CN117179787B - Head wearing equipment for detecting auditory evoked potential and detection method thereof - Google Patents
Head wearing equipment for detecting auditory evoked potential and detection method thereof Download PDFInfo
- Publication number
- CN117179787B CN117179787B CN202311460714.6A CN202311460714A CN117179787B CN 117179787 B CN117179787 B CN 117179787B CN 202311460714 A CN202311460714 A CN 202311460714A CN 117179787 B CN117179787 B CN 117179787B
- Authority
- CN
- China
- Prior art keywords
- auditory
- signal
- head
- aep
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000763 evoking effect Effects 0.000 title claims abstract description 32
- 238000001514 detection method Methods 0.000 title abstract description 17
- 238000004458 analytical method Methods 0.000 claims abstract description 52
- 238000012545 processing Methods 0.000 claims abstract description 42
- 210000004556 brain Anatomy 0.000 claims abstract description 37
- 230000006870 function Effects 0.000 claims abstract description 37
- 230000005291 magnetic effect Effects 0.000 claims abstract description 26
- 238000010219 correlation analysis Methods 0.000 claims abstract description 24
- 238000011156 evaluation Methods 0.000 claims abstract description 23
- 230000000638 stimulation Effects 0.000 claims abstract description 23
- 210000005036 nerve Anatomy 0.000 claims abstract description 21
- 230000003068 static effect Effects 0.000 claims abstract description 9
- 230000004044 response Effects 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 25
- 230000008569 process Effects 0.000 claims description 15
- 238000012544 monitoring process Methods 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 9
- 230000007177 brain activity Effects 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 210000000860 cochlear nerve Anatomy 0.000 claims description 4
- 230000001934 delay Effects 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 210000003901 trigeminal nerve Anatomy 0.000 claims description 3
- 210000003273 vestibular nerve Anatomy 0.000 claims description 3
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 238000003066 decision tree Methods 0.000 description 6
- 230000005856 abnormality Effects 0.000 description 5
- 210000003710 cerebral cortex Anatomy 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000000653 nervous system Anatomy 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 239000011295 pitch Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000000133 brain stem Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 229910001172 neodymium magnet Inorganic materials 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 238000012307 MRI technique Methods 0.000 description 1
- QJVKUMXDEUEQLH-UHFFFAOYSA-N [B].[Fe].[Nd] Chemical compound [B].[Fe].[Nd] QJVKUMXDEUEQLH-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 210000003984 auditory pathway Anatomy 0.000 description 1
- 208000027115 auditory system disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Abstract
The invention discloses a head wearing device for detecting auditory evoked potential and a detection method thereof, comprising the following steps: a wearing component, an auditory stimulation component, a main magnet, a processor, a positioning component and a processing module. The head wearing equipment is adopted, and an auditory stimulation component, a main magnet and a radio frequency coil are arranged on the head wearing equipment, so that auditory stimulation is realized, a static magnetic field is generated, and radio frequency pulses are received. The main magnet, the radio frequency coil and the processor are utilized twice, the head nerve image with high resolution can be acquired for the first time, the accurate positioning of the electrode plate is realized, the second time is used for forming a BOLD signal for providing the activity level of the brain region, the AEP potential signal and the BOLD signal are utilized for carrying out time-course feature analysis, spatial distribution feature analysis and correlation analysis, and the comprehensive evaluation of the hearing function is carried out, and the comprehensive evaluation provides the comprehensive evaluation of the hearing function.
Description
Technical Field
The invention relates to a diagnostic instrument, in particular to a diagnostic instrument for auditory stimulation, and specifically relates to head wearing equipment for auditory evoked potential detection and a detection method thereof.
Background
Auditory evoked potentials are bioelectric responses of the central nervous system caused by stimulation of the auditory nervous system, after acoustic stimulation is received by the human ear, the auditory nervous system and the cerebral cortex produce a series of electrophysiological responses, and the auditory evoked potentials are extracted from various noise-intensive backgrounds by utilizing various digital signal processing algorithms, namely auditory brainstem evoked potentials, which are important indexes for evaluating the integrity of auditory conduction systems and monitoring the functions of the nervous system and can be classified into auditory brainstem responses, medium latency responses and late latency responses according to latency, and are one of important means for researching auditory diseases, and are commonly used for passive aural hearing examinations of otorhinolaryngology.
Conventional auditory evoked potential detection devices employ independent sound stimulation equipment and electroencephalogram acquisition equipment, and test patients by the mutual cooperation of the two, however, auditory evoked potential detection devices in the prior art have the following problems: 1. the bonding positions of the electrode plates are mostly manually bonded by operators, the bonding positions are approximate positions, and the selected positions can possibly cause poor obtained signal waveforms to influence the detection effect; 2. the conventional device evaluates auditory functions mainly by recording the potential changes generated by neurons after receiving acoustic stimuli, and this method can detect whether the transmission of auditory signals is normal, but cannot provide detailed information about auditory areas in the cerebral cortex, and cannot fully reflect auditory functions.
Accordingly, there is a need for improvements in the detection of auditory functions in the prior art to address the above-described problems.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides head wearing equipment for detecting auditory evoked potentials and a detection method thereof.
In order to achieve the above purpose, the invention adopts the following technical scheme: a head-worn device for auditory evoked potential detection, comprising:
a wear assembly for securing a head, comprising: the device comprises a frame body and a plurality of elastic belts connected with the frame body;
an auditory stimulus component for stimulating an auditory response; comprising the following steps: a movable electrode sheet provided on the frame, and sound stimulation units provided on both sides of the frame;
a main magnet disposed at one side of the wearing assembly for generating a static magnetic field;
the radio frequency coil is used for generating and receiving radio frequency pulses and is connected to the elastic belts;
a processor for receiving and integrating the radio frequency pulses output from the radio frequency coil and converting them into MRI images;
the positioning component is used for controlling the movable electrode plate to move to a designated nerve position according to the image;
the processing module comprises an acquisition unit, a characteristic extraction unit and an evaluation unit which are connected in sequence; the acquisition unit is used for acquiring an AEP potential signal of the electrode slice and a BOLD signal output by the processor, the feature extraction unit is used for extracting key features, and the evaluation unit sequentially uses the key features to perform time-course feature analysis, spatial distribution feature analysis and correlation analysis and comprehensively evaluate hearing functions;
wherein, the time-course characteristic analysis refers to analysis of the time characteristics of the AEP potential signal and the BOLD signal; the spatial distribution characteristic analysis refers to the analysis of the processing path and the active region of the auditory stimulus in the brain; the correlation analysis is to calculate the correlation between the AEP potential signal and the BOLD signal.
In a preferred embodiment of the present invention, the main magnet includes: superconducting magnets and permanent magnets for generating a stable and uniform static magnetic field having a magnetic field strength of 1.5T-3T.
In a preferred embodiment of the present invention, the radio frequency coil is connected to the signal generator, the amplifier, the data acquisition system and the processor sequentially through a cable connection, and the connection mode is cable connection or wireless connection.
In a preferred embodiment of the present invention, the positioning assembly comprises: a stereotactic system, a registration unit and a control unit; the three-dimensional positioning system is used for scanning the face and acquiring three-dimensional structure information of the face; the registration unit adopts an image registration algorithm to align the coordinate systems of the face image and the MRI image and form electrode slice positioning information; the control unit is used for controlling the movable electrode slice to move to a designated nerve position.
In a preferred embodiment of the present invention, the sound stimulation unit is configured to play different types of sound stimulation to stimulate the auditory system response, wherein the different types include, but are not limited to: sound click stimulus, sound pulse stimulus, sound tone stimulus, and sound voice stimulus.
In a preferred embodiment of the present invention, the elastic band has a strip structure, and includes: the elastic part is arranged at two sides of the middle part; the middle parts of the elastic bands are fixed, and the elastic parts are connected with different positions of the frame body.
In a preferred embodiment of the present invention, the designated nerve is a nerve associated with the auditory system, including an auditory nerve, a vestibular nerve, or a trigeminal nerve.
In a preferred embodiment of the present invention, the evaluation unit considers that the auditory function is normal if the results of the time-course feature analysis, the spatial distribution feature analysis and the correlation analysis indicate that the response process of the auditory stimulus in the brain is normal according to the results of the time-course feature analysis, the spatial distribution feature analysis and the correlation analysis; if any one or more of the displays are abnormal, the hearing function is indicated to be problematic.
In a preferred embodiment of the present invention, the key features include: waveform characteristics, phase delays, and amplitude variations.
In a preferred embodiment of the present invention, a massage unit is further connected to the top of the plurality of elastic bands, and the massage unit is concentrically arranged with the frame.
In a preferred embodiment of the present invention, the evaluation unit of the processor includes: the system comprises a time course characteristic analysis module, a spatial distribution characteristic analysis module, a correlation analysis module and a comprehensive evaluation module; the time course feature analysis module may be implemented using a signal processing algorithm, such as a fourier transform or wavelet transform processing algorithm; the spatial distribution characteristic analysis module can be realized by using a frequency spectrum analysis or a time-frequency analysis algorithm or a chip, such as a DSP chip, an FPGA chip or a CWT chip; the correlation analysis module can be realized through a general signal processing chip, such as a DSP chip or an FPGA chip, and the calculation of the Pearson correlation coefficient is realized through programming; the comprehensive evaluation module can use a decision tree model, can take results of time course feature analysis, spatial distribution feature analysis and correlation analysis as features of a decision tree, takes auditory functions as classification labels, and can obtain a classifier for judging whether auditory functions are normal by training the decision tree model.
The invention solves the defects existing in the background technology, and has the following beneficial effects:
according to the invention, the head wearing equipment is adopted, and the auditory stimulation component, the main magnet and the radio frequency coil are arranged on the head wearing equipment, so that auditory stimulation, static magnetic field generation and radio frequency pulse reception can be realized, the equipment can accurately control the movable electrode plate to move to a designated nerve position according to the MRI image, and the accuracy of the measured AEP potential signal measurement is ensured.
The invention utilizes the main magnet, the radio frequency coil and the processor twice, can acquire the head nerve image with high resolution for the first time, realizes the accurate positioning of the electrode plate, is used for forming the BOLD signal for providing the activity level of the brain region for the second time, utilizes the AEP potential signal and the BOLD signal for carrying out time course feature analysis, space distribution feature analysis and correlation analysis, and carries out comprehensive evaluation on the hearing function, and the comprehensive evaluation provides the comprehensive evaluation on the hearing function.
The wearing assembly provided by the invention considers the ergonomics principle, adopts the annular frame body with adjustable size and the elastic belt, can provide stable support and fix the head, can adapt to different head sizes and shapes, ensures that the equipment is tightly attached to the head and is not easy to slide or loose, and has the advantages of stability, comfort, adjustability and quick fixing and releasing.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present invention, and other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art;
fig. 1 is a schematic structural view of a head-wearing device for auditory evoked potential monitoring according to a preferred embodiment of the present invention;
FIG. 2 is a schematic diagram of auditory evoked potential monitoring in accordance with a preferred embodiment of the present invention;
FIG. 3 is a flow chart of a method of acquiring an image of the cranial nerve using a main magnet, a radio frequency coil and a processor according to a preferred embodiment of the present invention;
FIG. 4 is a flow chart of a method of evaluating auditory function using a BOLD signal and an AEP potential signal in accordance with a preferred embodiment of the invention;
in the figure: 1. a frame; 2. moving the clamping strip; 3. an elastic belt; 4. a bracket; 5. a movable electrode sheet; 6. a sound stimulation unit; 7. a radio frequency coil; 8. a massage unit.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those described herein, and therefore the scope of the present invention is not limited to the specific embodiments disclosed below.
In the description of the present application, it should be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the scope of protection of the present application.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application can be understood by those of ordinary skill in the art in a specific context.
As shown in fig. 1 and 2, a schematic structural diagram and a schematic diagram of a head-wearing device for auditory evoked potential monitoring according to the present invention are shown. The head wearing device for auditory evoked potential detection comprises: a wearing component, an auditory stimulation component, a main magnet, a radio frequency coil 7, a processor and a positioning component.
The wearing component is used for fixing the head and comprises: a frame 1, and a plurality of elastic bands 3 connected with the frame 1.
In the invention, the frame body 1 is of an annular structure, and the frame body 1 is placed around the head to provide a stable supporting structure. The frame 1 has certain flexibility and can be made of plastic materials. The frame body 1 is provided with a telescopic function, in one embodiment, a movable clamping strip 2 is arranged on one side of the frame body 1, and the movement of the movable clamping strip 2 can be controlled by a motor, so that the movable clamping strip can adapt to different head sizes and shapes, and the fixation of different heads is realized. By using such a wearing assembly, the head can be effectively fixed so as to be stable. The annular frame 1 design may also provide additional comfort and adaptability, making the wearing assembly more ergonomic.
The elastic band 3 has a strip-shaped structure, and two ends of the elastic band are respectively connected with the frame body 1 for fixing the frame body 1 on the head. The elastic band 3 includes: the elastic parts are arranged at two sides of the middle part; the intermediate portions of the several elastic bands 3 are always fixed together, while the elastic portions are used for connection with different positions of the frame 1. The middle part is made of hard materials which are not easy to deform, and can be made of plastic materials, leather materials and the like; the elastic portion is made of a soft and elastic material, and in one embodiment the elastic band 3 is rubber or an elastic fabric.
The number of elastic bands 3 here is 3-6 for connection to different locations of the frame 1 to provide uniform fixing force and stability. In some embodiments, a sliding type adjuster, a torsion type adjuster, or a magic tape is used to change the length of the elastic part, to tighten or loosen the elastic part, to adapt to different head sizes and shapes, and to provide proper tension. These means of attachment allow easy adjustment and fixing of the elastic band 3 and quick release as required.
The elastic band 3 and the frame body 1 of the present invention play a role in fixing and stabilizing the head in the wearing assembly, and their softness and elasticity enable them to adapt to different head shapes and sizes and provide a comfortable fixing feeling.
According to the wearable assembly, the support 4 can be arranged at the bottom of the frame body 1, the support 4 is rotatably connected with the frame body 1, and the support 4 can also increase the stability of the frame body 1 and prevent the frame body from tilting or shaking in the use process.
In one embodiment, the massage unit 8 is provided on the elastic band 3 of the wearing assembly, the massage unit 8 being arranged concentrically with the frame 1.
The main magnet of the present invention includes: superconducting and permanent magnets for generating a stable and uniform static magnetic field for magnetizing nuclei in a human body under examination, the static magnetic field having a magnetic field strength of 1.5T-3T.
The superconducting magnet herein is a magnet that generates a strong magnetic field by conducting current through a superconducting material, and can generate a strong magnetic field without energy loss. The superconducting magnet needs to use a cryogenic coolant such as liquid nitrogen or liquid helium to maintain a superconducting state. A permanent magnet is a magnet that generates a magnetic field using a permanent magnetic material. These magnets are made of a ferromagnetic material, such as neodymium iron boron (NdFeB) or cobalt magnets (SmCo), which can produce a permanent magnetic field without the need for an external power source. By combining the superconducting magnet and the permanent magnet together, the superconducting magnet provides a higher magnetic field strength, while the permanent magnet provides a more stable magnetic field, achieving a higher magnetic field strength and better stability.
In one embodiment, the main magnet of the present invention is placed inside a magnet saddle, which is annular or semi-annular in shape to accommodate the shape of the head. The head of the person to be examined is placed in the central position of the magnet saddle to ensure that the magnetic field generated by it can cover the head area of the person to be examined. Wherein the superconducting magnet is arranged at the central position of the magnet saddle and maintains a superconducting state by a cooling system of liquid nitrogen or liquid helium; and a permanent magnet is disposed around the superconducting magnet to provide a more stable magnetic field.
Here, the magnet saddle is arranged around the outside of the head or wearing component, and is not in contact with the head or wearing component, and the head is ensured to be positioned at the central position of the magnet saddle during detection.
The radio frequency coil 7 in the present invention is a device for generating and receiving radio frequency signals, which is made of a wire or coil, the shape of which includes, but is not limited to, circular, elliptical or square. The radio frequency coil 7 is connected to the intermediate portions of the plurality of elastic bands 3 at crossing positions.
The rf coil 7 serves to generate rf pulses and receive signals, one of which the main magnet generates a static magnetic field, and the rf coil 7 serves to generate an alternating magnetic field of a specific frequency, i.e. rf pulses. The RF pulse magnetizes atomic nuclei in the examined human tissue, providing a necessary signal source for subsequent signal reception; secondly, the rf coil 7 is used for receiving signals, and when rf pulses act on nuclei in human head tissue, the nuclei release signals. The radio frequency coil 7 receives these signals and converts them into electrical signals.
The radio frequency coil 7 is connected to other devices, such as a signal generator, an amplifier or a data acquisition system, by means of a cable, which may be a cable connection or a wireless connection.
The signal generator in the present invention is a device for generating a signal of a specific frequency and amplitude. In a radio frequency coil 7 system, a signal generator may provide an input signal for exciting the radio frequency coil 7 to generate an electromagnetic field of a particular frequency and amplitude. The frequency of the signal generator is 127.8MHz-199.3MHz. The amplifier is used in a radio frequency coil 7 system to boost the amplitude of the signal. The amplifier may amplify the lower power signal generated by the signal generator to the required power level to ensure that the output of the radio frequency coil 7 system meets the detection requirements. The data acquisition system is used for acquiring and recording the output signals of the radio frequency coil 7 system. Thus, the signal generator, amplifier and data acquisition system work cooperatively in the radio frequency coil 7 system for generating and controlling radio frequency signals.
The processor of the present invention is used for receiving and integrating the radio frequency pulse output from the radio frequency coil 7, converting the radio frequency pulse into an image, and displaying the image in a display mode. Specifically, the data acquisition system acquires and records the output signal of the radio frequency coil 7 system and transmits the output signal to the processor.
After the processor receives the radio frequency signals, a series of signal processing and image reconstruction algorithms are performed to convert the radio frequency signals into MRI images. These algorithms include fourier transforms, filtering, image reconstruction in the spatial and frequency domains, etc. The processor digitizes, filters, denoises, etc. the signals, and then reconstructs the processed data into an image to generate a final MRI image.
In addition, the processor may post-process the image, such as enhancing contrast, noise reduction, spatial resolution enhancement, etc., to improve image quality and visualization. The processor outputs the processed image to a display.
The invention can help doctors to accurately locate nerves through the MRI images. MRI techniques can provide high resolution anatomical images that can clearly show the location, orientation, and relationship of nerves.
Next, a method for acquiring an image of the head nerve using the main magnet, the radio frequency coil 7 and the processor will be described as an example, as shown in fig. 3, and the specific steps are as follows:
a1, placing the head of a person to be detected in the center of a magnet saddle, and ensuring that a magnetic field generated by a main magnet can cover the head area of a detected human body, wherein the strength of the magnetic field is 3T; connecting the radio frequency coil 7 to a signal generator, an amplifier and a data acquisition system through cables;
a2, turning on a power supply of the signal generator, inputting a 199.3MHz radio frequency pulse frequency value on an interface of the signal generator, wherein the amplitude of the radio frequency pulse is 80 volts, and confirming the setting and starting the signal generator;
a3, amplifying the lower power signal generated by the signal generator to a power level of 200W by using an amplifier;
a4, the data acquisition system acquires and records the output signal of the radio frequency coil 7 system;
and A5, after the processor receives the radio frequency signals, performing a series of signal processing and image reconstruction algorithms to convert the radio frequency signals into MRI images, and outputting the MRI images to a display, so that the images of the head nerves can be obtained.
By means of the main magnet, the radio frequency coil 7 and the processor in the device described above, the head can be scanned and neuro-images generated, which show the internal structure and the nerve distribution of the head, providing a reference for the subsequent electrode slice positioning.
The invention scans the face by using a three-dimensional positioning system to acquire three-dimensional structure information of the face. Registering the obtained three-dimensional structure information with the MRI image, thereby realizing accurate electrode slice positioning. The stereotactic system herein may be a 3D scanning device, laser scanning or other facial scanning technique.
In one embodiment, a stereotactic system includes: camera, tracking unit and computer software; the camera is used for capturing images of the face, is arranged in front of the tester, and can capture the images of the face at different angles and visual angles by using a plurality of cameras so as to acquire more accurate three-dimensional structure information. The tracking unit is used for tracking the position and the posture of the camera, determining the position and the direction of the camera relative to the head of the patient, and registering the facial image with the MRI image.
The computer software is used for processing and analyzing the facial image captured by the camera and generating three-dimensional structure information of the face.
In the registration process, an image registration algorithm is used to align the coordinate systems of the facial image and the MRI image, thereby mapping the electrode slice positioning information to the anatomy of the MRI image. Among them, image registration algorithms include, but are not limited to, using point-to-point registration, feature point matching, or morphological registration.
After the registration process, the invention can be used for driving the movable electrode sheet 5 on the wearing assembly to position the movable electrode sheet 5 around the appointed nerve by utilizing the registered electrode sheet positioning information.
The driving method of the movable electrode piece 5 and the frame 1 in the present invention may be implemented by a mechanical or electric driver. In one embodiment, a mechanical device is provided on the frame 1, and the position of the electrode plate is controlled by a motor or other driving device, where the mechanical device may be a gear device or a sliding rail device, etc. In one embodiment, the electric energy is converted into a driving force pushing the movable electrode sheet 5 to move on the frame body 1 by the action of electric power or a magnetic field using an electric motor or a linear actuator. Such a device may be connected to an external power source via an electric wire, and when the power source is turned on, an electric motor or a linear actuator drives the movable electrode sheet 5 to move on the frame body 1.
The nerve designated in the present invention is a nerve associated with the auditory system, and may be an auditory nerve, vestibular nerve or trigeminal nerve. Here, the auditory nerve is preferred, which always transmits at the highest speed in auditory evoked potential detection, ensuring that auditory stimulus signals are transmitted to the brain in the shortest time, thereby generating corresponding auditory evoked potential responses. The rapid transmission speed can reduce delay of signal transmission, improve real-time performance, and help to more accurately locate and activate specific nerve regions, which means that signals can reach a target region more quickly, thereby improving detection accuracy and real-time performance.
The auditory stimulation assembly according to the present invention further comprises sound stimulation units 6 arranged on both sides of the housing 1, wherein the sound stimulation units 6 may be audio devices such as headphones or speakers. The auditory system is stimulated by playing different types of sound stimuli, including but not limited to: sound click stimulus, sound pulse stimulus, sound tone stimulus, and sound voice stimulus.
By using different types of sound stimuli, the processing and response of the auditory system of the test person to different stimulus characteristics, such as short sound clicks, sound pulses of a specific frequency and amplitude, sounds of different tones or pitches, speech segments or words, can be determined, as can the sensitivity of the auditory system, the response speed, the pitch coding capability and the processing and understanding capability of the speech information. By combining different types of sound stimuli, the functional state of the auditory system can be more comprehensively evaluated, and more accurate information is provided for the evaluation of auditory ability.
It should be noted that the sound click stimulus is a short sound click, such as a short pulse sound or a short audio clip, played to excite the auditory system to respond. The sound pulse stimulus is a response that excites the auditory system by playing sound pulses of a particular frequency and amplitude. Acoustic tone stimulation is by playing sounds with different tones or pitches to excite the auditory system's response. Acoustic speech stimulation is by playing a segment of speech or word to evoke a response from the auditory system.
