CN208596113U - Biosensor based on optical fiber mach-Zeng Deer interferometer - Google Patents
Biosensor based on optical fiber mach-Zeng Deer interferometer Download PDFInfo
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- CN208596113U CN208596113U CN201821134010.4U CN201821134010U CN208596113U CN 208596113 U CN208596113 U CN 208596113U CN 201821134010 U CN201821134010 U CN 201821134010U CN 208596113 U CN208596113 U CN 208596113U
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Abstract
The utility model provides a kind of biosensor based on optical fiber mach-Zeng Deer interferometer, for detecting the concentration of biological tissue's solution, solves in manufacturing process that producer is more dangerous, and the problem that biosensor reliability, sensitivity are low；Comprising: micro flow chip, microchannel is offered in micro flow chip, micro flow chip offers inlet, and inlet is connected to microchannel；Light guide assemblies in microchannel are set, and light guide assemblies offer MZ chamber, and MZ chamber is connected to microchannel；The light source that micro flow chip side is arranged in provides part；And the spectrometer of micro flow chip side is set；The setting of light guide assemblies is avoided using dangerous corrosive liquid during making biosensor, so that producer be made to be ensured safely.
Description
Technical field
The utility model belongs to field of biosensors more particularly to a kind of based on optical fiber mach-Zeng Deer interferometer
Biosensor.
Background technique
Mach-Zehnder (Mach-Zehnder, MZ) interferometer, is a kind of interferometer, can be used to observe from independent light
After the beam splitting of source transmitting is at twice collimated light beam, change by relative phase shift caused by different paths and medium.Horse
Conspicuous-Zeng Deer interferometer has in various fields to be widely applied, and one of them application is namely based on the bio-sensing of MZ interferometer
Device.
However, existing, based on the biosensor of optical fiber MZ interferometer, there are many defects.In production biosensor
During, it needs to be processed optical fiber, some processing methods are needed using unwanted corrosion liquid (such as: hydrofluoric acid
Chemical agent) inside of optical fibre is corroded to form MZ chamber, and these corrosive liquids may damage processing staff,
To be processed optical fiber in the presence of greatly dangerous using this processing method.
In general, it is existing based on the biosensor of optical fiber MZ interferometer during production, producer's
Safety cannot ensure.
Utility model content
The technical problem to be solved by the utility model is to provide a kind of lifes based on optical fiber mach-Zeng Deer interferometer
Object sensor, it is intended to solve it is existing based on the biosensor of optical fiber MZ interferometer during production, producer compared with
The problem of making the safety of producer for danger cannot ensure.
In order to solve the above technical problems, the utility model is realized in this way, one kind is interfered based on optical fiber mach-Zeng Deer
The biosensor of instrument characterized by comprising micro flow chip offers microchannel, the miniflow in the micro flow chip
Chip offers inlet, and the inlet is connected with the microchannel；Light guide group in the microchannel is set
Part offers MZ chamber in the light guide assemblies, and the MZ chamber is connected with the microchannel；It is arranged in the micro flow chip one
The light source of side provides part, and the light source provides part and is connected with one end of the light guide assemblies；And it is arranged in the miniflow core
The spectrometer of piece side, the spectrometer are connected with one end that the light guide assemblies provide part far from the light source.
By using above-mentioned technical proposal, when using the biosensor based on optical fiber mach-Zeng Deer interferometer, first
By biological tissue's solution out of inlet injection microchannel, and the MZ chamber for entering biological tissue's solution in light guide assemblies,
After the optical signal that light source provides part offer enters light guide assemblies, and when optical signal enters MZ chamber, optical signal enters biology simultaneously
The reference arm that the interfere arm and light guide assemblies itself that tissue solution is formed are formed, in optical signal after MZ chamber, in light guide group
Aggregation in part, since the optical index between interfere arm and reference arm has differences, so that optical signal is made to generate refringence, from
And optical path difference is generated, interference is formed, last optical signal is incident upon on spectrometer from light-emitting window, so that interference spectrum is formed, at this
In utility model, using light guide assemblies instead of optical fiber in the prior art, since light guide assemblies offer MZ chamber, so there is no need to
The hazardous chemicals medicament such as hydrofluoric acid corrodes light guide assemblies, so making producer during making biosensor
The safety of member is ensured, and is handled without carrying out drawing cone to light guide assemblies, and cost of manufacture can not only be reduced, and
Each position diameter of light guide assemblies can be made to be consistent, to reduce light loss, the sensitivity of biosensor is improved, make
Biosensor is relatively reliable.
