CN108680505A - A kind of multi-channel wavelength modulation type optical fiber detecting system - Google Patents
A kind of multi-channel wavelength modulation type optical fiber detecting system Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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Abstract
The invention belongs to fiber-optic biosensor technical fields, disclose a kind of multi-channel wavelength modulation type optical fiber detecting system.Light source connects multimode fibre photoswitch, and photoswitch 1 goes out into N, and N number of outlet is separately connected N number of optical fiber SPR sensor.Afterwards spectrometer is aggregated by Y type 1 × N bifurcation fibers.Sampling system includes sample cell, multi-channel peristaltic pump, the micro- flow cell of multichannel and waste liquid pool.The micro- flow cell of multichannel in series or in parallel can use.The control system and data acquisition processing system are computer, and specified light path is registered to by data line traffic control photoswitch, read corresponding spectral information, carry out spectral normalization and peak-seeking processing.Computer control carries out the automatic cycle sampling of multichannel.The present invention keeps extending sense channel number under small, highly sensitive, real-time response the advantage of optical fiber system bulk, can be applied to disease and diagnoses in time, the multiple analytes detection field such as food security and environmental monitoring.
Description
Technical field
The invention belongs to fiber-optic biosensor technical fields to extend traditional optical fiber detection system using controllable photoswitch
The sense channel number of system.Keep optical fiber SPR sensor is highly sensitive, label-free, real-time response, can remote detection, be easy to small
While the advantage of type, non-interfering multi-pass detection is realized.
Background technology
Fiber Optic Sensor Based on Surface Plasmon Resonance (SPR) is by highly sensitive surface plasma resonance sensing technology
The product organically combined with the optical fiber transmission technique of low-energy-consumption.It has gathered SPR effects to surrounding medium variations in refractive index
Very sensitive advantage, at the same have concurrently again optical fiber itself it is soft, can flexing, electrical isolation, corrosion-resistant, when use do not generate heat, without spoke
It penetrates, unique advantage such as can work under the complicated environmental conditions such as strong electromagnetic, inflammable and explosive, poisonous gas.When light is from light
It can be totally reflected in the interface of two media when close medium incident optically thinner medium, the electromagnetic field intensity of light wave is being demarcated at this time
It is not reduced to zero at face immediately, but exponentially decays with incident depth, forms evanescent waves.The effective depth of evanescent waves is general
For 100-200nm, the depth due to optical fiber SPR sensor gold category film thickness less than evanescent waves, in metal film and solution or air
Interface, evanescent waves still work.Simultaneously in the interface of metal film and sample, the free electron of metal surface is excited, shape
At surface plasma wave.When evanescent waves wave vector is equal with surface plasma-wave wave vector, there is minimum reflectance.It can be to passing
The minor change of sensor surfaces testing medium composition makes sensitive response, the substance suitable for research sensor surface sensitive layer
Biology with medium solution and chemical reaction, and then quantitative determine the micro biological and chemical active material in medium solution.
Relative to conventional prism structure SPR detecting systems, optical fiber SPR sensor has portability, and low manufacture cost, fits
For Site Detection application.Such as heavy metal ion or hormone pollute Site Detection, disease care diagnostic etc. in water.Due to reality
Usually necessary not only for a kind of substance of detection in the application scenarios of border, but the mixture of plurality of target detectable substance, such as disease are examined
The disconnected concentration for usually requiring a variety of disease markers of detection in the process needs to detect multiple pollutant level during water quality detection
Deng, build it is a kind of low cost, miniaturization, it is highly sensitive, and can with the SPR sensorgram system of multi-channel detection become Fibre Optical Sensor neck
The active demand in domain.
Spectrum modulation type Fiber Optic Sensor Based on Surface Plasmon Resonance uses wide spectrum light source and high resolution spectrometer, in real time
The drift for detecting SPR resonant wavelengths is sensed relative to angle modulated formula, intensity modulated formula, and stability is high, and light path system is simpler
Single, easily realization, is the optical fiber modulation means being most widely used at present.However, transmission spectra modulation type SPR sensorgram system
It is only capable of realizing single sense channel, or Dual channel detection is realized by being coated with different film layers.It is fast that multi-pass may be implemented in one kind
Speed switching, low cost, miniaturization, multichannel optical fiber SPR detecting systems are in necks such as environmental monitoring, food security and medicals diagnosis on disease
Domain has broad application prospects.
