CN106667483A - Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique - Google Patents
Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique Download PDFInfo
- Publication number
- CN106667483A CN106667483A CN201710063055.0A CN201710063055A CN106667483A CN 106667483 A CN106667483 A CN 106667483A CN 201710063055 A CN201710063055 A CN 201710063055A CN 106667483 A CN106667483 A CN 106667483A
- Authority
- CN
- China
- Prior art keywords
- sound
- head
- testee
- eeg
- sensor array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/06—Accessories for medical measuring apparatus
Abstract
The invention provides a noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with a sound source localization technique. The method combines a high intensity magnetostatic field with a low frequency acoustic sensor array to conduct measurements of noninvasive biological electroencephalographies; the head of a test subject is placed in the magnetostatic field, the electroencephalogram of the head of the test subject receives a Lorentz force from the magnetostatic field, and produces at a corresponding location a vibration signal with the same amplitude and frequency as the electroencephalogram; the low frequency acoustic sensor array is fixed on the head of the test subject to measure the vibration signals. The noninvasive biological electroencephalography measurement method combines the electroencephalogram, the magnetoacoustic coupling technique and the source localization technique and is applied in the accurate locating of noninvasive biological electroencephalogram. Because of the use of the acoustical signal produced by magnetoacoustic coupling to measure the electroencephalogram, the real time accurate locating of electroencephalogram is achieved by a multi-sensor; the method provides a new measurement method for the brain science related scientific research field.
Description
Technical field
The present invention relates to a kind of biological EEG measuring method.It is more particularly to a kind of by brain electricity, magnetosonic coupling technique, sound source
The coupling of combination magnetosonic and the noinvasive biology EEG measuring method of sound source location technology that location technology is combined together.
Background technology
Cerebral nerve function is the content of current scientific research forefront.The wherein placement technology of EEG signals, more
It is the difficult point of brain science research.At present, scientific research field is mainly scalp EEG (EEG) for the technology of brain electricity non-invasive measurement,
The reasons such as the low electric conductivity because of skull, cause EEG spatial resolution relatively low, it is impossible to be accurately positioned the position that corresponding electric signal occurs
Put.Other EEG measuring technologies, such as electrocorticogram (ECoG) and extracellular EEG measuring technology (LFP), are required for opening cranium
Bone is measured, and injures larger to subjectss, is the scientific research for not being suitable for carrying out human body.
The excitement simultaneously of multiple neurocytes in brain certain area can be produced and can survey electric current, and Lip river is subject under externally-applied magnetic field
Lun Zili and produce vibrations, formed sound source.Signal is gathered using acoustic sensor array outside cranium, can be to sound source position, i.e. brain
The position of the signal of telecommunication is positioned.Brain electricity, magnetosonic coupling technique, sound localization technology are combined together, and are applied by the principle
The core that field is the present invention is accurately positioned in noinvasive EEG signals.
The content of the invention
The technical problem to be solved is to provide and a kind of can realize the real-time of EEG signals by multisensor
Property the coupling of pinpoint combination magnetosonic and sound source location technology noinvasive biology EEG measuring method.
The technical solution adopted in the present invention is：A kind of combination magnetosonic coupling and the noinvasive biological brain electricity of sound source location technology
Measuring method, is a kind of noinvasive biology EEG measuring method that combined high-strength magnetostatic field and all-bottom sound sensor array are carried out,
It is that person's head to be tested is located in magnetostatic field, the EEG signals of testee's head are subject to Lorentz force in magnetostatic field, and
Produce and EEG signals amplitude-frequency identical vibration signal in relevant position；Low frequency acoustic sensor array is fixed on tested
Person's head is so as to measuring vibration signal.Comprise the steps：
1) laboratory door and window is closed using Sound-proof material, and makes the sound proof box for accommodating testee's head, to
The noise of shielding castle interior instrument；
2) noise of sound proof box internal medium is determined with sensor, computer is stored in；
3) whether sound proof box internal medium noise is judged less than the experiment noise threshold for setting, be then to enter next step,
Otherwise checking experiment room sound insulation state, return to step 2 after the hidden danger that abates the noise)
4) make testee lie low on the vibration isolators being located between upper and lower two blocks of electric magnet, testee's head is coated with
Lead and be placed in sound proof box after sound cream, and low frequency acoustic sensor array is fixed on into testee's head；
5) it is powered to electric magnet；
6) magnetoacoustic signals of brain electricity are gathered using low frequency acoustic sensor array, by magnetoacoustic signals relevant position brain electricity is obtained
The amplitude of signal and the information of frequency, and it is stored in computer；
7) using phase computation system is postponed, the positional information of EEG signals is calculated, obtains sound distribution image；
8) testee's brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtained final
Audio and video.
Step 4) described in vibration isolators and sound proof box, be according to measured signal frequency requirement formulate low frequency sound arrester.
