CN106645092A - Liquid-core waveguide Raman spectrum detection device based on centrifuging - Google Patents
Liquid-core waveguide Raman spectrum detection device based on centrifuging Download PDFInfo
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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Abstract
The invention provides a liquid-core waveguide Raman spectrum detection device based on centrifuging. The liquid-core waveguide Raman spectrum detection device comprises a bracket, a multi-head spiral disc body and a light source probe translation stage, wherein the bracket is provided with a motor; the multi-head spiral disc body is fixed on the bracket and can horizontally rotate around a vertical rotary shaft of the motor; the multi-head spiral disc body comprises a disc head and a circular platform located below the disc head; the disc head is provided with a plurality of through holes; a positioning groove is formed in the upper part of each through hole; spiral channels, which have the quantity the same as that of the through holes, are opposite to the through holes, and are used for containing liquid-core waveguide tubes, are arranged on a side wall of the circular platform; the spiral channels are spirally diffused from top to bottom; the light source probe translation stage is fixed on the bracket, is located above the multi-head spiral disc body, and comprises a light source probe capable of moving linearly and a positioning mechanism matched with the positioning grooves; the positioning mechanism is located at the front end of the light source probe, can move forward along with the light source probe, and abuts against the positioning grooves.
Description
Technical field
The present invention relates to a kind of spectrum test device, and in particular to one kind is using the enough light paths of centrifugal method acquisition, without gas
The liquid core waveguide pipe of bubble simultaneously carries out the device of Raman spectrum detection.
Background technology
Teflon AF have the refractive index less than water, so working as to be full of water or water-soluble in pipeline made by Teflon AF
During liquid, on water and the interface of Teflon AF total reflection condition can be met, similar optical fiber is produced to the incident light of certain angle
Conducting power, forms so-called liquid core waveguide.Because liquid core waveguide has very strong guide-lighting ability, therefore can wherein obtain longer
Light path, so as to realize the enhanced sensitivity to the various optical detective technologies based on the principle such as transmitting, absorption, fluorescence, scattering, there is fine
Application prospect.
For example, can be used for Raman spectrum detection field.Raman spectrum belongs to molecular vibration spectrum, can obtain from molecular level
To the information that group and chemical bond and microenvironment affect on sample structure, can real-time detection sample such as albumen, nucleic acid, esters etc.
The finger print information of structure, and its signal will not disturb by water, therefore it is particularly suitable for the detection of biomolecule, in clinical disease
There are huge potentiality in monitoring and early diagnosis.
But due to Teflon AF materials hydrophobic parent's gas itself, and the Teflon AF calibers being usually used are thinner, are less than
10mm, the skin effect of hydrophobic is even more serious, so easily forming bubble in pipe.Once and bubble formation, then bubble position
Total reflection phenomenon disappear, light path will be interrupted, and can have a strong impact on sensitivity and the stability of optical measurement.Therefore using front,
Need to Teflon AF liquid core waveguide pipes sample introduction bubble removing side by side.
Eliminating the method for bubble in pipe has two kinds, and a kind of is the mode using centrifugation, allows liquid core waveguide pipe to pivot, profit
Bubble removing is realized in centrifugal condition bubble buoyancy increase with liquid, however, with the increase of centrifugal force, bubble is received in pipe
Pressure to solution is sharply increased, and volume is compressed continuously, and buoyancy increase is not obvious, and along with the obstruction in space, bubble is difficult
With whole removings;Another kind of method is using vacuum outgas method, the such as Chinese invention patent of Application No. 201310415459.3
Proposition adopts Ngatively pressurized sampling, and the bubble in liquid core waveguide pipe is eliminated while feed liquor, but every liquid core waveguide pipe is required to match somebody with somebody
Set is controlled, high cost using a vavuum pump and several magnetic valves by certain program, and control is complicated.
Because the removing of liquid core waveguide pipe bubble is totally difficult, traditional Raman spectrum detecting device does not possess the function,
Conventional way is all previously prepared bubble-free liquid core waveguide pipe, including sample introduction, and using said method bubble, Yi Jijian are removed
Survey whether bubble removes totally, it is ensured that just take after liquid core waveguide pipe bubble-free in Raman test device and tested, be very much fiber crops
The liquid core waveguide pipe light path that tired and traditional method is obtained is short, is carrying out less effective when Raman spectrum is detected.
The content of the invention
To overcome above-mentioned deficiency, the present invention to provide a kind of liquid core waveguide Raman spectrum detecting device based on centrifugation, utilize
Centrifugal action realizes liquid core waveguide pipe sample introduction and excludes bubble, and is detected by Raman spectrum, has liquid core waveguide pipe gas concurrently
The dual-use function that bubble removing is detected with Raman spectrum, and long light path can be obtained, improve spectral detection effect.
To solve above-mentioned technical problem, the present invention is adopted the following technical scheme that:
A kind of liquid core waveguide Raman spectrum detecting device based on centrifugation, including:
One support, is provided with a motor;
One multi-head spiral disk body, is fixed on support, can horizontally rotate around the vertical rotating shaft of motor, including a coiled hair and position
A round platform below the coiled hair;The coiled hair is provided with some through holes, and a locating slot is contained on the top of each through hole;The round platform
Side wall be provided with the helical duct for accommodating liquid core waveguide pipe with through hole equal number and relative, the helical duct is from upper
And lower spiral diverging;
One light source probe translation stage, is fixed on support, above multi-head spiral disk body, including one movable linearly
Light source probe and the detent mechanism coordinated with locating slot, the detent mechanism is located at the light source probe front end, can be with light source probe
Move forward and against locating slot.
Further, helical duct is uniformly distributed on the wall of round platform side.
Further, coiled hair upper surface is the low V-arrangement face in the high center in edge, and through hole is uniformly distributed along the circumference on V-arrangement face.
Further, each through hole contains one and is used to fix the clamping apparatus of liquid core waveguide pipe.
Further, locating slot is taper, spherical, elliposoidal, cylindrical locating slot, detent mechanism is correspondingly taper,
Spherical, elliposoidal, cylindrical detent mechanism.
Further, helical duct is strip groove structure.
Further, the spiral diverging direction of helical duct is contrary with the rotation direction of multi-head spiral disk body.
Further, the lower port of each helical duct is provided with a flow-stop valve, and the flow-stop valve contains a startup ball, the startup
Ball can under the action of the centrifugal force open flow-stop valve to discharge liquid in liquid core waveguide pipe when multi-head spiral disk body exceedes preset rotation speed
Body.
Further, the tube wall of liquid core waveguide pipe has gas permeability.
Further, liquid core waveguide pipe is fixed in helical duct by way of clamping or adhesive tape sticking.
Beneficial effects of the present invention are as follows:
This device when in use, liquid core waveguide pipe is fixed in helical duct, and upper end is connected in the through hole of coiled hair, under
End is connected to flow-stop valve, and fluid sample is put in the locating slot of coiled hair, and under the influence of centrifugal force, liquid can slowly enter liquid
Core waveguide, ultimately forms an analysis channel.This device adopts helical duct, and multichannel and long light are realized under less volume
Journey, while ensureing that whole passage has larger bending radius;Multi-head spiral disk body adopts this up-small and down-big structure of round platform,
So that centrifugation radius increases with the increase of helical duct length, the centrifugal force at each section caliber of liquid core waveguide pipe is all
Sequentially it is incremented by, so as to ensure that the bubble in whole pipeline is effectively excluded.
Because the internal diameter of liquid core waveguide pipe is very little, this requires that radiation source is aligned in a small range, and this device is in light
Source probe front be provided with detent mechanism, when a certain analysis channel with motor rotate reach analysis position when, light source probe along
Light source probe platform straight line is moved forward, and until detent mechanism and locating slot coordinate, realizes correcting to the heart for passage.Analysis terminates
Afterwards, fluid sample need to be discharged liquid core waveguide pipe, and detergent line, when preset rotation speed is reached, starts ball in enough centrifugations
Power effect is lower to start flow-stop valve, so that fluid sample flows out, cleaning liquid is then injected into, using said method, by centrifugal force
Cleaning liquid input liquid core waveguide pipe is then exhausted from conveniently being analyzed next time.
Description of the drawings
Fig. 1 is a kind of liquid core waveguide Raman spectrum detecting device generalized section based on centrifugation in embodiment.
