CN106668197A - Pharmaceutical composition for constipation and preparation method thereof - Google Patents

Pharmaceutical composition for constipation and preparation method thereof Download PDF

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Publication number
CN106668197A
CN106668197A CN201611252809.9A CN201611252809A CN106668197A CN 106668197 A CN106668197 A CN 106668197A CN 201611252809 A CN201611252809 A CN 201611252809A CN 106668197 A CN106668197 A CN 106668197A
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parts
constipation
starch
cellulose
pharmaceutical composition
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不公告发明人
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Zhengzhou Palm Network Technology Co Ltd
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Zhengzhou Palm Network Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
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  • Medical Informatics (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Insects & Arthropods (AREA)
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  • Inorganic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a pharmaceutical composition for constipation. The composition is composed of the following raw materials in parts by weight: 2-6 parts of rhubarb-soda tablets, 0.1-0.6 part of cistanche, 0.3-1 part of fructus cannabis, 0.1-0.5 part of carbamazepine tablets, 5-10 parts of olive oil, 0.5-2 parts of compound vitamins, 0.1-1.5 parts of carotene, 4-9 parts of polyethylene glycol, 0.5-1 part of starch, 2-7 parts of cellulose and 3-8 parts of honey. The invention further discloses a preparation method of the suppository. According to the composition disclosed by the invention, the raw materials are wide in source, the preparation process is simple, and the production equipment is low in input cost, so that the composition is suitable for industrial production on a large scale. The components in the composition disclosed by the invention have synergistic effects, so that the composition is simple and convenient to use, short in responding time, free of side effects and good in using effect.

