CN117045255A - Audio brain magnetic measurement system of multichannel SERF atomic magnetometer - Google Patents
Audio brain magnetic measurement system of multichannel SERF atomic magnetometer Download PDFInfo
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- CN117045255A CN117045255A CN202311038573.9A CN202311038573A CN117045255A CN 117045255 A CN117045255 A CN 117045255A CN 202311038573 A CN202311038573 A CN 202311038573A CN 117045255 A CN117045255 A CN 117045255A
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- 210000004556 brain Anatomy 0.000 title claims abstract description 57
- 238000005259 measurement Methods 0.000 title claims abstract description 18
- 230000008859 change Effects 0.000 claims abstract description 27
- 230000005284 excitation Effects 0.000 claims abstract description 18
- 238000002582 magnetoencephalography Methods 0.000 claims abstract description 16
- 230000006870 function Effects 0.000 claims description 17
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- 239000000523 sample Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 8
- 230000005389 magnetism Effects 0.000 claims description 4
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- 210000003625 skull Anatomy 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 238000001514 detection method Methods 0.000 abstract description 3
- 238000003384 imaging method Methods 0.000 abstract description 2
- 238000013480 data collection Methods 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 229910052734 helium Inorganic materials 0.000 description 4
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- 241000238366 Cephalopoda Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
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- 238000001816 cooling Methods 0.000 description 2
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- 238000010146 3D printing Methods 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/245—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
- A61B5/246—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals using evoked responses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/245—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/30—Assessment of water resources
Abstract
An audio magnetoencephalography measuring system of a multichannel SERF atomic magnetometer comprises a multichannel SERF magnetometer which is placed in a clamping groove of a wearable nonmagnetic helmet and is clung to a brain auditory function area. The upper computer controls the acquisition card to output sine or wave signals, and sound is played through the sound box to provide sound stimulus with different amplitudes, frequencies and times for volunteers positioned in the magnetic shielding room. The excitation can enable the auditory function of the brain to generate signals of magnetic field change, and then the signals are detected by the multichannel SERF atomic magnetometer and collected by the multichannel data collection card device to the upper computer. The invention has the advantages of detection integration, miniaturization and high sensitivity, and is suitable for the fields of detection medical treatment, brain magnetic measurement imaging and the like.
Description
Technical Field
The invention relates to the field of brain magnetic measurement technology and medical diagnosis, in particular to an audio brain magnetic measurement system of a multichannel SERF atomic magnetometer.
Background
Compared with other brain functional area imaging technologies, the brain magnetic measurement technology has the greatest advantages that the brain magnetic has higher time and spatial resolution and can track the neural activity of the brain in real time. The magnetoencephalography is a completely non-invasive measurement process, which provides a new thought for the research of the brain field in modern medicine, and is widely applied to judging brain function injury at present, and the magnetoencephalography plays an important role in clinical medicine such as brain function positioning before craniocerebral operation. The magnetoencephalography signals are about one billion of geomagnetic field, and the measuring difficulty is extremely high, so that the magnetoencephalography requires extremely high sensitivity of a detector, and at present, a superconducting quantum interferometer (Superconducting quantuminterference devices, superconducting quantum interferometer) and a SERF atomic magnetometer (Spin-Exchange Relaxation-Free, no Spin-exchange collision relaxation) are mainly arranged in an instrument capable of realizing magnetoencephalography.
SQUID magnetometers must function properly in ultra-low temperature environments, thus requiring liquid helium cooling. The necessary liquid helium brings huge manufacturing cost and maintenance cost, on the other hand, the liquid helium environment maintained by the Dewar bottle generally needs to occupy 2-4 cm of space, the magnetic field rapidly decays along with the increase of the distance, and the detection distance is not negligible in the extremely weak brain magnetic measurement. The atomic magnetometer can work at normal temperature, does not need liquid helium cooling, has sensitivity close to that of the SQUID magnetometer, is easy to miniaturize, and is the preference for replacing the SQUID magnetometer at present.
The brain excitation signals are intersected with other excitation signals, such as color, emotion and the like, so that the brain excitation signals generated by the brain are stimulated to generate magnetoencephalic differences, and the research on magnetoencephalic signals generated by the brain through audio excitation is relatively less, on one hand, the brain excitation signals are limited by a measuring instrument, and the sensitivity of the instrument cannot meet the requirements of measuring the magnetoencephalic signals through audio excitation; on the other hand, the brain magnetic signals generated by the excitation of the audio signals have no complete system design, and the measurement of the brain magnetic signals involves a plurality of key technical links such as stimulation, data acquisition of hardware equipment, processing and outputting of software signal algorithms, evaluation and comparison of results and the like.
