CN109115727A - A kind of surface plasma resonance biological sensing detection device of multichannel - Google Patents
A kind of surface plasma resonance biological sensing detection device of multichannel Download PDFInfo
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- CN109115727A CN109115727A CN201810895836.0A CN201810895836A CN109115727A CN 109115727 A CN109115727 A CN 109115727A CN 201810895836 A CN201810895836 A CN 201810895836A CN 109115727 A CN109115727 A CN 109115727A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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Abstract
The present invention relates to surface plasma resonance biological detection field more particularly to a kind of surface plasma resonance biological sensing detection devices of multichannel.The device includes sample feeding pond, miniflow plate, rotary drive mechanism, support frame, semicolumn prism, laser, photoelectric detector, data acquisition unit and shading cabinet；Support frame in the device can be swung under the drive of rotary drive mechanism, laser is also slided on the support frame while as the swing of support frame changes position, enter to set to obtain angle to greatly change laser, due to rotary drive mechanism driving support frame and then laser is driven repeatedly to be swung, to improve the number that plasma resonance occurs for bio-sensing area, it is analyzed according to the data that several times of plasma resonance detects, it can be concluded that the concentration of more accurate detection solution, improves the detection precision of the present apparatus.
Description
Technical field
The present invention relates to surface plasma resonance biological detection field more particularly to a kind of surface plasma of multichannel are total
Vibration bio-sensing detection device.
Background technique
In numerous biochemistry sensing analysis technologies, surface plasma resonance biological sensing technology for it is biomedical,
The detection of environment, agricultural, biological sample in food safety has become new research hotspot.Surface plasma resonance detection
Technology has strong real-time, exempts from compared with the technologies such as matter phase chromatography, liquid chromatogram, infrared and ultraviolet absorption techniques and atomic emissions
Indicate and detect the features such as not damaged.Surface plasma resonance biological sensing technology be using light high refractive index substrate with it is valuable
After the transmitting total reflection of golden film interface, the evanescent wave for penetrating interface certain depth is generated, the free electron inside precious metal is excited
Collective's concussion is generated, plasma wave (surface plasma-wave) is generated in precious metal surface, when the propagation constant of surface plasma-wave
When identical as the propagation constant of incident light wave, that is, surface plasma resonance phenomenon is generated, intensity of reflected light is minimum at this time.Pass through inspection
The variation for generating the least resonance angle of intensity of reflected light is surveyed, determines the dielectric constant of sample to be tested, and then analyze sample to be tested
Biochemical characteristic.Fig. 2 is the schematic diagram of surface plasma resonance biological sensing device in the prior art, and surface plasma is total
Vibration biosensing device includes the semicolumn prism 23 of diamond structure, and setting has substrate 21 and metal layer 22 on prism
Optical system 24 and photoelectric detector 25 of the semicolumn prism two sides as light source is arranged in chip.The metal layer is by film-form
Flat part 26 and configuration spaced at intervals metal particle 27 formed protrusion constitute.But existing equipment still has
Some problems: the laser in existing equipment often during the swing, as long as a plasma resonance has occurred, just no longer
Continue to swing, so that the solution concentration inaccuracy of detection affects the accuracy of device detection in turn.
Summary of the invention
For the accuracy for solving the problems, such as above-mentioned device, the present invention adopts the following technical scheme:
A kind of surface plasma resonance biological sensing detection device of multichannel include support frame and setting on the support frame
Semicolumn prism, the two sides of the semicolumn prism are separately installed with the laser towards semicolumn prism shaft section incident beam
Pass through with the upper surface of the photoelectric detector for detecting semicolumn prism shaft section reflected beam energy, the semicolumn prism
Index-matching fluid is connected with sheet glass, the glass sheet surface metal-plated membrane, on the metal film there are two coverings
The bio-sensing areas of plasma resonances occur so as to form two or more for the miniflow plate for accommodating different detection solution above, described
Laser is swung by connecting rod rest and support frame as described above and is connected, and support frame as described above is equipped with for driving the connecting rod rest around described
Semicolumn prism reciprocally swinging is to adjust the rotary drive mechanism of the incident angle for the laser that the laser issues.