Invention content
The present invention is intended to provide a kind of multi-channel wavelength modulation type optical fiber detecting system, including optical sensor system, into
Sample system, control system and data acquisition processing system.
A kind of multi-channel wavelength modulation type optical fiber detecting system, including optical sensor system, sampling system, control system
System and data acquisition processing system；
The optical sensor system includes wide spectrum light source 1,1 × N multimode fibres photoswitch 2,3 and of optical fiber SPR sensor
High resolution spectrometer 6；Wide spectrum light source 1 connects 1 × N multimode fibres photoswitch 2, and 1 × N multimode fibres photoswitch 2 is 1 import
N number of outlet, N number of outlet are separately connected N number of optical fiber SPR sensor 3；Afterwards high-resolution is aggregated by Y 1 × N of type bifurcation fibers 5
Spectrometer 6；The output order control 1 × N multimode fibres of computer 10 photoswitch 2 is switched to specified path channels, and optical signal passes through
It is finally sent to high resolution spectrometer 6 after optical fiber SPR sensor 3, then signal acquisition and demodulation is carried out through computer 10, realized more
Channel fiber SPR sensorgram.
The sampling system includes the micro- flow cell 4 of multichannel, sample cell 7, multi-channel peristaltic pump 8 and waste liquid pool 9；By light
After fine spr sensor 3 carries out functional modification, carry out multiple while the detection of plurality of target molecule mixture or same molecule
Detection；Micro- 4 serial or parallel connection of flow cell of multichannel uses；When being used in series, the same sample flows successively through the micro- flow cell of multichannel
4；When used in parallel, each micro- flow cell is as independent sector, and using multi-channel peristaltic pump 8, sample introduction is detected experiment simultaneously；
The control system and data acquisition processing system is computer 10, passes through data line traffic control 1 × N multimode fibres
Photoswitch 2 is switched to specified light path, reads corresponding spectral information, carries out spectral normalization and filtering, peak-seeking and data record；Meter
The control of calculation machine 101 carries out the automatic cycle sampling of multichannel.
1 × N multimode fibres photoswitch 2 is made of multimode silica fibre, and core diameter is 200-600 μm, numerical aperture
Diameter 0.22-0.37, configures SMA905 connectors, and channel switching takes as 5-30ms.
The optical fiber SPR sensor 3 uses the optical fiber that core diameter is not less than 0.22 for 300-500 μm, numerical aperture,
One section of coat and the covering on plastic envelope multimode fibre are peelled off, sensing unit, length 5mm-10mm are formed；In sensing unit table
Face is coated with 30-60nm golden films, and resonant wavelength is in visible light and near infrared band, thus can reduce detecting system cost.
Golden film spr sensor is more stablized, and reuse can be repeatedly regenerated.Antibody modification is carried out in conjunction with ripe ammonia coupling method, to
Realize that specific protein quantitatively detects.Multiple sense channels of the multichannel SPR detecting systems are not interfere with each other, have compared with
High sensitivity and stability, average level is in 2000nm/RIU or so.
The micro- flow cell 4 of the multichannel, is made of PDMS material, and each microchannel includes entrance and exit, more
A microchannel in series or in parallel can use.
The wide spectrum light source 1 is visible light/infrared band wide spectrum light source.
The wavelength detection range 400-1100nm of the high resolution spectrometer 6.
The multi-channel wavelength modulation type optical fiber detecting system of the present invention has the advantages that：
It is opened the light using the multimode fibre light that quickly can controllably switch, extension tradition wavelength modulation type light that can be simple and fast
Fine SPR detecting systems number of active lanes.Repeated detection while realizing multiple target objects detection simultaneously or same target substance.Have
The application field and detection efficiency for extending optical fiber SPR sensor of effect.
The multimode fibre photoswitch used in the present invention can quickly be controlled by computer.Configuration SMA905 connects
Head can be quickly bonded with optical fiber SPR sensor.Light path switch speed is fast.
Description of the drawings
Fig. 1 is multi-channel wavelength modulation type optical fiber detecting system schematic diagram.
Fig. 2 is optical fiber SPR sensor schematic diagram.
Fig. 3 is the micro- flow cell schematic diagram of multichannel.
In figure：1 wide spectrum light source；21 × N multimode fibre photoswitches；3 optical fiber SPR sensors；The micro- flow cell of 4 multichannels；5Y
Type 1 × N bifurcation fibers；6 high resolution spectrometers；7 sample cells；8 multi-channel peristaltic pumps；9 waste liquid pools；10 computers；11USB points
Line device；12 photoswitch data lines；13 spectrometer data lines；14 are coated with the sensing unit on golden film surface；15SMA905 connectors；16 first
Independent microchannel；17 second independent microchannels；The independent microchannel of 18 thirds；19 the 4th independent miniflows are logical
Road.
Specific implementation mode
It describes the specific implementation mode of the present invention in detail below in conjunction with technical solution and attached drawing, but this hair should not be limited with this
Bright protection domain.
Referring to an embodiment of the invention shown in figure one.A kind of multi-channel wavelength modulation type optical fiber detection system
System realizes that the SPR sensorgram in four channels measures.Including optical sensor system, sampling system, control system and data acquisition process
System.
The optical sensor system includes wide spectrum light source, 1 × 4 multimode fibre photoswitch, optical fiber SPR sensor and high-resolution
Rate spectrometer.Light source connects multimode fibre photoswitch, and photoswitch 1 into 4 goes out, and 4 outlets are separately connected 4 optical fiber SPR sensors.
Afterwards spectrometer is aggregated by 1 × 4 bifurcation fiber of Y types.The sampling system includes sample cell, multi-channel peristaltic pump, multichannel
Micro- flow cell and waste liquid pool.After optical fiber SPR sensor is carried out functional modification, plurality of target molecule mixture can be carried out
Repeated detection while detection or same molecule.The micro- flow cell of multichannel in series or in parallel can use.When being used in series, together
Kind sample flows successively through the micro- flow cell of multichannel；When used in parallel, each micro- flow cell is compacted using multichannel as independent sector
Sample introduction is detected experiment to dynamic pump simultaneously.The control system and data acquisition processing system are a computer, pass through data line
Control photoswitch is switched to specified light path, reads corresponding spectral information, carries out spectral normalization and filtering, peak-seeking and data note
Record.Computer control carries out the automatic cycle sampling of multichannel.
In the embodiment of the present invention, using marine optics HL2000 halogen tungsten lamp light sources, optical wavelength range is
360-2400nm；Using the miniature high resolution spectrometers of marine optics HR4000, spectral detection ranging from 200-1100nm.Using
1 point of 4Y type bifurcation fiber wire jumper realizes the connection between four sensing light paths and spectrometer
1 × 4 multimode fibre photoswitch is made of multimode silica fibre, and core diameter is 400 μm, numerical aperture 0.22,
Configure SMA905 connectors.Adjacency channel switching time is less than 10ms.By computer end, it can be achieved that specified light path is switched fast,
And the spectral information for acquiring respective channel carries out the calculating of follow-up resonant wavelength.
The optical fiber SPR sensor that this embodiment uses uses core diameter for 400 μm, the multimode light of numerical aperture 0.37
Fibre peels off one section of coat and covering on plastic envelope multimode fibre, forms sensing unit, length 5mm；On sensing unit surface
50nm golden films are coated with, deionized water environment low-resonance wavelength is 610nm or so, and refractive index sensitivity is 2000nm/RIU or so.
1 × 4 bifurcation fiber of Y types used, core diameter are 400 μm, numerical aperture 0.22, overall length 1m.
The micro- flow cell of multichannel of designed, designed, is made of PDMS material, and each microchannel includes entrance and exit,
Multiple microchannels in series or in parallel can use.Multichannel sample introduction is carried out using Lange BT100-2J type multi-channel peristaltic pumps.