In the auditory evoked process, after stimulating the response of the auditory system with different types of acoustic stimuli, electrode pads are typically connected to an electrographic meter for recording electrophysiological signals triggered by the auditory stimuli.
Since the stimulus is transmitted to the cortex by external sound stimulus during auditory induction, not to the nerve by the cortex. Specifically, external sound stimuli are first received by the ear and transmitted through the auditory pathway to the auditory area of the cerebral cortex. In the auditory area, stimulation triggers the activation of neurons and produces corresponding electrophysiological signals, such as Auditory Evoked Potentials (AEP). Thus, for the detection of Auditory Evoked Potentials (AEP), it is necessary to detect simultaneously the electrical signals of the electrode pads, the auditory area activity of the cerebral cortex, and the connectivity between them.
In auditory evoked potential monitoring, the magnetic field generated by the main magnet polarizes the hydrogen nuclei in the human body and generates a signal. When an external rf coil 7 applies an rf pulse, the hydrogen nuclei absorb energy and resonate, and the auditory stimulus causes an increase in blood flow in the auditory area, resulting in a change in hemodynamic response BOLD signals. By analyzing these changes in BOLD signals, functional activity of auditory areas in the cerebral cortex can be deduced.
As shown in fig. 4, the present invention employs a BOLD signal and an AEP potential signal to evaluate auditory functions, and the method specifically includes the steps of:
b1: time course characteristic analysis: processing the monitored BOLD signal and AEP potential signal, extracting key features, and analyzing the key features to obtain time course features of auditory stimulus in brain, wherein the key features comprise: waveform characteristics, phase delay, and amplitude variation;
b2: analyzing the spatial distribution characteristics: comparing the spatial distribution of the BOLD signal and the AEP potential signal, observing the spatial distribution of brain activity caused by auditory stimulus, and determining the processing path and active region of auditory stimulus in the brain;
b3: correlation analysis was performed: calculating the correlation between the BOLD signal and the AEP potential signal, and evaluating the consistency and the correlation degree between the BOLD signal and the AEP potential signal;
b4: in combination with analyzing the time course characteristics, spatial distribution characteristics and correlations of the BOLD signal and the AEP potential signal, the transmission, processing and response processes of auditory stimuli in the brain are evaluated.
The time course characteristic analysis in the invention B1 refers to analysis of the time characteristics of an Auditory Evoked Potential (AEP) signal and a BOLD signal, wherein the time characteristics reflect waveform characteristics, phase delay and amplitude variation; wherein the Auditory Evoked Potential (AEP) signal reflects the electrophysiological response of the neuron to the auditory stimulus, and the BOLD signal reflects the degree and sensitivity of the brain region to the stimulus of hearing.
And B1, processing the monitored BOLD signal and the AEP potential signal, and extracting key characteristics including waveform characteristics, phase delay and amplitude variation. By processing and analyzing the signals, the time course characteristics of the auditory stimuli in the brain, i.e. their duration, delay and intensity variations, are obtained.
Specifically, the phase delay of the AEP potential signal appears as a delay or offset of the waveform, and the amplitude variation of the AEP potential signal appears as an amplitude variation of the waveform; in one embodiment, according to the waveform form, determining a time difference of the phase delay by comparing the starting point of the stimulation signal and the starting point of the AEP waveform, and obtaining the characteristic of the phase delay of the AEP potential signal; the amplitude variation of the AEP potential signal is characterized by comparing the peak size of the AEP waveform or the amplitude variation of the waveform to determine the degree of the amplitude variation according to the waveform form.
In particular, the phase delay of the BOLD signal refers to the time delay required to communicate neural information between different brain regions; the amplitude variation of the BOLD signal appears as a variation in the intensity of brain activity. In one embodiment, the time domain analysis is performed on the BOLD signal to extract waveform characteristics of the BOLD signal, including peak values, time intervals between peak and valley, and periodicity of the waveform; the method comprises the steps of obtaining phase delay among different brain areas by carrying out cross-correlation analysis on BOLD signals of a plurality of brain areas, and obtaining the phase delay characteristic of the BOLD signals; amplitude variation characteristics of brain activities are extracted by performing amplitude adjustment, normalization and other processing on the BOLD signals, and the amplitude variation characteristics of the BOLD signals are obtained.
By analyzing the BOLD signal and the AEP potential signal separately, the function and state of the auditory system can be evaluated. For example, if there is an abnormality in the phase delay or amplitude variation of the BOLD signal or the AEP potential signal or a significant difference from the normal population, it may indicate that there is a problem with the function of the auditory system.
In step B2, the spatial distribution feature analysis in B2 uses the key features extracted in B1, and determines the processing path and active region of auditory stimulus in brain by analyzing BOLD signal intensity and activation degree of different brain regions. Meanwhile, comparing the amplitude and phase delay of the AEP potential signal of the brain region to obtain the processing path and the active region of the auditory stimulus in the brain. And comprehensively analyzing the spatial distribution characteristics of the BOLD signal and the AEP potential signal to obtain the transmission, processing and response processes of the auditory stimulus in the brain, and evaluating the functions and states of the auditory system.
In the above B3 of the present invention, the correlation analysis is to calculate the correlation between the BOLD signal and the AEP potential signal to evaluate the degree of consistency and the correlation therebetween. B3 is a feature vector between the BOLD signal and the AEP potential signal using the key features extracted in B1, such as waveform feature, phase delay, and amplitude variation.
In one embodiment, pearson correlation coefficients of characteristic variables of the BOLD signal and the AEP potential signal are calculated. If the correlation coefficient is close to 1, the two variables have strong positive correlation; if the correlation coefficient is close to-1, the two variables have strong negative correlation; if the correlation coefficient is close to 0, it means that there is no linear relationship between the two variables. In practical applications, the evaluation unit may use special data analysis software or programming languages to implement the above-described calculation and analysis steps.