At present, human brain research mainly includes methods such as electroencephalogram, nuclear magnetic resonance and the like, but most of the methods are not vector measurement, and many important information cannot be obtained. And the measurement of the magnetic field can be vector, and the measurement of the magnetoencephalography can obtain richer and more comprehensive information. Has important effects on the problems of human cognition brain, pathogenesis of serious brain diseases, focus determination and the like.
Disclosure of Invention
In order to overcome the problems, the invention provides an audio brain magnetic measurement system of a multichannel SERF atomic magnetometer.
The technical scheme adopted by the invention is as follows: an audio brain magnetic measurement system of a multichannel SERF atomic magnetometer comprises a magnetic shielding room (1) for shielding an external environment magnetic field, a wearable helmet (6) arranged in the magnetic shielding room (1), a multichannel SERF atomic magnetometer (2) and a loudspeaker, a multichannel acquisition card (4) arranged outside the magnetic shielding room (1), a Labview upper computer (5) and a sound box (3);
the wearable helmet (6) is provided with a clamping groove at a position corresponding to the brain hearing function region, and the probe of the multichannel SERF atomic magnetometer (2) is arranged in the clamping groove and clings to the brain hearing function region; the SERF atomic magnetometer (2) is electrically connected with the multichannel acquisition card (4), and the multichannel acquisition card (4) is electrically connected with the Labview upper computer (5);
the loudspeaker is electrically connected with the sound box (3), and the sound box (3) is electrically connected with the Labview upper computer (5) through the multichannel acquisition card (4); the Labview upper computer (5) controls the sound box (3) to change the amplitude, frequency and time parameters of the audio played by the loudspeaker (7) to excite the brain in the magnetic shielding room (1); the excitation enables the auditory function of the brain to generate a magnetic field change signal, and then the magnetic field change signal is detected by the multichannel SERF atomic magnetometer (2);
the SERF atomic magnetometer (2) transmits the detected magnetic field change signal to the multichannel acquisition card (4), and the multichannel acquisition card (4) transmits the magnetic field change signal to the Labview upper computer (5); and the Labview upper computer (5) processes the received magnetic field change signal to obtain magnetoencephalography information.
Further, the magnetic shielding house (1) is made of multiple layers of permalloy so as to shield an external environment magnetic field; the residual magnetic field of the head space in the magnetic shielding room (1) is about 2nT, and the magnetic field gradient is less than 15nT/m.
Furthermore, the working mode of the multichannel SERF atomic magnetometer (2) is a biaxial working mode, and the multichannel SERF atomic magnetometer (2) can acquire brain magnetic signals in two directions perpendicular to and parallel to the skull.
Further, the residual magnetism of the magnetic shielding room (1) is smaller than 10nT.
Further, the SERF atomic magnetometers (2) of the channels have no crosstalk.
The beneficial effects of the invention are as follows:
(1) The multichannel SERF atomic magnetometer clings to a brain hearing function area, the sound source board card controlled by the upper computer can excite the brain in the magnetic shielding room by changing parameters such as amplitude, frequency, time and the like of the audio, the excitation can enable the hearing function of the brain to generate signals of magnetic field change, the multichannel SERF atomic magnetometer is further detected, the multichannel data acquisition card equipment acquires the upper computer, the process of acquiring data can not only change parameters such as amplitude, frequency, period change and the like of sound by changing the sound source board card, but also set excitation time, and the acquired time is convenient for processing the excitation and magnetic field change process.
(2) The invention has the core components of a multichannel SERF magnetometer, which consists of a plurality of independent, integrated and miniaturized single-channel SERF magnetometers, the number of probes can be set according to actual requirements, the vector measurement of brain auditory function areas can be accurately realized, and further, brain information of the auditory function areas can be obtained through brain magnetism generated by audio excitation, thereby having important roles in medical diagnosis, pathogenesis of hearing and the like.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic diagram of the assembly of the wearable helmet and SERF atomic magnetometer probe of the invention.
Reference numerals illustrate: 1. magnetic shielding house; 2. multichannel SERF atomic magnetometers; 3. a sound box; 4. a multichannel acquisition card; 5. a Labview upper computer; 6. a wearable helmet.
