CN106728348A - A kind of suppository with treatment constipation effect and preparation method thereof - Google Patents
A kind of suppository with treatment constipation effect and preparation method thereof Download PDFInfo
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- CN106728348A CN106728348A CN201611095411.9A CN201611095411A CN106728348A CN 106728348 A CN106728348 A CN 106728348A CN 201611095411 A CN201611095411 A CN 201611095411A CN 106728348 A CN106728348 A CN 106728348A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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Abstract
The invention discloses a kind of suppository with treatment constipation effect, it is made up of according to weight portion following raw material：38 parts of 26 parts of rhubarb soda tablet, 0.1 0.6 parts of phenolphthalein tablet, 0.3 1 parts of Semen daturae tablet, 0.1 0.5 parts of Carbamazepine Tablets, 5 10 parts of glycerine, 0.5 2 parts of vitamin E, 1.5 parts of carrotene A0.1,49 parts of polyethylene glycol, 0.5 1 parts of starch, 27 parts of cellulose and honey.The present invention also disclosed the preparation method of the suppository.Raw material sources of the present invention are extensive, preparation process is simple, investment of production equipment low cost, it is adaptable to large-scale industrial production；Synergy is played between each component in the present invention, easy to use, responding time is fast, is free from side effects, and using effect is good.
Description
Technical field
The present invention relates to a kind of medicine, specifically a kind of suppository with treatment constipation effect.
Background technology
With the increase and the formation of various bad life habits of life stress, the various defect of people's body start to increase
Many, constipation is exactly one of which.Constipation is clinical common complicated symptom, rather than a kind of disease, is primarily referred to as defecation frequency
Reduce, excrement amount is reduced, situations such as excrement is dry and hard, defecation is laborious, according to the data of State Statistics Bureau, illness of the constipation in crowd
Rate is up to 27%, but only sub-fraction constipation person can go to a doctor.Constipation can influence the people of each age group, women in constipation patient
More than male, old age is more than the young and prime of life.Because the constipation incidence of disease is high, the cause of disease is complicated, patient often has manifold vexations, and constipation is serious
When can influence quality of life.Constipation includes organic constipation and functional consitipation, and organic constipation is that organ reason causes
Constipation, functional consitipation is that various factors causes.Constipation patient firstly the need of exclude organic disease caused by constipation,
Then according to constipation weight, the cause of disease and type, using complex treatment, including general life treatment, drug therapy, biofeedback instruction
Practice and operative treatment, to recover normal defecation physiology.But the treatment time of this treatment method is long, and therapeutic effect is not enough managed
Want there is side effect, this is just for patient brings difficulty.
The content of the invention
It is an object of the invention to provide a kind of suppository with treatment constipation effect, to solve to be carried in above-mentioned background technology
The problem for going out.
To achieve the above object, the present invention provides following technical scheme：
A kind of suppository with treatment constipation effect, is made up of following raw material according to weight portion：Rhubarb soda tablet 2-6 parts,
Phenolphthalein tablet 0.1-0.6 parts, Semen daturae tablet 0.3-1 parts, Carbamazepine Tablets 0.1-0.5 parts, glycerine 5-10 parts, vitamin E 0.5-2 parts,
Carrotene A0.1-1.5 parts, polyethylene glycol 4-9 parts, starch 0.5-1 parts, cellulose 2-7 parts and honey 3-8 parts.
As further scheme of the invention：Cellulose uses hydroxypropyl methyl cellulose or ethyl cellulose.
As further scheme of the invention：Starch uses green starch, wheaten starch, farina, cornstarch
With one or more mixture of Rhizoma Nelumbinis starch.
The preparation method of the suppository with treatment constipation effect, comprises the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer is used
Crush, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer exists
Stirred 10-25 minutes with the rotating speed of 60-120rpm under 45-60 degrees Celsius, obtain the first mixed solution；
Step 3, by the first mixture add the first mixed solution in and be stirred, cellulose is added while stirring
And honey, cellulose and honey added after finishing, and mixer is stirred 30-50 minutes with the rotating speed of 150-240rpm at normal temperatures,
Stirring in 60-80 degrees Celsius of water-bath pours into bolt mould after terminating, and cooling shaping and packs and can obtain finished product.
Compared with prior art, the beneficial effects of the invention are as follows：Extensively, preparation process is simple is raw for raw material sources of the present invention
Produce equipment investment cost low, it is adaptable to large-scale industrial production；Synergy is played between each component in the present invention, is used
Simple and convenient, responding time is fast, is free from side effects, and using effect is good.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of suppository with treatment constipation effect, is made up of following raw material according to weight portion：2 parts of rhubarb soda tablet, fruit
0.1 part of guide card, 0.3 part of Semen daturae tablet, 0.1 part of Carbamazepine Tablets, 5 parts of glycerine, 0.5 part of vitamin E, carrotene A0.1 parts, poly- second
3 parts of 4 parts of glycol, 0.5 part of starch, 2 parts of cellulose and honey.Cellulose uses hydroxypropyl methyl cellulose.
The preparation method of the suppository with treatment constipation effect, comprises the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer is used
Crush, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer exists
Stirred 12 minutes with the rotating speed of 80rpm under 45 degrees Celsius, obtain the first mixed solution；
Step 3, by the first mixture add the first mixed solution in and be stirred, hydroxypropyl is added while stirring
Methylcellulose and honey, cellulose and honey are added after finishing, and mixer stirs 30 points with the rotating speed of 150rpm at normal temperatures
Clock, stirring in 60 degrees Celsius of water-bath pours into bolt mould after terminating, and cooling shaping and packs and can obtain finished product.
Embodiment 2
A kind of suppository with treatment constipation effect, is made up of following raw material according to weight portion：3 parts of rhubarb soda tablet, fruit
0.3 part of guide card, 0.5 part of Semen daturae tablet, 0.2 part of Carbamazepine Tablets, 7 parts of glycerine, vitamin e1 part, carrotene A0.6 parts, poly- second two
5 parts of 6 parts of alcohol, 0.7 part of starch, 4 parts of cellulose and honey.Starch is using green starch and the mixture of Rhizoma Nelumbinis starch.
The preparation method of the suppository with treatment constipation effect, comprises the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer is used
Crush, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer exists
Stirred 16 minutes with the rotating speed of 80rpm under 50 degrees Celsius, obtain the first mixed solution；
Step 3, by the first mixture add the first mixed solution in and be stirred, cellulose is added while stirring
And honey, cellulose and honey added after finishing, and mixer is stirred 38 minutes with the rotating speed of 180rpm at normal temperatures, and stirring terminates
In pouring into bolt mould in 66 degrees Celsius of water-bath afterwards, cooling shaping and pack i.e. can obtain finished product.
Embodiment 3
A kind of suppository with treatment constipation effect, is made up of following raw material according to weight portion：4.5 parts of rhubarb soda tablet,
0.4 part of phenolphthalein tablet, 0.8 part of Semen daturae tablet, 0.4 part of Carbamazepine Tablets, 8 parts of glycerine, vitamin e1 .5 parts, carrotene A1.2 parts, it is poly-
7 parts of 8 parts of ethylene glycol, 0.9 part of starch, 6 parts of cellulose and honey.Cellulose uses ethyl cellulose.Starch using wheaten starch,
The mixture of farina and cornstarch.
The preparation method of the suppository with treatment constipation effect, comprises the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer is used
Crush, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer exists
Stirred 22 minutes with the rotating speed of 100rpm under 55 degrees Celsius, obtain the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and adds ethyl fine while stirring
Dimension element and honey, cellulose and honey are added after finishing, and mixer is stirred 46 minutes with the rotating speed of 210rpm at normal temperatures, stirring
In pouring into bolt mould in 75 degrees Celsius of water-bath after end, cooling shaping and pack i.e. can obtain finished product.
Embodiment 4
A kind of suppository with treatment constipation effect, is made up of following raw material according to weight portion：6 parts of rhubarb soda tablet, fruit
0.6 part of guide card, 1 part of Semen daturae tablet, 0.5 part of Carbamazepine Tablets, 10 parts of glycerine, vitamin E2 part, carrotene A1.5 parts, poly- second two
8 parts of 9 parts of alcohol, 1 part of starch, 7 parts of cellulose and honey.Cellulose uses hydroxypropyl methyl cellulose.Starch using green starch,
The mixture of wheaten starch, farina, cornstarch and Rhizoma Nelumbinis starch.
The preparation method of the suppository with treatment constipation effect, comprises the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer is used
Crush, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer exists
Stirred 20 minutes with the rotating speed of 120rpm under 60 degrees Celsius, obtain the first mixed solution；
Step 3, by the first mixture add the first mixed solution in and be stirred, hydroxypropyl is added while stirring
Methylcellulose and honey, cellulose and honey are added after finishing, and mixer stirs 45 points with the rotating speed of 240rpm at normal temperatures
Clock, stirring in 80 degrees Celsius of water-bath pours into bolt mould after terminating, and cooling shaping and packs and can obtain finished product.
The application method of the suppository is：Anus is included with one piece every time, suppository is pushed into distance with forefinger or special rod
Anal margin 2-4 centimeters, are never inserted directly into excrement, if one piece still not all right by 15-30 minutes, people can be again
Using another piece.
Model case is verified：Case one, Korea Spro, female 66 years old, suffers from elderly constipation 6 years, arranges a hard sphere just within 6-8 days, every time
2-4 branch enema must be used, just preabdomen distending pain, after an action of the bowels anus pain.Using one piece of the product of embodiment 1, arrange within 25 minutes
Except ball just, the same day reuse one piece again, exclude within 60 minutes substantial amounts of ball just with a small amount of soft stool, do not have in defecation process and after defecation
There is pain, using 5 pieces of the product of embodiment 1, constipation occurs again in half a year.
Case two, Wang, man 3 years old, is hard and dry and slobbers, through frequently with phenolphthalein tablet defecation, continuing after drug withdrawal again
Generation constipation.Abdominal distension is more than, using one piece of the product of embodiment 2, carries out defecation and exhaust within five minutes, continues every other day using real
One piece of the product of example 2 is applied, stool is normal, and saliva mitigates, and is not recurred in half a year.
Case three, Lee, female 35 years old, defecates more than ten days and does not understand, with abdominal distension severity, dry real, the flushing rough, mouth of feeling of fullness
Smelly and thirsty symptom, abdomen examination visible intestines shape sometimes, with hemorrhoid are seen, must use enema before stool, repeated constipation.
Using 1 piece of the product of embodiment 3, a large amount of Melaenas are discharged within 15 minutes, the same day is again using 1 piece, 20 minutes of the product of embodiment 3
Discharge Melaena and a small amount of soft stool, using 3 pieces of the product of embodiment 3, stool is normal, and abdominal distension disappears, halitosis and thirsty symptom
Disappear, constipation is not occurring in half a year.
Case four, Huang, man, 46 years old, constipation 2 years and with abdominal discomfort, insomnia and dreaminess, using embodiment 4
No longer recurred in 4 pieces of product, constipation half a year, abdominal discomfort and insomnia phenomenon disappear, dreaminess remission.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (4)
1. it is a kind of with the suppository for treating constipation effect, it is characterised in that to be made up of according to weight portion following raw material：Rhubarb-soda
Piece 2-6 parts, phenolphthalein tablet 0.1-0.6 parts, Semen daturae tablet 0.3-1 parts, Carbamazepine Tablets 0.1-0.5 parts, glycerine 5-10 parts, vitamin
E0.5-2 parts, carrotene A0.1-1.5 parts, polyethylene glycol 4-9 parts, starch 0.5-1 parts, cellulose 2-7 parts and honey 3-8 parts.
2. it is according to claim 1 with the suppository for treating constipation effect, it is characterised in that the cellulose uses hydroxypropyl
Ylmethyl cellulose or ethyl cellulose.
3. it is according to claim 1 and 2 with the suppository for treating constipation effect, it is characterised in that the starch is using green
One or more mixture of beans starch, wheaten starch, farina, cornstarch and Rhizoma Nelumbinis starch.
4. it is a kind of as described in claim 1-3 is any with treatment constipation effect suppository preparation method, it is characterised in that
Comprise the following steps that：
Step one, rhubarb soda tablet, phenolphthalein tablet, Semen daturae tablet and Carbamazepine Tablets are mixed and pulverizer powder is used
It is broken, stirred after crushing, obtain the first mixture；
Step 2, by glycerine, vitamin E, carrotene A, polyethylene glycol and starch addition deionized water, mixer is in 45-60
Stirred 10-25 minutes with the rotating speed of 60-120rpm under degree Celsius, obtain the first mixed solution；
Step 3, by the first mixture add the first mixed solution in and be stirred, while stirring add cellulose and honeybee
Honey, cellulose and honey are added after finishing, and mixer is stirred 30-50 minutes with the rotating speed of 150-240rpm at normal temperatures, stirring
In pouring into bolt mould in 60-80 degrees Celsius of water-bath after end, cooling shaping and pack i.e. can obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611095411.9A CN106728348A (en) | 2016-12-02 | 2016-12-02 | A kind of suppository with treatment constipation effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611095411.9A CN106728348A (en) | 2016-12-02 | 2016-12-02 | A kind of suppository with treatment constipation effect and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106728348A true CN106728348A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611095411.9A Withdrawn CN106728348A (en) | 2016-12-02 | 2016-12-02 | A kind of suppository with treatment constipation effect and preparation method thereof |
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| CN (1) | CN106728348A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900000268A1 (en) * | 2019-01-09 | 2020-07-09 | "COMPOSITIONS FOR THE TREATMENT OF THE CONSTIPATION" |
-
2016
- 2016-12-02 CN CN201611095411.9A patent/CN106728348A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900000268A1 (en) * | 2019-01-09 | 2020-07-09 | "COMPOSITIONS FOR THE TREATMENT OF THE CONSTIPATION" |
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Application publication date: 20170531 |
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