In evaluating auditory function, time course characteristics of the processed BOLD signal and AEP potential signal, such as response delay, duration, and amplitude variation, are observed. If the time course characteristics of the two signals show consistent changes under the auditory stimulus, namely response delay and duration are similar, and amplitude change trend is consistent, the auditory function can be considered to be normal; if there is a significant time course characteristic difference, it may indicate that there is an abnormality in auditory function. And comparing the spatial distribution of the BOLD signal and the AEP potential signal, and observing the spatial distribution of brain activity caused by auditory stimulus. If the spatial distribution characteristics of the two signals are similar, namely, the two signals are displayed actively in similar brain areas, the auditory function can be considered to be normal; if there is a significant spatial distribution difference, it may indicate that there is an abnormality in auditory function. And calculating the correlation between the BOLD signal and the AEP potential signal, and evaluating the consistency and the correlation degree between the BOLD signal and the AEP potential signal. If there is a high correlation between the two signals, indicating that they have consistent results in assessing auditory function, a low correlation may indicate that there is an abnormality in auditory function.
In step B4, the time course profile in B1, the spatial distribution profile in B2 and the correlation profile in B3 are combined to comprehensively evaluate the transmission, processing and response processes of auditory stimuli in the brain.
Firstly, the time course characteristics of the auditory stimulus in the brain are obtained through time course characteristic analysis, wherein the time course characteristics comprise waveform characteristics, phase delay and amplitude change, and the response mode and the change trend of the auditory stimulus in time are reflected.
Secondly, the spatial distribution of brain activities caused by auditory stimulus is obtained through spatial distribution feature analysis, wherein the spatial distribution of brain activities caused by auditory stimulus comprises a processing path and an active region, and the response modes and the spatial distribution of auditory stimulus in different brain regions in the brain are reflected. Finally, through correlation analysis, the correlation between the BOLD signal and the AEP potential signal is calculated, and the consistency and the degree of correlation between the BOLD signal and the AEP potential signal are obtained, so that the consistency and the consistency of the transmission and the processing process of the auditory stimulus in the brain are reflected. By combining the analysis results of the three aspects, the transmission, processing and response processes of the auditory stimulus in the brain can be more comprehensively evaluated, and then the functions and states of the auditory system can be evaluated.
In one embodiment, hearing function may be considered normal if the results of the time course profile, the spatial distribution profile, and the correlation profile all indicate that the hearing stimulus is responding normally in the brain; if any one or more of the aspects show an abnormality, this may indicate a problem with auditory function.
The links between steps B1-B4 are complementary and supportive, together forming a complete analysis procedure for revealing the course and activity of auditory stimuli in the brain.
The above steps are all performed for a comprehensive assessment of the delivery, processing and response of auditory stimuli in the brain. Time-course feature analysis in B1 the time-course characteristics of auditory stimuli in the brain are obtained by extracting waveform features, phase delays and amplitude variations of the AEP potential signal and the BOLD signal. B2-B3 respectively utilize the key characteristics extracted in B1, B2 determines the processing path and the active region of auditory stimulus in the brain by comparing the spatial distribution of the BOLD signal and the AEP potential signal, and correlation analysis in B3 calculates the correlation between the BOLD signal and the AEP potential signal and evaluates the consistency and the degree of correlation between the BOLD signal and the AEP potential signal; b4 combines the time course characteristics, the spatial distribution characteristics and the correlation analysis results to comprehensively evaluate the transmission, processing and response processes of the auditory stimulus in the brain. These steps are interrelated, together, more comprehensive and accurate, with the results of the assessment of the delivery, processing and response processes of auditory stimuli in the brain, and thus the function and status of the auditory system.
In one embodiment, the steps B1 to B4 are implemented by a processing module, where the processing module includes an acquisition unit, a feature extraction unit, and an evaluation unit that are sequentially connected;
the acquisition unit is used for acquiring the AEP potential signal of the electrode slice and the BOLD signal output by the processor; the feature extraction unit is used for extracting key features including waveform features, phase delay and amplitude variation of the BOLD signal and the AEP potential signal; the evaluation unit sequentially performs time course feature analysis, spatial distribution feature analysis and correlation analysis, and comprehensively evaluates auditory functions.
The processing module may be implemented in hardware, for example using a dedicated signal processing chip or a hardware device such as an FPGA (field programmable gate array), or in software, for example using a programming language and a library of related algorithms. The processing module can process and analyze the obtained BOLD signal and AEP potential signal and output the evaluation result no matter in hardware or software implementation.
In one embodiment, the evaluation unit of the processor includes: the system comprises a time course characteristic analysis module, a spatial distribution characteristic analysis module, a correlation analysis module and a comprehensive evaluation module. The time course feature analysis module can be implemented by using a signal processing algorithm, such as a Fourier transform or wavelet transform processing algorithm; the spatial distribution characteristic analysis module can be realized by using a frequency spectrum analysis or a time-frequency analysis algorithm or a chip, such as a DSP chip, an FPGA chip or a CWT chip; the correlation analysis module can be realized through a general signal processing chip, such as a DSP chip or an FPGA chip, and the calculation of the Pearson correlation coefficient is realized through programming; the comprehensive evaluation module can use a decision tree model, can take results of time course feature analysis, spatial distribution feature analysis and correlation analysis as features of a decision tree, takes auditory functions as classification labels, and can obtain a classifier for judging whether auditory functions are normal by training the decision tree model.
