CN106668654A - Six-herb cancer-stopping particles as traditional Chinese medicine of Hui nationality and preparation method of six-herb cancer-stopping particles - Google Patents

Abstract

The invention detailedly describes a formula and a preparation method of six-herb cancer-stopping particles as a traditional Chinese medicine of the Hui nationality. The six-herb cancer-stopping particles are green high-tech Chinese herbal medicines for treating an esophageal cancer. The six-herb cancer-stopping particles are traditional Chinese medicine particles prepared by mixing subprostrate sophora, rhizoma zedoariae, glabrous sarcandra herbs, rhizoma arisaematis and other Chinese herbal medicines according to a certain proportion, adding water, decocting, extracting, concentrating and pelleting, are mainly used for treating the esophageal cancer and has the effect of treating a throat cancer, a gastric cancer, a cervical cancer, a gastrointestinal cancer, a skin cancer and the like. The six-herb cancer-stopping particles described by the invention have the characteristics of being more in medicine taste and moderate in dosage; the selected medicines are proved to be able to treat the cancers by a modern pharmacological experiment; the six-herb cancer-stopping particles fundamentally improve body functions at a low cost, and prevent and treat cancer cells, thereby restoring body health.

Description

Hui ethnic group's Chinese medicine Six-element stops cancer particle and preparation method thereof

Technical field

It is a kind of green high-tech Chinese herbal medicine of the prevention and treatment cancer of the esophagus that Hui ethnic group's Chinese medicine Six-element according to the present invention stops cancer particle.The invention further relates to the preparation method of the medicine, belongs to traditional Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China for each person 74 years old life-span calculate, Chinese all one's life suffer from malignant tumour probability be 22%, average minute clock has 6 people to be diagnosed as malignant tumour, and tumour has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for Alimentary System patient, wherein patient with esophageal carcinoma accounts for the 29.7% of Alimentary System patient, almost half.

Cancer of the esophagusDisease locus are typically organized in epithelium of esophagus, and it is exactly swallowing and digestive function for patient that it directly affects, and health is slowly etched with regard to this.The pathogenic factor of cancer of the esophagus mainly has three, and one is malnutritive, though that is, now the living standard of people improves, due to the change of diet hobby and mode, will also result in malnutritive and trace element shortage；Two is that diet is lack of standardization, and in the grain and drinking-water of district occurred frequently, nitrate, nitrite and secondary amine content significantly increase, and these materials are easily-synthesized carcinogen nitrosamine in stomach；Three is esophageal injury and disease induction, and esophageal injury and some esophagel diseases are likely to become the inducement for causing cancer of the esophagus, and long-term chronic inflammation, ulcer, or chronic stimulation, and then esophageal epithelial proliferation are caused because of being detained in oesophagus, finally result in canceration.Although cancer of the esophagus does not possess infectiousness, the destruction to human body is but not allow to look down upon.

Though the early symptom of the cancer of the esophagus is more substantially, generally always flu etc is mistakenly considered by people, therefore often ignored, but do not know that the speed that cancer of the esophagus slowly deteriorates is very fast, once and feel increasingly apparent to be difficult to swallow, most likely deteriorated as cancer.Afterwards may be by operation to the process of cancerization Regional resection, to reduce the death rate of cancer of the esophagus.

At present treatment cancer of the esophagus the best way is operation, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, patient suffering is difficult to stand, and success rate is also very low, the life cycle after most Chemotherapy in Patients was with regard to 1 year or so --- certainly this is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some perform the operation, held due to a variety of causes and can't stand chemotherapy,Can only palliative treatment, expect that miracle comes ...