Further, the light guide assemblies include: the first optical fiber；The light guide of first optical fiber one end, institute are set
It states and offers cavity inside light guide, the cavity is MZ chamber；And it is arranged in the light guide far from first optical fiber one
Second optical fiber at end, first optical fiber and second optical fiber are symmetrical arranged along the light guide.
Further, the light guide includes: glass tube, the opposite end of the glass tube respectively with first optical fiber
And the second optical fiber phase welding, the glass tube side offer communication port, the communication port both ends are respectively to described first
Optical fiber and second extension of optical fiber, and extend to the opposite both ends of the glass tube, the MZ chamber by the communication port with
The external world is connected；And it is filled in the intracavitary filling member of MZ, the diameter of the filling member is less than the diameter of the MZ chamber, described
First optical fiber and second fused fiber splice are on the inner wall that one end of the glass tube is respectively positioned on the cavity, and part and institute
Filling member is stated to be in contact.
Further, the filling member and the closure member are uv-curable glue, the refractive index of the uv-curable glue
It is 1.36.
It is reduced after the uv-curable glue filling glass pipe for being 1.36 with refractive index by using above-mentioned technical proposal
The refractive index of biosensor provided by the invention, so that biosensor sensitivity provided by the invention is 40000nm/RIU,
And common biosensor sensitivity is 10000nm/RIU in the market, to improve the sensitivity of biosensor.
Further, the glass length of tube is 100 μm, and the glass tube external diameter and internal diameter are respectively 125 μm and 75 μm.
Further, first optical fiber and second optical fiber are single mode optical fiber fibre core.
Further, the light source provides part for providing wideband light source.
Further, plastic flexible pipe is provided at the inlet that the micro flow chip opens up.
Further, the micro flow chip offers liquid outlet, and the liquid outlet is connected with the microchannel, described
Micro flow chip side is provided with waste collecting device, and the waste collecting device is connected with the liquid outlet.
Compared with prior art, beneficial effect is the utility model: by using glass tube both ends welding optic fibre, then
The method that rubbing down is begun to speak from side replaces the cavity in the biosensor of MZ interferometer in the prior art, makes the sky in glass tube
Chamber is as MZ chamber, without being corroded using hazardous chemicals medicaments such as hydrofluoric acid to optical fiber, so in production bio-sensing
During device, ensure the safety of producer；And the filling member for being 1.36 by using refractive index is to glass
Glass pipe is filled, so that biosensor sensitivity provided by the invention is 40000nm/RIU, for most of lifes in the market
4 times of object transducer sensitivity, to improve the sensitivity of biosensor in the prior art.
Detailed description of the invention
Fig. 1 is the structural representation of biosensor of the utility model embodiment based on optical fiber mach-Zeng Deer interferometer
Figure, and section view processing is done to micro flow chip；
Fig. 2 is the micro flow chip of biosensor of the utility model embodiment based on optical fiber mach-Zeng Deer interferometer
And the cross-sectional view of light guide assemblies；
Fig. 3 is the analog simulation wave crest of biosensor of the embodiment of the present invention based on optical fiber mach-Zeng Deer interferometer
With the drift figure of variations in refractive index.