Detailed Description
The following description of the embodiments of the present invention will be made more apparent and fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be noted that, as the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like are used for convenience in describing the present invention and simplifying the description based on the azimuth or positional relationship shown in the drawings, it should not be construed as limiting the present invention, but rather should indicate or imply that the devices or elements referred to must have a specific azimuth, be constructed and operated in a specific azimuth. Furthermore, the terms "first," "second," "third," and the like, as used herein, are used for descriptive purposes only and are not to be construed as indicating or implying any relative importance.
In the description of the present invention, it should be noted that unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" should be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Referring to the drawings, an audio brain magnetic measurement system of a multichannel SERF atomic magnetometer is characterized in that: the magnetic shielding room comprises a magnetic shielding room 1 for shielding the magnetic field of the external environment, a wearable helmet 6 arranged in the magnetic shielding room 1, a multichannel SERF atomic magnetometer 2, a loudspeaker, a multichannel acquisition card 4 arranged outside the magnetic shielding room 1, a Labview upper computer 5 and a sound box 3;
the wearable helmet 6 is provided with a clamping groove at a position corresponding to the brain hearing function region, and the probe of the multichannel SERF atomic magnetometer 2 is arranged in the clamping groove and clings to the brain hearing function region; the SERF atomic magnetometer 2 is electrically connected with the multichannel acquisition card 4, and the multichannel acquisition card 4 is connected with the Labview upper computer 5;
the loudspeaker is electrically connected with the loudspeaker box 3, and the loudspeaker box 3 is electrically connected with the Labview upper computer 5 through the multichannel acquisition card 4; the Labview upper computer 5 controls the loudspeaker 3 to change the amplitude, frequency and time parameters of the audio played by the loudspeaker 7, and excites the brain in the magnetic shielding room 1; the excitation enables the auditory function of the brain to generate magnetic field change signals, and then the signals are detected by the multichannel SERF atomic magnetometer 2;
the SERF atomic magnetometer 2 transmits the detected magnetic field change signal to the multichannel acquisition card 4, and the multichannel acquisition card 4 transmits the magnetic field change signal to the Labview upper computer 5; and the Labview upper computer 5 processes the received magnetic field change signal to obtain magnetoencephalography information.
In the embodiment of the invention, the magnetic shielding room material is multi-layer permalloy, so that the magnetic shielding room material can effectively shield the external environment magnetic field, shield the residual magnetic field of the head space of the indoor volunteer by about 2nT, and the magnetic field gradient is less than 15nT/m. Meets the working environment requirement of the multichannel SERF atomic magnetometer.
In the embodiment of the invention, the working mode of the multichannel SERF atomic magnetometer is a biaxial working mode, the magnetoencephalic signals in two directions perpendicular to and parallel to the skull can be acquired, and the multichannel SERF atomic magnetometers can collect more magnetic signals in auditory sense and the brain area acted by the auditory sense.
In the embodiment of the invention, the Labview program control needs to realize two functions, on one hand, a multichannel acquisition card needs to be controlled to acquire magnetic field change data of the multichannel SERF atomic magnetometer; on the other hand, the acquisition card is required to be synchronously controlled to output an analog signal to the sound box, the sound box is used for outputting audio after amplifying the analog signal, and the amplitude, the frequency and the stimulation time parameters of the audio are all controlled to be output through a Labview upper computer program.
In the embodiment of the invention, the multichannel acquisition card can effectively acquire the magnetic field change signal of the multichannel SERF atomic magnetometer while outputting the analog signal.
In the embodiment of the invention, the multichannel acquisition card can synchronously control the sound box, and the parameter can be changed for a plurality of times through the upper computer to stimulate the brain.
In an embodiment of the invention, the residual magnetism of the magnetic shielding room is smaller than 10nT.
In the embodiment of the invention, crosstalk does not exist among the SERF atomic magnetometers of all the channels.
In embodiments of the present invention, the multichannel SERF atomic magnetometer is placed as much as possible in the auditory functional area of the brain.
In the embodiment of the invention, the sound box and the multichannel data acquisition card are all arranged outside the magnetic shielding room.
In the embodiment of the invention, the labview program can control parameters such as amplitude, frequency, period and the like of the audio, and can keep data synchronization with the acquisition of the multichannel data acquisition card.
