CN107260168A - The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic - Google Patents
The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic Download PDFInfo
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- CN107260168A CN107260168A CN201710555927.5A CN201710555927A CN107260168A CN 107260168 A CN107260168 A CN 107260168A CN 201710555927 A CN201710555927 A CN 201710555927A CN 107260168 A CN107260168 A CN 107260168A
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- sound
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- proof box
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- electromagnet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/06—Accessories for medical measuring apparatus
Abstract
The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic, device includes the power supply powered to N poles electromagnet and S poles electromagnet, vibration isolators and the sound proof box on vibration isolators are provided between N poles electromagnet and S poles electromagnet, sample is located in sound proof box, is additionally provided with the Tesla meter for detecting magnetic field intensity and the low frequency sound detection array module for detecting sample acoustical signal.Method includes：To laboratory sound insulation and make sound proof box；Determine the noise deposit computer of sound proof box internal environment；Judge sound proof box internal environment noise whether less than the experiment noise threshold set；Sample is coated with after leading sound cream and be placed in sound proof box, and low frequency acoustic sensor array is fixed on tested sample；It is powered to electromagnet；Corresponding information is obtained by magnetoacoustic signals and is stored in computer；The positional information of EEG signals is calculated, sound distribution image is obtained；Obtain final audio and video.The present invention can realize that the real-time of EEG signals is accurately positioned by multisensor.
Description
Technical field
The present invention relates to a kind of EEG measuring device.It is more particularly to a kind of by brain electricity, magnetosonic coupling technique, auditory localization
The coupling of combination magnetosonic and the EEG measuring device and monitoring method of auditory localization that technology is combined together.
Background technology
Cerebral nerve function is the content of current scientific research forefront.The wherein placement technology of EEG signals, more
It is the difficult point of brain science research.At present, the technology that scientific research field is used for the electric non-invasive measurement of brain is mainly scalp EEG (EEG),
The reasons such as the low electric conductivity because of skull, cause EEG spatial resolutions relatively low, it is impossible to be accurately positioned the position for occurring corresponding electric signal
Put.Other EEG measuring technologies, such as electrocorticogram (ECoG) and extracellular EEG measuring technology (LFP), are required for opening cranium
Bone is measured, and injures larger to subject, is the scientific research for not being suitable for carrying out human body.
Multiple nerve cells excitement simultaneously in brain certain area, which can be produced, can survey electric current, by Lip river under externally-applied magnetic field
Lun Zili and produce vibrations, formed sound source.Signal is gathered using acoustic sensor array outside cranium, can be to sound source position, i.e. brain
The position of electric signal is positioned.Brain electricity, magnetosonic coupling technique, auditory localization technology are combined together, and applied by the principle
The core that field is the present invention is accurately positioned in noninvasive EEG signals.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of combination magnetic for being studied cerebral nerve function
Acoustical coupling and the EEG measuring device and monitoring method of auditory localization.
The technical solution adopted in the present invention is：A kind of EEG measuring device of the coupling of combination magnetosonic and auditory localization, bag
Include N poles electromagnet and S poles electromagnet for providing sample magnetostatic field and N poles electromagnet and S poles electromagnet powered
Power supply, is provided with vibration isolators and the sound proof box on vibration isolators, the sample between N poles electromagnet and S poles electromagnet
In the sound proof box, the described sample of correspondence is separately provided for detecting the Tesla meter of magnetic field intensity and for detecting
The low frequency sound detection array module of sample acoustical signal.
Described low frequency sound detection array module includes the all-bottom sound for being used to detect sample acoustical signal set gradually and passed
Sensor array, the amplifier being amplified to the signal detected, the collection for carrying out triggering collection to the signal after amplification
Card, the computer for the data for collecting signal to be stored and shown.
Described vibration isolators and sound proof box are low frequency sound arrester.
Described low frequency acoustic sensor array is 5 × 5 microphone array, and is uniformly positioned on sample.
Thickness is posted on the inside of the tank wall of the sound proof box for 2mm deadening felts, thickness 30mm Sound-proof material is posted on the outside of tank wall.