The cancer of the esophagus is at present more refractory disease more as cancer of the stomach, all, but refractory representative cannot be controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively treatment methods.The traditional Chinese medical science, according to the whole body feature diagnosis and treatment of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effect is slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band knurl, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as traditional Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medicinal material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatable poor, high level evidence-based medicine EBM be theoretical and the relative shortage of evidence,Thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided one kind reduces the incidence of disease of the cancer of the esophagus from the beginning of prevention, start to slow down its tempo from canceration, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumour.Specifically, the present invention one is particularly suited for use in esophageal ulcer before treatment cancer in case its canceration, two is can to treat cancer just ulcer, in case it continues to deteriorate, three is inducible into the cancerous swelling atrophy apoptosis of knurl, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancer cell and differentiation, promote cancerous swelling progressively atrophy.In specific formula, also coordinate diagnosis and treatment based on an overall analysis of the illness and the patient's condition, induced because of esophageal injury, disease according to the origin cause of formation of cancer of the esophagus, dietary preferences nutrient imbalance causes immunologic hypofunction, cause normal cell to be compromised because of Helicobacter pylori infection, apoptosis, digestive tract ulcer, canceration " taking advantage of a weak point ", because " weakened body resistance poison poly- ", " empty in healthy tendency " and the characteristics of causes the basic pathology interpretation of the cause, onset and process of an illness such as metastases, utilization or strengthening vital QI to eliminate pathogenic factors, orTonification and purgation in combination, or regulating qi to disperse stagnation, or the strongly fragrant resolving sputum of solution, or it is clearing heat and detoxicating, or reinforcing and reducing methods and the method used, it is empty in healthy tendency to correct, poly- and internal organs imbalance of yin and yang function reduction the deficiency of the solidifying poison of heresy, adjust and improve the immunologic function of body, to reach the purpose of overall tumor suppression, so as to improve the overall curative effect and late result of carninomatosis treatment, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for esophageal cancer patients, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, finally recover healthy.Thus also to patient one select different treatment methods or several method to share particularly traditional Chinese and western medicine to combine the leeway of complex treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

Hui ethnic group's Chinese medicine Six-element of the first, the described prevention and treatment cancer of the esophagus stops cancer particle and preparation method thereof, is by made by following weight proportion raw material：

Subprostrate sophora 30g, iron thorn Siberian cocklebur 30g, salvia chinensis 10g, fiveleaf akebia fruit 30g,

Radix Glycyrrhizae 10g, pseudo-ginseng 7g,

This side is the substantially square of one decoction on the one, in practical application, can also increase the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory according to the physique of patient and conditions“Dialectical compatibility " medicine.

In view of with this, basic side's decoction decoction of medicinal ingredients amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes middle particle of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to pseudo-ginseng, Radix Glycyrrhizae, all amplify 10 times, after clean water, be placed in BT-2 stainless steels and extract in kettle, plus after 7-9 times of running water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.

（3）, powder processed

Pseudo-ginseng 7g, Radix Glycyrrhizae 10g are respectively amplified 10 times, it is end together to crush, and crosses 100 mesh sieves, standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey and is sufficiently mixed, stir.

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated.

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed.

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

B, packaging

First the particle for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Three times a day, every time 1 bag, on an empty stomach (taking half an hour after can not drink water in a large number, in order to avoid water down liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.

The effect of each raw material of the present invention：

Subprostrate sophora,ForLegume root of subprostrate sophoraRoot.Bitter cold in nature.Effect is to relieve inflammation or internal heat, detoxifying, subsiding a swelling, pain relieving.Cure mainly：Laryngalgia, sore-throat,Larynx numbness,Swelling and aching of gum,Breathe heavily fullHeat is coughed,Jaundice, diarrhea, heat is swollen,Mange, snakeworm dog bite.Its is rightThe cancer of the esophagus、Nasopharyngeal carcinoma, cervical carcinoma,Carcinoma of urinary bladder, leukaemia have inhibitory action.Composition pharmacology：Containing TA about 0.93%, whereinMatrine(Matrine) 0.52%,Oxymatrine(Oxymatrine) 0.35%, Yi JihanD-maackianin-β-D-glucoside(Sophoraponicin)、Red sandalwoodPlain (Pterorepine),Screw oil expeller axleGrass roots glucoside (TrifolirhiZin),Albizzia kalkoraPlain (Maackian), sophoradin (Sophra) etc..DNA and RNA synthesis of the subprostrate sophora to tumour cell has obvious inhibitory action, so as to block the propagation of tumour cell, lymphocyte transformation can be promoted, excite or strengthen the CDCC of lymphocyte, T cell ratio is improved, strengthens or adjust macrophage phagocytic function, moreover it is possible to adjust endocrine, strengthen adrenocortical function, thus affect the occurrence and development of tumour.