Fig. 2 is light source probe and coiled hair position view.
Fig. 3 is light source probe translation stage partial sectional view.
Fig. 4 is multi-head spiral disk body schematic perspective view.
Fig. 5 is taper locating slot sectional view.
Fig. 6 is flow-stop valve schematic diagram.
Fig. 7 is that flow-stop valve assembles explosive view.
In figure:1- supports;11- rotating shafts;12- motors;2- light source probe translation stages;21- light source probes;22- tapers are positioned
Mechanism;3- multi-head spiral disk bodies;31- coiled hairs;311- taper locating slots;312- through holes;32- round platforms;321- helical ducts;4- liquid
Core waveguide;5- flow-stop valves;51- starts ball;52- cushions.
Specific embodiment
Features described above and advantage to enable the present invention becomes apparent, special embodiment below, and coordinates institute's accompanying drawing to make
Describe in detail as follows.
The present embodiment provides a kind of liquid core waveguide Raman spectrum detecting device based on centrifugation, as shown in figure 1, including support
1 and the light source probe translation stage 2 that is fixed on support 1 and multi-head spiral disk body 3.Wherein, support 1 is provided with a rotating shaft 11 upwards
Motor 12, multi-head spiral disk body 3 is fixed in the rotating shaft 11, in the case where motor 12 drives, as the occurred level of rotating shaft 11 turns
It is dynamic.
As shown in Figure 2 and Figure 3, light source probe translation stage 2 is obliquely fixed on the top of multi-head spiral disk body 3, including a light source
Probe 21, the light source probe 21 contains a Raman spectrum detecting device, for carrying out Raman spectrum detection to fluid sample, can edge
The one-dimensional straight line back and forth movement of light source probe translation stage 2.A taper detent mechanism 22 is provided with the front end of light source probe 21, it is therefore intended that
It is accurately positioned.In a particular application, detent mechanism is not limited to taper, can be spherical, cylindrical, elliposoidal or other convex surfaces
Shape, taper can be cone or pyramid etc..
As shown in Figure 2, Figure 4 shows, multi-head spiral disk body 3 is made up of the round platform 32 of circular coiled hair 31 above and lower section.
The upper surface of coiled hair 31 is the low V-arrangement face in the high center in edge, and the V-arrangement face center can contain a circular flat, have no effect on
General introduction to the shape, it is preferred that emphasis is inclined-plane is contained in the V-arrangement face, be uniformly distributed along the circumference some through holes 312 on the inclined-plane, that is, own
Distance of the through hole 312 apart from VXing Mian centers is equal, and the distance between arbitrary neighborhood through hole 312 is equal, the direction of through hole 312 and institute
It is vertical on place inclined-plane, can ensure that the two center line on the same line when with light source probe 21 just pair.Through hole in the present embodiment
312 quantity are 6, but are not limited.Contain a taper locating slot 311 in the upper port of each through hole 312, it is positioned with taper
Mechanism 22 is engaged, and when Raman spectrum detection is carried out, taper detent mechanism 22 can be moved forward and against taper positioning
Groove 311, realizes being accurately positioned.In a particular application, locating slot is not limited to taper, can for spherical, cylindrical, elliposoidal or
Other concaves, taper can be cone or pyramid etc., consistent with the shape of detent mechanism and can coordinate.In addition,
Taper locating slot 311 can hold a certain amount of fluid sample, be easy to as the sample introduction of liquid core waveguide pipe 4.As shown in figure 5, through hole 312
Containing clamping apparatus, with clamping, fixed liquid core waveguide pipe 4, and downward seal can be ensured, be prevented in taper locating slot 311
Liquid passes through gap between through hole 312 and pipe and flows out.
Uniform some helical ducts 321 on the side wall of round platform 32, according to the architectural feature that round platform 32 is up-small and down-big, spiral leads to
The little by little spiral diverging from top to bottom of road 321, diverging direction is with the direction of rotation of round platform 32 conversely, i.e. helical duct 321 is such as along suitable
Hour hands (or counterclockwise) diverging, then the direction of rotation of round platform 32 is (or clockwise) counterclockwise, it is ensured that liquid stress is downward during rotation,
Do not flow out from upper end.Helical duct 321 is 6 in the present embodiment, but is not limited.To cause liquid core waveguide pipe 4 easily to pacify
It is mounted on helical duct 321, helical duct 321 is designed as strip groove structure, groove shapes are not limited, as long as size is able to ensure that
Liquid core waveguide pipe 4 is accommodated, just can ensure that liquid core waveguide pipe 4 in rotating centrifugal process by clamping or adhesive tape bonding notch
In do not fall off.The shape of round platform 32 can cause helical duct 321 to have concurrently from top to bottom and from inside to outside, and liquid flow is met well
Dynamic and centrifugation characteristic, and long light path can be realized in the volume of very little.The upper port of helical duct 321 is logical with coiled hair 31
Hole is relative about 312, due at a distance, allowing in the horizontal direction with the presence of relatively large deviation in the middle of the two.
The lower port of helical duct 321 is provided with flow-stop valve 5, and the lower port of liquid core waveguide pipe 4 connects the flow-stop valve 5, such as Fig. 6,
Shown in Fig. 7.The flow-stop valve 5 is located at the side wall lower section of round platform 32, and containing one the cushion 52 of ball 51 and is started.Round platform 32 it is static or
In preset rotation speed, flow-stop valve 5 is closed rotating speed, can prevent liquid in liquid core waveguide pipe 4 from flowing out.Due to wick-containing ripple
The tube wall of conduit 4 has good gas permeability (liquid-tight), when in preset rotation speed, bubble passes through pipe under the extruding of liquid in pipe
Wall is discharged.When more than preset rotation speed, start ball 51 due to lower section cushion 52 dozens by larger centrifugal action, can be oppressed
Flow-stop valve 5 is opened, so as to discharge liquid in pipe under centrifugal force.
In use, the upper end of liquid core waveguide pipe 4 is connected in through hole 312, lower end is connected to flow-stop valve 5 to this device, from
In the presence of mental and physical efforts, liquid is slowly entered in pipe in taper locating slot 311, and bubble can be discharged through tube wall in managing, and work as bubble
When draining completely, analysis channel is just constituted, Raman spectrum detection can be carried out to analysis channel by light source probe 21.If
Bubble is not excluded totally, and liquid core waveguide pipe 4 does not just constitute total reflection, and light source probe 21 just can not receive raman spectral signal, therefore
Can judge whether to exclude totally by light source probe 21.Because the size of device is fixed, liquid in pipe quality is (or close
Degree) scope is substantially at, therefore by formula F=m ω2R understands that centrifugal force depends primarily on rotating speed, after repeating to test,
Just pre-set velocity is can determine that, such as this example preset rotation speed is 500~1000rpm (rev/min).Therefore in practical application, typically pre-
If bubble just can be drained under speed, can seldom use light source probe 21 to judge whether bubble drains.To ensure liquid core waveguide pipe 4
Use next time, using cleaning liquid, can complete clear using identical method to cleaning in pipe using after finishing
Wash.
It is exemplified below two concrete application examples:
Example 1
Add 5 microlitre 10% of ethanol molten in liquid storage tank (i.e. taper locating slot 311) in sample disc (i.e. coiled hair 31)
Liquid, causes the solution to pass through from liquid storage tank and the Teflon AF full of 10cm length with the speed rotation sample disc of more than 500rpm
Pipe (i.e. liquid core waveguide pipe 4).Accessing Raman detection probes (i.e. light source probe 21) can measure the Raman letters of 10% ethanol solution
Number, the signal strength signal intensity improves more than 50 times compared with the intensity measured in cuvette, and stability repeatability is preferably, illustrates this
Device can be effectively realized bubble-free sample introduction of the liquid in Teflon AF pipes.
Example 2
100 microlitres of DNA extracts are added in liquid storage tank (i.e. taper locating slot 311) in sample disc (i.e. coiled hair 31),
With the speed rotation sample disc of more than 500rpm the solution is passed through from liquid storage tank and the Teflon AF pipes full of 20cm length
(i.e. liquid core waveguide pipe 4).The optical fiber receiving transducer (i.e. light source probe 21) of the LED/light source of 260nm is accessed, DNA solution pair is measured
The absorption signal of 260nm light, the signal strength signal intensity improves more than 10 times, and stability compared with the intensity measured in 1cm cuvettes
Repeatability preferably, illustrates that the device can effectively realize bubble-free sample introduction of the liquid in Teflon AF pipes.