A kind of monitoring method of the EEG measuring device of the coupling of combination magnetosonic and auditory localization, comprises the following steps：
1) laboratory door and window is closed using Sound-proof material, and makes the sound proof box for accommodating sample, to screening experiment
The noise of chamber interior instrument；
2) noise of sound proof box internal environment is determined with low frequency acoustic sensor array, computer is stored in；
3) judge that sound proof box internal environment noise, whether less than the experiment noise threshold set, is then to enter next step,
Otherwise return to step 2 after checking experiment room sound insulation state, the hidden danger that abates the noise)
4) sample is coated with to lead and be placed in after sound cream in sound proof box, and low frequency acoustic sensor array is fixed on tested sample
On；
5) it is powered to electromagnet；
6) using the electric magnetoacoustic signals of the brain of low frequency acoustic sensor array collecting sample, corresponding positions are obtained by magnetoacoustic signals
The amplitude of EEG signals and the information of frequency are put, and is stored in computer；
7) using delay phase computation system, the positional information of EEG signals is calculated, sound distribution image is obtained；
8) tested sample brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtained finally
Audio and video.
The combination magnetosonic coupling of the present invention and the EEG measuring device and monitoring method of auditory localization, by brain electricity, magnetosonic coupling
Conjunction technology, auditory localization technology are combined together, and being accurately positioned applied to noninvasive EEG signals.Due to being coupled by magnetosonic
The acoustical signal measurement EEG signals of generation, can realize that the real-time of EEG signals is accurately positioned by multisensor, the present invention
A kind of new measurement apparatus and method are provided for the related scientific research field of brain science.
Brief description of the drawings
Fig. 1 is the structural representation for the EEG measuring device that the present invention combines magnetosonic coupling and auditory localization；
Fig. 2 is the schematic flow sheet of acquisition EEG signals positional information in the present invention.
In figure
1：Power supply 2：N poles electromagnet and S poles electromagnet
3：Tesla meter 4：Sample
5：Vibration isolators 6：Sound proof box
7：Low frequency sound detection array module 71：Low frequency acoustic sensor array
72：Amplifier 73：Capture card
74：Computer
Embodiment
With reference to embodiment and accompanying drawing to the EEG measuring device of the coupling of combination magnetosonic and the auditory localization of the present invention and
Monitoring method is described in detail.
The present invention combination magnetosonic coupling and auditory localization EEG measuring device, be a kind of combined high-strength magnetostatic field and
The noninvasive biological brain electrical measurement that all-bottom sound sensor array is carried out, is that testee head is located at into as shown in Figure 1 quiet
In magnetic field, the EEG signals on testee head are produced and brain telecommunications in magnetostatic field by Lorentz force, and in relevant position
Number amplitude-frequency identical vibration signal；Low frequency acoustic sensor array is fixed on to the head of testee, so as to measure vibrations
Signal.The present invention, due to coupling the acoustical signal measurement EEG signals produced by magnetosonic, can realize brain electricity by multisensor
The real-time of signal is accurately positioned.
The combination magnetosonic coupling of the present invention and the EEG measuring device of auditory localization, as shown in figure 1, including for sample
4 (testee heads) provide the N poles electromagnet and S poles electromagnet 2 of magnetostatic field and N poles electromagnet and S poles electromagnet 2 are supplied
The power supply 1 of electricity, is provided with vibration isolators 5 for shielding noise and positioned at shockproof between N poles electromagnet and S poles electromagnet 2
Sound proof box 6 on platform 5, the sample 4 is located in the sound proof box 6, and described vibration isolators 5 and sound proof box 6 fill for low frequency sound insulation
Put.The described sample 4 of correspondence is separately provided for detecting the Tesla meter 3 of magnetic field intensity and for detecting the acoustical signal of sample 4
It is accurately positioned the low frequency sound detection array module 7 of shock position.
Described low frequency sound detection array module 7 includes the all-bottom sound for being used to detect sample acoustical signal set gradually and passed
Sensor array 71, the amplifier 72 that is amplified to the signal detected, for carrying out triggering collection to the signal after amplification
Capture card 73, the computer 74 for the data for collecting signal to be stored and shown.Described low frequency sound sensor array
Row 71 are 5 × 5 microphone arrays, and are uniformly positioned on sample 4.
In the EEG measuring device of the coupling of combination magnetosonic and the auditory localization of the present invention, the power supply 1 for output current can
To use but be not limited to the electric matt HY-17 power supplys of Beijing state or the general XD-30K power supplys of Changchun English；The electromagnet 2 is used for basis
Different supply currents, produces the magnetic fields of different magnetic induction intensity in testee head, can use but be not limited to Changchun
English general SBV-300 or SBV-380；The Tesla meter 3 is used for the monitoring for realizing magnetic field, and the magnetic induction in display magnetic field is strong in real time
Degree, can use but be not limited to U.S. Lakeshore 475, or space ring Thailand 931 in Qingdao；Described low frequency acoustic sensor array 71
For obtaining vibration signal, it can use but be not limited to 16 Bruel＆The 4955 of company's production constitute 4*4 square battle array
Row are uniformly arranged in sensor distance 2cm on scalp；Amplification module 72 can use but be not limited to Bruel＆Company produces
Pre-amplifying module 2690 and AR companies of the U.S. production power amplifier 500A250C maximum amplifications can reach
80dB；Capture card 23 is changed for data acquisition modulus, can use but be not limited to the data acquisition system of NI companies of U.S. production
Unite PXI5122,5922.
Described sound proof box 6 is used but is not limited to long 300mm, and wide 300mm, thick 5mm lucite is processed, internal
Thickness 2mm deadening felts are sticked, thickness 30mm Sound-proof material is sticked in outside.Vibration isolators 5, can use but be not limited to Wuhan Air China generation
The customization vibration isolators of Ji companies production, size is long 500mm, wide 500mm, thick 200mm, height 500mm.
In the EEG measuring device of the coupling of combination magnetosonic and the auditory localization of the present invention, N poles electromagnet and S poles electromagnet 2
The magnetic field magnetic induction line direction (z-axis direction in such as Fig. 1) of generation is vertical with the direction of described low frequency sound detection array module 7.Magnetic
The vector product direction for feeling the direction of line direction EEG signals is acoustic vibration direction.Need to be determined according to the direction of the electric current phasor of brain
Testee head placing direction.
Testee head EEG signals result from EEG signals in magnetostatic field by Lorentz force, and in relevant position
Amplitude-frequency identical vibration signal；Low frequency acoustic sensor array is fixed on this i.e. measurable signal of sample to be tested head.This
Invention, due to coupling the acoustical signal measurement EEG signals produced by magnetosonic, can realize EEG signals by multisensor
Real-time is accurately positioned.
The monitoring method that the EEG measuring of the coupling of combination magnetosonic and the auditory localization of the present invention is filled, comprises the following steps：
1) for shielding castle outside noise, laboratory door and window is closed using Sound-proof material, and made for accommodating sample
The sound proof box on this (testee head), the noise to shielding castle interior instrument；
2) noise of sound proof box internal environment is determined with low frequency acoustic sensor array, computer is stored in；
3) judge that sound proof box internal environment noise, whether less than the experiment noise threshold set, is then to enter next step,
Otherwise return to step 2 after checking experiment room sound insulation state, the hidden danger that abates the noise)
4) testee is made to lie low on the vibration isolators between two blocks of electromagnet up and down, by sample (testee's head
Portion) be coated with lead sound cream after be placed in sound proof box, and low frequency acoustic sensor array is fixed on tested sample, described is shockproof
Platform and sound proof box, are the low frequency sound arresters formulated according to measured signal frequency requirement；
5) it is powered to electromagnet；
6) using the electric magnetoacoustic signals of the brain of low frequency acoustic sensor array collecting sample, corresponding positions are obtained by magnetoacoustic signals
The amplitude of EEG signals and the information of frequency are put, and is stored in computer；
7) according to Fig. 2, using delay phase computation system, the positional information of EEG signals is calculated, sound distribution shadow is obtained
Picture；
8) tested sample brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtained finally
Audio and video.
The combination magnetosonic coupling of the present invention and the EEG measuring device and monitoring method of auditory localization, in the feelings of externally-applied magnetic field
Under condition, producing the position of EEG signals by Lorentz force and can produce vibrations.In the case of the additional acoustic sensor array of cranium,
The generation position of corresponding brain electricity can be accurately positioned by auditory localization technology.