The combination magnetosonic coupling of the present invention and the noinvasive biology EEG measuring method of sound source location technology, by brain electricity, magnetosonic
Coupling technique, sound localization technology are combined together, and are applied to being accurately positioned for noinvasive EEG signals.Due to by magnetosonic coupling
The acoustical signal measurement EEG signals for producing are closed, can realize that the real-time of EEG signals is accurately positioned by multisensor, this
The bright scientific research field related for brain science provides a kind of new measuring method.
Description of the drawings
Fig. 1 is with reference to magnetosonic coupling and the dress of the noinvasive biology EEG measuring method of sound source location technology for the present invention
Put；
Fig. 2 is the schematic flow sheet that EEG signals positional information is obtained in the present invention.
In figure
1：Magnetic field occurs and detection module 2：All-bottom sound sensor array module
3：The shockproof module 11 of sound insulation：Electric magnet
12：Power supply 13：Tesla meter
21：Low frequency acoustic sensor array 22：Amplify filtration module
23：Data collecting card 24：PC PC
31：Sound proof box 32：Vibration isolators
Specific embodiment
The combination magnetosonic coupling to the present invention and the noinvasive biological brain of sound source location technology with reference to embodiment and accompanying drawing
Electrical measurement method is described in detail.
The combination magnetosonic of the present invention couples the noinvasive biology EEG measuring method with sound source location technology, is that one kind combines height
The noinvasive biology EEG measuring method that intensity magnetostatic field and all-bottom sound sensor array are carried out, is to be located at testee's head such as
In magnetostatic field shown in Fig. 1, the EEG signals of testee's head are subject to Lorentz force in magnetostatic field, and produce in relevant position
Raw and EEG signals amplitude-frequency identical vibration signal；Low frequency acoustic sensor array is fixed on into the head of testee, from
And measure vibration signal.The present invention, due to coupling the acoustical signal measurement EEG signals for producing by magnetosonic, can be by many sensings
Device realizes that the real-time of EEG signals is accurately positioned.
Device used by the combination magnetosonic coupling of the present invention and the noinvasive biology EEG measuring method of sound source location technology is such as
Shown in Fig. 1, include：Be arranged on testee's head upper end for producing magnetic field and putting on testee's head simultaneously
The magnetic field of the magnetic induction in monitoring magnetic field occurs and detection module 1, is fixed on testee's head for being accurately positioned vibrations
The low frequency sound detection array module 2 of position, the shockproof module 3 of the sound insulation for shielding noise.
Described magnetic field occur the magnetic field magnetic induction line direction (such as z-axis direction in Fig. 1) that produces with detection module 1 with it is described
The direction of low frequency sound detection array module 2 is vertical.The vector product direction in the direction of magnetic induction line direction EEG signals is acoustic vibration side
To.Need to determine testee's head placing direction according to the direction of brain electricity current phasor.
Described magnetic field occurs to be included with detection module 1：Power supply 12, for output current, the power supply 12 can be adopted
With but be not limited to Beijing state electricity Asia light HY-17 power supplys or general XD-30K power supplys of Changchun English；Electric magnet 11, is arranged at testee
Above-head, link power supply 12 is used for according to different supply currents, produces the action of a magnetic field of different magnetic induction in tested
On examination person's head, the electric magnet 11 can adopt but be not limited to Changchun English general SBV-300 or SBV-380；Tesla meter 13, is arranged
In the side of electric magnet 11, for realizing the monitoring in magnetic field, the magnetic induction in magnetic field is shown in real time, the Tesla meter 13 can
Using but be not limited to U.S. Lakeshore 475, or space ring safe 931 is realized in Qingdao.
Described low frequency sound detection array module 2 includes being sequentially connected in series：Low frequency acoustic sensor array 21, for obtaining shake
Dynamic signal, described low frequency acoustic sensor array 21 can adopt but be not limited to 16 Bruel＆4955 structures of company's production
Square array into 4*4 is uniformly arranged in sensor distance 2cm on scalp.Amplification module 22, for amplifying signal, can adopt
But it is not limited to Bruel＆The pre-amplifying module 2690 of company's production and the power amplifier of AR companies of U.S. production
500A250C maximum amplifications can reach 80dB.Capture card 23, for the conversion of data acquisition modulus, can adopt but not limit
In NI companies of the U.S. production data collecting system PXI5122,5922, computer 24.
The shockproof module 3 of described sound insulation is included, and 31 sound proof boxs, 32 vibration isolators, sound proof box is fixed on vibration isolators, tested
Examination person's head is located in sound proof box.Wherein described sound proof box is adopted but is not limited to long 300mm, and wide 300mm, thick 5mm's is organic
Glass processing is formed, and thickness 2mm deadening felts are sticked in inside, and the Sound-proof material of thickness 30mm is sticked in outside.32 vibration isolators, can adopt
But be not limited to Wuhan ShiJi Co., Ltd of Air China production customization vibration isolators, size be long 500mm, wide 500mm, thick 200mm, height
500mm。
Testee's head EEG signals are subject to Lorentz force in magnetostatic field, and result from EEG signals in relevant position
Amplitude-frequency identical vibration signal；Low frequency acoustic sensor array is fixed on into i.e. measurable this signal of sample to be tested head.This
Invention, due to coupling the acoustical signal measurement EEG signals for producing by magnetosonic, can realize EEG signals by multisensor
Real-time is accurately positioned.
The combination magnetosonic coupling of the present invention and the noinvasive biology EEG measuring method of sound source location technology, specifically include as follows
Step：
1) for shielding castle outside noise, laboratory door and window is closed using Sound-proof material, and makes 30*30*30cm
The sound proof box for accommodating testee's head, to the noise of shielding castle interior instrument；
2) noise of sound proof box internal medium is determined with sensor, computer is stored in；
3) whether sound proof box internal medium noise is judged less than the experiment noise threshold for setting, be then to enter next step,
Otherwise checking experiment room sound insulation state, return to step 2 after the hidden danger that abates the noise)
4) make testee lie low on the vibration isolators being located between upper and lower two blocks of electric magnet, testee's head is coated with
Lead and be placed in sound proof box after sound cream, and low frequency acoustic sensor array is fixed on into testee's head, described vibration isolators and every
Audio amplifier, is the low frequency sound arrester formulated according to measured signal frequency requirement；
5) it is powered to electric magnet；
6) magnetoacoustic signals of brain electricity are gathered using low frequency acoustic sensor array, by magnetoacoustic signals relevant position brain electricity is obtained
The amplitude of signal and the information of frequency, and it is stored in computer；
7) according to Fig. 2, using phase computation system is postponed, the positional information of EEG signals is calculated, obtains sound distribution shadow
Picture；
8) testee's brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtained final
Audio and video.
The combination magnetosonic coupling of the present invention and the noinvasive biology EEG measuring method of sound source location technology, in externally-applied magnetic field
In the case of, producing the position of EEG signals can be subject to Lorentz force and produce vibrations.In the situation of the additional acoustic sensor array of cranium
Under, the generation position of corresponding brain electricity can be accurately positioned by sound localization technology.
Claims (3)
1. a kind of noinvasive biology EEG measuring method of combination magnetosonic coupling and sound source location technology, is that a kind of combined high-strength is quiet
The noinvasive biology EEG measuring method that magnetic field and all-bottom sound sensor array are carried out, it is characterised in that be by person's head to be tested
In magnetostatic field, the EEG signals of testee's head are subject to Lorentz force in magnetostatic field, and relevant position produce with
EEG signals amplitude-frequency identical vibration signal；Low frequency acoustic sensor array is fixed on into testee's head so as to measure shake
Dynamic signal.
2. combination magnetosonic according to claim 1 couples the noinvasive biology EEG measuring method with sound source location technology, its
It is characterised by, comprises the steps：
1) laboratory door and window is closed using Sound-proof material, and makes the sound proof box for accommodating testee's head, to shield
The noise of laboratory internal instrument；
2) noise of sound proof box internal medium is determined with sensor, computer is stored in；
3) whether sound proof box internal medium noise is judged less than the experiment noise threshold for setting, be then to enter next step, otherwise
Checking experiment room sound insulation state, return to step 2 after the hidden danger that abates the noise)
4) make testee lie low on the vibration isolators being located between upper and lower two blocks of electric magnet, testee's head is coated with and leads sound
It is placed in sound proof box after cream, and low frequency acoustic sensor array is fixed on into testee's head；
5) it is powered to electric magnet；
6) magnetoacoustic signals of brain electricity are gathered using low frequency acoustic sensor array, by magnetoacoustic signals relevant position EEG signals is obtained
Amplitude and frequency information, and be stored in computer；
7) using phase computation system is postponed, the positional information of EEG signals is calculated, obtains sound distribution image；
8) testee's brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtain final sound
Image.
