CN106619617A - Melatonin composition and preparation method thereof - Google Patents
Melatonin composition and preparation method thereof Download PDFInfo
- Publication number
- CN106619617A CN106619617A CN201611094238.0A CN201611094238A CN106619617A CN 106619617 A CN106619617 A CN 106619617A CN 201611094238 A CN201611094238 A CN 201611094238A CN 106619617 A CN106619617 A CN 106619617A
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- CN
- China
- Prior art keywords
- epiphysin
- starch
- premix
- cobastab
- magnesium stearate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a melatonin composition and a preparation method thereof, and belongs to the technical field of health products. In an inventory ration of 1000 grains, the melatonin composition contains the following materials by weight: 2-3.5g of melatonin, 1.5-2.5g of vitamin B6, 80-120g of starch, 200-250g of powdered sugar, 5-9g of silicon dioxide, and 1.5-2.5g of magnesium stearate. By virtue of the composition having the effects of soothing the nerves and improving sleeping and prepared by mixing of the melatonin, the vitamin B6 and the like, disclosed by the invention, the problem of different injuries to a body due to long-time taking of sleeping pills is solved, and the composition has the advantages of improving sleeping, delaying senescence and adjusting immunity.
Description
Technical field
The invention belongs to health product technology field, and in particular to a kind of epiphysin composition and preparation method thereof.
Background technology
People has 1/3rd time among all one's life spent in sleep, and not sleeping within five days to die, it is seen that sleep
It is the physiological requirements of people, sleeps as process necessary to life, is the important step of body recovery, integration and consolidating memory,
It is healthy indispensable part.Sleep refers to the inertia and non-reactiveness of recurrence, during sleep level of consciousness reduction or
Disappear, most physiological activity and be reacted into inert condition, by sleep, the nerve cell for making fatigue recovers normal raw
Reason function, spirit and muscle power are restored.Anterior pituitary growth hormone secretion substantially increases during sleep, may advantageously facilitate body life
It is long, and increase nucleoprotein synthesis, be conducive to the storage remembered.Sleep failure refers to exception and length of one's sleep of sleep quality
It is abnormal, or there are some clinical symptoms in sleep, such as sleep is reduced or hypersomnia, somnambulism etc., is affected to fall asleep or is kept
The various obstacles of ortho ability, also including hypersomnia, or the behavior of the sleep correlation of exception.Occur sleep failure when
Wait, often take the medicine of hypnotic etc, but long-term taking hypnotic has different degrees of injury to human body, such as can
Cause liver and kidney failure, in addition long-term taking hypnotic has different degrees of injury to human body, such as can cause liver kidney work(
Energy exhaustion, phrenoblabia, or even induction other diseases.
The content of the invention
According to above the deficiencies in the prior art, the technical problem to be solved is to propose a kind of epiphysin composition
And preparation method thereof, by mixing epiphysin, Cobastab6Etc. system with the composition calmed the nerves, improve the health care of sleep, length is solved
Phase takes the problems that hypnotic causes different injuries to body, has the advantages that to improve the health care of sleep, anti-aging, adjusts immunity.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is：A kind of epiphysin composition, with 1000
Feed intake gauge, comprising following material and its content：Epiphysin 2-3.5g, Cobastab61.5-2.5g, starch 80-120g, Icing Sugar
200-250g, silica 5-9g, magnesium stearate 1.5-2.5g.
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2-2.9g,
Cobastab61.5-1.9g, starch 90-105g, Icing Sugar 210-240g, silica 6-8g, magnesium stearate 1.6-2.4g.
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2.8g, dimension
Raw element B61.8g, starch 95g, Icing Sugar 240g, silica 8g, magnesium stearate 2.4g.
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2.7g, dimension
Raw element B61.9g, starch 98g, Icing Sugar 238g, silica 7.2g, magnesium stearate 2.2g.
A kind of preparation method of epiphysin composition, methods described step includes：
Step one, take epiphysin and Cobastab6Sieve respectively prepared fine powder, and prepared premix is well mixed with silica
Material A；Epiphysin and Cobastab6Sieve and use 100 mesh sieves；
Step 2, starch sieve prepared starch dust, and prepared premix B is well mixed by equal increments method with premix A；
Step 3, white sugar sieve prepared Icing Sugar, and 30 minutes prepared premix C are mixed with premix B；
Step 4, take magnesium stearate and mix with premix C 15 minutes, total mixed powder is obtained after being well mixed；
After step 5, the inspection of total mixed powder, send into capsule machine filling and capsule is obtained.
Present invention has the advantages that:Epiphysin, epiphysin enzymatic reaction and non-enzymatic in body is employed herein
May produce free radical during reaction, free radical and aging have it is close contact, the effect with anti-aging, epiphysin in addition
Can shorten and sleep front awakening time and time for falling asleep, improve the health care of sleep quality, number of times of awakening in sleep is significantly reduced, shallow to sleep the stage short,
Deep sleep stages extend, and morning next day threshold wake-up value declines, and have stronger jet lag function and adjust immunologic function, and this product is adapted to
Adult is edible, and raw material sources fully, can be produced throughout the year.It may be said that the product integrates nutrition, health care,
Dimensions of market is big, and rationally, input and output are high for process design, and high financial profit can have good return rate.
Specific embodiment
Below against by the description to embodiment, the shape of for example involved each component of specific embodiment of the invention
Mutual alignment and annexation, the effect of each several part and operation principle, manufacturing process and operation between shape, construction, each several part
Using method etc., is described in further detail, to help inventive concept, technical scheme of the those skilled in the art to the present invention
There is more complete, accurate and deep understanding.
Embodiment one,
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2-3.5g,
Cobastab61.5-2.5g, starch 80-120g, Icing Sugar 200-250g, silica 5-9g, magnesium stearate 1.5-2.5g.
The preparation method of above-mentioned epiphysin composition is：
Step one, take epiphysin and Cobastab6100 mesh sieves are crossed respectively fine powder is obtained, be well mixed with silica prepared
Premix A.
Step 2, starch cross 100 sieve series and obtain starch dust, and prepared premix is well mixed by equal increments method with premix A
Material B；
Step 3, white sugar cross 100 sieve series and obtain Icing Sugar, and 30 minutes prepared premix C are mixed with premix B；
Step 4, take magnesium stearate and mix with premix C 15 minutes, total mixed powder is obtained after being well mixed；
After step 5, the inspection of total mixed powder, capsule machine is sent into, capsule is obtained with every 0.35g filling, capsule is thrown
Light, select and packed after certified products, choose the underproof packaging product of outward appearance in time during inner packing, inner packing (60/
Bottle) after capsule put in storage Jing after external packing, quality inspection.
Embodiment two,
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2-2.9g,
Cobastab61.5-1.9g, starch 90-105g, Icing Sugar 210-240g, silica 6-8g, magnesium stearate 1.6-2.4g.
Embodiment three,
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2.8g, dimension
Raw element B61.8g, starch 95g, Icing Sugar 240g, silica 8g, magnesium stearate 2.4g.
Example IV,
A kind of epiphysin composition, with 1000 gauge that feed intake, comprising following material and its content：Epiphysin 2.7g, dimension
Raw element B61.9g, starch 98g, Icing Sugar 238g, silica 7.2g, magnesium stearate 2.2g.
Above in conjunction with being exemplarily described to the present invention, it is clear that the present invention is implemented and do not limited by aforesaid way
System, if the improvement of the various unsubstantialities that method of the present invention design and technical scheme are carried out is employed, or not improved general
The design and technical scheme of the present invention directly applies to other occasions, within protection scope of the present invention.The present invention's
The protection domain that protection domain should be limited by claims is defined.
Claims (6)
1. a kind of epiphysin composition, it is characterised in that with 1000 gauge that feed intake, comprising following material and its content：Take off black
Plain 2-3.5g, Cobastab61.5-2.5g, starch 80-120g, Icing Sugar 200-250g, silica 5-9g, magnesium stearate 1.5-
2.5g。
2. epiphysin composition according to claim 1, it is characterised in that with 1000 gauge that feed intake, comprising following thing
Matter and its content：Epiphysin 2-2.9g, Cobastab61.5-1.9g, starch 90-105g, Icing Sugar 210-240g, silica 6-
8g, magnesium stearate 1.6-2.4g.
3. epiphysin composition according to claim 1, it is characterised in that with 1000 gauge that feed intake, comprising following thing
Matter and its content：Epiphysin 2.8g, Cobastab61.8g, starch 95g, Icing Sugar 240g, silica 8g, magnesium stearate 2.4g.
4. epiphysin composition according to claim 1, it is characterised in that with 1000 gauge that feed intake, comprising following thing
Matter and its content：Epiphysin 2.7g, Cobastab61.9g, starch 98g, Icing Sugar 238g, silica 7.2g, magnesium stearate
2.2g。
5. the preparation method of epiphysin composition according to claim 1, it is characterised in that methods described step includes：
Step one, take epiphysin and Cobastab6Sieve respectively prepared fine powder, and prepared premix A is well mixed with silica；
Step 2, starch sieve prepared starch dust, and prepared premix B is well mixed by equal increments method with premix A；
Step 3, white sugar sieve prepared Icing Sugar, and 30 minutes prepared premix C are mixed with premix B；
Step 4, take magnesium stearate and mix with premix C 15 minutes, total mixed powder is obtained after being well mixed；
After step 5, the inspection of total mixed powder, send into capsule machine filling and capsule is obtained.
6. the preparation method of epiphysin composition according to claim 5, it is characterised in that epiphysin in the step one
And Cobastab6Sieve and use 100 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611094238.0A CN106619617A (en) | 2016-12-02 | 2016-12-02 | Melatonin composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611094238.0A CN106619617A (en) | 2016-12-02 | 2016-12-02 | Melatonin composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619617A true CN106619617A (en) | 2017-05-10 |
Family
ID=58814109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611094238.0A Pending CN106619617A (en) | 2016-12-02 | 2016-12-02 | Melatonin composition and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN106619617A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407761A (en) * | 2020-04-28 | 2020-07-14 | 广东润源中天生物科技有限公司 | Melatonin vitamin B6 tablet and production method thereof |
| CN114246834A (en) * | 2021-12-30 | 2022-03-29 | 宣城柏维力生物工程有限公司 | Melatonin orally disintegrating preparation for improving sleep and production process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416884A (en) * | 2002-12-03 | 2003-05-14 | 沈阳药科大学 | Melatonin composition with soporific effect and its prepn |
| US20060246129A1 (en) * | 2005-04-29 | 2006-11-02 | Linardakis Nikos M | Composition for use in treatment of sleep problems and method for same |
| CN101642455A (en) * | 2009-09-04 | 2010-02-10 | 芜湖市诺康生物科技有限公司 | Nerve-soothing capsule |
| CN102973561A (en) * | 2012-11-23 | 2013-03-20 | 西安泰科迈医药科技有限公司 | Drug composite for improving sleep and preparation method thereof |
-
2016
- 2016-12-02 CN CN201611094238.0A patent/CN106619617A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416884A (en) * | 2002-12-03 | 2003-05-14 | 沈阳药科大学 | Melatonin composition with soporific effect and its prepn |
| US20060246129A1 (en) * | 2005-04-29 | 2006-11-02 | Linardakis Nikos M | Composition for use in treatment of sleep problems and method for same |
| CN101642455A (en) * | 2009-09-04 | 2010-02-10 | 芜湖市诺康生物科技有限公司 | Nerve-soothing capsule |
| CN102973561A (en) * | 2012-11-23 | 2013-03-20 | 西安泰科迈医药科技有限公司 | Drug composite for improving sleep and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 孙艳梅等: "三维荧光光谱结合二阶校正法测定保健品中的褪黑素", 《高等学校化学学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407761A (en) * | 2020-04-28 | 2020-07-14 | 广东润源中天生物科技有限公司 | Melatonin vitamin B6 tablet and production method thereof |
| CN111407761B (en) * | 2020-04-28 | 2021-06-18 | 广东润源中天生物科技有限公司 | Melatonin vitamin B6 tablet and production method thereof |
| CN114246834A (en) * | 2021-12-30 | 2022-03-29 | 宣城柏维力生物工程有限公司 | Melatonin orally disintegrating preparation for improving sleep and production process thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |
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