In the accompanying drawings, each appended drawing reference indicates: 1, microchannel；101, syringe；102, light source provides part；103, feed liquor
Mouthful；104, liquid outlet；105, waste collecting device；106, spectrometer；107, micro flow chip；11, light inlet；12, light-emitting window；
13, light guide assemblies；131, glass tube；132, communication port；14, closure member；15, plastic flexible pipe；201, the first optical fiber；202,MZ
Chamber；203, filling member；204, the second optical fiber.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
A kind of biosensor based on optical fiber mach-Zeng Deer interferometer, as shown in Figures 1 and 2, comprising: miniflow core
Piece 107, light guide assemblies 13, closure member 14, light source provide part 102 and spectrometer 106；It is logical that miniflow is offered in micro flow chip 107
Road 1, microchannel 1 are connected by light inlet 11 and light-emitting window 12 with the external world, and micro flow chip 107 offers inlet 103
And liquid outlet 104；Light guide assemblies 13 are arranged in microchannel 1, and MZ chamber 202 are offered in light guide assemblies 13, and MZ chamber
202 are connected with microchannel 1, and biological tissue's solution is entered in microchannel 1 and MZ chamber 202 by inlet 103, and raw
After object tissue solution enters in MZ chamber 202, as the interfere arm of biosensor, part light guide assemblies 13 are used as biosensor
Reference arm；Closure member 14 is arranged on micro flow chip 107, for will go out after light guide assemblies 13 are placed in microchannel 1
Optical port 12 and light inlet 11 are closed, thus prevent biological tissue's solution from flowing out micro flow chip 107 from light-emitting window 12 and light inlet 11,
To reduce the probability that biological tissue's solution adversely affects light guide assemblies 13, while biological tissue's solution can be prevented
Waste, and reduce the probability that biological tissue's solution corrodes micro flow chip 107；Light source provides part 102 and is arranged in micro flow chip
107 open up the side of light inlet 11, for providing light source, for improve light source spectral width, to improve the survey of biosensor
Sensitivity is measured, in the present embodiment, light source provides part 102 for providing wideband light source；Spectrometer 106 is arranged in micro flow chip
107 open up the side of light-emitting window 12, when light source, which provides the broadband light that part 102 provides, passes through interfere arm and reference arm simultaneously, by
Optical index between interfere arm and reference arm has differences, to make broadband light generate refringence, to generate light path
Difference forms interference, and last broadband light is assembled in light guide assemblies 13, and is incident upon on spectrometer 106 from light-emitting window 12, thus shape
At interference spectrum.
In the present embodiment, microchannel 1 is beeline channel, and light inlet 11 and light-emitting window 12 are symmetrical, set in this way
It sets, distance and time of the broadband light across the needs of micro flow chip 107 can be reduced and improve bio-sensing to reduce light loss
The detectivity of device.
Wherein, light guide assemblies 13 include: the first optical fiber 201, light guide and the second optical fiber 204, the first optical fiber 201 and second
Optical fiber 204 is separately positioned on the opposite both ends of light guide, offers cavity inside light guide, and the cavity is as MZ chamber 202, filling
Part 203 is filled in cavity.
In the present embodiment, the first optical fiber 201 and the second optical fiber 204 are single mode optical fiber fibre core, since single-mode optics are long and slender
Core has the advantages that low-loss and minimum dispersion when transmitting optical signal, so as to improve the detection accuracy of biosensor.
Light guide includes: glass tube 131 and filling member 203；First optical fiber 201 and the second optical fiber 204 are fused to glass tube
131 opposite both ends, the chamber in glass tube 131 offer communication port 132 in the side of glass tube 131 as MZ chamber 202,
Communication port 132 extends to the first optical fiber 201 and the second optical fiber 204 respectively, and extends to the opposite both ends of light guide, MZ chamber
202 are connected by communication port 132 with the external world；Filling member 203 is filled in MZ chamber 202, as the reference arm of biosensor,
And the diameter of filling member 203 is less than the diameter of cavity, in order to which biological tissue's solution flows into MZ chamber and forms interfere arm.
In the present embodiment, one end that the first optical fiber 201 and the second optical fiber 204 are fused to glass tube 131 is located at cavity
On inner wall, and part is in contact with filling member 203, and the first optical fiber 201 is located at 11 side of light inlet of microchannel 1, and second
Optical fiber 204 is located at 12 side of light-emitting window of microchannel 1, in this way, in broadband light after the first optical fiber 201, convenient for width
Optical path difference is generated by the medium of different refractivity with light, so that interference is formed, after broadband light passes through glass tube 131,
Converge at second optical fiber 204, the broadband light for having generated optical path difference is incident upon on spectrometer 106 by the second optical fiber 204, thus shape
At interference spectrum.
As shown in Figures 2 and 3, in the present embodiment, filling member 203 and closure member 14 are uv-curable glue, ultraviolet solid
The refractive index for changing glue is 1.36, when using uv-curable glue as filling member 203, the refractive index of reference arm is made to be more nearly water
The refractive index of solution, so that the refractive index of biosensor provided by the invention is reduced, so that biology provided by the invention passes
Sensor sensitivity is 40000nm/RIU, and common biosensor sensitivity is 10000nm/RIU in the market, to improve
The sensitivity of biosensor.When using uv-curable glue as closure member 14, due to uv-curable glue have quick solidifying,
Energy consumption less, solvent-free pollution the advantages that, so as to reduce the time of glue curing, reduce the waste of the energy, reduce to biology
Tissue solution adversely affects.