Claims (6)
1. a kind of combination magnetosonic coupling and the EEG measuring device of auditory localization, including for providing sample (4) N of magnetostatic field
Pole electromagnet and S poles electromagnet (2) and the power supply (1) powered to N poles electromagnet and S poles electromagnet (2), it is characterised in that
Vibration isolators (5) and the sound proof box (6) on vibration isolators (5), institute are provided between N poles electromagnet and S poles electromagnet (2)
Sample (4) is stated in the sound proof box (6), the described sample (4) of correspondence is separately provided for detecting the spy of magnetic field intensity
Si La counts (3) and the low frequency sound detection array module (7) for detecting sample (4) acoustical signal.
2. combination magnetosonic coupling according to claim 1 and the EEG measuring device of auditory localization, it is characterised in that described
Low frequency sound detection array module (7) include being used for of setting gradually and detect the low frequency acoustic sensor array of sample acoustical signal
(71) amplifier (72), being amplified to the signal detected, the collection for carrying out triggering collection to the signal after amplification
Block (73), the computer (74) for the data for collecting signal to be stored and shown.
3. combination magnetosonic coupling according to claim 1 and the EEG measuring device of auditory localization, it is characterised in that described
Vibration isolators (5) and sound proof box (6) be low frequency sound arrester.
4. combination magnetosonic coupling according to claim 2 and the EEG measuring device of auditory localization, it is characterised in that described
Low frequency acoustic sensor array (71) be 5 × 5 microphone array, and be uniformly positioned on sample (4).
5. combination magnetosonic coupling according to claim 1 and the EEG measuring device of auditory localization, it is characterised in that described
Thickness is posted on the inside of the tank wall of sound proof box (2) for 2mm deadening felts, thickness 30mm Sound-proof material is posted on the outside of tank wall.
6. a kind of monitoring method of the EEG measuring device of the coupling of combination magnetosonic and auditory localization described in claim 1, it is special
Levy and be, comprise the following steps：
1) laboratory door and window is closed using Sound-proof material, and makes the sound proof box for accommodating sample, in screening experiment room
The noise of portion's instrument；
2) noise of sound proof box internal environment is determined with low frequency acoustic sensor array, computer is stored in；
3) judge that sound proof box internal environment noise, whether less than the experiment noise threshold set, is then to enter next step, otherwise
Return to step 2 after checking experiment room sound insulation state, the hidden danger that abates the noise)
4) sample is coated with to lead and be placed in after sound cream in sound proof box, and low frequency acoustic sensor array is fixed on tested sample；
5) it is powered to electromagnet；
6) using the electric magnetoacoustic signals of the brain of low frequency acoustic sensor array collecting sample, pass through magnetoacoustic signals and obtain relevant position brain
The amplitude of electric signal and the information of frequency, and it is stored in computer；
7) using delay phase computation system, the positional information of EEG signals is calculated, sound distribution image is obtained；
8) tested sample brain structure image is obtained using MRI or CT, and is superimposed with sound distribution image, obtain final sound
Image.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN2017100630550 | 2017-01-26 | ||
| CN201710063055.0A CN106667483A (en) | 2017-01-26 | 2017-01-26 | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique |
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| CN201710555927.5A Pending CN107260168A (en) | 2017-01-26 | 2017-07-07 | The EEG measuring device and monitoring method with auditory localization are coupled with reference to magnetosonic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112683992A (en) * | 2020-12-22 | 2021-04-20 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
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| CN110301915A (en) * | 2019-05-14 | 2019-10-08 | 武汉闻道复兴智能科技有限责任公司 | A kind of bladder muscle electrical signal detection device and detection system |
| TWI749796B (en) | 2020-09-30 | 2021-12-11 | 瑞軒科技股份有限公司 | Resonance test system and resonance test method |
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- 2017-07-07 CN CN201710555927.5A patent/CN107260168A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112683992A (en) * | 2020-12-22 | 2021-04-20 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
| CN112683992B (en) * | 2020-12-22 | 2022-05-17 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
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