CN106692660A - Preparation method of Xuanmai Ganjie granules - Google Patents
Preparation method of Xuanmai Ganjie granules Download PDFInfo
- Publication number
- CN106692660A CN106692660A CN201611220284.0A CN201611220284A CN106692660A CN 106692660 A CN106692660 A CN 106692660A CN 201611220284 A CN201611220284 A CN 201611220284A CN 106692660 A CN106692660 A CN 106692660A
- Authority
- CN
- China
- Prior art keywords
- preparation
- hours
- content
- xuanmai
- harpagoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a preparation method of Xuanmai Ganjie granules. The method comprises the following steps: decocting and concentrating radix scrophulariae, radix ophiopogonis, liquorice and platycodon grandiflorus; and performing refluxing treatment on the concentrate for 2.5-3.5 hours while keeping the refluxing temperature at 55-65 DEG C to finally obtain granules. In the finished product of Xuanmai Ganjie granules prepared in the invention, the contents of active ingredients, namely harpagoside and glycyrrhizic acid, are remarkably increased, and the treatment effect of the medicine is correspondingly enhanced, which is a great beneficial technical progress; and on the premise of neither increasing production equipment nor changing production flow, low cost and high yield are realized, and tremendous economic and social benefits are created by the most economical way.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine preparation, more particularly to a kind of preparation method of Xuanmai Ganju grains.
Background technology
Xuanmai Ganju grains are made up of radix scrophulariae, the tuber of dwarf lilyturf, Radix Glycyrrhizae and balloonflower root four traditional Chinese medicine material, with heat-clearing enriching yin, eliminating the phlegm profit
Effect of pharynx, for fire excess from yin deficiency, asthenic fire floating upward, mouth and nose are dried, abscess of throat.
Radix scrophulariae is main ingredient in we, and radix scrophulariae is conventional Chinese medicine, is one of representative Chinese medicine of clearing heat and cooling blood, Ming Dynasty Li Zhongzi institute
Write《Explaining abstruseness of the canon of materia medica》In, the black bitter cold of its color of radix scrophulariae, kidney channel medicine, the fire of clear kidney man, solution spot oozes, sharp bright larynx, diuresis, bright eye
Mesh, dissipates knurl carbuncle, and the mad heresy hair of reason typhoid fever is thirsty, intracardiac frightened tired, for diseases such as consumption of YIN caused by febrile disease, Tianjin hinder constipation, hot eyes, pharyngalgia.Ha Bae
Glycosides and cinnamic acid are content characteristic chemical constituent higher in radix scrophulariae, document report its there is anti-chronic inflammation, step-down, analgesia, solution
Convulsion, anti-hepatitis virus, cholagogic, increasing leucocyte and immunologic enhancement, modern pharmacological research show that radix scrophulariae, the tuber of dwarf lilyturf are respectively provided with suppression
Bacterium acts on, and has obvious inhibiting effect to Diplococcus pneumopniae, hemolytic streptococcus, Bacillus influenzae etc..Radix Glycyrrhizae has invigorates the spleen and benefits qi, clearly
Thermal detoxification, expelling phlegm and arresting coughing, relieving spasm to stop pain, the work(of coordinating the drug actions of a prescription, principle active component are glycyrrhizic acid and liquiritin, and Radix Glycyrrhizae has anti-
Scorching, anti-allergic effects.Balloonflower root can promote respiratory mucosa to secrete, and play dispelling phlegm and relieving sore-throat.Our all medicines share, to respiratory tract disease
Disease has preferable therapeutic action.
Isolated chemical composition has various from radix scrophulariae, mainly containing iridoid glycosides, Phenylpropanoid Glycosides glycoside, still contains
Phytosterol, organic acid, flavonoids, triterpenoid saponin, volatile oil, carbohydrate, alkaloid and micro monoterpene and Diterpene etc.,
And iridoid glycosides and Phenylpropanoid Glycosides glycosides compound are considered as the active ingredient of radix scrophulariae, the pharmacological activity and work of these compositions
With the main pharmacological that also determine radix scrophulariae.
Iridoid glycosides compound in radix scrophulariae, mainly there is harpagoside（Harpagoside), harpagide
(harpagide), peach leaf coral tide glycosides（Aucubin), geniposide（Geniposide), 6- ο-α -- D- galactosyls breathe out bar ester
Glycosides（6- ο-α -- D-glc-harpagoside), 6- ο-methycatalpol（6- ο-methyl catalpol), 8- ο-asafoetide acyl group
Harpagide（8- ο-feruloy hapagide), Catalpol（Catalpol), different radix scrophulariae aglycon（) and 1- removes hydroxyl ningpopgenin
Base -3,4- dihydro peach jaurel aglycons（1-dehydroxy-3,4-dihydroaucubigenin）Deng, and 6- ο-α -- D- galas
Glycosyl harpagoside, 8- ο-asafoetide acyl group harpagide under the appropriate temperature conditions, can partial hydrolysis generation harpagosides.
The influence of iridoid glycosides and the easy light of Phenylpropanoid Glycosides glycoside, heat, oxygen and enzyme in radix scrophulariae, easily oxidation and water
Solution, generates cinnamic acid or other compositions.
Radix Glycyrrhizae is pulse family herbaceos perennial（Glycyrrhiza uralensis Fisch）, main product is in Inner Mongol, sweet
The ground such as respectful, Shanxi, Xinjiang, Radix Glycyrrhizae is clinically extremely to commonly use traditional tonic medicine simply, its medicinal part be root, rhizome, mainly into
It is glycyrrhizic acid to divide（Also known as glycyrrhizin）And enoxolone, the general content of glycyrrhizic acid is 5~11%, and Determination of glycyrrhetic acid 3 ~ 7% grinds
How much the content for studying carefully discovery glycyrrhizic acid is the important parameter for determining licorice medicinal materials quality quality.
Glycyrrhizic acid has anti-inflammatory, antiallergy, removing toxic substances, antipyretic, liver protection, antibechic, antineoplastic action.Antivirus action：Most
Recent studies on finds that glycyrrhizic acid has good curative effect in terms for the treatment of hepatitis B and AIDS.It can be polymerized with the DNA of virus
Enzyme is combined, and stops the growth of viral DNA chain, so as to prevent the duplication of virus, but the archaeal dna polymerase of people is not influenceed then.
In terms of AIDS is treated, its effect and toxic and side effect are substantially better than nitrine deoxidation chest former times (Zidovudine) and double deoxidation chest former times
There is (Videx), Radix Glycyrrhizae pharmacological research display glycyrrhizic acid nospecific immunity to adjust, and it can the immune work of reinforcement inner cell
With, and can also optionally strengthen the multiplication capacity and activity of helper lymphocyte T, therefore be immunized with regulation enhancing patient
The effect of power.
Pharmaceutical research shows that glycyrrhizic acid is a kind of compound with various curative effects, has broad application prospects, because
This how to effectively utilize will be exhausted Licorice it is particularly important.
Above-mentioned data shows that radix scrophulariae has strengthens immune, antitumor, hypotensive, anti-oxidant, liver protection, antigout, patron saint
Through all many effects such as system and raising memory；And the active principle of Radix Glycyrrhizae have anti-inflammatory, antiallergy, removing toxic substances, it is antipyretic,
Various medicinal effects such as liver protection, antibechic, antitumor, so active principle harpagoside and glycyrrhizic acid are improved, in this medicine
Content has positive role and good beneficial help.
The customary preparation methods of Xuanmai Ganju grains are that radix scrophulariae, the tuber of dwarf lilyturf, Radix Glycyrrhizae, balloonflower root four traditional Chinese medicine material are added water to cook three times,
Liquid is concentrated into the medicinal extract of 1.32~1.35g/ml of relative density after standing 12 hours（Or dry cream is dried to, it is ground into fine powder）,
Again with cane sugar powder, dextrin（Or other auxiliary materials）Mixing pelleting, mixing, particle is obtained granule, glue through filling, compressing tablet, packaging
Wafer or tablets and other formulations.After testing, the medicinal extract for being concentrated out with this kind of Conventional concentration method, harpagoside content 0.18~
0.25 mg/g, 3.87~6.45mg/g of glycyrrhizic acid content, the granule harpagoside content produced with this kind of medicinal extract are 0.28
~0.40mg/10g particles, the mg/10g particles of glycyrrhizic acid content 6~10, it has been investigated that, in conventional vacuum concentration process,
Be concentrated thing temperature and be up to 75~85 DEG C, and harpagoside is easily aoxidized and hydrolyzed at this temperature, generation cinnamic acid or its
His composition, and glycyrrhizic acid can also be partially converted into other compositions, so effective in kind the method medicinal extract and granule produced
Composition harpagoside, glycyrrhizic acid content it is relatively low, accordingly, cause the reduction of active principle content in finished medicines, accordingly
Reduce the therapeutic effect of the medicine.
The content of the invention
The purpose of the present invention, is to provide a kind of preparation method of Xuanmai Ganju grains, with solve in customary preparation methods because
Be concentrated thing temperature and be up to 75~85 DEG C, and harpagoside is easily aoxidized at this temperature and is hydrolyzed, generation cinnamic acid or
Other compositions, and glycyrrhizic acid can also be partially converted into other compositions, therefore cause the reduction of active principle content in finished medicines, accordingly
The therapeutic effect for reducing the medicine defect.
For achieving the above object, the invention provides following scheme：
A kind of preparation method of Xuanmai Ganju grains：
Prescription：Radix scrophulariae 80g, tuber of dwarf lilyturf 80g, Radix Glycyrrhizae 80g, balloonflower root 80g；
Preparation method：The taste of the above four, adds water to cook three times, 1.5 hours for the first time, second, three each 1 hour, collecting decoctions, filter
Cross, filtrate stands 12 hours, takes supernatant concentration to the g/ml of relative density 1.32（70~80 DEG C of measure）When, maintain the temperature at
55~65 DEG C, flow back 2.5~3.5 hours, then collect medicinal extract, take thick paste, add appropriate auxiliary material（Sucrose, dextrin）, it is made
Grain, obtains final product.
Wherein, preferably 60 DEG C of keeping temperature after supernatant concentration.
Wherein, return time preferably 3 hours.
Fig. 1 is shown harpagoside with the different content curve map of reflux temperature, when the time that maintains the reflux for is constant, with
The rising of reflux temperature, harpagoside content increases in liquid, and when uniform temperature value is reached, content reaches maximum, if
Heating content is further continued for decline on the contrary, therefore it is reflux temperature to choose 55~65 DEG C.
Fig. 2 shows, when maintaining the reflux for temperature-resistant, with the increase of return time, harpagoside content increases in liquid
Plus, when in the range of certain hour, content reaches maximum, and return time extends again, and content can be reduced, therefore chooses 2.5
It is within~3.5 hours return time.
Fig. 3 shows, in the temperature controlling range of 55~65 DEG C of setting, glycyrrhizic acid content increases in liquid, when reaching one
During constant temperature angle value, content reaches maximum, if be further continued for heating content decline on the contrary, therefore it is backflow temperature to choose 55~65 DEG C
Degree.
Beneficial effect：
1st, the medicinal extract produced using the customary preparation methods of Xuanmai Ganju grains, wherein, harpagoside content is 0.18~0.25
Mg/g, 3.87~6.45mg/g of glycyrrhizic acid content, the granule harpagoside content produced with this kind of medicinal extract for 0.28~
0.40mg/10g, the mg/10g of glycyrrhizic acid content 6~10, and the preparation method of present invention offer is provided, the harpagoside in medicinal extract
Content breathes out bar in 0.23~0.33mg/g, 5.81~10.32mg/g of glycyrrhizic acid content, the granule produced with this kind of medicinal extract
Russia's glycosides content is 0.36~0.52mg/10g, 9~16mg/10g of glycyrrhizic acid content, the active ingredient harpagoside content in finished product
Increased significantly with glycyrrhizic acid content.
2nd, the present invention is heated to reflux by by concentrated extract in 55~65 DEG C, and 6- ο-α-D- galactosyls can be promoted to breathe out bar
The compositions such as ester glycosides, 8- ο-asafoetide acyl group harpagide further hydrolyze the active ingredient harpagoside of cost pharmaco, can also promote
Other compositions in Radix Glycyrrhizae are converted into glycyrrhizic acid, so as to promote the content of active ingredient in medicinal extract increase.
3rd, invention increases the reflow treatment in concentration process, i.e. supernatant concentration to relative density 1.32g/ml（70
~80 DEG C of measure）Shi Huiliu 2.5~3.5 hours, the process of this backflow further promotes the accumulation of harpagoside composition, while returning
Also the conversion of glycyrrhizic acid is further promoted during stream, the concentration and content of glycyrrhizic acid is increased, this is flowed back by increasing
Link, improves the effective rate of transform of active principle and content, is conducive to formulation products steady quality and strengthens curative effect of medication.
4th, in the preparation method of the Xuanmai Ganju grains that the present invention is provided, the side of backflow temperature control is increased by concentrated medicament
Method, its extraction efficiency makes extraction medicinal extract harpagoside content, glycyrrhizic acid effectively be lifted, effectively far above former directly method for concentration
Increasing for content of material, enhances the therapeutic effect of medicine accordingly, is that a big beneficial technology is entered, and is set production is not increased
It is standby, on the premise of not changing production procedure, inexpensive high production is reached, huge economic society is produced in the way of most saving
Benefit and social benefit.
Brief description of the drawings
Fig. 1 shows harpagoside with the different content curve map of reflux temperature
Fig. 2 shows harpagoside with the different content curve map of return time
Fig. 3 shows glycyrrhizic acid with the different content curve map of temperature.
Specific embodiment
Embodiment 1
【Prescription】Radix scrophulariae 80g tuber of dwarf lilyturf 80g Radix Glycyrrhizae 80g balloonflower roots 80g
【Preparation method】The taste of the above four, 8 times of dosing material amount, 5 times, 3 times of water, decoct three times respectively, 1.5 hours for the first time, second, the
Three times each 1 hour, merges three decocting liquids, and filtration, filtrate stands 12 hours, takes supernatant concentration to the g/ml of relative density 1.32
（70~80 DEG C of measure）When, maintain the temperature at 55 DEG C, flow back 2.5 hours, then collect medicinal extract, added in medicinal extract appropriate sucrose and
Dextrin, is made particle, obtains final product.
After testing, the harpagoside content in medicinal extract is in 0.32mg/g, and glycyrrhizic acid content 9.61mg/g, finished particle is Sino-Kazakhstan
Bar Russia glycosides content is 0.50mg/10g, glycyrrhizic acid content 14.9mg/10g.
Embodiment 2
【Prescription】Radix scrophulariae 80g tuber of dwarf lilyturf 80g Radix Glycyrrhizae 80g balloonflower roots 80g
【Preparation method】The taste of the above four, 8 times of dosing material amount, 5 times, 3 times of water, decoct three times respectively, 1.5 hours for the first time, second, the
Three times each 1 hour, merges three decocting liquids, and filtration, filtrate stands 12 hours, takes supernatant concentration to the g/ml of relative density 1.32
（70~80 DEG C of measure）When, maintain the temperature at 65 DEG C, flow back 3.5 hours, then collect medicinal extract, added in medicinal extract appropriate sucrose and
Dextrin, is made particle, obtains final product.
After testing, the harpagoside content in medicinal extract is in 0.33mg/g, glycyrrhizic acid content 10.21mg/g, in finished particle
Harpagoside content is 0.52mg/10g, glycyrrhizic acid content 15.8mg/10g.
Embodiment 3
【Prescription】Radix scrophulariae 80g tuber of dwarf lilyturf 80g Radix Glycyrrhizae 80g balloonflower roots 80g
【Preparation method】The taste of the above four, 8 times of dosing material amount, 5 times, 3 times of water, decoct three times respectively, 1.5 hours for the first time, second, the
Three times each 1 hour, merges three decocting liquids, and filtration, filtrate stands 12 hours, takes supernatant concentration to the g/ml of relative density 1.32
（70~80 DEG C of measure）When, 60 DEG C are maintained the temperature at, flow back 3 hours, then medicinal extract is collected, appropriate sucrose and paste is added in medicinal extract
Essence, is made particle, obtains final product.
After testing, the harpagoside content in medicinal extract is in 0.32mg/g, and glycyrrhizic acid content 9.10mg/g, finished particle is Sino-Kazakhstan
Bar Russia glycosides content is 0.50mg/10g, glycyrrhizic acid content 14.1mg/10g.
Claims (4)
1. a kind of preparation method of Xuanmai Ganju grains, it is characterised in that comprise the following steps：
Radix scrophulariae, the tuber of dwarf lilyturf, Radix Glycyrrhizae, balloonflower root four traditional Chinese medicine material are taken, is added water to cook three times, 1.5 hours for the first time, second, third time each 1
Hour, merging the decocting liquid of three times, filtration, filtrate stands 12 hours, when to take supernatant concentration to relative density be 1.32 g/ml,
Concentrate temperature is maintained at 55~65 DEG C, reflow treatment 2.5~3.5 hours, then collects medicinal extract, and being added in medicinal extract can pharmaceutically connect
The auxiliary material received, is made particle, obtains final product.
2. the preparation method of Xuanmai Ganju grains as claimed in claim 1, it is characterised in that：The radix scrophulariae is 80g, the tuber of dwarf lilyturf
For 80g, Radix Glycyrrhizae be 80g, balloonflower root be 80g.
3. the preparation method of Xuanmai Ganju grains as claimed in claim 1, it is characterised in that：The concentrate temperature is maintained at
60℃。
4. the preparation method of Xuanmai Ganju grains as claimed in claim 1, it is characterised in that：The reflow treatment is 3 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611220284.0A CN106692660A (en) | 2016-12-26 | 2016-12-26 | Preparation method of Xuanmai Ganjie granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611220284.0A CN106692660A (en) | 2016-12-26 | 2016-12-26 | Preparation method of Xuanmai Ganjie granules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692660A true CN106692660A (en) | 2017-05-24 |
Family
ID=58903359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611220284.0A Pending CN106692660A (en) | 2016-12-26 | 2016-12-26 | Preparation method of Xuanmai Ganjie granules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106692660A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403923A (en) * | 2017-12-25 | 2018-08-17 | 宁夏多维药业有限公司 | A kind of preparation method of Xuanmai Ganju grains medicinal extract |
| CN111956734A (en) * | 2020-07-23 | 2020-11-20 | 贵州科辉制药有限责任公司 | Optimized extraction method of yankang buccal tablets |
| CN112972589A (en) * | 2021-02-20 | 2021-06-18 | 江苏省中医院 | Application of sore-throat relieving plant medicine composition and preparation method thereof |
| CN114848749A (en) * | 2022-06-09 | 2022-08-05 | 四川旭阳药业有限责任公司 | Preparation method of Xuanmai Ganju granules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596409A (en) * | 2016-01-16 | 2016-05-25 | 四川美大康药业股份有限公司 | Medicament for dental ulcer and preparation method thereof |
-
2016
- 2016-12-26 CN CN201611220284.0A patent/CN106692660A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596409A (en) * | 2016-01-16 | 2016-05-25 | 四川美大康药业股份有限公司 | Medicament for dental ulcer and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典：2015年版 一部》", 30 June 2015, 中国医药科技出版社 * |
| 窦增花等: "3种干燥方法对玄参中哈巴俄苷和肉桂酸含量的影响", 《中药材》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403923A (en) * | 2017-12-25 | 2018-08-17 | 宁夏多维药业有限公司 | A kind of preparation method of Xuanmai Ganju grains medicinal extract |
| CN111956734A (en) * | 2020-07-23 | 2020-11-20 | 贵州科辉制药有限责任公司 | Optimized extraction method of yankang buccal tablets |
| CN112972589A (en) * | 2021-02-20 | 2021-06-18 | 江苏省中医院 | Application of sore-throat relieving plant medicine composition and preparation method thereof |
| CN114848749A (en) * | 2022-06-09 | 2022-08-05 | 四川旭阳药业有限责任公司 | Preparation method of Xuanmai Ganju granules |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103690783B (en) | Chinese medicine preparation being used for the treatment of diabetes and preparation method thereof | |
| CN106692660A (en) | Preparation method of Xuanmai Ganjie granules | |
| CN104352887A (en) | Anti-tumor comprehensive conditioning cream and preparing technology thereof | |
| CN105796883A (en) | Haze-based lung-moistening and sore throat-relieving botanical functional beverage | |
| CN101011562A (en) | Novel formulation of shenqiwendan decoction and production method thereof | |
| CN116941700A (en) | Throat-clearing and throat-moistening candy rich in vitamin C and preparation method thereof | |
| CN104474472A (en) | Broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose and production method of buccal tablet | |
| CN1320917C (en) | Dripping pills of 'Xiao Chaihu' | |
| CN101045153A (en) | Traditional Chinese medicine for treating cold | |
| CN103623120B (en) | A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof | |
| CN102784215B (en) | Snow pear cough-relieving syrup and preparation method | |
| CN1739755A (en) | Intensified loquet distillate and its prepn | |
| CN106310068A (en) | Traditional Chinese medicine compound for relieving cough and moistening lung for children and preparation method thereof | |
| CN101491645A (en) | Medicine preparation for treating diabetes and complicating disease thereof and preparation method thereof | |
| CN106138494B (en) | Kidney nourishing composition and production method thereof | |
| CN102805766B (en) | Chinese medicinal composition and preparation method thereof | |
| CN107823384A (en) | A kind of reducing blood lipid hypoglycemic traditional Chinese medicine composition and preparation method thereof | |
| CN107596107B (en) | Heat-clearing, sore-throat-relieving and anti-allergic traditional Chinese medicine preparation and preparation method thereof | |
| CN101129489A (en) | Compound kidney reinforcing patch | |
| CN103120715B (en) | Traditional Chinese medicine composition for preparing medicament for prevention and treatment of focal glomeruloscerosis | |
| CN104306663A (en) | Traditional Chinese medicine composition for subsidiarily treating diabetes | |
| CN104435651A (en) | Traditional Chinese medicine for protecting eyes and relieving visual fatigue | |
| CN109550008A (en) | A kind of application of pharmaceutical composition in preparation treatment tonsillitis and sphagitis drug | |
| CN103623203A (en) | Method for preparing cough-suppressing oral preparation | |
| CN108186747A (en) | A kind of preparation method for the Chinese medicinal composition granules for treating lower urinary tract infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170524 |