According to the invention, the SERF atomic magnetometer probe 2 is placed in a clamping groove of the wearable helmet 6 and is clung to a brain hearing function area, the sound box 3 controlled by the upper computer 5 is used for exciting the brain positioned in the magnetic shielding room 1 by changing parameters such as amplitude, frequency and time of audio, the excitation can enable the hearing function of the brain to generate a signal of magnetic field change, the signal is further detected by the multichannel SERF atomic magnetometer 2, the multichannel data acquisition card 4 equipment is used for acquiring the upper computer 5, the acquisition card can realize the acquisition of multichannel brain magnetic signals while outputting analog audio signals, the process of acquiring data can be used for stimulating the brain hearing area by changing different parameters such as amplitude, frequency and period change of sound through changing the sound box 3, so that different types of magnetic field information can be obtained as much as possible, the excitation time and the acquisition time can be set, and the excitation and magnetic field change process can be conveniently processed.
The brain magnetic measurement steps are as follows:
(1) The 3D printing helmet 6 which can be inserted into the SERF atomic magnetometer probe and is wearable is designed and used, so that the atomic magnetometer probe is as close to the scalp of the brain as possible, and aerogel is used for heat insulation treatment, so that the brain is prevented from being scalded by the probe.
(2) The upper computer 5 controls the multichannel acquisition card 4 system, and the triaxial SERF magnetometer probe 2 is used for measuring the magnetoencephalic signals;
(3) And processing the measured magnetoencephalography information to obtain magnetoencephalography.
The embodiments described in the present specification are merely examples of implementation forms of the inventive concept, and the scope of protection of the present invention should not be construed as being limited to the specific forms set forth in the embodiments, and the scope of protection of the present invention and equivalent technical means that can be conceived by those skilled in the art based on the inventive concept.
Claims (5)
1. An audio frequency brain magnetic measurement system of multichannel SERF atom magnetometer which characterized in that: the magnetic shielding system comprises a magnetic shielding room (1) for shielding the magnetic field of the external environment, a wearable helmet (6) arranged in the magnetic shielding room (1), a multichannel SERF atomic magnetometer (2) and a loudspeaker, a multichannel acquisition card (4) arranged outside the magnetic shielding room (1), a Labview upper computer (5) and a sound box (3);
the wearable helmet (6) is provided with a clamping groove at a position corresponding to the brain hearing function region, and the probe of the multichannel SERF atomic magnetometer (2) is arranged in the clamping groove and clings to the brain hearing function region; the SERF atomic magnetometer (2) is electrically connected with the multichannel acquisition card (4), and the multichannel acquisition card (4) is electrically connected with the Labview upper computer (5);
the loudspeaker is electrically connected with the sound box (3), and the sound box (3) is electrically connected with the Labview upper computer (5) through the multichannel acquisition card (4); the Labview upper computer (5) controls the sound box (3) to change the amplitude, frequency and time parameters of the audio played by the loudspeaker (7) to excite the brain in the magnetic shielding room (1); the excitation enables the auditory function of the brain to generate a magnetic field change signal, and then the magnetic field change signal is detected by the multichannel SERF atomic magnetometer (2);
the SERF atomic magnetometer (2) transmits the detected magnetic field change signal to the multichannel acquisition card (4), and the multichannel acquisition card (4) transmits the magnetic field change signal to the Labview upper computer (5); and the Labview upper computer (5) processes the received magnetic field change signal to obtain magnetoencephalography information.
2. An audio magnetoencephalography system of a multichannel SERF atomic magnetometer according to claim 1, wherein: the magnetic shielding house (1) is made of multi-layer permalloy to shield an external environment magnetic field; the residual magnetic field of the head space in the magnetic shielding room (1) is about 2nT, and the magnetic field gradient is less than 15nT/m.
3. An audio magnetoencephalography system of a multichannel SERF atomic magnetometer according to claim 1, wherein: the multichannel SERF atomic magnetometer (2) is in a double-shaft working mode, and the multichannel SERF atomic magnetometer (2) can acquire brain magnetic signals in two directions perpendicular to and parallel to the skull.
4. An audio magnetoencephalography system of a multichannel SERF atomic magnetometer according to claim 1, wherein: the residual magnetism of the magnetic shielding room (1) is smaller than 10nT.
5. An audio magnetoencephalography system of a multichannel SERF atomic magnetometer according to claim 1, wherein: and crosstalk does not exist among the SERF atomic magnetometers (2) of all the channels.
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| CN202311038573.9A CN117045255A (en) | 2023-08-17 | 2023-08-17 | Audio brain magnetic measurement system of multichannel SERF atomic magnetometer |
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| CN202311038573.9A CN117045255A (en) | 2023-08-17 | 2023-08-17 | Audio brain magnetic measurement system of multichannel SERF atomic magnetometer |
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