Claims (10)
1. a kind of multi-channel wavelength modulation type optical fiber detecting system, which is characterized in that the multi-channel wavelength modulation type light
Fine SPR detecting systems include optical sensor system, sampling system, control system and data acquisition processing system；
The optical sensor system includes wide spectrum light source (1), 1 × N multimode fibres photoswitch (2), optical fiber SPR sensor (3)
With high resolution spectrometer (6)；Wide spectrum light source 1 connects 1 × N multimode fibres photoswitch (2), 1 × N multimode fibres photoswitch (2)
For 1 N number of outlet of import, N number of outlet is separately connected N number of optical fiber SPR sensor (3)；Afterwards by Y 1 × N of type bifurcation fibers (5)
It is aggregated into high resolution spectrometer (6)；Computer (10) output order control 1 × N multimode fibres photoswitch (2) is switched to specified
Path channels, optical signal are finally sent after optical fiber SPR sensor (3) to high resolution spectrometer (6), then through computer (10)
Signal acquisition and demodulation are carried out, realizes multichannel optical fiber SPR sensorgram；
The sampling system includes the micro- flow cell of multichannel (4), sample cell (7), multi-channel peristaltic pump (8) and waste liquid pool (9)；
By optical fiber SPR sensor (3) carry out functional modification after, carry out plurality of target molecule mixture detection or same molecule it is same
When repeated detection；The micro- flow cell of multichannel (4) serial or parallel connection uses；When being used in series, the same sample flows successively through multichannel
Micro- flow cell (4)；When used in parallel, each micro- flow cell as independent sector, using multi-channel peristaltic pump (8) while sample introduction into
Row test experience；
The control system and data acquisition processing system is computer (10), passes through data line traffic control 1 × N multimode fibre light
Switch (2) is switched to specified light path, reads corresponding spectral information, carries out spectral normalization and filtering, peak-seeking and data record；Meter
The control of calculation machine 101 carries out the automatic cycle sampling of multichannel.
2. multi-channel wavelength modulation type optical fiber detecting system according to claim 1, which is characterized in that described 1 ×
N multimode fibres photoswitch (2) is made of multimode silica fibre, and core diameter is 200-600 μm, and numerical aperture 0.22-0.37 matches
Set SMA905 connectors.
3. multi-channel wavelength modulation type optical fiber detecting system according to claim 1 or 2, which is characterized in that described
Optical fiber SPR sensor (3) uses core diameter to be not less than 0.22 optical fiber for 300-500 μm, numerical aperture, peels off plastic envelope
One section of coat on multimode fibre and covering form sensing unit, length 5mm-10mm；It is coated with 30- on sensing unit surface
60nm golden films, resonant wavelength are in visible light and near infrared band.
4. multi-channel wavelength modulation type optical fiber detecting system according to claim 1 or 2, which is characterized in that described
The micro- flow cell of multichannel (4), is made of PDMS material, and each microchannel includes entrance and exit, and multiple microchannels can
Serial or parallel connection uses.
5. multi-channel wavelength modulation type optical fiber detecting system according to claim 3, which is characterized in that described is more
The micro- flow cell in channel (4), is made of PDMS material, and each microchannel includes entrance and exit, and multiple microchannels can go here and there
Connection is used in parallel.
6. the multi-channel wavelength modulation type optical fiber detecting system according to claim 1,2 or 5, which is characterized in that described
Wide spectrum light source (1) be visible light/infrared band wide spectrum light source.
7. multi-channel wavelength modulation type optical fiber detecting system according to claim 3, which is characterized in that the width
It is visible light/infrared band wide spectrum light source to compose light source (1).
8. multi-channel wavelength modulation type optical fiber detecting system according to claim 4, which is characterized in that the width
It is visible light/infrared band wide spectrum light source to compose light source (1).
9. the multi-channel wavelength modulation type optical fiber detecting system according to claim 1,2,5,7 or 8, which is characterized in that
The wavelength detection range 400-1100nm of the high resolution spectrometer (6).
10. multi-channel wavelength modulation type optical fiber detecting system according to claim 6, which is characterized in that the height
The wavelength detection range 400-1100nm of resolution spectrometer (6).