The laser is arranged on the connecting rod rest, and the connecting rod rest is equipped with for driving the laser in institute
State the straight line driving mechanism slided on connecting rod rest.
Support frame as described above includes two columns being oppositely arranged, and the both ends of the semicolumn prism are correspondingly arranged at accordingly
On column, the connecting rod rest includes two side connecting rods, and one end of two side connecting rods is rotatably assorted with corresponding column, is another
End slidable fit has cross bar, and the laser setting is on the cross bar.
The rotary drive mechanism includes the angle motor of setting on the support frame, the power output shaft of angle motor and institute
Connecting rod rest connection is stated, the straight line driving mechanism includes slide motor, and slide motor drives institute by nut screw transmission mechanism
It states laser to move on connecting rod rest, the surface plasma resonance biological sensing detection device of the multichannel further includes for controlling
Make the control unit of the angle motor and slide motor.
The surface plasma resonance biological sensing detection device of the multichannel further includes the screening for exterior light photograph to be isolated
Light box body, so as to form opacus darkroom.
The side of the photoelectric detector setting on the support frame, is oppositely arranged with the laser.
A kind of surface plasma resonance biological sensor detection device of multichannel further includes sample container, described
Sample container at least provided with two, the sample container is connected by pipeline with the miniflow plate.
A kind of surface plasma resonance biological sensing detection device of multichannel further includes and photoelectric detector phase
It is used in conjunction in the data acquisition unit of acquisition data.
The support frame, connection frame, rotary drive mechanism, straight line driving mechanism, semicolumn prism, laser, photoelectricity
Detector is arranged in shading cabinet.
The beneficial effects of the present invention are: the support frame in the device can be put under the drive of rotary drive mechanism
Dynamic, laser is also slided on the support frame while as the swing of support frame changes position, thus greatly
It changes laser and enters to set to obtain angle, due to rotary drive mechanism driving support frame and then laser is driven repeatedly to be swung, from
And the number that plasma resonance occurs for bio-sensing area is improved, divided according to the data that several times of plasma resonance detects
Analysis, it can be deduced that the concentration of more accurate detection solution improves the detection precision of the present apparatus.
Detailed description of the invention
Fig. 1 is the schematic diagram of surface plasma resonance biological sensing device in the prior art；
Fig. 2 is the structural schematic diagram of the surface plasma resonance biological sensing detection device of the multichannel of the embodiment of the present invention；
Fig. 3 is the structural schematic diagram that the shading box house relevant device of Fig. 2 is connected；
Fig. 4 is the partial enlarged view of miniflow plate in Fig. 2；
Fig. 1: 21, substrate；22 metal layers；23, prism；24, optical system；25, photoelectric detector；26, flat part；27, metal
Particle；
Fig. 2: 1, sample container；2, laser；3, semicolumn prism；4, rotary drive mechanism；5, miniflow plate；6, Photoelectric Detection
Device；7, support frame；8, data acquisition unit；9, shading cabinet；A, the first side lever；B, the second side lever；C, cross bar；10, miniflow plate；
Fig. 4: 101, groove.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The embodiment of multiple channel surface plasma resonant bio-sensing detection device of the invention includes sample as shown in Figure 1:
Product sample inlet pool 1, sheet glass 5, rotary drive mechanism 4, by a, b and c connecting rod rest, support frame 7, semicolumn prism3, laser2, light
Photodetector 6, data acquisition unit 8, shading cabinet 9.Sample feeding pond 1 is connected by pipeline with miniflow plate, enables sample
Enough resonate；9 body of shading case is in outermost layer, is wrapped in all components；Support frame 7 is among shading cabinet, is set up separately
The left and right sides is clipped semicolumn prism 3 by the groove protective shell of semicircle among support frame 7；Adhere to one on semicolumn prism 3
Layer metal film, is covered on metal film with reeded miniflow plate 10 by index-matching fluid, the groove 101 on sheet glass 10
It is connect by pipeline with sample inlet pool；There is the hole slot of installation rotary drive mechanism 4 in the outside of support frame 7, and the bipod of connecting rod is fixed on
On rotary drive mechanism, the intermediate whippletree of connecting rod is removable, mobile by the interior side slideway of two sides connecting rod, and intermediate horizontal
Laser 2 is installed at bar；Photoelectric detector 6 is placed on Photoelectric Detection in the other side of semicolumn prism 3, horizontal by angle
On the fixed frame of device 6 itself, it is connect by data line with power supply, data acquisition unit.
Preferably, the metal film on semicolumn prism uses 50nm precious metal film, and the 50nm precious metal film refers to
The gold or silverskin of 50nm are deposited on the sheet glass of BK7, one layer of biomolecule is then grown on the precious metal film of 50nm
Identify film, biochemical to be detected flows through 50nm precious metal film, and knows with biomolecule on 50nm precious metal film
Other film interacts, and the concentration of biological sample to be measured is reflected in resonance spectrum by the variation of refractive index.
Plasma biological detection is carried out using multichannel technology, a variety of biomaterials can be disposably carried out and be detected, is imitated
Rate is greatly improved, and inspection greatly improved using plasma detection technique in the biggish time for shortening detection process
The sensitivity and stability of survey.
Sample feeding pond 1 includes sample injection hole, sample container, injection port, wriggling bar, heating rod, pipe joint；Detection
Detection solution is added dropwise into sample container by sample injection hole by personnel, and after sample enters sample container, heating rod will be to test sample
In suitably detection temperature range, wriggling bar makes solution enter miniflow by circulation duct driven by the motor for product control
The sample inlet of plate connects, and sample is contacted in the groove 101 of miniflow intralamellar part with bio-sensing area, and is gone out in the sample of miniflow plate
The outflow of mouth end.Plasma biological detection is carried out using multichannel technology, a variety of biomaterials can be disposably carried out and be detected, is imitated
Rate is greatly improved, and inspection greatly improved using plasma detection technique in the biggish time for shortening detection process
The sensitivity and stability of survey.
There is sample flow conduit i.e. groove 101 inside miniflow plate 10, at the panel both ends by the nipple orifice of screw tap form, leads to
Circulation duct and the panel are attached by the nipple orifice for crossing tap-type；The interference for considering veiling glare simultaneously, by panel black
Resistant material be made, in the joint face of panel and semicolumn, be coated with the fusion agent of approximate optical characteristic, guarantee joint face
Leakproofness and stability.
For rotary drive mechanism 4 using the servo motor of angle control, angular scan rate, scanning range and direction are controllable,
Rotary drive mechanism 4 is fixed on the right side of support frame 7；Connecting rod rest is made of three connecting rods, the first side lever a and rotary drive mechanism
Connection, the second side lever b are fixed on the left side of support frame 7, cross bar c connection the first side lever a above-mentioned and the second side lever by bearing
b；Wherein there is movable slide on the inside of the first side lever a, the second side lever b, sliding block is by lead screw motor in the first side lever a, second side
It is moved forward and backward on bar b, cross bar c is fixed on two inside blocks of the first side lever a, the second side lever b, and laser 2 is fixed on cross
The inside of bar c.
Support frame 7 is for fixing the second side lever b, rotary drive mechanism 4, semicolumn prism 3；The outside on 7 right side of support frame
There is the hole slot of fixed rotary drive mechanism 4, rotary drive mechanism 4 is mounted in hole slot；Have on the inside of the right side of support frame solid
Determine the hole slot of semicolumn prism 3, semicolumn prism 3 is mounted in hole slot；There is fixed second side on the outside of the left side of support frame 7
The hole slot of bar b connection bearing, connection bearing are fixed in hole slot；There is fixed semicolumn prism on the inside of the left side of support frame 7
Hole slot, semicolumn prism 3 is mounted in hole slot；There is the concave station of fixed semicolumn prism 3 in the inside of support frame 7 simultaneously, it is recessed
Platform or so has the wire hole for putting semicolumn prism protection shell.
