CN106692463A - Tongqi powder for nasal obstruction and manufacturing method thereof - Google Patents

Tongqi powder for nasal obstruction and manufacturing method thereof Download PDF

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Publication number
CN106692463A
CN106692463A CN201710138562.6A CN201710138562A CN106692463A CN 106692463 A CN106692463 A CN 106692463A CN 201710138562 A CN201710138562 A CN 201710138562A CN 106692463 A CN106692463 A CN 106692463A
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parts
medicament
ight
farina
daily
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孟庆军
杨旭东
许小丽
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a tongqi powder for nasal obstruction and a manufacturing method thereof. The tongqi powder for nasal obstruction is prepared from the following raw materials in parts by weight: for daytime use, 15-27 parts of honeysuckle flower, 15-27 parts of Bighead Atractylodes Rhizome, 11-17 parts of dried orange peel, 5-9 parts of licorice root, 20-31 parts of potato starch, 5-7 parts of mint and 5-7 parts of borneol; and for night use, 15-27 parts of honeysuckle flower, 15-27 parts of Bighead Atractylodes Rhizome, 11-17 parts of dried orange peel, 5-9 parts of licorice root, 5-7 parts of pearl powder, 6-9 parts of albizia bark and 10-14 parts of wild jujube kernel. The tongqi powder for nasal obstruction realizes physical and pharmaceutical dual treatment means, and has the advantages of quick action and favorable effect.

Description

One kind nasal obstruction ventilates scattered and preparation method thereof
Technical field
The present invention relates to nasal obstruction treatment medicinal material and preparation method thereof that rhinitis triggers, specifically a kind of nasal obstruction ventilation dissipate and Its preparation method.
Background technology
Nasal obstruction is one of common symptom of hals,Nasen und Ohrenheilkunde, shows as breathing obstructed, and nasal cavity has foreign matters from being blocked sense;Nose Hole, nasal cavity are narrow, therefore slightly secretion or mucous membrane swelling just easily block.Most common reason of having a stuffy nose includes rhinitis, in nose Every partially bent, nasal polyp, nasosinusitis etc..
The content of the invention
The technical problems to be solved by the invention are to provide a kind of nasal obstruction and ventilate scattered and preparation method thereof.
In order to solve the above technical problems, the technical scheme is that:One kind nasal obstruction ventilation dissipates, by the original of following weight portion Material is made:Daily medicament:Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, Radix Glycyrrhizae 5-9 parts, farina 20-31 parts, peppermint 5-7 parts, borneol 5-7 parts;Ight medicament:Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, it is sweet It is careless 5-9 parts, pearl powder 5-7 parts, cortex albiziae 6-9 parts, spina date seed 10-14 parts.
Used as preferred technical scheme, a kind of nasal obstruction ventilation dissipates, and is made up of following raw material:Daily medicament: 21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, 14 parts of dried orange peel, 7 parts of Radix Glycyrrhizae, 26 parts of farina, 6 parts of peppermint, 6 parts of borneol;Ight medicament: 21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, 14 parts of dried orange peel, 7 parts of Radix Glycyrrhizae, 26 parts of farina, 6 parts of pearl powder, 8 parts of cortex albiziae, wild jujube 12 parts of benevolence.
Present invention also offers above-mentioned preparation method, comprise the following steps:
Step 1:Daily medicament and ight medicament are respectively put into frying pan in addition to farina, add 10 times of quality of medicinal material part Water, slow fire is fried, when water is reduced to as quality of medicinal material part half, leaches the dregs of a decoction and stays liquid standby;
Step 2:The liquid that step 1 is obtained, moisture is removed through high-temperature spray tower, is separately put according to daily medicament and ight medicament Put;
Step 3:During farina to be put into daily medicament and ight medicament respectively;
Step 4:Using the medicinal material for mixing step 3, take on a small quantity, held up with forefinger and thumb, nose downside is placed on, by powder End suction nasal cavity.
By adopting the above-described technical solution, a kind of nasal obstruction ventilation dissipates, it is made up of following raw material:Daily medicament: Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, Radix Glycyrrhizae 5-9 parts, farina 20-31 parts, peppermint 5-7 parts, Borneol 5-7 parts;Ight medicament:Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, Radix Glycyrrhizae 5-9 parts, pearl powder 5-7 Part, cortex albiziae 6-9 parts, spina date seed 10-14 parts;
The invention has the advantages that:
1st, the present invention is because the physical characteristic of its medicine, along with farina is added with, can quickly absorb the interior of nasal cavity Secretion, make the quick desiccation of secretion, at the same promote nasal cavity inwall shrink, suppress secretion, so as to play the effect for taking effect and being exceedingly fast Really;
2nd, physical treatment and drug therapy double treatment method, secretion is quickly absorbed by physical characteristic, simultaneously as secretion The reason for thing, drug ingedient dilution is played, and at direct effect disease, medicine using effect is good;
3rd, to prevent dust from sucking lung, this drug withdrawal is used under normal circumstances in nasal cavity, and in the medicinal material of daily medicament Addition peppermint and borneol, promote patient to sneeze, and clear up the medicament residue of nasal cavity.
Pharmacology analysis:
Nasal cavity moisture is mediated with honeysuckle, the bighead atractylodes rhizome, nasal cavity environment is repaired supplemented by dried orange peel, Radix Glycyrrhizae, promote qi and blood circulation, day The mental status that peppermint, borneol improve sufferer are also used with medicament, other complication, ight medicament are reduced:With pearl powder, close Joyous skin, spina date seed qi-regulating are enriched blood, and promote the running of sufferer autoimmunity system;Daily medicament and ight medicament add horse simultaneously Bell sweet potato starch, farina water imbibition is especially strong, can quickly improve environment in nasal cavity.
Therapeutic effect:
The people of nasal obstruction stuffiness patient 200 is chosen, wherein nose breathing can not can be used with the people of patient with severe symptoms 98 of nose breathing But the slack people of light patient with severe symptoms 102 is breathed, this medicine is used in rhinostegnosis, entered by autonomous suction or equipment investment Enter nasal cavity, medicine can take effect into nasal cavity in one minute, can be with unimpeded use nose breathing using medicine through statistics The people of patient 194, cure rate 97% turns the people of patient with slight symptoms 6, treatment rate 100% by severe.
Attached 2 cases are further illustrated:
Lin, chronic nasosinusitis after diagnosing, because flu causes rhinitis to recur, nasal polyp enlargement, nasal cavity stays yellow nasal mucus, through determining to feel Emit rehabilitation but nasal mucus is still more than, cannot use nose breathing, consultation time:On April 12nd, 2016, age:34 Year, sex:Man, 1 minute after medication, hence it is evident that feel that nasal cavity inwall shrinks, while nose breathing, 10 points of medication can be used slowly Zhong Hou, can normally use nose breathing, slightly block sense, but not influence life, pay a return visit within 7 hours after medication, not yet There is the situation that nasal obstruction occurs again.
So-and-so is revived, after diagnosing for the nasal obstruction that flu causes is had a running nose, nasal mucus is in light clear color, and viscosity is general, and nasal cavity is indefinite When block, especially in sleeping at night, it is impossible to normally using nose breathing, consultation time:On August 15th, 2016, age:24 Year, sex:Female, 1 minute after medication, it is already possible to normally using nose breathing, without sense is substantially blocked, breathes smooth, until 7 is small When after pay a return visit, also there is no nasal obstruction feel.
The present invention is described further with reference to specific embodiment.
Embodiment 1
One kind nasal obstruction ventilation dissipates, and is made up of following raw material:Daily medicament:27 parts of honeysuckle, 27 parts of the bighead atractylodes rhizome, dried orange peel 17 Part, 9 parts of Radix Glycyrrhizae, 31 parts of farina, 7 parts of peppermint, 7 parts of borneol;Ight medicament:27 parts of honeysuckle, 27 parts of the bighead atractylodes rhizome, dried orange peel 17 Part, 9 parts of Radix Glycyrrhizae, 7 parts of pearl powder, 9 parts of cortex albiziae, 14 parts of spina date seed.
Above-mentioned preparation method, comprises the following steps:
Step 1:Daily medicament and ight medicament are respectively put into frying pan in addition to farina, add 10 times of quality of medicinal material part Water, slow fire is fried, when water is reduced to as quality of medicinal material part half, leaches the dregs of a decoction and stays liquid standby;
Step 2:The liquid that step 1 is obtained, moisture is removed through high-temperature spray tower, is separately put according to daily medicament and ight medicament Put;
Step 3:During farina to be put into daily medicament and ight medicament respectively;
Step 4:Using the medicinal material for mixing step 3, take on a small quantity, held up with forefinger and thumb, nose downside is placed on, by powder End suction nasal cavity.
Embodiment 2
One kind nasal obstruction ventilation dissipates, and is made up of following raw material:Daily medicament:15 parts of honeysuckle, 15 parts of the bighead atractylodes rhizome, dried orange peel 11 Part, 5 parts of Radix Glycyrrhizae, 20 parts of farina, 5 parts of peppermint, 5 parts of borneol;Ight medicament:15 parts of honeysuckle, 15 parts of the bighead atractylodes rhizome, dried orange peel 11 Part, 5 parts of Radix Glycyrrhizae, 5 parts of pearl powder, 6 parts of cortex albiziae, 10 parts of spina date seed.
Above-mentioned preparation method, comprises the following steps:
Step 1:Daily medicament and ight medicament are respectively put into frying pan in addition to farina, add 10 times of quality of medicinal material part Water, slow fire is fried, when water is reduced to as quality of medicinal material part half, leaches the dregs of a decoction and stays liquid standby;
Step 2:The liquid that step 1 is obtained, moisture is removed through high-temperature spray tower, is separately put according to daily medicament and ight medicament Put;
Step 3:During farina to be put into daily medicament and ight medicament respectively;
Step 4:Using the medicinal material for mixing step 3, take on a small quantity, held up with forefinger and thumb, nose downside is placed on, by powder End suction nasal cavity.
Embodiment 3
One kind nasal obstruction ventilation dissipates, and is made up of following raw material:Daily medicament:21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, dried orange peel 14 Part, 7 parts of Radix Glycyrrhizae, 26 parts of farina, 6 parts of peppermint, 6 parts of borneol;Ight medicament:21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, dried orange peel 14 Part, 7 parts of Radix Glycyrrhizae, 26 parts of farina, 6 parts of pearl powder, 8 parts of cortex albiziae, 12 parts of spina date seed.
Above-mentioned preparation method, comprises the following steps:
Step 1:Daily medicament and ight medicament are respectively put into frying pan in addition to farina, add 10 times of quality of medicinal material part Water, slow fire is fried, when water is reduced to as quality of medicinal material part half, leaches the dregs of a decoction and stays liquid standby;
Step 2:The liquid that step 1 is obtained, moisture is removed through high-temperature spray tower, is separately put according to daily medicament and ight medicament Put;
Step 3:During farina to be put into daily medicament and ight medicament respectively;
Step 4:Using the medicinal material for mixing step 3, take on a small quantity, held up with forefinger and thumb, nose downside is placed on, by powder End suction nasal cavity.
Schematical specific embodiment of the invention is the foregoing is only, the scope of the present invention is not limited to.It is any Those skilled in the art, done equivalent variations and modification on the premise of design of the invention and principle is not departed from, The scope of protection of the invention should be belonged to.

