CN1066269A - 乳腺炎的治疗方法 - Google Patents
乳腺炎的治疗方法 Download PDFInfo
- Publication number
- CN1066269A CN1066269A CN92103134A CN92103134A CN1066269A CN 1066269 A CN1066269 A CN 1066269A CN 92103134 A CN92103134 A CN 92103134A CN 92103134 A CN92103134 A CN 92103134A CN 1066269 A CN1066269 A CN 1066269A
- Authority
- CN
- China
- Prior art keywords
- group
- alkyl
- halogen
- hydroxyl
- lactation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 18
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 claims abstract description 33
- 241001465754 Metazoa Species 0.000 claims abstract description 24
- 230000006651 lactation Effects 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 12
- 241000283690 Bos taurus Species 0.000 claims description 21
- -1 ethylenedioxy, benzyl Chemical group 0.000 claims description 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
- 230000035606 childbirth Effects 0.000 claims description 8
- DWCDIJFGUYALMH-UHFFFAOYSA-N (2-phenylacetyl) benzenecarboperoxoate Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)CC1=CC=CC=C1 DWCDIJFGUYALMH-UHFFFAOYSA-N 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 244000309465 heifer Species 0.000 claims description 5
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 3
- 230000035935 pregnancy Effects 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 description 28
- 210000004080 milk Anatomy 0.000 description 14
- 239000008267 milk Substances 0.000 description 14
- 235000013336 milk Nutrition 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 241000191940 Staphylococcus Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 0 **C([C@](C1O)O*)OC(*)[C@@]1O Chemical compound **C([C@](C1O)O*)OC(*)[C@@]1O 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000004396 mastitis Diseases 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000282849 Ruminantia Species 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000005075 mammary gland Anatomy 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010006262 Breast inflammation Diseases 0.000 description 1
- UQLLWWBDSUHNEB-CZUORRHYSA-N Cefaprin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CSC1=CC=NC=C1 UQLLWWBDSUHNEB-CZUORRHYSA-N 0.000 description 1
- 238000010268 HPLC based assay Methods 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193985 Streptococcus agalactiae Species 0.000 description 1
- 241000194042 Streptococcus dysgalactiae Species 0.000 description 1
- 241000194054 Streptococcus uberis Species 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960004350 cefapirin Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940115920 streptococcus dysgalactiae Drugs 0.000 description 1
- 229940115922 streptococcus uberis Drugs 0.000 description 1
- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000223 tilmicosin Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69472091A | 1991-05-02 | 1991-05-02 | |
| US694,720 | 1991-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1066269A true CN1066269A (zh) | 1992-11-18 |
Family
ID=24790008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92103134A Pending CN1066269A (zh) | 1991-05-02 | 1992-04-30 | 乳腺炎的治疗方法 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0512779A1 (enExample) |
| JP (1) | JPH05186355A (enExample) |
| KR (1) | KR920021142A (enExample) |
| CN (1) | CN1066269A (enExample) |
| AU (1) | AU652443B2 (enExample) |
| CA (1) | CA2067520A1 (enExample) |
| CZ (1) | CZ133592A3 (enExample) |
| IE (1) | IE921419A1 (enExample) |
| IL (1) | IL101749A0 (enExample) |
| MX (1) | MX9202034A (enExample) |
| NO (1) | NO921720L (enExample) |
| NZ (1) | NZ242557A (enExample) |
| TW (1) | TW221028B (enExample) |
| ZA (1) | ZA923125B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103923141A (zh) * | 2014-04-21 | 2014-07-16 | 西南大学 | 一种依托替米考星的合成方法 |
| CN106692137A (zh) * | 2016-12-27 | 2017-05-24 | 王�华 | 一种急性乳腺炎的乳导管治疗方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6608033B1 (en) | 1999-08-27 | 2003-08-19 | Pfizer Inc. | Treatment or prevention of coccidiosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820695A (en) * | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| FR2646081A1 (enExample) * | 1989-04-20 | 1990-10-26 | Adir |
-
1992
- 1992-04-29 CA CA002067520A patent/CA2067520A1/en not_active Abandoned
- 1992-04-29 TW TW081103349A patent/TW221028B/zh active
- 1992-04-29 ZA ZA923125A patent/ZA923125B/xx unknown
- 1992-04-30 IL IL101749A patent/IL101749A0/xx unknown
- 1992-04-30 CZ CS921335A patent/CZ133592A3/cs unknown
- 1992-04-30 NZ NZ242557A patent/NZ242557A/en unknown
- 1992-04-30 KR KR1019920007370A patent/KR920021142A/ko not_active Withdrawn
- 1992-04-30 CN CN92103134A patent/CN1066269A/zh active Pending
- 1992-04-30 NO NO92921720A patent/NO921720L/no unknown
- 1992-04-30 AU AU15937/92A patent/AU652443B2/en not_active Expired - Fee Related
- 1992-04-30 MX MX9202034A patent/MX9202034A/es unknown
- 1992-05-01 EP EP92304005A patent/EP0512779A1/en not_active Ceased
- 1992-05-01 JP JP4112525A patent/JPH05186355A/ja not_active Withdrawn
- 1992-07-01 IE IE141992A patent/IE921419A1/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103923141A (zh) * | 2014-04-21 | 2014-07-16 | 西南大学 | 一种依托替米考星的合成方法 |
| CN103923141B (zh) * | 2014-04-21 | 2016-04-27 | 西南大学 | 一种依托替米考星的合成方法 |
| CN106692137A (zh) * | 2016-12-27 | 2017-05-24 | 王�华 | 一种急性乳腺炎的乳导管治疗方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX9202034A (es) | 1992-11-01 |
| AU1593792A (en) | 1992-11-05 |
| NO921720D0 (no) | 1992-04-30 |
| NO921720L (no) | 1992-11-03 |
| IE921419A1 (en) | 1992-11-04 |
| EP0512779A1 (en) | 1992-11-11 |
| CA2067520A1 (en) | 1992-11-03 |
| JPH05186355A (ja) | 1993-07-27 |
| NZ242557A (en) | 1993-10-26 |
| TW221028B (enExample) | 1994-02-11 |
| KR920021142A (ko) | 1992-12-18 |
| ZA923125B (en) | 1993-10-29 |
| IL101749A0 (en) | 1992-12-30 |
| CZ133592A3 (en) | 1993-01-13 |
| AU652443B2 (en) | 1994-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination |