CN106687457B - 用于激酶抑制的杂芳基化合物 - Google Patents

用于激酶抑制的杂芳基化合物 Download PDF

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Publication number
CN106687457B
CN106687457B CN201580037958.0A CN201580037958A CN106687457B CN 106687457 B CN106687457 B CN 106687457B CN 201580037958 A CN201580037958 A CN 201580037958A CN 106687457 B CN106687457 B CN 106687457B
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China
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amino
group
methyl
alkyl
dihydro
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Expired - Fee Related
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CN201580037958.0A
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English (en)
Chinese (zh)
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CN106687457A (zh
Inventor
黄卫生
李峰
戴维·C·达尔加诺
巩永进
阿乐克谢·V·爱什陈科
安娜·科尔曼
威廉·C·莎士比亚
安吉拉·V·维斯特
徐永进
杨颖文
张蕴
周天军
朱笑天
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Takeda Pharmaceutical Co Ltd
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Ariad Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580037958.0A 2014-05-13 2015-05-13 用于激酶抑制的杂芳基化合物 Expired - Fee Related CN106687457B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992742P 2014-05-13 2014-05-13
US61/992,742 2014-05-13
PCT/US2015/030522 WO2015175632A1 (en) 2014-05-13 2015-05-13 Heteroaryl compounds for kinase inhibition

Publications (2)

Publication Number Publication Date
CN106687457A CN106687457A (zh) 2017-05-17
CN106687457B true CN106687457B (zh) 2020-01-10

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CN201580037958.0A Expired - Fee Related CN106687457B (zh) 2014-05-13 2015-05-13 用于激酶抑制的杂芳基化合物

Country Status (5)

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US (1) US20170166598A1 (https=)
EP (1) EP3143015B1 (https=)
JP (1) JP6468611B2 (https=)
CN (1) CN106687457B (https=)
WO (1) WO2015175632A1 (https=)

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US12466825B2 (en) 2019-11-14 2025-11-11 Amgen Inc. Synthesis of KRAS G12C inhibitor compound

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WO2016173438A1 (zh) 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 稠环或三环芳基嘧啶化合物用作激酶抑制剂
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CN106810553B (zh) * 2015-11-30 2020-03-17 江苏正大丰海制药有限公司 3-(4,5-取代氨基嘧啶)苯基衍生物及其应用
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TW202317106A (zh) * 2021-08-27 2023-05-01 南韓商柳韓洋行 作為egfr抑制劑之取代胺基吡啶化合物
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466825B2 (en) 2019-11-14 2025-11-11 Amgen Inc. Synthesis of KRAS G12C inhibitor compound

Also Published As

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EP3143015B1 (en) 2019-02-20
JP6468611B2 (ja) 2019-02-13
EP3143015A4 (en) 2017-11-01
JP2017518282A (ja) 2017-07-06
CN106687457A (zh) 2017-05-17
EP3143015A1 (en) 2017-03-22
WO2015175632A1 (en) 2015-11-19
US20170166598A1 (en) 2017-06-15

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