It is covered with layer of metal film on the surface of the rectangular section of semicolumn prism 3, surface will occur on metal membrane interface
Plasma resonance phenomenon；Have sheet glass 5 above semicolumn prism 3, the test sample on sheet glass sheet glass 5 groove with
Metal diaphragm contacts on semicolumn prism 3；Semicolumn prism protection shell is protected for fixing semicolumn prism 3, semicolumn prism
Protective case body is made of semicolumn slot shell and semicircle rubber pad, semicircle rubber ring；It is needed when installation by semicircle rubber ring sleeve half
On cylinder-prism, semicircle rubber pad is put in semicolumn slot shell, then shell is covered in the semi-circular section of semicolumn prism 3
On.
Preferably, the metal film of the present apparatus uses 50nm precious metal film, and 50nm precious metal film refers to the glass in BK7
The gold or silverskin of 50nm is deposited on piece, and one layer of biomolecule is then grown on the precious metal film of 50nm and identifies film, to be checked
The biochemical of survey flows through 50nm precious metal film, and occurs mutually with biomolecule identification film on 50nm precious metal film
Effect, the concentration of biological sample to be measured are reflected in resonance spectrum by the variation of refractive index.
Laser 2 will be built in multiple lasers in panel；Laser 2 is fixed on connecting rod rest, the output beam of laser
It is strong and weak controllable, and laser is rotated around semicolumn prism centers axis.
Preferably, photoelectric detector 6 uses linear array change couple device, double channel linear charge-coupled array.
Preferably, data acquisition unit 8 carries out the acquisition of data for connecting relevant component.
Preferably, shading cabinet 9 uses black shading cabinet, and the plasma for avoiding extraneous light from interfering with box house is total
Vibration process.
The course of work of the device: before biochemical samples start detection, rotary drive mechanism 4 drives connecting rod rest to make laser
Device 2 scans certain angle, and laser passes through the middle line position of semicolumn prism 3 and directive semicolumn cross section at different angles
It sets, in sheet glass 5 and 3 interface of semicolumn prism the variation such as reflection or refraction occurs for laser, while remembering on photoelectric detector 6
The angle and laser of record detection scanning are in the weak variation of light intensity for being not engaged in sample detection, and control unit is according to photoelectric detector 6
The light intensity situation of detection, position and laser 2 of the appropriate basic angle, laser 2 for changing the detection of rotary drive mechanism 4 in connecting rod
Issue the power of light beam.
When starting detection, a certain amount of difference can be added to test sample by the sample container into sample feeding pond simultaneously
Product, the heating rod in sample container is by the temperature control of sample in detection proper range, and the wriggling stick of sample container is in motor
Lower sample is driven to be flowed on the channel of miniflow plate 10 by the pipeline in different channels, rotary drive mechanism 4 is since the detection of basis
It rotates clockwise, while laser 2 issues multiple laser, the miniflow that has sample solution of the laser in 3 interface of semicolumn prism
As in some angle surface plasma resonance can occur for the variation of laser scanning angle on plate 10, photoelectric detector 6 can be examined
The variation of the angle change and laser power of entire reaction process is measured, the data of real-time detection will be uploaded to by data-interface
Embedded control unit or computer platform, embedded control unit or computer platform draw data with corresponding inspection software
The homologous thread of resonance angle and light intensity is made；After the completion of Scanning Detction clockwise, rotary drive mechanism 4 will be from maximum rotation angle
Position is spent, initial position is rotated counterclockwise to, this time scanning process will record testing result again, twice Analysis of test results
It compares, keeps testing result more accurate, and exclude influence of the disturbing factor to detection data.
Beneficial effects of the present invention: the support frame in the device can be swung under the drive of rotary drive mechanism,
Laser also while is on the support frame slided while as the swing of support frame changes position, thus greatly
It changes laser and enters to set to obtain angle, due to rotary drive mechanism driving support frame and then laser is driven repeatedly to be swung, from
And the number that plasma resonance occurs for bio-sensing area is improved, divided according to the data that several times of plasma resonance detects
Analysis, it can be deduced that the concentration of more accurate detection solution improves the detection precision of the present apparatus.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, this field is common
Other modifications or equivalent replacement that technical staff makes technical solution of the present invention, without departing from technical solution of the present invention
Spirit and scope, be intended to be within the scope of the claims of the invention.