Claims (10)
1. it is a kind of based on centrifugation liquid core waveguide Raman spectrum detecting device, including:
One support, is provided with a motor;
One multi-head spiral disk body, is fixed on support, can horizontally rotate around the vertical rotating shaft of motor, including a coiled hair and positioned at this
A round platform below coiled hair;The coiled hair is provided with some through holes, and a locating slot is contained on the top of each through hole;The side of the round platform
Wall is provided with the helical duct for accommodating liquid core waveguide pipe with through hole equal number and relative, and the helical duct is from top to down
Spiral dissipates;
One light source probe translation stage, is fixed on support, above multi-head spiral disk body, including a light source movable linearly
Probe and the detent mechanism coordinated with locating slot, the detent mechanism is located at the light source probe front end, can move forward with light source probe
And against locating slot.
2. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that spiral leads to
Road is uniformly distributed on the wall of round platform side.
3. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that on coiled hair
Surface is the low V-arrangement face in the high center in edge, and through hole is uniformly distributed along the circumference on V-arrangement face.
4. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that Mei Yitong
Hole contains one to be used to fix the clamping apparatus of liquid core waveguide pipe.
5. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that locating slot
For taper, spherical, elliposoidal, cylindrical locating slot, detent mechanism is correspondingly taper, spherical, elliposoidal, cylindrical localization machine
Structure.
6. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that spiral leads to
Road is strip groove structure.
7. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that spiral leads to
The spiral diverging direction in road is contrary with the rotation direction of multi-head spiral disk body.
8. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that each spiral shell
The lower port of rotation passage is provided with a flow-stop valve, and the flow-stop valve contains a startup ball, and the startup ball can exceed in multi-head spiral disk body
During preset rotation speed, flow-stop valve is opened under the action of the centrifugal force to discharge liquid in liquid core waveguide pipe.
9. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that wick-containing ripple
The tube wall of conduit has gas permeability.
10. it is according to claim 1 based on the liquid core waveguide Raman spectrum detecting device being centrifuged, it is characterised in that wick-containing
Waveguide is fixed in helical duct by way of clamping or adhesive tape sticking.
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Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4640592A (en) * | 1983-01-22 | 1987-02-03 | Canon Kabushiki Kaisha | Optical display utilizing thermally formed bubble in a liquid core waveguide |
US5604587A (en) * | 1995-11-16 | 1997-02-18 | World Precision Instruments, Inc. | Long capillary waveguide raman cell |
WO1999057584A1 (en) * | 1998-05-01 | 1999-11-11 | University Of South Florida | Liquid core waveguide |
CN1680814A (en) * | 2004-04-09 | 2005-10-12 | 太阳诱电株式会社 | Method of nucleic acid analysis, nucleic acid analysis device and disk for nucleic acid analysis |
US20060251371A1 (en) * | 2003-06-16 | 2006-11-09 | The Regents Of The University Of California | Integrated electrical and optical sensor for biomolecule analysis with single molecule sensitivity |
US20060257089A1 (en) * | 2005-04-08 | 2006-11-16 | Arryx, Inc. | Apparatus for optically-based sorting within liquid core waveguides |
CN101398436A (en) * | 2008-09-27 | 2009-04-01 | 东北大学 | Rotating micro-example auto-introducing device |