3. combination magnetosonic according to claim 2 couples the noinvasive biology EEG measuring method with sound source location technology, its
Be characterised by, step 4) described in vibration isolators and sound proof box, be according to measured signal frequency requirement formulate low frequency sound arrester.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063055.0A CN106667483A (en) | 2017-01-26 | 2017-01-26 | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique |
| CN201710555927.5A CN107260168A (en) | 2017-01-26 | 2017-07-07 | The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063055.0A CN106667483A (en) | 2017-01-26 | 2017-01-26 | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106667483A true CN106667483A (en) | 2017-05-17 |
Family
ID=58860141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710063055.0A Withdrawn CN106667483A (en) | 2017-01-26 | 2017-01-26 | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique |
| CN201710555927.5A Pending CN107260168A (en) | 2017-01-26 | 2017-07-07 | The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710555927.5A Pending CN107260168A (en) | 2017-01-26 | 2017-07-07 | The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN106667483A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301915A (en) * | 2019-05-14 | 2019-10-08 | 武汉闻道复兴智能科技有限责任公司 | A kind of bladder muscle electrical signal detection device and detection system |
| TWI749796B (en) * | 2020-09-30 | 2021-12-11 | 瑞軒科技股份有限公司 | Resonance test system and resonance test method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112683992B (en) * | 2020-12-22 | 2022-05-17 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5402786A (en) * | 1992-09-11 | 1995-04-04 | James E. Drummond | Magneto-acoustic resonance imaging |
| EP1885243A4 (en) * | 2005-05-11 | 2014-05-21 | Univ Minnesota | Methods and apparatus for imaging with magnetic induction |
| CN102788836B (en) * | 2012-07-26 | 2015-06-24 | 中国科学院电工研究所 | Magneto-acoustic microscopic imaging method and imaging system |
| CN102860825B (en) * | 2012-10-16 | 2014-03-26 | 中国科学院电工研究所 | System and method of magnetosonic impedance imaging based on lorentz force mechanic effect |
| CN104483384B (en) * | 2014-12-14 | 2017-04-19 | 中国科学院电工研究所 | Magnetic-acoustic multi-field coupling imaging experiment device |
| CN105852814A (en) * | 2016-04-22 | 2016-08-17 | 中国医学科学院生物医学工程研究所 | Magnetic acoustic signal detecting and imaging system based on optical fiber F-P-cavity acoustic sensor |
-
2017
- 2017-01-26 CN CN201710063055.0A patent/CN106667483A/en not_active Withdrawn
- 2017-07-07 CN CN201710555927.5A patent/CN107260168A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301915A (en) * | 2019-05-14 | 2019-10-08 | 武汉闻道复兴智能科技有限责任公司 | A kind of bladder muscle electrical signal detection device and detection system |
| TWI749796B (en) * | 2020-09-30 | 2021-12-11 | 瑞軒科技股份有限公司 | Resonance test system and resonance test method |
| US11641462B2 (en) | 2020-09-30 | 2023-05-02 | Amtran Technology Co., Ltd. | Resonant testing system and resonant testing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107260168A (en) | 2017-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2010049B1 (en) | Ultrasound in magnetic spatial imaging apparatus | |
| CN104080397B (en) | Diagnostic system for detection of fluid changes | |
| CN102805621B (en) | Magnetic, acoustic and electric imaging system and imaging method | |
| CN106667483A (en) | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique | |
| HU218528B (en) | Device for controlling low-frequency electric and magnetic fields | |
| Wodicka et al. | Measurement of respiratory acoustic signals: effect of microphone air cavity depth | |
| CN112450935B (en) | Magnetocardiogram measuring method and system based on unshielded atom magnetometer | |
| CN107991634A (en) | magnetic resonance audio unit | |
| US9864023B2 (en) | Combined shim and RF coil arrangement | |
| US20200178827A1 (en) | Noise removal in magnetometer for medical use | |
| Janawadkar et al. | SQUID-based measurement of biomagnetic fields | |
| Herrmann et al. | MRI compatible small animal monitoring and trigger system for whole body scanners | |
| CN214174233U (en) | Positioning device with noise shielding and capable of detecting magnetoacoustic signal and electric field simultaneously | |
| Xiong et al. | A multi-channel high-speed magnetic field detection system based on FPGA for transcranial magnetic stimulation | |
| Rudd et al. | Evaluation of MRI compatible headphones for active noise control | |
| CN113080926A (en) | Coil detection type magnetoacoustic-electric imaging device and method | |
| CN113171098A (en) | Detection device and detection method for magnetoencephalography signals in cerebral oscillation | |
| CN117179787B (en) | Head wearing equipment for detecting auditory evoked potential and detection method thereof | |
| RU2636816C2 (en) | Rheological unit for mri with built-in oscillation generator and rf antenna | |
| Přibil et al. | Comparison of mechanical vibration and acoustic noise in the open-air MRI | |
| Chen et al. | Planar MIT sensor array with gradiometers for local hemorrhage detection | |
| CN112683992B (en) | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding | |
| CN117045255A (en) | Audio brain magnetic measurement system of multichannel SERF atomic magnetometer | |
| Souza et al. | A multi-channel TMS system enabling accurate stimulus orientation control during concurrent ultra-high-field MRI for preclinical applications | |
| WO2019073674A1 (en) | Noise generation source search device and noise generation source search method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170517 |
|
| WW01 | Invention patent application withdrawn after publication |