Iron pierces Siberian cocklebur,Nature and flavor：It is sweet；Acid；It is mild-natured.Return through：Liver Channel；Kidney channel.Indication：Wines used as antirheumatic, diuresis, detumescence poison.Arthralgia is controlled, muscle is numb, has loose bowels, dysentery, oedema, gonorrhoea, furunculosis, pyogenic infections, scrofula, hemorrhoid.Jiangxi《Chinese herbology》：Removing toxic substances wind-dispelling, is sore carbuncle key medicine.Control severe and migratory arthralgia gout（Rheumatoid arthritis）, muscular paralysis,Cancer of the esophagus, psoriasis.

Salvia chinensis,For the herb of Labiatae annual herb plant salvia chinensis, flavor efficacy：It is bitter, mild-natured.It is clearing heat and detoxicating, cool blood flat liver, inducing diuresis for removing edema, dissipating bind.Clinical practice：It is usually used in treating the cancer of the esophagus, carcinoma of parotid gland, liver cancer, cancer of the stomach, cardia cancer etc..Medical science religion ' educate net compile additionally, be additionally operable to treat virus hepatitis, hot summer weather rush down dysentery, infantile acute nephritis, oedema, rheumatic arthritis, chyluria, treating swelling and pain by traumatic injury, venomous snake bite, boil swell and ache, metrorrhagia etc..

Fiveleaf akebia fruit,ForLardizabalaceaePlantAkebi threeleaf akebiaOrAkebia trifoliata varaustralisDry mature fruit.It is sweet, cold in nature, function isDispersing stagnated hepatoqi, promoting blood circulation and stopping pain, relieving restlessness diuresis.Cure mainlyStomachache due to emotional depression and the hyperactive liver-qi attacking the stomach、Stomach energyFood is slow-witted, polydipsia,Dysentery、Pain in the back、Hypochondriac pain, hernia etc..The less single of fiveleaf akebia fruit is used for kinds of tumors with his medicine phases 5 more with controlling in tumour, and has preferable curative effect more.

Radix Glycyrrhizae,Root and root system master contain triterpenoid saponin, wherein main one kind is commonly called as glycyrrhizin, and the 4',7-Dihydroxyflavanone of chlorins compound containing flavones, liquiritin etc., the also Radix Glycyrrhizae of compound containing Coumarins coumarin, glycyol etc., separately containing compounds such as alkaloid, Radix Glycyrrhizae glucan GBW.Sweet, mild-natured, returns spleen, stomach, the heart, lung channel, invigorating middle warmer and replenishing QI, relieving spasm to stop pain moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.Burnout deficiency of food is cured mainly, the thin face of flesh is yellow, palpitation, suffer from abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, abscess of throat, ulcerative carbuncle pyogenic infections, infant fetal toxin and medicine, food poisoning.Radix Glycyrrhizae has removing toxic substances antibacterial action, anti-AIDS toxic action, licorice polysaccharide has obvious inhibiting effect to vesicular stomatitis virus, adenovirus II type, herpes simplex virus I type and vaccinia virus in vitro, not only can directly inactivate this several virus, and also have effect to intracellular virus, additionally, Radix Glycyrrhizae also has Antitussive and Expectorant Effect, with anti-inflammatory, affect digestive system, immune system and cardiovascular system, the effect such as antitumor and anti-mutation, corticotropin sample, anti-oxidant.The acute and chronic viral hepatitis of clinical treatment, treatment diabetes, treatment gastric and duodenal ulcer etc..