In the present embodiment, the length of glass tube 131 is 100 μm, and the internal diameter and outer diameter of glass tube 131 are respectively 125 μm
And 75 μm, the communication port 132 that glass tube 131 opens up is to throw except the thickness of 40 μm of 131 side of glass tube is formed.
Plastic flexible pipe 15 is provided at the inlet 103 of micro flow chip 107, the use of plastic flexible pipe 15 can be more
Convenient for importing biological tissue's solution in microchannel 1, in the present embodiment, using syringe 101 at a predetermined velocity to plastics
Hose 15 injects biological tissue's solution, and biological tissue's solution is imported microchannel 1.
It is provided with waste collecting device 105 at the liquid outlet 104 of micro flow chip 107, a biological tissue is molten obtaining
After the interference spectrum of liquid, biological tissue's solution in micro flow chip 107 is imported in waste collecting device 105, and clear with ethyl alcohol
Microchannel 1 and light guide assemblies 13 are washed, are then imported ethyl alcohol in waste collecting device 105, waste collecting device 105 is set
It sets, can temporarily store waste liquid caused by many experiments, require to launch waste liquid to prevent experimenter from testing every time
To waste liquid release position, the labor intensity of experimenter is reduced, and reduces the time that experimenter launches waste liquid, to improve
The efficiency of continuous several times experiment.
A kind of biosensor based on optical fiber mach-Zeng Deer interferometer provided by the utility model, working principle
Or process is as follows: when making biosensor, first light guide assemblies 13 being placed in the microchannel 1 of micro flow chip 107, then
The light inlet 11 at 1 both ends of microchannel and light-emitting window 12 are sealed with uv-curable glue, then by the first optical fiber 201 far from glass
One end of pipe 131 provides part 102 with light source and is connected, one end and spectrometer by the second optical fiber 204 far from glass tube 131
106 are connected, so that so that light source is provided the broadband light that part 102 provides passes through the first optical fiber 201, glass tube 131 and second
Optical fiber 204 and be incident upon on spectrometer 106, one end of plastic flexible pipe 15 is then fixed on to the inlet 103 of micro flow chip 107
Place makes plastic flexible pipe 15 be connected by inlet 103 with microchannel 1, finally at the liquid outlet 104 of micro flow chip 107
Waste collecting device 105 is installed, to complete the production of biosensor, therefore during production, has ensured producer
The safety of member.
When using biosensor, biological tissue's solution first is extracted with syringe 101, then by syringe 101 and modeling
Material hose 15 is connected, and biological group is injected into microchannel 1 by plastic flexible pipe 15 and inlet 103 under set rate
Solution is knitted, after biological tissue's solution enters microchannel 1 and MZ chamber 202, starting light source provides part 102, and light source is made to provide part
102 provide broadband light, and broadband light is transmitted in the first fibre core, and when broadband light reaches MZ chamber 202, while it is molten to enter biological tissue
The reference arm that the interfere arm and filling member 203 that liquid is formed are formed, and the second optical fiber 204 in interfere arm and reference arm end
Locate bout, since there are refringences between interfere arm and reference arm, therefore broadband light generates optical path difference, forms interference, and in width
After band light projection is on spectrometer 106, interference spectrum is formed, data are recorded after spectrum-stable, then change ethanol injection miniflow
In chip 107, microchannel 1 and MZ chamber 202 is cleaned, and the waste liquid of generation is imported in waste collecting device 105, then changed another
In the biological tissue's solution injection microchannel 1 and MZ chamber 202 of a kind of various concentration, and successively test biological group of various concentration
The spectrogram for knitting solution, by MZ chamber 202 fill refractive index be 1.36 uv-curable glue as reference arm, make reference arm
Refractive index be closer to the refractive index of aqueous solution, to make provided by the utility model dry based on optical fiber mach-Zeng Deer
The biosensor of interferometer detectivity with higher.
The density of biological tissue's solution of various concentration has differences, thus had differences in terms of refractive index, and it is different
After biological tissue's solution injection MZ chamber 202 of concentration, change the refractive index of interfere arm, so as to cause interfere arm and reference arm it
Between refringence change, thus make interference spectrum occur wave length shift, pass through detection interference spectrum wave length shift, energy
Enough concentration variations for detecting measured biological tissue's solution indirectly, are using biosensor provided by the utility model
Afterwards, make the biosensor provided by the utility model based on optical fiber mach-Zeng Deer interferometer refractive index spirit with higher
Sensitivity and lower refractive index detection limit, therefore excellent sensing spy is also shown in terms of detecting biological tissue's solution concentration
Property.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in the utility model within the spirit and principle of utility model
Protection scope within.
