KR20070013640A - Therapeutic agent for narcotics addiction - Google Patents

Abstract

A therapeutic agent for narcotics addiction is provided to inhibit drug addiction of the narcotic anodynes, so that side effects of the narcotic anodynes are suppressed. The therapeutic agent for narcotics addiction comprises the Scutellariae radix extract and betaine as effective ingredients, and a pharmaceutically acceptable carrier, wherein the Scutellariae radix extract is prepared by extracting Scutellariae radix with hot water, and drying and pulverizing it; and the mixing ratio of Scutellariae radix extract and betaine is 4:6 to 7:3.

Description

Drug Addiction Cure {Therapeutic Agent for Narcotics Addiction}

1 is a graph comparing the effect of natural products that can suppress the climbing behavior by administration of apomorphine.

Figure 2a is a graph showing the effect of the golden extract and betaine on the spontaneous momentum by morphine.

Figure 2b is a graph showing the effect of golden extract and betaine on the spontaneous momentum by nalbuphine.

Figure 3a is a graph showing the effect of the golden extract and betaine on the site-dependence formed by the administration of morphine.

Figure 3b is a graph showing the effect of the gold extract and betaine on the site-dependence formed by the administration of nalbuphine.

The present invention relates to a drug addiction treatment. More specifically, the present invention relates to a drug addiction therapeutic agent comprising a golden extract, betaine or a mixture thereof as an active ingredient and a pharmaceutically acceptable carrier.

In general, "narcotics" refers to compounds that have similar effects to opiates and derivatives thereof, and include addictive or addictive drugs such as morphine, codeine, noscapine, papaverine, thebaine, heroin, and the like. Opiate drugs or opiate-like drugs, which are natural combinations derived from poppy plants (Stedman's Medical Dictionary, 26th edition, Williams & Wilkins Publ., 1995). In order for a compound to be classified as a drug, it must be able to induce "significant changes in feelings and behaviours", be able to induce a state of "coat pain" and present serious risks such as dependency, tolerance and / or addiction. It must be proved.

Most drug addicts initially use narcotic substances for pain relief, but gradually become addicted to narcotic substances to find more powerful drugs. Common pathological symptoms of these addicts include fatigue, emotional instability, anti-coma, and vomiting. When the electrical symptoms intensify, antisocial and anti-ethical behaviors occur, resulting in social problems. As a result, efforts to treat drug addicts are being carried out at the national level, but the majority of drug addicts are not completely treated. The reason for this is that the drug addiction mechanism is complicated, and various factors such as environment, genetics, race, medication behavior, and drug type are involved. In order to treat drug addiction, it is necessary to alleviate withdrawal symptoms and suppress re-administration. Withdrawal symptoms are not particularly effective drugs and can be used for symptomatic therapy.

In addition, the understanding of the physiological function of addiction is important in terms of treatment to mitigate re-dosing. There are many theories about the causes of addiction, but the most commonly accepted is an increase in craving. This is a major symptom of drug addiction, and it is the main target of treatment because it is a cause of easy re-dosing after years of medication.

Continued administration of drugs results in activation of the brain reward system (especially the dopamine nervous system), and withdrawal of the drug results in the suppression of the central nervous system dopamine nervous system due to the sudden absence of dopamine nervous system stimulants. Because of this duality, dopamine neurological agonists and antagonists have been used for the treatment of drug addiction, but dopamine receptor agonists alleviate narcolepsy and discomfort after medication, When exposed to time, place, and stress, the addicts have an increased desire to take the drug), so there is a risk of recurrence of drug administration, and the drug itself has a risk of poisoning. Dopamine receptor antagonists, on the other hand, reduce the response to conditional stimuli and the rewarding properties of the drug itself, but have side effects that are typical dopamine nervous system suppression symptoms such as feelings of discomfort, discomfort, Parkinson's disease, or dyskinesia. In order to overcome these shortcomings, efforts have been made to develop therapeutics, but there are no results.