Pseudo-ginseng,Pseudo-ginseng is one of ten big Chinese herbal medicine for preventing, meridian distribution of property and flavor：Sweet, slight bitter, tepor, Return liver, stomach.Indication removing blood stasis and hemostasis, activating blood circulation and reducing swelling analgesic therapy.It is clinicalOn applying clinical commonly use control lung cancer, the cancer of the esophagus,Cervical carcinomaBelong to stagnation of blood stasis or and bleeder etc. carcinoma.Cure mainly it is various go out blood trouble, fall servant's stasis of blood swell, chest impediment and cardialgia.Arasaponin Rd is suppressed can the tumour cell 92% of culture, and Rd also has obvious inhibiting effect to the oncocyte cultivated.Saponin Rhl can suppress murine melanoma（B16）Growth, again induction is reversed into non-cancerous cells to make cancer cell.Pseudo-ginseng decoction has inhibitory action to JYC26 in vivo；Polysaccharide body in pseudo-ginseng can substantially suppress in vivo murine sarcoma -180；Pseudo-ginseng also has antiphagin activity.

The effect of the present invention：

Cure mainly：The cancer of the esophagus, particularly the early stage cancer of the esophagus, fundamentally improve physical function, and control tumour continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as throat cancer, cardiac cancer, pylorus cancer, cancer of the stomach, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are few, little in dosage, spend low, do not waste.

2nd, selected flavour of a drug are all to be proved that for cancer the cancer of the esophagus particularly can be treated by modern medicine pharmacological evaluation.And then always have in existing proved recipe for cancer, folk prescription --- even more than medicine more than half be all not by modern medicine pharmacological evaluation proved function for cancer and effect.Really it is that the traditional Chinese medical science is seen a doctor by rule of thumb, folk prescription is cured the disease by risk！

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, be as a result that " dragon " does not harness the river on the contrary more.

4th, as much as possible " neutralisation ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, a bit " stopping leak ", the medicine of " fall fire " are specifically solved for interim addition.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequences.

The conventional taking dose of the present invention, method are：Three times a day, every time 1 bag, administered at empty stomach is used；The foods larger to gastrointestinal irritation such as relatively more pungent comparison is sweet are eaten during medication.This medicine is a course for the treatment of in three months, typically takes two to three courses for the treatment of, at most takes four courses for the treatment of.

Specific embodiment：Subprostrate sophora 30g, iron thorn Siberian cocklebur 30g, salvia chinensis 10g, fiveleaf akebia fruit 30g are respectively amplified into 10 times, after clean water, BT-2 stainless steels is placed in and is extracted in kettle, plus after 7-9 times of running water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Pseudo-ginseng 7g, Radix Glycyrrhizae 10g are respectively amplified 10 times, it is end together to crush, and crosses 100 mesh sieves, standby.Dispensing：In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey and is sufficiently mixed, stir.Drying, crushing：The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.Granulation：The spice being well mixed is inserted in comminutor and is granulated.Whole grain：The particle for making is carried out into whole grain, 35 mesh sieves are crossed.It is dried：Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Packaging：First the particle for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.Warehouse-in：Irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine Six-element stops cancer particle and preparation method thereof, it is characterised in that it is by made by the raw material of following weight proportion：

Subprostrate sophora 30g, iron thorn Siberian cocklebur 30g, salvia chinensis 10g, fiveleaf akebia fruit 30g,

Radix Glycyrrhizae 10g, pseudo-ginseng 7g

This side is the substantially square of one decoction on the one, in practical application, can also increase the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory according to the physique of patient and conditions“Dialectical compatibility " medicine.

2. the Hui ethnic group's Chinese medicine Six-element according to claim 1 stops the weight proportion of cancer particle, it is characterised in that including following preparation processes：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to pseudo-ginseng, Radix Glycyrrhizae, all amplify 10 times, after clean water, be placed in BT-2 stainless steels and extract in kettle, plus after 7-9 times of running water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby；

（3）, powder processed

By pseudo-ginseng 7g, Radix Glycyrrhizae 10g, each 10 times of amplification, it is end together to crush, and crosses 100 mesh sieves, standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey and is sufficiently mixed, stir；

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves；

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated；

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed；

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

B, packaging

First the particle for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.