Description

One kind is for constipation pharmaceutical composition and preparation method thereof
Technical field
The present invention relates to a kind of medicine, specifically a kind of to be used for constipation pharmaceutical composition.
Background technology
With the increase and the formation of various bad life habits of life stress, the various defect of people's body start to increase Many, constipation is exactly one of which.Constipation is clinical common complicated symptom, rather than a kind of disease, is primarily referred to as defecation frequency Reduce, feces amount is reduced, situations such as feces are dry and hard, defecation is laborious, according to the data of State Statistics Bureau, illness of the constipation in crowd Rate is up to 27%, but only sub-fraction constipation person can go to a doctor.Constipation can affect the people of each age group, women in constipation patient More than male, old age is more than the young and prime of life.Because constipation sickness rate is high, the cause of disease is complicated, patient often has manifold vexations, and constipation is serious When can affect quality of life.Constipation includes organic constipation and functional constipation, and organic constipation is that organ reason causes Constipation, functional constipation is that various factors causes.Constipation patient firstly the need of exclude organic disease institute caused by constipation, Then according to constipation weight, the cause of disease and type, using Comprehensive Treatment, including general life treatment, Drug therapy, biofeedback instruction Practice and operative treatment, to recover normal defecation physiology.But the treatment time of this Therapeutic Method is long, and therapeutic effect is not enough managed Want there is side effect, this just brings difficulty for patient.
The content of the invention
It is an object of the invention to provide a kind of be used for constipation pharmaceutical composition, to solve above-mentioned background technology in propose Problem.
For achieving the above object, the present invention provides following technical scheme：
One kind is used for constipation pharmaceutical composition, is made up of according to weight portion following raw material：Rhubarb soda tablet 2-6 parts, meat clump Rong's 0.1-0.6 parts, Fructus Cannabiss 0.3-1 parts, Carbamazepine Tablets 0.1-0.5 part, olive oil 5-10 parts, compound vitamin 0.5-2 parts, Carotene A0.1-1.5 parts, Polyethylene Glycol 4-9 parts, starch 0.5-1 parts, cellulose 2-7 parts and Mel 3-8 parts.
As further scheme of the invention：Cellulose is using hydroxypropyl methyl cellulose or ethyl cellulose.
As further scheme of the invention：Starch adopts green starch, wheaten starch, potato starch, corn starch With one or more mixture of Rhizoma Nelumbinis starch.
The preparation method for constipation pharmaceutical composition, comprises the following steps that：
Rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and are adopted pulverizer by step one Crush, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch is added in deionized water, stirring Machine stirs 10-25 minutes under 45-60 degree Celsius with the rotating speed of 60-120rpm, obtains the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and cellulose is added while stirring And Mel, cellulose and Mel added after finishing, and blender stirs 30-50 minutes with the rotating speed of 150-240rpm at normal temperatures, Stirring terminate after pour in 60-80 degree Celsius of water-bath in bolt mould, cooling shaping and packaging finished product is obtained.
Compared with prior art, the invention has the beneficial effects as follows：Extensively, preparation process is simple is raw for raw material sources of the present invention Produce equipment investment cost low, it is adaptable to large-scale industrial production；Synergism is played between each component in the present invention, is used Simple and convenient, responding time is fast, is free from side effects, and using effect is good.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
One kind is used for constipation pharmaceutical composition, is made up of according to weight portion following raw material：2 parts of rhubarb soda tablet, Herba Cistanches 0.1 part, it is 0.3 part of Fructus Cannabiss, 0.1 part of Carbamazepine Tablets, 5 parts of olive oil, 0.5 part of compound vitamin, carotene A0.1 parts, poly- 3 parts of 4 parts of ethylene glycol, 0.5 part of starch, 2 parts of cellulose and Mel.Cellulose adopts hydroxypropyl methyl cellulose.
The preparation method for constipation pharmaceutical composition, comprises the following steps that：
Rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and are adopted pulverizer by step one Crush, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch is added in deionized water, stirring Machine is stirred 12 minutes under 45 degrees Celsius with the rotating speed of 80rpm, obtains the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and hydroxypropyl is added while stirring Methylcellulose and Mel, cellulose and Mel are added after finishing, and blender stirs 30 points with the rotating speed of 150rpm at normal temperatures Clock, stirring terminate after pour in 60 degrees Celsius of water-bath in bolt mould, cooling shaping and packaging finished product is obtained.
Embodiment 2
One kind is used for constipation pharmaceutical composition, is made up of according to weight portion following raw material：3 parts of rhubarb soda tablet, Herba Cistanches 0.3 part, 0.5 part of Fructus Cannabiss, 0.2 part of Carbamazepine Tablets, 7 parts of olive oil, 1 part of compound vitamin, carotene A0.6 parts, poly- second 5 parts of 6 parts of glycol, 0.7 part of starch, 4 parts of cellulose and Mel.Starch is using green starch and the mixture of Rhizoma Nelumbinis starch.
The preparation method for constipation pharmaceutical composition, comprises the following steps that：
Rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and are adopted pulverizer by step one Crush, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch is added in deionized water, stirring Machine is stirred 16 minutes at 50 c with the rotating speed of 80rpm, obtains the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and cellulose is added while stirring And Mel, cellulose and Mel added after finishing, and blender is stirred 38 minutes at normal temperatures with the rotating speed of 180rpm, and stirring terminates Pour in bolt mould in 66 degrees Celsius of water-bath afterwards, cooling shaping and packaging finished product is obtained.
Embodiment 3
One kind is used for constipation pharmaceutical composition, is made up of according to weight portion following raw material：4.5 parts of rhubarb soda tablet, meat clump 0.4 part of Rong, 0.8 part of Fructus Cannabiss, 0.4 part of Carbamazepine Tablets, 8 parts of olive oil, 1.5 parts of compound vitamin, carotene A1.2 parts, 7 parts of 8 parts of Polyethylene Glycol, 0.9 part of starch, 6 parts of cellulose and Mel.Cellulose adopts ethyl cellulose.Starch is formed sediment using Semen Tritici aestivi The mixture of powder, potato starch and corn starch.
The preparation method for constipation pharmaceutical composition, comprises the following steps that：
Rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and are adopted pulverizer by step one Crush, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch is added in deionized water, stirring Machine is stirred 22 minutes under 55 degrees Celsius with the rotating speed of 100rpm, obtains the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and adds ethyl fine while stirring Dimension element and Mel, cellulose and Mel are added after finishing, and blender is stirred 46 minutes at normal temperatures with the rotating speed of 210rpm, stirring Pour in bolt mould in 75 degrees Celsius of water-bath after end, cooling shaping and packaging finished product is obtained.
Embodiment 4
One kind is used for constipation pharmaceutical composition, is made up of according to weight portion following raw material：6 parts of rhubarb soda tablet, Herba Cistanches 0.6 part, 1 part of Fructus Cannabiss, 0.5 part of Carbamazepine Tablets, 10 parts of olive oil, 2 parts of compound vitamin, carotene A1.5 parts, poly- second two 8 parts of 9 parts of alcohol, 1 part of starch, 7 parts of cellulose and Mel.Cellulose adopts hydroxypropyl methyl cellulose.Starch using green starch, The mixture of wheaten starch, potato starch, corn starch and Rhizoma Nelumbinis starch.
The preparation method for constipation pharmaceutical composition, comprises the following steps that：
Rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and are adopted pulverizer by step one Crush, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch is added in deionized water, stirring Machine is stirred 20 minutes at 60 c with the rotating speed of 120rpm, obtains the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and hydroxypropyl is added while stirring Methylcellulose and Mel, cellulose and Mel are added after finishing, and blender stirs 45 points with the rotating speed of 240rpm at normal temperatures Clock, stirring terminate after pour in 80 degrees Celsius of water-bath in bolt mould, cooling shaping and packaging finished product is obtained.
The using method of the suppository is：Every time anus is included with one piece, suppository is pushed into distance with forefinger or special rod Anal margin 2-4 centimeters, are never inserted directly in feces, if one piece still not all right through 15-30 minutes, people can be again Apply another piece.
Model case is verified：Case one, Korea Spro, female 66 years old, suffers from senile constipation 6 years, arranges a hard sphere just within 6-8 days, every time Glycerin must be propped up using 2-4, just preabdomen distending pain, after an action of the bowels proctalgia.Using one piece of the product of embodiment 1, arrange within 25 minutes Except ball just, the same day reuse one piece again, exclude within 60 minutes substantial amounts of ball just with a small amount of soft stool, do not have in defecation process and after defecation There is pain, using 5 pieces of the product of embodiment 1, constipation occurs again in half a year.
Case two, Wang, man 3 years old, is hard and dry and sialorrhea, and Jing continues again frequently with Herba Cistanches defecation after drug withdrawal Generation constipation.Abdominal distention is more than, using one piece of the product of embodiment 2, carries out defecation and aerofluxuss within five minutes, continues every other day using real One piece of the product of example 2 is applied, stool is normal, and saliva mitigates, and does not recur in half a year.
Case three, Lee, female 35 years old, defecates more than ten days and does not understand, with abdominal distention severity, dry real, the flushing rough, mouth of feeling of fullness Smelly and thirsty symptom, abdominal examination visible intestinal shape sometimes, with hemorrhoid are seen, must adopt glycerin before stool, repeated constipation. Using 1 piece of the product of embodiment 3, a large amount of Melaenas are discharged within 15 minutes, the same day is again using 1 piece, 20 minutes of the product of embodiment 3 Melaena and a small amount of soft stool are discharged, using 3 pieces of the product of embodiment 3, stool is normal, and abdominal distention disappears, halitosis and thirsty symptom Disappear, constipation is not occurring in half a year.
Case four, Huang, man, 46 years old, constipation 2 years and with abdominal discomfort, insomnia and dreaminess, using embodiment 4 No longer recur in 4 pieces of product, constipation half a year, abdominal discomfort and insomnia phenomenon disappear, dreaminess remission.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped Containing an independent technical scheme, this narrating mode of description is only that for clarity those skilled in the art should Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art Understandable other embodiment.