Claims (9)
1. a kind of biosensor based on optical fiber mach-Zeng Deer interferometer characterized by comprising micro flow chip
(107), it is offered microchannel (1) in the micro flow chip (107), the micro flow chip (107) offers inlet
(103), the inlet (103) is connected with the microchannel (1)；
The light guide assemblies (13) being arranged in the microchannel (1), the light guide assemblies (13) are interior to offer MZ chamber (202),
The MZ chamber (202) is connected with the microchannel (1)；
Light source in the micro flow chip (107) side is set, part (102) are provided, the light source provides part (102) and the light
One end of guide assembly (13) is connected；And
Spectrometer (106) in the micro flow chip (107) side, the spectrometer (106) and the light guide assemblies are set
(13) one end for providing part (102) far from the light source is connected.
2. the biosensor according to claim 1 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
Stating light guide assemblies (13) includes: the first optical fiber (201)；
Light guide in described first optical fiber (201) one end is set, cavity is offered inside the light guide, the cavity is MZ
Chamber (202)；And
It is arranged in second optical fiber (204) of the light guide far from described first optical fiber (201) one end, first optical fiber
(201) and second optical fiber (204) is symmetrical arranged along the light guide.
3. the biosensor according to claim 2 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
Stating light guide includes:
Glass tube (131), the opposite end of the glass tube (131) respectively with first optical fiber (201) and second light
Fine (204) phase welding, glass tube (131) side offer communication port (132), communication port (132) both ends respectively to
First optical fiber (201) and second optical fiber (204) extend, and extend to the opposite both ends of the glass tube (131), institute
It states MZ chamber (202) and is connected by the communication port (132) with the external world；And it is filled in the filling member in MZ chamber (202)
(203), the diameter of the filling member (203) is less than the diameter of the MZ chamber (202), first optical fiber (201) and described the
One end that two optical fiber (204) are fused to the glass tube (131) is respectively positioned on the inner wall of the cavity, and part and the filling
Part (203) is in contact.
4. the biosensor according to claim 3 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
Stating filling member (203) is uv-curable glue, and the refractive index of the uv-curable glue is 1.36.
5. the biosensor according to claim 3 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
Stating glass tube (131) length is 100 μm, and glass tube (131) outer diameter and internal diameter are respectively 125 μm and 75 μm.
6. the biosensor according to claim 2 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
It states the first optical fiber (201) and second optical fiber (204) is single mode optical fiber fibre core.
7. the biosensor according to claim 1 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
It states light source and provides part (102) for providing wideband light source.
8. the biosensor according to claim 1 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
It states and is provided with plastic flexible pipe (15) at the inlet (103) that micro flow chip (107) opens up.
9. the biosensor according to claim 1 based on optical fiber mach-Zeng Deer interferometer, it is characterised in that: institute
It states micro flow chip (107) to offer liquid outlet (104), the liquid outlet (104) is connected with the microchannel (1), described
Micro flow chip (107) side is provided with waste collecting device (105), the waste collecting device (105) and the liquid outlet
(104) it is connected.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821134010.4U CN208596113U (en) | 2018-07-17 | 2018-07-17 | Biosensor based on optical fiber mach-Zeng Deer interferometer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821134010.4U CN208596113U (en) | 2018-07-17 | 2018-07-17 | Biosensor based on optical fiber mach-Zeng Deer interferometer |
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| CN208596113U true CN208596113U (en) | 2019-03-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110006846A (en) * | 2019-04-19 | 2019-07-12 | 哈尔滨工程大学 | A kind of the trace quantity liquid refractivity measuring device and preparation method of V-type special optical fiber |
| CN111398222A (en) * | 2020-04-23 | 2020-07-10 | 哈尔滨工程大学 | Optical fiber refractive index sensor based on Mach-Zehnder interferometry |
-
2018
- 2018-07-17 CN CN201821134010.4U patent/CN208596113U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110006846A (en) * | 2019-04-19 | 2019-07-12 | 哈尔滨工程大学 | A kind of the trace quantity liquid refractivity measuring device and preparation method of V-type special optical fiber |
| CN111398222A (en) * | 2020-04-23 | 2020-07-10 | 哈尔滨工程大学 | Optical fiber refractive index sensor based on Mach-Zehnder interferometry |
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