As such, the dopaminergic agonist or antagonist developed in the prior art causes serious side effects, and according to the need for a therapeutic agent that can minimize the side effects even if the therapeutic effect is lowered, the extract extracted from natural products or a mixed composition thereof Research is also in progress. For example, Korean Patent Publication No. 1988-1296 discloses Gyeji, Ginger, Jujube, Peony, Shiho, Banja, Bokryeong, Golden, Ginseng, Rhubarb, Licorice, Gyotae, Mochi and Keel, and then hot water extraction and concentration. A method for preparing a composition that can alleviate poisoning such as tobacco and coffee, as well as manufactured addictive drugs, is disclosed. Korean Patent Publication No. 1990-2793 discloses rich, cinnamon, peppermint, gilcho root, licorice, pepper, Peony, sandalwood, white paper, Hyunho colors, Bokryeong, motherwort, Hyuncho and ginseng are mixed and then hot water extracted and concentrated to produce a drug-free detoxifying agent, and Korean Patent Publication No. 1992-3986 discloses sulfur, The mixture of rich powder, gallium powder and alum powder is heated to high temperature for a long time and then immersed and filtered in water to obtain a filtrate, which is dried to obtain a dry powder, and then licorice powder, ginseng powder and dragon Drug treatment for drug addiction prepared by mixing with and a method for manufacturing the same are disclosed, Korean Patent No. 54246 No. ethanol extract, powder of a mixture of Sanjago, Shando Geun, Daegeok, Sugija, Pangolin, Donkey, Cheongung, Chihwang and Count And a drug poisoning antidote prepared by mixing Sanjoin powder, and Korean Patent No. 313454 discloses Kang Ho-ri, Ginseng, Hyunho-color, Rich, Hemp, Cucumber, Cheon horse sprout, Astragalus, Honeysuckle, Guergi, White ginseng, Cinnamon and Disclosed are compositions for inhibiting withdrawal symptoms against drugs, alcohols and tobacco obtained from a mixture of mints and methods for their preparation. Extracts or mixed compositions thereof extracted from natural products thus developed are excellent in safety and do not show fatal side effects, but the effects of treating drug addiction are extremely low, and thus are not used for the treatment of substantial drug addiction. .

If there is no fatal side effect and a therapeutic agent that can treat the drug addiction at a certain level can be developed, it is expected that a biography can be provided in the treatment of the drug addiction. There is no situation.

Therefore, there is a constant need to develop a therapeutic agent that can safely and effectively treat the symptoms of drug addiction.

Accordingly, the present inventors have made a thorough research and efforts to develop a safe and effective treatment for drug addiction symptoms, and as a result, the extract and betaine of Scutellariae radix derived from natural products proved to be safe, morphine and nalbuphine The present invention has been confirmed to suppress the site-dependence, hypersensitivity of dopamine receptors and climbing behavior formed by co-administration of.

After all, the main object of the present invention is to provide a therapeutic agent that can treat the symptoms of drug addiction.

The drug addiction therapeutic agent of the present invention is a golden extract, betaine or a mixture thereof as an active ingredient, and includes a pharmaceutically acceptable carrier: wherein the golden extract is not particularly limited, but can be heated to Scutellariae radix It is preferable to use an extract powder obtained by extracting and drying the extract, and the mixture of golden extract and betaine is not particularly limited, but the extract powder and betaine obtained by hydrothermal extraction of golden ( Scutellariae radix ) and drying it are 4: 6. It is preferable to use a mixture mixed at a ratio of from 7: 3 (w / w).

When the narcotic analgesics are administered to a patient, the inventors have increased the resistance and dependence on the drugs, and consequently, the drug resistance and dependence on the drugs are used while the narcotic analgesics are used to prevent the phenomenon of drug abuse. To study how to prevent the increase, natural products were searched for substances that can effectively treat the symptoms of poisoning. As a result, it was confirmed that the extract of natural gold and betaine can suppress the site-dependence formed by the combination of morphine and nalbuphine, a type of narcotic analgesic, the hypersensitive form of dopamine receptor and the climbing behavior.

First, Scutellariae radix is a perennial herb belonging to the moss family of the moss family. Morphological features are fusiform, semi-tubular or flat, 5-20 cm long, 0.5-3 cm in diameter, yellowish brown on the outside, with vertical folds, and lateral spots. In the old roots, the neck is rotten, often hollow, dark brown, and the quality is hard but soft, and the cut side is yellow, fibrous, has a weak smell, and tastes bitter.

When used as a herbal medicine, greenish-yellowish yellow, dense quality and strong bitterness are recognized as upper grades. In Chinese medicine, it is mainly prescribed for diseases involving anti-inflammatory, fever, hari, abdominal pain, etc.

The main pharmacologically active ingredients in gold include wogonin, wogonin-glucuronide, baicalin, baicalein, oroxylin A, and skull. Capflavon I, II, chrysin and dihydrooroxylin A are known, and the extracts of gold are antipyretic, promote bile secretion, inhibit gastric juice secretion, and prevent atherosclerosis. It is effective in type I allergic diseases (atopic dermatitis, asthma, etc.), and has been reported to have anti-inflammatory, antiviral, antioxidant and anti-cancer effects, and in particular, has central nervous system effects such as sedative and anticonvulsive effects. Reported.

