates and heroin, through raw material handles, prepare burden, grind, make extractum, adding an amount of excipient and deodorant tune, to be shaped to containing sugared, chewing gum, sanitary inspection and packaging and other steps are made.

2, according to claim 1. described " Fan Shi rehabilitation sugar ", it is characterized in that contained multiple Chinese herbal medicine and amount are in the sugared body: Flos Daturae 1g Radix Ginseng 6g Rhizoma Atractylodis Macrocephalae 10g Poria 10g Rhizoma Corydalis 2g Rhizoma Coptidis 1g Ramulus Cinnamomi 1g crust halberd 1g Fructus Corni 1g Cornu Cervi Pantotrichum 2g Semen Ziziphi Spinosae 1g Herba Cynomorii 2g Caulis Spatholobi 5g Colla Corii Asini 5g Radix Notoginseng 2g Radix Salviae Miltiorrhizae 5g Rhizoma Chuanxiong 1g Ramulus Uncariae Cum Uncis 1g Radix Angelicae Dahuricae 1g Rhizoma Et Radix Notopterygii 1g Cordyceps 2g starch 19g sugar 20g.

3, according to claim 1. described " Fan Shi rehabilitation sugar ", it is characterized in that adopting the Chinese herbal medicine mix homogeneously that cooks to prepare by a certain percentage, the proportioning of Chinese herbal medicine is: Flos Daturae 1% Radix Ginseng 6% Rhizoma Atractylodis Macrocephalae 10% Poria 10% Rhizoma Corydalis 2% Rhizoma Coptidis 1% Ramulus Cinnamomi 1% crust halberd 1% Fructus Corni 1% Cornu Cervi Pantotrichum 2% Semen Ziziphi Spinosae 1% Herba Cynomorii 2% Caulis Spatholobi 5% Colla Corii Asini 5% Radix Notoginseng 2% Radix Salviae Miltiorrhizae 5% Rhizoma Chuanxiong 1% Ramulus Uncariae Cum Uncis 1% Radix Angelicae Dahuricae 1% Rhizoma Et Radix Notopterygii 1% Cordyceps 2% starch 19% sugar 20%.

4, according to claim 1. described " Fan Shi rehabilitation sugar ", it is characterized in that adding an amount of adjuvant is excipient and deodorant tune, and content is 39%; Excipient is pectin, starch, Mel or white sugar; Deodorant tune is cream flavour, Herba Menthae essence etc., selects adjuvant as required for use.