CN101522916A (en) * | 2006-08-02 | 2009-09-02 | 柳在泉 | Thin film chemical analysis apparatus and analysis method using the same |
CN101806726A (en) * | 2010-03-29 | 2010-08-18 | 浙江大学 | Double-wavelength absorbance detection device for analyzing trace liquid |
CN103454221A (en) * | 2013-09-12 | 2013-12-18 | 北京吉天仪器有限公司 | Negative-pressure liquid feeding device based on liquid core wave guide pipe |
CN103822910A (en) * | 2012-11-16 | 2014-05-28 | 福州高意通讯有限公司 | Raman probes for miniature Raman spectrometer |
CN104614363A (en) * | 2015-01-29 | 2015-05-13 | 上海如海光电科技有限公司 | Raman spectrum testing system based on liquid core waveguide |
CN105115809A (en) * | 2015-09-11 | 2015-12-02 | 北京本立科技有限公司 | Analysis sample preparation device and analysis sample preparation method |
CN105259358A (en) * | 2015-11-10 | 2016-01-20 | 中国科学院重庆绿色智能技术研究院 | Multi-channel rotary type Raman spectroscopy detection sample pool device and detecting method thereof |
CN205091174U (en) * | 2015-09-11 | 2016-03-16 | 北京本立科技有限公司 | Analysis sample preparation device |
CN106442081A (en) * | 2016-09-30 | 2017-02-22 | 北京本立科技有限公司 | Bubble-free liquid core waveguide tube liquid feeding device based on centrifuging |
CN206557101U (en) * | 2017-02-24 | 2017-10-13 | 北京本立科技有限公司 | A kind of liquid core waveguide Raman spectrum detecting device based on centrifugation |
-
2017
- 2017-02-24 CN CN201710103797.1A patent/CN106645092B/en active Active
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4640592A (en) * | 1983-01-22 | 1987-02-03 | Canon Kabushiki Kaisha | Optical display utilizing thermally formed bubble in a liquid core waveguide |
US5604587A (en) * | 1995-11-16 | 1997-02-18 | World Precision Instruments, Inc. | Long capillary waveguide raman cell |
WO1999057584A1 (en) * | 1998-05-01 | 1999-11-11 | University Of South Florida | Liquid core waveguide |
US20060251371A1 (en) * | 2003-06-16 | 2006-11-09 | The Regents Of The University Of California | Integrated electrical and optical sensor for biomolecule analysis with single molecule sensitivity |
CN1680814A (en) * | 2004-04-09 | 2005-10-12 | 太阳诱电株式会社 | Method of nucleic acid analysis, nucleic acid analysis device and disk for nucleic acid analysis |
US20060257089A1 (en) * | 2005-04-08 | 2006-11-16 | Arryx, Inc. | Apparatus for optically-based sorting within liquid core waveguides |
CN101522916A (en) * | 2006-08-02 | 2009-09-02 | 柳在泉 | Thin film chemical analysis apparatus and analysis method using the same |
CN101398436A (en) * | 2008-09-27 | 2009-04-01 | 东北大学 | Rotating micro-example auto-introducing device |
CN101806726A (en) * | 2010-03-29 | 2010-08-18 | 浙江大学 | Double-wavelength absorbance detection device for analyzing trace liquid |
CN103822910A (en) * | 2012-11-16 | 2014-05-28 | 福州高意通讯有限公司 | Raman probes for miniature Raman spectrometer |
CN103454221A (en) * | 2013-09-12 | 2013-12-18 | 北京吉天仪器有限公司 | Negative-pressure liquid feeding device based on liquid core wave guide pipe |
CN104614363A (en) * | 2015-01-29 | 2015-05-13 | 上海如海光电科技有限公司 | Raman spectrum testing system based on liquid core waveguide |
CN105115809A (en) * | 2015-09-11 | 2015-12-02 | 北京本立科技有限公司 | Analysis sample preparation device and analysis sample preparation method |
CN205091174U (en) * | 2015-09-11 | 2016-03-16 | 北京本立科技有限公司 | Analysis sample preparation device |
CN105259358A (en) * | 2015-11-10 | 2016-01-20 | 中国科学院重庆绿色智能技术研究院 | Multi-channel rotary type Raman spectroscopy detection sample pool device and detecting method thereof |
CN106442081A (en) * | 2016-09-30 | 2017-02-22 | 北京本立科技有限公司 | Bubble-free liquid core waveguide tube liquid feeding device based on centrifuging |
CN206557101U (en) * | 2017-02-24 | 2017-10-13 | 北京本立科技有限公司 | A kind of liquid core waveguide Raman spectrum detecting device based on centrifugation |
Non-Patent Citations (2)
Title |
---|
周靖;顾爱平;: "基于液芯波导激光诱导荧光检测器的缝管自动进样毛细管电泳仪的研制及其在DNA分析中的应用" * |
杜文斌,方群,方肇伦: "基于液芯波导原理的微流控芯片长光程光度检测系统" * |
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