Claims (9)
1. a kind of surface plasma resonance biological sensing detection device of multichannel, it is characterised in that: including support frame and set
Semicolumn prism on the support frame is set, the two sides of the semicolumn prism are separately installed with towards semicolumn prism shaft section
The laser of irradiating light beam and photoelectric detector for detecting semicolumn prism shaft section reflected beam energy, the semicolumn rib
The upper surface of mirror is connected with sheet glass, the glass sheet surface metal-plated membrane, the metal by index-matching fluid
More than two miniflow plates for accommodating different detection solution are covered on film so as to form more than two generation plasma resonances
Bio-sensing area, the laser are swung by connecting rod rest and support frame as described above and are connected, and support frame as described above is equipped with for driving
The connecting rod rest adjusts the rotation of the incident angle for the laser that the laser issues around the semicolumn prism reciprocally swinging
Driving mechanism.
2. the surface plasma resonance biological sensing detection device of multichannel according to claim 1, it is characterised in that: institute
It states laser to be arranged on the connecting rod rest, and the connecting rod rest is equipped with for driving the laser in the connecting rod rest
The straight line driving mechanism of sliding.
3. the surface plasma resonance biological sensing detection device of multichannel according to claim 2, it is characterised in that: institute
Stating support frame includes two columns being oppositely arranged, and the both ends of the semicolumn prism are correspondingly arranged on corresponding column, institute
Stating connecting rod rest includes two side connecting rods, and one end of two side connecting rods is rotatably assorted with corresponding column, other end sliding fills
Equipped with cross bar, the laser setting is on the cross bar.
4. the surface plasma resonance biological sensing detection device of multichannel according to claim 3, it is characterised in that: institute
Stating rotary drive mechanism includes the angle motor of setting on the support frame, and the power output shaft of angle motor and the connecting rod rest connect
It connects, the straight line driving mechanism includes slide motor, and slide motor drives the laser to exist by nut screw transmission mechanism
It is moved on connecting rod rest, the surface plasma resonance biological sensing detection device of the multichannel further includes for controlling the angle
The control unit of motor and slide motor.
5. a kind of surface plasma resonance biological sensing detection device of multichannel according to claim 4, feature exist
In: the surface plasma resonance biological sensing detection device of the multichannel further includes the shading case for exterior light photograph to be isolated
Body, so as to form opacus darkroom.
6. a kind of surface plasma resonance biological sensing detection device of multichannel according to claim 1, feature exist
In: the side of the photoelectric detector setting on the support frame is oppositely arranged with the laser.
7. a kind of surface plasma resonance biological sensing detection device of multichannel according to claim 1, feature exist
In: a kind of surface plasma resonance biological sensor detection device of multichannel further includes sample container, the sample
At least provided with two, the sample container is connected by pipeline with the miniflow plate product container.
8. a kind of surface plasma resonance biological sensing detection device of multichannel according to claim 1, feature exist
In: a kind of surface plasma resonance biological sensing detection device of multichannel further includes being connected to be used for photoelectric detector
Acquire the data acquisition unit of data.
9. a kind of surface plasma resonance biological sensing detection device of multichannel according to claim 5, feature exist
In: the support frame, connection frame, rotary drive mechanism, straight line driving mechanism, semicolumn prism, laser, photoelectric detector
It is arranged in shading cabinet.
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| CN201810895836.0A CN109115727A (en) | 2018-08-08 | 2018-08-08 | A kind of surface plasma resonance biological sensing detection device of multichannel |
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| CN201810895836.0A CN109115727A (en) | 2018-08-08 | 2018-08-08 | A kind of surface plasma resonance biological sensing detection device of multichannel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109985676A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A kind of Multi-channel liquid sample collection storage device suitable for hand-held SPR detector |
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