Claims (3)

1. a kind of nasal obstruction ventilation dissipates, including daily medicament and ight medicament, it is characterised in that by the raw material system of following weight portion Into:Daily medicament:Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, Radix Glycyrrhizae 5-9 parts, farina 20-31 Part, peppermint 5-7 parts, borneol 5-7 parts;Ight medicament:Honeysuckle 15-27 parts, bighead atractylodes rhizome 15-27 parts, dried orange peel 11-17 parts, Radix Glycyrrhizae 5-9 Part, pearl powder 5-7 parts, cortex albiziae 6-9 parts, spina date seed 10-14 parts.
2. a kind of nasal obstruction ventilation dissipates as claimed in claim 1, including daily medicament and ight medicament, it is characterised in that by following The raw material of weight portion is made:Daily medicament:21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, 14 parts of dried orange peel, 7 parts of Radix Glycyrrhizae, farina 26 Part, 6 parts of peppermint, 6 parts of borneol;Ight medicament:21 parts of honeysuckle, 21 parts of the bighead atractylodes rhizome, 14 parts of dried orange peel, 7 parts of Radix Glycyrrhizae, farina 26 Part, 6 parts of pearl powder, 8 parts of cortex albiziae, 12 parts of spina date seed.
3. the preparation method that a kind of ventilation of having a stuffy nose as claimed in claim 1 or 2 dissipates, it is characterised in that comprise the following steps:
Step 1:Daily medicament and ight medicament are respectively put into frying pan in addition to farina, add 10 times of quality of medicinal material part Water, slow fire is fried, when water is reduced to as quality of medicinal material part half, leaches the dregs of a decoction and stays liquid standby;
Step 2:The liquid that step 1 is obtained, moisture is removed through high-temperature spray tower, is separately put according to daily medicament and ight medicament Put;
Step 3:During farina to be put into daily medicament and ight medicament respectively;
Step 4:Using the medicinal material for mixing step 3, take on a small quantity, held up with forefinger and thumb, nose downside is placed on, by powder End suction nasal cavity.
CN201710138562.6A 2017-03-09 2017-03-09 Tongqi powder for nasal obstruction and manufacturing method thereof Withdrawn CN106692463A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062226A (en) * 2007-05-21 2007-10-31 王军 Incense-making influenza powder
CN104147574A (en) * 2014-08-26 2014-11-19 李浩成 Heat-clearing and exterior-releasing traditional Chinese medicine composition for treating cold and fever and preparation method thereof
CN104288724A (en) * 2014-10-08 2015-01-21 山东理工大学 Traditional Chinese medicine preparation for treating rhinitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062226A (en) * 2007-05-21 2007-10-31 王军 Incense-making influenza powder
CN104147574A (en) * 2014-08-26 2014-11-19 李浩成 Heat-clearing and exterior-releasing traditional Chinese medicine composition for treating cold and fever and preparation method thereof
CN104288724A (en) * 2014-10-08 2015-01-21 山东理工大学 Traditional Chinese medicine preparation for treating rhinitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
忻耀杰,郑昌雄: "自拟" 鼻渊方"治疗慢性化脓性鼻窦炎58例", 《上海中医药杂志》 *

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Application publication date: 20170524