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109655431A (en) * | 2018-12-12 | 2019-04-19 | 桂林电子科技大学 | Toroidal cores optical fiber SPR sensor |
| CN109738395A (en) * | 2019-01-11 | 2019-05-10 | 重庆大学 | Using the SPR detection device and SPR detection method of optical dispersion |
| CN109916815A (en) * | 2019-03-18 | 2019-06-21 | 上海陶术生物科技有限公司 | A kind of medicament screening apparatus based on SPR |
| CN110617875A (en) * | 2019-10-29 | 2019-12-27 | 大连理工大学 | Wavelength phase-shifting type optical fiber acoustic sensing array demodulation system and method |
| CN112461783A (en) * | 2019-10-17 | 2021-03-09 | 山东金璋隆祥智能科技有限责任公司 | Light path switching technology of GSA near-infrared spectrometer |
| CN112834464A (en) * | 2021-02-22 | 2021-05-25 | 宁波海歌电器有限公司 | Sample introduction system suitable for multi-channel terminal reflection type optical fiber SPR sensor and use method thereof |
| CN113049496A (en) * | 2021-03-25 | 2021-06-29 | 大连理工大学 | Tunable mid-infrared optical fiber SPR biosensor |
| CN113155782A (en) * | 2021-04-27 | 2021-07-23 | 大连理工大学 | Multi-channel terminal reflection type optical fiber surface plasmon resonance sensing detection system |
| CN113203711A (en) * | 2021-03-13 | 2021-08-03 | 杭州纽蓝科技有限公司 | Cross channel structure for SPR detection |
| CN114002171A (en) * | 2021-10-29 | 2022-02-01 | 苏州品赛医疗科技有限公司 | Solution sample detection and analysis method and thin film interferometer |
| CN115575355A (en) * | 2022-10-12 | 2023-01-06 | 大连理工大学 | Multichannel prism surface plasmon resonance sensor |
| CN117705765A (en) * | 2023-12-12 | 2024-03-15 | 大连海事大学 | Near infrared SPR integrated sensing device with high-performance multichannel |
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| CN109738395A (en) * | 2019-01-11 | 2019-05-10 | 重庆大学 | Using the SPR detection device and SPR detection method of optical dispersion |
| CN109916815B (en) * | 2019-03-18 | 2021-08-10 | 上海陶术生物科技有限公司 | Drug screening device based on SPR |
| CN109916815A (en) * | 2019-03-18 | 2019-06-21 | 上海陶术生物科技有限公司 | A kind of medicament screening apparatus based on SPR |
| CN112461783A (en) * | 2019-10-17 | 2021-03-09 | 山东金璋隆祥智能科技有限责任公司 | Light path switching technology of GSA near-infrared spectrometer |
| CN110617875A (en) * | 2019-10-29 | 2019-12-27 | 大连理工大学 | Wavelength phase-shifting type optical fiber acoustic sensing array demodulation system and method |
| CN112834464A (en) * | 2021-02-22 | 2021-05-25 | 宁波海歌电器有限公司 | Sample introduction system suitable for multi-channel terminal reflection type optical fiber SPR sensor and use method thereof |
| CN113203711A (en) * | 2021-03-13 | 2021-08-03 | 杭州纽蓝科技有限公司 | Cross channel structure for SPR detection |
| CN113049496A (en) * | 2021-03-25 | 2021-06-29 | 大连理工大学 | Tunable mid-infrared optical fiber SPR biosensor |
| CN113049496B (en) * | 2021-03-25 | 2022-04-12 | 大连理工大学 | Tunable mid-infrared optical fiber SPR biosensor |
| CN113155782A (en) * | 2021-04-27 | 2021-07-23 | 大连理工大学 | Multi-channel terminal reflection type optical fiber surface plasmon resonance sensing detection system |
| CN114002171A (en) * | 2021-10-29 | 2022-02-01 | 苏州品赛医疗科技有限公司 | Solution sample detection and analysis method and thin film interferometer |
| CN115575355A (en) * | 2022-10-12 | 2023-01-06 | 大连理工大学 | Multichannel prism surface plasmon resonance sensor |
| CN117705765A (en) * | 2023-12-12 | 2024-03-15 | 大连海事大学 | Near infrared SPR integrated sensing device with high-performance multichannel |
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