The above-described preferred embodiments according to the present invention are intended to suggest that, from the above description, various changes and modifications can be made by the person skilled in the art without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (9)
1. A head-worn device for auditory evoked potential monitoring, comprising:
a wear assembly for securing a head, comprising: the device comprises a frame body and a plurality of elastic belts connected with the frame body;
an auditory stimulus component for stimulating an auditory response; comprising the following steps: a movable electrode sheet provided on the frame, and sound stimulation units provided on both sides of the frame;
a main magnet disposed at one side of the wearing assembly for generating a static magnetic field;
the radio frequency coil is used for generating and receiving radio frequency pulses and is connected to the elastic belts;
a processor for receiving and integrating the radio frequency pulses output from the radio frequency coil and converting them into MRI images;
the positioning component is used for controlling the movable electrode plate to move to a designated nerve position according to the image;
the processing module comprises an acquisition unit, a characteristic extraction unit and an evaluation unit which are connected in sequence; the acquisition unit is used for acquiring the AEP potential signal of the electrode slice and the BOLD signal output by the processor, the feature extraction unit is used for extracting key features, and the evaluation unit sequentially uses the key features to perform
Time course feature analysis, spatial distribution feature analysis and correlation analysis, and comprehensively evaluating auditory functions;
wherein, the time-course characteristic analysis refers to analysis of the time characteristics of the AEP potential signal and the BOLD signal; the spatial distribution characteristic analysis refers to the analysis of the processing path and the active region of the auditory stimulus in the brain; the correlation analysis is to calculate the correlation between the AEP potential signal and the BOLD signal;
wherein, adopt BOLD signal and AEP potential signal to assess hearing function comprehensively, include the following steps:
b1: time course characteristic analysis: processing the monitored BOLD signal and AEP potential signal, extracting key features, and analyzing the key features to obtain time course features of auditory stimulus in brain, wherein the key features comprise: waveform characteristics, phase delay, and amplitude variation;
b2: analyzing the spatial distribution characteristics: comparing the spatial distribution of the BOLD signal and the AEP potential signal, observing the spatial distribution of brain activity caused by auditory stimulus, and determining the processing path and active region of auditory stimulus in the brain;
b3: correlation analysis was performed: calculating the correlation between the BOLD signal and the AEP potential signal, and evaluating the consistency and the correlation degree between the BOLD signal and the AEP potential signal;
b4: in combination with analyzing the time course characteristics, spatial distribution characteristics and correlations of the BOLD signal and the AEP potential signal, assessing the transmission, processing and response processes of auditory stimuli in the brain;
the evaluation unit is used for judging whether the auditory function is normal according to the results of the time course feature analysis, the spatial distribution feature analysis and the correlation analysis, if the results of the time course feature analysis, the spatial distribution feature analysis and the correlation analysis show that the response process of the auditory stimulus in the brain is normal; if any one or more of the displays are abnormal, the hearing function is indicated to be problematic.
2. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the main magnet includes: superconducting magnets and permanent magnets for generating a stable and uniform static magnetic field having a magnetic field strength of 1.5T-3T.
3. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the radio frequency coil is sequentially connected with the signal generator, the amplifier, the data acquisition system and the processor through cables, and the connection mode is cable connection or wireless connection.
4. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the positioning assembly includes: a stereotactic system, a registration unit and a control unit; the three-dimensional positioning system is used for scanning the face and acquiring three-dimensional structure information of the face; the registration unit adopts an image registration algorithm to align the coordinate systems of the face image and the MRI image and form electrode slice positioning information; the control unit is used for controlling the movable electrode slice to move to a designated nerve position.
5. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the sound stimulation unit is used to play different types of sound stimuli to evoke a response of the auditory system, including but not limited to: sound click stimulus, sound pulse stimulus, sound tone stimulus, and sound voice stimulus.
6. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the elastic band is a strip structure, including: the elastic part is arranged at two sides of the middle part; the middle parts of the elastic bands are fixed, and the elastic parts are connected with different positions of the frame body.
7. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the designated nerve is a nerve associated with the auditory system, including an auditory nerve, vestibular nerve, or trigeminal nerve.
8. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the key features include: waveform characteristics, phase delays, and amplitude variations.
9. The head-wearing device for auditory evoked potential monitoring according to claim 1, wherein: the tops of the elastic belts are also connected with massage units, and the massage units are concentrically arranged with the frame body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311460714.6A CN117179787B (en) | 2023-11-06 | 2023-11-06 | Head wearing equipment for detecting auditory evoked potential and detection method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311460714.6A CN117179787B (en) | 2023-11-06 | 2023-11-06 | Head wearing equipment for detecting auditory evoked potential and detection method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117179787A CN117179787A (en) | 2023-12-08 |
| CN117179787B true CN117179787B (en) | 2024-02-06 |
Family
ID=88994570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311460714.6A Active CN117179787B (en) | 2023-11-06 | 2023-11-06 | Head wearing equipment for detecting auditory evoked potential and detection method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117179787B (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06269423A (en) * | 1993-03-18 | 1994-09-27 | Hitachi Ltd | Nuclear magnetic resonator |