Meanwhile. Betaine is a compound in which three methyl groups are added to glycine, an amino acid, and is contained in a large amount in liver, eggs, fish, sugar beet, legumes, and wolfberry. Betaine has a physiological action as a methyl donor, and lowers the level of homocysteine in the plasma, thereby lowering blood lipid concentration, improving liver function, improving vascular disease, treating osteoporosis, relieving rheumatism, and alleviating Alzheimer's disease. Can be used. In addition, it is used to treat obesity because it has an effect of promoting fat metabolism.

The drug treatment agent of the present invention comprising the composition of the electro-gold extract and betaine can effectively suppress drug dependency formed by the administration of narcotic analgesics, and thus can be widely used for relieving side effects of safe and effective narcotic analgesics. There will be.

On the other hand, the composition of the golden extract and betaine contained as an active ingredient of the drug treatment of the present invention is a pharmaceutically acceptable binder (eg, polyvinylpyrrolidone, hydroxypropyl cellulose), disintegrant (eg, carboxymethyl cellulose calcium) , Sodium starch glycolate), diluents (e.g. corn starch, lactose, soybean oil, crystalline cellulose, mannitol), glidants (e.g. magnesium stearate, talc), sweeteners (e.g. white sugar, fructose, sorbitol, aspartame), stabilizers ( Sodium carboxymethylcellulose, alpha or beta cyclodextrin, citric acid, white lead), preservatives (e.g. methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoate) and flavors (e.g. ethyl vanillin, masking flavor, menthol flavono, herb) Fragrance) can be prepared into pharmaceutical preparations such as tablets, capsules, soft capsules, and liquids.

Acute Toxicity Test

Drug drug of the present invention was used as a raw material, the composition of the gold extract and betaine has been used as a conventional medicine and proven safety, and did not perform a separate acute toxicity test.

Effective amount

According to the age, sex, symptoms, administration method or purpose of prevention of the drug treatment of the present invention, it is preferable to administer 10 to 100 mg per kg body weight per day in the case of golden extract, kg in case of betaine It is preferable to administer 10 to 50 mg per day, and in the case of a composition in which golden extract and betaine are mixed at 4: 6 to 7: 3 (w / w), it is preferable to administer 1 to 10 mg per kg per day. . Dosage levels for patients with specific symptoms may vary by those skilled in the art depending on the patient's weight, age, sex, health condition, diet, time of administration, method of administration, rate of excretion, severity of disease, and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Example 1 Search for Natural Products That Can Suppress Climbing Behavior

Subcutaneous injection of apomorphine in mice is known to activate the dopamine nervous system, resulting in climbing behavior patterns (Saito et al., Jpn. J. Pharmacol., 27: 509-616, 1977). As such, we searched for natural products that could have an effect of suppressing the climbing behavior caused by apomorphine.

First, dopamine receptor apomorphine, a dopamine receptor agonist, was injected subcutaneously in an amount of 2 mg / kg, followed by physiological saline, 500 mg / kg gardenia extract, 500 mg / kg golden extract, and 500 mg / kg red ginseng powder (Korea Ginseng Corporation). , 500 mg / kg of betaine (Sigma Chem. Co., USA) or 500 mg / kg of Bergenin (berganin, Sigma Chem. Co., USA) was orally administered or intraperitoneally to 20 mice, respectively, Dopamine nervous system activation was measured by measuring the average frequency at which the mice exhibited three crawling behaviors per minute for 30 minutes at 10 minute intervals. In this case, as a control group, mice administered with saline instead of apomorphine were used (see FIG. 1).

On the other hand, the gardenia extract was obtained by adding about 10 times the weight of distilled water to the dry powder of gardenia and heat-extracting for 2 hours to obtain a filtrate, which was then concentrated under reduced pressure and lyophilized. About 10-fold weight of distilled water was added thereto, followed by heat extraction for 2 hours to obtain a filtrate, which was then concentrated under reduced pressure and lyophilized. In addition, the gardenia extract, golden extract, red ginseng powder, betaine and bernine were dissolved in physiological saline and orally administered or intraperitoneally to mice.

1 is a graph comparing the effect of natural products that can suppress the climbing behavior by administration of apomorphine. In Figure 1 Sal represents the frequency of the experimental group administered with saline, gar represents the frequency of the experimental group administered with gardenia extract, Scu represents the frequency of the experimental group administered with golden extract, RG is administered red ginseng powder Bet represents the frequency of one experimental group, Bet represents the frequency of the experimental group administered betaine, and Ber represents the frequency of the experimental group administered Bergenin. As shown in Figure 1, compared to the control group that did not administer apomorphine, the experimental group (Sal) administered apomorphine was found to increase the frequency of the climbing behavior sharply, in the case of administering the golden extract and betaine, It was found that the frequency of climbing behavior can be reduced more than natural products.

From the above results, since the climbing behavior caused by the administration of apomorphine is caused by the activation of the dopamine nervous system, it was predicted that the electrogold extract and the betaine exhibited the action of inhibiting the activation of the dopamine nervous system.

Example 2 Effect of Golden Extract and Betaine on Spontaneous Momentum by Narcotic Analgesics

From the results of Example 1, it can be seen that the golden extract and betaine can inhibit the activation of the dopamine nervous system, the effect of the golden extract and betaine on the spontaneous momentum by the administration of narcotic morphine or nalbuphine Confirmed.

Example 2-1 : Effect of Golden Extract and Betaine on Spontaneous Momentum by Morphine

First, an experimental group was intraperitoneally injected with 5 mg / kg morphine in rats under the same conditions as the control group in which rats were intraperitoneally injected with rats at 6-day intervals for 6 days.

Then, rats of the electric control group were intraperitoneally injected with physiological saline every two days for 6 days, and the rats of the electric experimental group were classified into three groups of experimental group 1, experimental group 2 and experimental group 3. At this time, the experimental group 1 was intraperitoneally injected with 5 mg / kg of morphine every two days for 6 days to the rats of the electrical experimental group again, Experimental group 2 was 500 mg / kg of gold every other day for 6 days to the rats of the electrical experimental group again 30 minutes after oral administration of the extract, 5 mg / kg of morphine was intraperitoneally injected, and Experimental group 3 was intraperitoneally injected with 500 mg / kg of betaine at 2 days intervals for 6 days in rats of the previous experimental group. Next, 5 mg / kg morphine was intraperitoneally injected. As in the first 6 days, physiological saline was orally administered to the control group and each experimental group the day after physiological saline or morphine was administered.

Finally, the day after oral administration of saline, the control group and each experimental group were subcutaneously injected with dopamine receptor agonist apomorphine in an amount of 0.5 mg / kg, followed by conventional methods known in the art (Protais P. et al., Psychopharmacology, 50: 1-6, 1976), measured the distance (cm) the rats traveled for 30 minutes in each control and experimental group and considered it as spontaneous momentum (see FIG. 2A). Figure 2a is a graph showing the effect of the golden extract and betaine on the spontaneous momentum by morphine, lane 1 is the control group, lane 2 is experimental group 1, lane 3 is experimental group 2 and lane 4 experimental group 3 Indicates. As shown in Figure 2a, when the morphine was administered (experimental group 1) compared to the physiological saline administration (control), the distance traveled significantly increased, but when administered with morphine and gold extract (experimental group 2) When the morphine was administered (experimental group 1), the distance traveled was reduced by about 50%.

From this, it was confirmed that the golden extract can reduce the increased spontaneous motility by administration of morphine.

Example 2-2 : Effect of Golden Extract and Betaine on Spontaneous Momentum by Nalbuphine

The effect of golden extract and betaine on the spontaneous momentum by nalbuphine was measured in the same manner as in Example 2-1, except that 0.01 mg / kg nalbuphine was used instead of 5 mg / kg morphine. (See FIG. 2B). Figure 2b is a graph showing the effect of golden extract and betaine on the spontaneous momentum by nalbuphine, lane 1 is a control group, lane 2 is experimental group 1, lane 3 is experimental group 2 and lane 4 is experimental group 3, respectively. . As shown in Figure 2b, when the nalbuphine was administered (experimental group 1) compared to the physiological saline administration (control), the distance moved significantly increased, but when the nalbuphine and the golden extract was administered together (experimental group 2) and When nalbuphine and betaine were administered together (experimental group 3), it was found that the distance traveled was significantly reduced than when nalbuphine was administered (experimental group 1).

From this, it was confirmed that the golden extract and betaine can reduce the increased spontaneous motility by the administration of nalbuphine.

Example 3 Effect of Golden Extract and Betaine on Site Dependence Formed by Narcotic Analgesics

From the results of Example 1, it can be seen that the golden extract and betaine can suppress the climbing behavior caused by the administration of apomorphine, the site-dependent formation by the administration of the drug morphine or morphine nalbuphine The effect of gold extract and betaine on

Example 3-1 : Effect of Golden Extract and Betaine on Place Dependence Formed by Morphine

First, the rats were placed in the white and black rooms for 15 minutes each for 1 day, and then adapted to each site, and then the time for which the rats spontaneously stayed in the white and black rooms for 1 day was measured. Subsequently, the experimental group intraperitoneally injected with 5 mg / kg morphine in the rats was left in the white room for 1 hour under the same conditions as the control group in which rats were intraperitoneally injected with rats at 6-day intervals for 6 days. On the day after the administration of physiological saline or morphine, physiological saline was orally administered to the control and experimental groups, and left in the black room for 1 hour.

Then, rats of the electric control group were intraperitoneally injected with physiological saline every two days for 6 days, and the rats of the electric experimental group were classified into three groups of experimental group 1, experimental group 2 and experimental group 3. At this time, the experimental group 1 was intraperitoneally injected with 5 mg / kg of morphine every two days for 6 days to the rats of the electrical experimental group again, Experimental group 2 was 500 mg / kg of gold every other day for 6 days to the rats of the electrical experimental group again 30 minutes after oral administration of the extract, 5 mg / kg of morphine was intraperitoneally injected, and Experimental group 3 was intraperitoneally injected with 500 mg / kg of betaine at 2 days intervals for 6 days in rats of the previous experimental group. Next, 5 mg / kg morphine was intraperitoneally injected. As in the first 6 days, the control group and each experimental group were left in the white room for 1 hour, and the day after administration of physiological saline or morphine, oral administration of physiological saline to the control group and each experimental group and black for 1 hour. It was left in the room.

Finally, the day after oral administration of physiological saline, the rats of the control group and the experimental group were placed on the boundary between the white and black rooms, and the spontaneous dwelling time in the white and black rooms was measured for 15 minutes, and the staying time in the black room was measured. Time was subtracted from time and the effect of the gold extract and betaine on the site dependence formed by morphine was analyzed using the previously calculated values (see FIG. 3A). Figure 3a is a graph showing the effect of the golden extract and betaine on the site-dependence formed by the administration of morphine, lane 1 is the control group, lane 2 is experimental group 1, lane 3 is experimental group 2 and lane 4 is experimental group 3 Respectively. As shown in Figure 3a, when the morphine was administered (experimental group 1) compared to the physiological saline administration (control group), the residence time in the white room was significantly increased, but when the morphine and the golden extract was administered together (experimental group 2) ) And when morphine and betaine were administered together (experimental group 3), the residence time in the white room was significantly reduced than when morphine alone was administered (experimental group 1).

From this, it was confirmed that the golden extract and betaine can reduce the location dependence caused by the administration of morphine.

Example 3-2 Effect of Golden Extracts and Betaine on Place Dependence Formed by Nalbuphine

Analyzing the effect of golden extract and betaine on the site dependence formed by nalbuphine using the same method as Example 3-1, except that 0.01 mg / kg nalbuphine was used instead of 5 mg / kg morphine. (See FIG. 3B). Figure 3b is a graph showing the effect of the golden extract and betaine on the site-dependence formed by the administration of nalbuphine, lane 1 is the control group, lane 2 is experimental group 1, lane 3 is experimental group 2 and lane 4 is experimental group 3 Respectively. As shown in Figure 3b, when nalbuphine was administered (experimental group 1) compared to the physiological saline administration (control group), the time spent in the white room was significantly increased, but when nalbuphine and golden extract were administered together (experimental group 2) ) And when nalbuphine and betaine were administered together (experimental group 3), the residence time in the white room was significantly reduced than when nalbuphine alone was administered (experimental group 1), especially when nalbuphine and golden extract were administered together (experimental group 3). Most of the site dependence formed by the administration of nalbuphine (control) disappeared.

From this, it was confirmed that the golden extract and betaine can reduce the location dependence caused by the administration of nalbuphine.

Example 4 Effect of a Mixture of Golden Extracts and Betaine on Site Dependence Formed by Narcotic Analgesics

From the results of the above Examples 2 and 3, it was confirmed that the golden extract and betaine can suppress the site dependency formed by the narcotic analgesic. It was confirmed whether the locational dependence formed by the administration of nalbuphine can be more effectively suppressed.

Example 4-1 Effect of a Mixture of Golden Extract and Betaine on Site Dependence Formed by Morphine

First, the rats were placed in the white and black rooms for 15 minutes each for 1 day, and then adapted to each site, and then the time for which the rats spontaneously stayed in the white and black rooms for 1 day was measured. Subsequently, 5 mg / kg of morphine was intraperitoneally injected into rats at 6-day intervals for 6 days, and left in a white room for 1 hour. The day after morphine administration, physiological saline was intraperitoneally injected and left in a black room for 1 hour.

Afterwards, the saline solution, the golden extract and the betaine were added at 0:10, 1: 9, 2: 8, 3: 7, 4: 6, 5: 5, 6: 4, 7: 3, Each mixture of 8: 2, 9: 1 and 10: 1 (w / w) was intraperitoneally administered in an amount of 500 mg / kg, and after 30 minutes, rats were injected with 5 mg / kg of morphine. It was left in a white room for 1 hour. On the day after the administration of the morphine, the rats were intraperitoneally injected with saline, and left in the black room for 1 hour. Finally, the day after physiological saline was administered, rats of each experimental group were measured spontaneously dwelling in the white and dark rooms, and compared with the time measured before administration of morphine, it was confirmed that the pattern of place-dependent formation was changed ( See Table 1a).

Morphine-induced Changes in Place Dependence According to the Mixture Ratio of Golden Extract and Betaine Mixing ratio of golden extract and betaine (w / w) Place dependence 0:10 1: 9 2: 8 3: 7 4: 6 5: 5 6: 4 7: 3 8: 2 9: 1 10: 0 124 118 106 99 58 44 35 31 57 84 103

As shown in Table 1a, in the mixture of the golden extract and betaine, when the content of the golden extract is more than 40% (w / w), the location dependence is drastically reduced, the content of the golden extract is 80% (w / w) In the above case, the location dependence increased.

Therefore, it was confirmed that morphine-induced site dependency could be effectively reduced by administering a mixture of golden extract and betaine at 4: 6 to 8: 2 (w / w).

Example 4-2 Effect of Mixtures of Golden Extract and Betaine on Place Dependence Formed by Nalbuphine

Effect of a mixture of golden extract and betaine on the site dependence formed by nalbuphine using the same method as Example 2-1, except that 0.01 mg / kg nalbuphine was used instead of 5 mg / kg morphine. Was measured (see Table 1b).

Changes in place dependence induced by nalbuphine according to the mixing ratio of golden extract and betaine in seconds Mixing ratio of golden extract and betaine (w / w) Place dependence 0:10 1: 9 2: 8 3: 7 4: 6 5: 5 6: 4 7: 3 8: 2 9: 1 10: 0 76 71 66 64 33 18 10 13 18 21 23

As shown in Table 1b, in the mixture of the golden extract and betaine, when the content of the golden extract is more than 30% (w / w), the place dependency is drastically reduced, the content of the golden extract is 70% (w / w) In the above case, the location dependence increased.

Therefore, it was confirmed that nalbuphine induced site dependency can be effectively reduced by administering a mixture of golden extract and betaine at 3: 7 to 7: 3 (w / w).

Therefore, according to the results of the above Examples 4-1 to 4-2, the site-dependence caused by the administration of narcotic analgesics such as morphine and nalbuphine was 4: 6 to 7: 3 (w / It can be seen that by administering the mixture mixed in w), it can be effectively reduced.

As described and demonstrated in detail above, the present invention provides a drug for treating drug addiction comprising a golden extract, betaine or a mixture thereof as an active ingredient, and a pharmaceutically acceptable carrier. Since the drug treatment agent of the present invention can effectively suppress the drug dependency formed by the administration of the narcotic analgesic, it may be widely used to solve the side effects of the safe and effective narcotic analgesic.

Claims (4)

Golden extract, betaine or a mixture thereof as an active ingredient, comprising a pharmaceutically acceptable carrier, drug addiction therapeutic agent. The method of claim 1, Golden extract is characterized in that the extract powder obtained by hydrothermal extraction of gold ( Scutellariae radix ) and drying it Drug addiction treatment. The method of claim 1, The mixture of golden extract and betaine is characterized by mixing the extract powder and betaine obtained by hydrothermal extraction of gold ( Scutellariae radix ) and drying it in a ratio of 4: 6 to 7: 3 (w / w) Drug addiction treatment. A therapeutic drug for drug addiction, comprising an extract powder obtained by hydrothermal extraction of Scutellariae radix and drying it and a composition containing betaine at 6: 4 (w / w) as an active ingredient and a pharmaceutically acceptable carrier. .

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