Claims (4)

1. it is a kind of to be used for constipation pharmaceutical composition, it is characterised in that to be made up of according to weight portion following raw material：Rhubarb soda tablet 2- 6 parts, Herba Cistanches 0.1-0.6 parts, Fructus Cannabiss 0.3-1 parts, Carbamazepine Tablets 0.1-0.5 part, olive oil 5-10 parts, compound vitamin 0.5-2 parts, carotene A0.1-1.5 parts, Polyethylene Glycol 4-9 parts, starch 0.5-1 parts, cellulose 2-7 parts and Mel 3-8 parts.
2. it is according to claim 1 for constipation pharmaceutical composition, it is characterised in that the cellulose adopts hydroxypropyl first Base cellulose or ethyl cellulose.
3. it is according to claim 1 and 2 for constipation pharmaceutical composition, it is characterised in that the starch is formed sediment using Semen phaseoli radiati One or more mixture of powder, wheaten starch, potato starch, corn starch and Rhizoma Nelumbinis starch.
4. a kind of preparation method for constipation pharmaceutical composition as described in claim 1-3 is arbitrary, it is characterised in that concrete Step is as follows：
Step one, rhubarb soda tablet, Herba Cistanches, Fructus Cannabiss and Carbamazepine Tablets are mixed and using pulverizer powder It is broken, stir after crushing, obtain the first mixture；
Step 2, olive oil, compound vitamin, carotene A, Polyethylene Glycol and starch are added in deionized water, and blender exists 10-25 minutes are stirred with the rotating speed of 60-120rpm under 45-60 degree Celsius, the first mixed solution is obtained；
Step 3, the first mixture is added in the first mixed solution and is stirred, and cellulose and honeybee are added while stirring Honey, cellulose and Mel are added after finishing, and blender is stirred 30-50 minutes at normal temperatures with the rotating speed of 150-240rpm, stirring Pour in bolt mould in 60-80 degree Celsius of water-bath after end, cooling shaping and packaging finished product is obtained.
CN201611252809.9A 2016-12-30 2016-12-30 Pharmaceutical composition for constipation and preparation method thereof Pending CN106668197A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3846795A4 (en) * 2018-09-04 2022-05-25 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3846795A4 (en) * 2018-09-04 2022-05-25 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods

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Application publication date: 20170517