| WO1995021591A1 (en) * | 1994-02-09 | 1995-08-17 | University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic |
| US5842980A (en) * | 1993-12-28 | 1998-12-01 | Hitachi Medical Corporation | Magnetic resonance inspecting method and apparatus |
| US6195576B1 (en) * | 1998-03-09 | 2001-02-27 | New York University | Quantitative magnetoencephalogram system and method |
| WO2013026749A1 (en) * | 2011-08-24 | 2013-02-28 | Universite Libre De Bruxelles | Method of locating eeg and meg sensors on a head |
| CN103052012A (en) * | 2011-10-14 | 2013-04-17 | 奥迪康有限公司 | Automatic real-time hearing aid fitting based on auditory evoked potentials |
| US8593141B1 (en) * | 2009-11-24 | 2013-11-26 | Hypres, Inc. | Magnetic resonance system and method employing a digital squid |
| DE102013215521A1 (en) * | 2013-08-07 | 2015-02-12 | Siemens Aktiengesellschaft | Method for recording EEG data describing acoustically evoked potentials and magnetic resonance apparatus |
| WO2015138981A1 (en) * | 2014-03-14 | 2015-09-17 | ElectroCore, LLC | Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation |
| CN116504214A (en) * | 2023-06-28 | 2023-07-28 | 南昌大学第一附属医院 | Craniomagnetic stimulus masking noise generating device, electronic apparatus, and storage medium |
| WO2023177907A1 (en) * | 2022-03-18 | 2023-09-21 | Cognito Therapeutics, Inc. | Methods and systems for predicting treatment outcomes, patient selection and personalized therapy using patient response properties to sensory stimulation |
| WO2023197043A1 (en) * | 2022-04-14 | 2023-10-19 | The Bionics Institute Of Australia | Systems, methods and devices for assessing hearing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8684926B2 (en) * | 2008-02-25 | 2014-04-01 | Ideal Innovations Incorporated | System and method for knowledge verification utilizing biopotentials and physiologic metrics |
-
2023
- 2023-11-06 CN CN202311460714.6A patent/CN117179787B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06269423A (en) * | 1993-03-18 | 1994-09-27 | Hitachi Ltd | Nuclear magnetic resonator |
| US5842980A (en) * | 1993-12-28 | 1998-12-01 | Hitachi Medical Corporation | Magnetic resonance inspecting method and apparatus |
| WO1995021591A1 (en) * | 1994-02-09 | 1995-08-17 | University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic |
| US6195576B1 (en) * | 1998-03-09 | 2001-02-27 | New York University | Quantitative magnetoencephalogram system and method |
| US8593141B1 (en) * | 2009-11-24 | 2013-11-26 | Hypres, Inc. | Magnetic resonance system and method employing a digital squid |
| US10509084B1 (en) * | 2009-11-24 | 2019-12-17 | Hypres, Inc. | Magnetic resonance system and method employing a digital SQUID |
| WO2013026749A1 (en) * | 2011-08-24 | 2013-02-28 | Universite Libre De Bruxelles | Method of locating eeg and meg sensors on a head |
| CN103052012A (en) * | 2011-10-14 | 2013-04-17 | 奥迪康有限公司 | Automatic real-time hearing aid fitting based on auditory evoked potentials |
| DE102013215521A1 (en) * | 2013-08-07 | 2015-02-12 | Siemens Aktiengesellschaft | Method for recording EEG data describing acoustically evoked potentials and magnetic resonance apparatus |
| WO2015138981A1 (en) * | 2014-03-14 | 2015-09-17 | ElectroCore, LLC | Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation |
| WO2023177907A1 (en) * | 2022-03-18 | 2023-09-21 | Cognito Therapeutics, Inc. | Methods and systems for predicting treatment outcomes, patient selection and personalized therapy using patient response properties to sensory stimulation |
| WO2023197043A1 (en) * | 2022-04-14 | 2023-10-19 | The Bionics Institute Of Australia | Systems, methods and devices for assessing hearing |
| CN116504214A (en) * | 2023-06-28 | 2023-07-28 | 南昌大学第一附属医院 | Craniomagnetic stimulus masking noise generating device, electronic apparatus, and storage medium |
Non-Patent Citations (1)
| Title |
|---|
| Stephen D. Mayhew等.《EEG signatures of auditory activity correlate with simultaneously recorded fMRI responses in humans》.《NeuroImage》.2010,第49卷(第1期),849-864页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117179787A (en) | 2023-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hari et al. | Neuromagnetic steady‐state responses to auditory stimuli | |
| US11083401B2 (en) | Electric field encephalography: electric field based brain signal detection and monitoring | |
| US9636019B2 (en) | Device for use in electro-biological signal measurement in the presence of a magnetic field | |
| EP0827714B1 (en) | Device for the derivation of acoustically evoked cerebral potentials | |
| US20160143541A1 (en) | System and Method For Acousto-Electromagnetic Neuroimaging | |
| Mayhew et al. | EEG signatures of auditory activity correlate with simultaneously recorded fMRI responses in humans | |
| US20090105581A1 (en) | Ultrasound in magnetic spatial imaging apparatus | |
| KR20130135303A (en) | Personal eeg monitoring device with electrode validation | |
| CN109645999A (en) | It is a kind of that ultrasonic Neuroimaging methods are focused through cranium based on the 4D of acoustoelectric effect | |
| Zhou et al. | Coding biological current source with pulsed ultrasound for acoustoelectric brain imaging: application to vivo rat brain | |
| CN117179787B (en) | Head wearing equipment for detecting auditory evoked potential and detection method thereof | |
| Milner et al. | Towards neural correlates of auditory stimulus processing: a simultaneous auditory evoked potentials and functional magnetic resonance study using an odd-ball paradigm | |
| Ha et al. | Optimized individual mismatch negativity source localization using a realistic head model and the Talairach coordinate system | |
| WO2010112825A2 (en) | Nervous system monitoring method | |
| CN106667483A (en) | Noninvasive biological electroencephalography measurement method combining magnetoacoustic coupling with sound source localization technique | |
| CN114287944B (en) | Electrical stimulation induced nerve magnetic signal acquisition and analysis device and method | |
| Talavage et al. | Preliminary fMRI evidence for tonotopicity in human auditory cortex | |
| CN111643110A (en) | Electroencephalogram detection device based on focused ultrasound spatial coding | |
| CN117898677A (en) | Auditory nerve characterization device based on brain magnetic diagram and functional magnetic resonance imaging | |
| Souza et al. | A multi-channel TMS system enabling accurate stimulus orientation control during concurrent ultra-high-field MRI for preclinical applications | |
| Poudel et al. | Multimodal Neuroimaging with Simultaneous fMRI and EEG | |
| Song et al. | Phantom experiment-based validation for time-varying acoustoelectric brain imaging with non-stationary current source characteristics | |
| Laurinoja | Feasibility of EEG phase-triggered closed-loop TMS–EEG–MRI experiments | |
| Fokapu et al. | An experimental setup to characterize MR switched gradient-induced potentials | |
| Ginsberg | A Multi-Channel EEG Mini-Cap for Recording Auditory Brainstem Responses in Chinchillas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |